Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: p21.31    Gene: FKBP5

 

BP - Genomewide Association Studies for FKBP5


 

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Description

 
Shown here are the results for gene FKBP5 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
6rs377774735686980AG0.93100.93450.02432.28100036212128(Index SNP)
6rs1220049835793933AG0.96210.92030.03042.195519810894010.20885
6rs939431235780308CG0.98281.06230.02361.987162775294830.87395
6rs775703735656214AG0.95451.06280.02391.958607314841770.90374
6rs276653435793692GT0.83251.08120.03091.941194513324090.24243
6rs276653335793468AG1.00690.94320.02321.925549281045410.75706
6rs938052935783674AG0.98350.94310.02361.888401475119610.86857
6rs1761464235729899CT0.80530.88910.04891.789949150124860.11765
6rs276653535799760AG0.95331.05750.02391.714442690992230.80416
6rs380037435645384CT0.95271.06950.03141.49430749258780.11933
6rs276653835807065CG0.86411.07020.03171.487849463077970.30123
6rs929615735644630CG0.94740.93520.03141.479778564118040.11312
6rs379834635670618AG0.95131.06000.02781.446602489876120.32246
6rs1080715135648846CT0.95880.93460.03251.429924294678400.15569
6rs104380535649410AT0.95821.06740.03251.350275814070480.15294
6rs936689035670952AT0.98571.06320.03061.347656944937290.16221
6rs99210535663161AC0.96521.06650.03241.330683119433890.15294
6rs692613335687353AC0.98870.94300.03051.266000713461610.16221
6rs1045643235779629CT0.95600.94460.02991.248951965179810.29006
6rs1754246635722722AG0.96101.05380.02771.236272596234300.35438
6rs938052435697048AC0.60941.09100.04921.116054804965720.21583
6rs147577435727532AG0.80421.19600.10331.080660363212590.00643
6rs645783635688276CT0.98561.05410.03161.020087589665280.13495
6rs1687859135660605AG0.49390.75900.16681.007225635744640.00652
6rs471389935677259AG0.99010.94980.03150.9892761346082270.13495
6rs774685035712623AG0.98390.94970.03160.9888526392242030.13495
6rs774826635700722CT0.98761.05200.03150.966576244513050.13495
6rs214340435718659CT0.98451.05050.03160.92664829761310.13069
6rs929615835675060AG0.96680.96740.02620.6859220082207870.23392
6rs939430935729759AG0.98961.03070.02530.6339507901997650.27807
6rs1687937835705681AC0.85820.90660.08430.6111885865264760.00643
6rs1687880635677097CT0.89161.10620.08790.5999803649348420.00643
6rs946210435782823CT0.99580.97640.02520.4636941276489660.2549
6rs73705435683465AG0.79361.02800.02940.459795700157940.37965
6rs936887835693592CT0.95240.97610.02630.4478186611606640.24695
6rs691283335725563AT0.98450.97670.02570.4446636720047330.2437
6rs938052535741016CG0.97421.02310.02520.4365189146055890.29401
6rs777172235721976AG0.54121.12180.12880.4295738216410270.00643
6rs471390235722004CT0.81171.02590.02900.4218193903722220.37081
6rs133489435723108CT1.00350.96670.03960.4059390987295820.04737
6rs1252789335693077CT1.00431.03350.03970.3912600809312120.03601
6rs379834735709754AT0.95900.97890.02620.3808022842070530.2437
6rs947008035754413CT0.97641.02060.02510.3805935891132230.29401
6rs939431435791037AG0.95011.02160.02640.3780970391087700.18662
6rs1049873435667751AC1.00510.96950.03970.3608124400642460.04737
6rs75565835657648CT1.00820.97040.03960.3487219860018560.04737
6rs229480735663088CT1.00590.97090.03960.3405592181296820.04737
6rs775169335803252AG0.73791.05110.06810.3338565727084420.01296
6rs690232135778585CT0.95180.98130.02580.333388431580970.2549
6rs471142935791526AG0.94880.98130.02640.3234892897174460.23274
6rs1094756335761415AG0.98271.01810.02570.3134531009369940.2437
6rs776353535770084AC0.75391.02010.02970.2985183643790730.18998
6rs936888135742266AG0.98880.98390.02480.2886990400838340.29006
6rs281704035813584AG0.87060.98230.02790.2814152799725640.18742
6rs239563535779143AG0.98800.98470.02570.261298699565290.25353
6rs136078035715549CT0.98071.01460.02580.2410124531323810.2437
6rs281703235796597CT0.94090.98640.02620.2201871368294200.27175
6rs471390835755288AG0.38820.95200.15810.1216505777822250.00662
6rs281703835810865AG0.86751.00350.02590.04924581840649650.01262
6rs471391935784969AG0.33700.97810.19240.04181850243505220.00652
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.