Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: q21    Gene: FOXO3

 

BP - Genomewide Association Studies for FOXO3


 

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Description

 
Shown here are the results for gene FOXO3 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
6rs9386741109026663AG0.97810.84550.06821.85917781989069(Index SNP)
6rs9372191109030218CT0.97751.18070.06821.828858848971621
6rs9386740109023762AG0.98041.18020.06801.827689031478051
6rs1935957109055034AT0.78860.84740.06891.790484985457370.79167
6rs4946933109087810AG0.99701.16000.06731.562090964460501
6rs12174776108980454AG0.99861.11720.05861.232992636050200.7931
6rs9384680108991102GT0.99851.11460.05891.184555083755650.79304
6rs9386735108990852CT0.99830.89860.05891.158015195409890.7931
6rs9372189108991584CT0.99810.89920.05891.147093241203050.7931
6rs9384681108996762AG0.99920.90120.05831.129479049987240.7931
6rs12055603108998928AG0.99700.90160.05881.106515653781510.78723
6rs3813498109050858CT0.98611.04030.02980.7344746647809260.13793
6rs9400238108981044AG0.92571.05580.04270.690582774221860.31034
6rs9486916109120623CT0.98030.96690.02940.5989442742281560.1133
6rs3800230109104821GT0.99291.04120.03590.5836924129401170.28382
6rs9400239109084356CT0.98760.97180.02560.5783960731301690.08284
6rs9386734108981258AG0.99300.95680.04000.5675117442294940.28382
6rs9372187108982338GT0.99460.95720.04000.5624079677460390.30836
6rs2883881109004079AG0.99700.95710.04010.5624079677460390.28382
6rs17069635108981521CG0.99300.95730.04010.5589335933607370.28382
6rs2802288109002908AG1.01551.02590.02380.5509846836522140.04665
6rs768023108982695AG0.98460.97460.02410.5416643740080530.04665
6rs9384683109006528GT0.99501.04150.04010.5069604116823490.28191
6rs10499051109008873AG0.99600.96090.04010.4953932293580460.28382
6rs9398171109090220CT0.98561.02600.02580.4945786724167190.08374
6rs4946932109081439AC0.98901.02570.02560.4934949675951280.08019
6rs10457180109071732AG0.97760.97540.02570.47807775511650.08046
6rs13217795109080791CT0.97941.02460.02570.4636941276489660.08046
6rs2490272109002079CT1.01361.02230.02380.4509967379742120.04665
6rs9398172109101519AG1.00100.97680.02550.4462383016099960.07735
6rs2253310108995286CG1.01321.02130.02380.4262004177842590.04665
6rs2153960109094877AG1.00020.97770.02550.4250432242354930.07735
6rs2022464109052063AC0.96421.02270.02590.4136377766921340.08046
6rs13207511109060668AG0.78531.02670.03110.4015377995258500.00615
6rs2802290109012373AG1.01060.98000.02380.4011001129361170.04665
6rs13220810109019894CT0.78620.97430.03100.3952341152961130.00628
6rs9372190108996515GT1.01741.03350.03950.3926522232315870.28361
6rs1935952109105598CG0.99940.97900.02550.3909394500699130.07649
6rs3800229109103656GT0.99881.02090.02560.3778896396387810.07735
6rs2802292109015211GT1.01071.01940.02380.377061030788510.04762
6rs4946935109107435AG1.00361.02060.02560.3707943428976960.08046
6rs12198276108978657AC0.77910.97560.03120.3685562309868280.00615
6rs1935949109105980AG1.00121.02030.02550.3655227298392680.07735
6rs4946936109110014CT0.99950.98150.02550.3321736210492890.07563
6rs12211662109043516AT0.14401.15660.23120.2763801644845370.00059
6rs11153120109081146AC0.94790.98100.03910.2043284940539780.00402
6rs9285397109058348CT0.99361.01480.03170.1921944677293750.00703
6rs17310529109064223CT1.00300.98270.03890.1854860476317620.00351
6rs17598747109048086AG0.99811.01670.03890.1738603820640850.00351
6rs17069665109048161AG0.93871.01670.03900.1728246517013070.00391
6rs7341233109046973CT0.96170.98380.03860.1721785723171980.00391
6rs12154031109081271CG0.99151.01660.03900.1718558926962140.00351
6rs12207868109071578AG0.99971.01550.03890.1593921209907100.00355
6rs12197634109078349CG0.99570.98510.03890.1545298670183260.00351
6rs12209092109077373AG0.99641.01500.03890.1533536714228830.00351
6rs12202049109075370CG0.99520.98540.03890.1509493094304880.00351
6rs9486902108984745CT0.98390.98870.03130.1438150732728300.00917
6rs12202209109066718GT1.00420.98630.03880.1415229581866590.00351
6rs9486913109067533CG0.99270.98910.03180.1356669449666070.00697
6rs9480866109069335CT0.99390.98940.03180.1328272488213500.00697
6rs12202234109045776CG0.99711.01260.03880.1266212635908590.00351
6rs12206094109012893CT1.00890.99220.02560.1188436789244360.01618
6rs7762395109051800AG0.99101.00960.03180.1169634899723200.00697
6rs1536057108992316CT1.00520.99250.02560.1146387799684880.0166
6rs1268166109114925CT0.94651.00720.02520.1102502247359620.07162
6rs7747393109008832CT0.98630.99200.03130.09875969792669080.00901
6rs1159806109113531AT0.99250.99390.02440.09560907998763830.06897
6rs1268171109113997CG0.99320.99410.02440.09301884677114590.06897
6rs9486901108982792CT0.94671.00760.03140.09151498112135020.00816
6rs9480867109082339AG0.99441.00770.03180.09135416109288670.00697
6rs1268170109114215AG0.99310.99430.02440.08926890195661930.06897
6rs1268164109115109AG0.99530.99520.02440.0743785452091710.06897
6rs1935958109116339CT0.99040.99380.03160.07427547306393740.00791
6rs12200646109004354AG0.97621.00730.03670.07386342893255120.00423
6rs1268165109115071CT0.99351.00480.02440.0729377565070.06897
6rs9480865109023266CT0.98611.00610.03130.0723730375550460.00917
6rs1268169109114670GT0.99501.00470.02440.07175781684269090.06897
6rs761779109118020AG0.99081.00580.03160.06828793294324440.00782
6rs3800226109095288CT0.98821.00750.04080.06823711151882230.00282
6rs7753734109034534CT0.98470.99450.03140.06535007709928910.00917
6rs1268162109115887AG0.99260.99570.02440.0649464107689350.06897
6rs7746906108985506AG0.97311.00630.03670.06293368798257180.00427
6rs768024108982801AG0.97281.00610.03670.06168045665784430.00391
6rs1268167109114876AG0.99321.00400.02440.06018133717862050.06897
6rs1268161109118526AG0.99071.00470.03160.05418687341266150.00782
6rs2207731109120357AG0.99460.99710.02440.04349540968330250.06897
6rs3778586109093299AG0.83411.00400.04580.03119028608714180.00282
6rs3800227109100854AG0.96651.00220.02710.02853859497541330.01268
6rs12196996109090760AG0.97390.99700.04140.02594909720712260.00285
6rs7772662109083800AG0.96910.99770.03870.02118061326715770.00387
6rs12203834109082255CT0.96951.00200.03860.01813610900864960.00387
6rs12203787109082157CG0.96811.00140.03860.01287023234010290.00391
6rs3778588109103246CT0.95890.99900.03180.01108447948731330.00826
6rs12212067109087889GT0.99161.00070.03900.006607862550997470.00316
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.