Metamoodics Gene Information

 

  Chromosome: chr12    Cytoband: p13.31    Gene: GNB3

 

BP - Genomewide Association Studies for GNB3


 

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Description

 
Shown here are the results for gene GNB3 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
12rs20710586831154AT0.88050.97880.02660.376750709602100(Index SNP)
12rs54466826723CT0.86810.97930.02690.3589226866746260.96429
12rs22269556835455AG0.85540.98040.02680.3373365904259620.96339
12rs23013396824885AG0.83391.01920.02730.3139897086847140.92976
12rs22381146836001AC0.88461.01850.02650.3093609882840331
12rs10477716811282AG0.46080.97500.03870.2900519834892390.00191
12rs49635186816754CT0.50430.98260.03380.2192507688964480.01531
12rs107447206834474CT0.51201.01930.04070.1947710857965740.1249
12rs49635176818061CT0.54930.98540.03210.1890286001777930.01703
12rs107447166810111AG0.40241.01580.03700.1725014918665410.00071
12rs108495276816621CT0.46141.01490.03840.1548399223480540.00806
12rs54406819160AG0.52140.98790.03250.1494762911210060.03591
12rs49635166818289GT0.53050.98460.04670.1306509192409070.02181
12rs37593486817993CT0.52351.01090.03550.1194722218011950.00206
12rs22693556816175CG0.47381.00990.03430.1111468330170640.00054
12rs10477766818953AG0.56740.99090.03270.1083510561294410.13422
12rs37593476817941AG0.53130.99220.03560.08265206237222840.00218
12rs49635116813631AG0.48171.00870.04960.06519865825346330.01286
12rs54426825125AG0.55391.00980.05720.06293368798257180.07012
12rs54396819143AC0.43900.99210.05840.04987865248862661e-05
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.