Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q25.3    Gene: HABP2

 

BP - Genomewide Association Studies for HABP2


 

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Description

 
Shown here are the results for gene HABP2 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
10rs10749136115323050AT0.85310.92590.02642.44867201199615(Index SNP)
10rs1535426115325413GT0.99921.07050.02342.442372511573170.61111
10rs2419840115322088AC1.00251.06920.02342.378512135419370.59961
10rs7101144115322840CT0.98901.06840.02352.310424784240060.61111
10rs3740530115324114CT1.01141.06810.02432.170760571858610.22289
10rs10749135115322230CT1.00570.93580.02452.167618839752960.21739
10rs7915951115298316CG0.93281.06770.02502.059383917662590.04224
10rs1157916115293733AG0.98490.93850.02432.045902279520810.00617
10rs7094824115311119CT1.00151.06470.02541.867100230055520.03073
10rs7079148115320376CT0.99571.05770.02461.650916831220410.1054
10rs911708115321935CG1.00651.07140.03061.611898798429480.11224
10rs911707115321608AC1.00811.07050.03061.585026652029180.11224
10rs10509981115306715AC1.00720.94800.02411.576754126063190.02867
10rs2240878115303333AC1.00511.05670.02491.573488738635420.0129
10rs6585234115320638CT1.00710.93440.03061.572189427324010.11224
10rs3850691115319336AG0.92990.93420.03091.555330769061480.125
10rs2286745115317183AG0.73041.06450.02851.546070407942270.0489
10rs4918852115317808AG0.72961.06450.02851.545002782690540.0399
10rs4918853115320120CT1.00780.93560.03061.527682453683160.11224
10rs7101303115321106AT1.00760.93690.03061.475344287642220.11224
10rs2240879115302801CT0.97931.05380.02471.468904453129970.0171
10rs3862019115318940CT0.60200.93290.03291.458046525541760.24528
10rs3781390115304108AG1.00601.05300.02481.428757149439780.01676
10rs10509980115304488AC1.00100.95070.02441.413862974769210.0215
10rs2419836115316403CT0.68490.94430.02831.365522729839270.01864
10rs11196370115299765AG0.99050.95210.02511.294136287716080.0104
10rs11196371115299918AC0.99201.05020.02511.292685366411290.00653
10rs2000278115300088AC0.99241.05010.02511.290730039024170.0104
10rs7097031115322265AC0.99650.95640.02381.213887716280170.16278
10rs1535427115323741AT1.00330.95100.02721.187086643357140.17416
10rs11196389115341995AG0.90710.93100.03921.165579296318470.02174
10rs7923349115326357GT0.99340.95100.02771.155584959526180.16667
10rs2419841115325973CT1.00511.06890.03761.117247844386920.02632
10rs11196390115342157CT0.90330.93300.03951.100617294466730.02174
10rs2240877115333576CT0.90360.93480.03951.058339521611610.02174
10rs2240880115302596AG0.90321.05700.03261.050951707684340.00102
10rs11575676115322921AG1.00611.06600.03781.042584285277330.02667
10rs10885478115338906AG0.90191.06840.03931.035598928837270.02174
10rs11575670115318850CT0.40730.94090.03661.020087589665280.26498
10rs4545483115312143AC0.97961.04030.02371.016463918397010.00263
10rs2286742115330482AG0.82620.95800.02581.015202742910710.09497
10rs2286744115328295CT0.99630.95500.02781.012870232340100.16667
10rs3781388115307022AG1.00521.04040.02470.966576244513050.01384
10rs11575693115341066AT0.40260.77540.15960.955068453850840.01282
10rs11575674115319876AG0.58931.14550.08860.902742690306580.02632
10rs2419839115319083AT0.84220.96410.02540.8227521637443770.82759
10rs10749134115316776AG0.57761.04870.03440.7765040590376050.00151
10rs11575661115315778CG0.68600.91590.06430.764219129672440
10rs11575634115311814CT0.93760.95410.03520.7404061211140510.01185
10rs11575631115309651CT0.93660.95460.03510.7325935812470960.01308
10rs3781386115308011CG0.99731.03130.02340.7290883605895190.00573
10rs3862016115312912CT0.95500.96930.02380.7187393129449870.00113
10rs3862015115312836CT0.97541.03120.02360.7137681459714470.00254
10rs11598490115343728AG0.90250.94250.04750.6734593314834380.01314
10rs11575624115307252CT0.96440.95680.03550.6708055849115490.02372
10rs10787493115340919AC0.95170.96550.02840.6643415477106980.16267
10rs7088038115314489AG0.94811.02980.02400.6540384581868596e-05
10rs4918858115343242CT0.94431.03550.02860.652474840001310.16267
10rs7898339115348810CG0.94150.96540.02910.6434005642750290.03548
10rs4918859115343691AG0.94271.03530.02900.6362000545208910.03744
10rs11575625115307701AG0.96611.04230.03540.6149302236680650.02647
10rs7917138115316151CG0.72430.95450.04320.5503673495299250.01448
10rs6585233115315299CG0.88910.95890.03960.5382014424748910.00475
10rs1885437115327383AG0.99361.02470.02390.5106040782728710.28947
10rs11575688115333047CG0.51821.10110.09700.4934949675951280.01299
10rs11575645115313632CT0.91600.97380.02690.4902599844296180.00846
10rs11575662115315998AG0.60111.04900.05900.3796557002455071e-05
10rs11575646115313908AG0.77300.97720.02970.3581294545236870.00851
10rs11575663115316093AG0.68551.04670.05900.3571399474155080.0045
10rs3850688115315857CT0.74781.02070.02690.3498868355564290.00048
10rs11575686115330191CT0.29111.08000.10380.338565949606080.02229
10rs3850689115316142CG0.83350.97890.02940.3289197672611510.00488
10rs11575690115339923CT0.24840.89490.15720.3187587626244130.02743
10rs10787491115334557GT0.92361.01700.02610.2865934678323090.26766
10rs3781383115309479AT1.00970.98510.02540.2561767783962500.00156
10rs4917657115308537AG1.00430.98570.02540.2428318077857270.00062
10rs11575687115331140CT0.81650.98440.02870.2333641136897320.03831
10rs11196386115334345AG0.88451.01670.03040.2329183786366780.38079
10rs11575664115316786CT0.82080.97650.04390.2312879196223360.04121
10rs3758591115300542CT0.98351.01370.02580.2225731776106890.00719
10rs2000277115300504CT0.98171.01370.02580.2221383758237580.0162
10rs11575668115317074AG0.82310.97750.04380.2199708726626620.03716
10rs10787490115309978AG1.00921.01320.02540.217455715989990.00156
10rs11196375115313596AC0.93990.98630.02820.2046066650687110.00144
10rs2419837115317389AG0.45980.97880.04490.1989394701521440.01163
10rs4918844115309701CT1.00751.01220.02530.1985276864785290.00156
10rs11575643115313492GT0.95591.01320.02790.1947030838420150.00958
10rs932652115334779GT0.96280.98880.02400.1940915449258030.1873
10rs12248978115297550AG0.99380.98460.03310.1936843301918860.0241
10rs2302373115333277CT0.92010.98890.02480.1852863873040230.04179
10rs1574675115334709AG0.91920.98950.02480.1734069460659520.02976
10rs11196379115314348AG0.94070.98820.02810.1721785723171980.00958
10rs10885477115322403CT0.98511.01900.04670.1627904721987940.04545
10rs4614370115315199AG0.93690.98880.02810.1612138550534050.01146
10rs4918851115315435AC0.93461.01130.02810.1610250450445320.01453
10rs7088443115315021AG0.93720.98890.02810.1603962705291630.01257
10rs2419813115315317AT0.93491.01070.02810.1515645446685290.00958
10rs3781387115307642AG0.92631.01240.03510.1391232035967028e-05
10rs2245058115331836AG0.90991.00810.02480.1276106115821790.20268
10rs2245056115331743AG0.90891.00800.02480.1266793981846010.20268
10rs10885476115320711AG0.99821.01000.03130.1249966463999590.00153
10rs11575623115305810AG0.97281.01000.03260.1189007816109830.00057
10rs11575685115329964CT0.77791.01520.05090.1152612622303680.01861
10rs7096084115321655AG0.99861.01280.04680.1047432468551050.04054
10rs11196391115345318AG0.98551.01020.03780.1032533843925940.00794
10rs3740532115323684AG0.98210.99250.02850.1015490808016250.15934
10rs11575683115327675AT0.91670.98790.04810.09669292003582620.04054
10rs3758589115301037AC0.97570.97900.08830.09124698081546630.02694
10rs4918842115306802CT0.99110.99170.03480.0909791457888440.00224
10rs4917658115308560AG0.98280.99350.03270.0743785452091719e-05
10rs1885434115340587AG0.98941.00480.02460.07201405290057140.08434
10rs12241995115347068AG0.92690.99470.02800.07073438174693450.00958
10rs1140115344562CT0.71430.99330.03580.07017251876930860
10rs7071251115327331CT0.97561.00540.02870.07007043991541210.15934
10rs2302374115326748AC0.98260.99520.02870.06183065360967970.15934
10rs932651115337311AG0.99480.99600.02450.06083032037482260.07703
10rs3911899115315989AG0.88681.00590.03620.06018133717862050.00024
10rs11196383115324626CT1.00151.00700.04670.05453141486818030.0411
10rs3850690115316183AG0.84761.00860.05940.05266432405126010
10rs932650115337349CT1.00741.00340.02430.05153812993871650.09226
10rs2181082115331535CG0.85251.00370.03200.04229695845116860.08516
10rs3781378115335840CT0.81270.99610.03620.03862637240519890.11781
10rs885567115347169CT0.92891.00290.02800.03800971255993520.00632
10rs911704115333690AG0.84541.00270.03290.02942069428514910.07237
10rs911701115333821AT0.84420.99770.03290.02484402159331060.07618
10rs10885479115341095CT0.92090.99830.02810.02140867317992530.00958
10rs911700115333842CG0.84460.99820.03290.01940584422377980.07237
10rs11575684115328605AG0.95650.99910.02900.01108447948731330.15934
10rs1853204115298446AG1.00020.99930.02670.009172949432521159e-05
10rs11196368115294604CT0.99870.99940.02680.008375265465994640
10rs4918838115293789AG0.99991.00020.02680.002832128554166040.00245
10rs1157915115293502AG1.00081.00020.02680.002002363591995679e-05
10rs4342960115294389AG0.99900.99990.02680.001784267629041680.00123
10rs7089883115340090AG0.93581.00010.02750.001304841688344280.01571
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.