Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q23.31    Gene: HTR7

 

BP - Genomewide Association Studies for HTR7


 

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Description

 
Shown here are the results for gene HTR7 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
10rs708446892594119AG0.99021.05310.03141.00256992620253(Index SNP)
10rs193535092570574AG0.97820.94770.03710.832387327272470.74657
10rs1118631492555933CG0.94091.07920.05290.825649402520620.19386
10rs791742292483177CG0.99941.05060.03460.8130436645345880.00695
10rs1118633892604382AG1.00360.95600.03170.8074325466634540.04213
10rs1224106192586199AT0.95120.92960.05280.7770235501066090.19386
10rs1118634192613428CG0.99480.95740.03180.7657358756212110.04213
10rs1050960892494034AG0.99530.95430.03490.7423214251308150.00911
10rs242036792516163AC0.85701.03420.02520.7408841558149340.14706
10rs1752669792490499AG0.93340.95130.03760.734239083282390.0276
10rs1710017892542254AT0.99100.90820.07360.7187393129449870.14511
10rs493319492501347CT0.98351.02890.02350.645699437654640.13732
10rs127444892480909CT1.00100.97420.02330.5816987086802550.14209
10rs1159125892524109CT0.93881.05950.05160.5808706922580240.34879
10rs1118630092504719AC1.00520.97430.02330.5780671867214920.14701
10rs1118629792494298CT1.00181.02600.02330.5676722077383960.14701
10rs1078597392588151AC0.81250.97030.02780.5579908408590480.08955
10rs127444692489598CT1.00011.02560.02330.5540845860488770.13977
10rs708953392595344CT0.99720.96170.03640.5483670525430090.74657
10rs790038692504010AC1.00591.02520.02330.5448504788201720.14251
10rs193534792495384AG1.00271.02500.02330.5386515663520170.14701
10rs242020392497843CT0.99031.03750.03500.5329841815615640.01138
10rs708412592614949GT0.93551.03860.03620.5306198641500750.86325
10rs193534692612406CT0.99581.03800.03590.5247647773958720.85475
10rs153972192482530CT1.00821.05550.05200.5247647773958720.19517
10rs790357292508223CT1.00431.02440.02330.5211450324713370.14701
10rs1276110592603397CT0.99451.03650.03590.4970269409343690.808
10rs1088183292538743CT0.99020.97750.02350.4795164672592080.15079
10rs1159992192523921CT0.97391.03020.03090.4750848524601330.04442
10rs791684892503857AT1.00411.02240.02330.4672456210075020.14466
10rs707471592599286AG0.99621.03510.03640.4652126413705080.74657
10rs193534992584323CT0.99510.96670.03650.4521022824369030.74657
10rs709360292586798CT0.99671.03360.03650.4384216316990390.74657
10rs110768892485316CT0.99730.97000.03440.4262004177842590.00695
10rs445920292592378AG0.99551.03290.03650.4260845595784490.74657
10rs1226416092590065AG0.99740.97290.03110.4236586497942070.04735
10rs1226101192570787AG0.98461.02710.03110.4090467648120140.05052
10rs1276863892520111AC0.99371.04470.05100.4076011538844360.20562
10rs218570692593125AG0.99661.03160.03640.4053864908399020.74657
10rs1224937792582936AC1.00120.97570.03110.3684547721656910.04676
10rs791640392549888GT0.98430.98150.02380.3632113109656250.23495
10rs790456092534746AG0.99631.02190.02810.3558569494900814e-05
10rs708255892566911CT0.99071.01780.02350.3451499094386060.14572
10rs374004692491448CT0.99790.97700.03120.3419886033428880.04213
10rs658373592577480AC0.99581.01750.02340.3378090091409930.14701
10rs141821392491630AG0.96031.02520.03460.3254143976970860.00517
10rs129805692484951AG0.99710.97810.03120.3201180578871380.0419
10rs1050960992495354CT0.99680.97900.03130.3039058400047770.04213
10rs791672092616547CT0.99430.98100.02880.2960211749916140.00024
10rs658373692583160AG0.99701.01560.02340.2948207551263240.14209
10rs1159251292499809CT0.99750.97960.03130.2923446764688130.04264
10rs222611692590219GT0.92881.02190.03310.2907300390241690.03571
10rs1088183092503229GT1.00121.03190.04800.2898826348881840.19386
10rs1159699192588438CT0.96030.96830.04980.2854187911604690.34879
10rs1225906292600025AG0.94970.98390.02550.2802545074704230.3435
10rs1088183392540773AT0.98220.97300.04550.2621714941042150.02004
10rs1118630692533466CT0.97370.97330.04570.2563334785537870.02186
10rs791910392605165CT0.97521.01370.02360.2471835688117290.14701
10rs157393592554807AG0.99030.98660.02360.246493543009030.22049
10rs1118629892501484CG0.98371.02570.04500.2420728168866710.02168
10rs1118629992503323AC0.99071.02550.04490.2403321553103690.0184
10rs1222086692495522CT0.98290.97560.04510.2335127937603060.02168
10rs792062792534625CT0.98361.02660.05120.2158107946190390.19386
10rs428432092485634CT0.99141.02320.04510.213674565609930.02357
10rs710012992615125CT0.85420.97460.05300.2024554856382740.25684
10rs95506492532479GT0.98191.02520.05240.1972946729256480.19386
10rs1159651892544991AG0.94010.98630.03140.1808510571928660.04497
10rs290112792585046CT0.99460.98250.04580.1549640064865850.02186
10rs707454892540604AG0.33120.93620.17430.1515645446685290.05663
10rs791216492509934CT0.98870.98930.02880.1497214474819630.31859
10rs1088183592571357CT0.95600.98370.04560.1433315163884650.02168
10rs189131192608596AG0.97570.98350.04780.1381670023420550.01982
10rs1118632092566428CT0.97601.00730.02610.1070154492892830.14686
10rs1118633392595099AG0.99471.01160.04600.09625905937846140.02186
10rs1088182992501801AC0.82301.01240.05030.093449480898550.00332
10rs708648492523709AG0.99501.00650.02640.09264239186882710.52941
10rs1181270892495245CT0.99400.99330.02900.08825662214406830.31859
10rs708372992614650CT0.98671.00530.02510.0801377464444620.35256
10rs1181736492488006AG0.99110.99450.02910.0704788993688960.31859
10rs1225439092610128CG0.98591.00470.02510.07037674848475970.34908
10rs708740092577160AG0.96710.99530.02620.0669178376302090.16452
10rs709103992524735AT0.98711.00480.02880.06148027482350810.31859
10rs1241249692536145AG0.98640.99620.02880.04803141550708920.31859
10rs1225940192584101GT0.94630.99680.02630.04488976902944820.13592
10rs1159990292588803CT0.98571.00290.02600.04000516167158380.15355
10rs427271392539952AG0.98761.00250.02880.03137697904301120.31897
10rs1118630992551537CT0.98710.99760.02880.02932775731028060.31859
10rs1159454892554171AG0.98600.99770.02870.02812138297373420.34945
10rs1276685192552811CT0.98521.00220.02870.02710321556345560.31859
10rs1088183892580213AG0.98440.99810.02600.02631808149601630.15355
10rs707252692519250CT0.99220.99800.02890.02415477453243290.31859
10rs452050492592353CT0.96410.99860.02640.01881586260164570.17345
10rs1078597292583780CT0.98131.00130.02610.01800028587012170.15355
10rs1277518192554437CG0.90421.00350.07380.01691522726221150.19386
10rs493360792535049AG0.98641.00140.02870.01664438566821170.31859
10rs1159747192588747CG0.98480.99910.02600.01237841787451620.15355
10rs193535192555705CT0.98490.99970.02870.003575896044908880.31859
10rs493319592564219AT0.98501.00020.02870.002133273760855240.31897
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.