Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: q23.3    Gene: MAP3K5

 

BP - Genomewide Association Studies for MAP3K5


 

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Description

 
Shown here are the results for gene MAP3K5 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
6rs4363056137039312CT1.01390.94220.02381.90483064856824(Index SNP)
6rs6928243137074186CT1.00720.95420.02311.371611069949690.23212
6rs1009709137059442CT0.92011.04930.02421.326610421811690.3099
6rs11752550137084520AG0.97381.04800.02361.326150022657050.38742
6rs1009711137062329CT0.91840.95350.02431.302857873724540.3099
6rs11154880137063217AG0.92100.95450.02421.265120197207370.3099
6rs9399193137083759CT0.95570.95760.02381.164563105198140.32797
6rs4896217137080595AG0.97301.04370.02351.162664131984990.32595
6rs9389429137084096CT0.97250.95820.02351.15583358954980.36552
6rs911185137075399CT1.00110.95920.02321.141282385139710.2695
6rs12525244137085414AT0.97251.04310.02351.137928280620010.32738
6rs1321477137083526CT0.97291.04290.02351.130533589919130.32439
6rs6570089137077773AT0.99671.04230.02321.128719027142030.2812
6rs911182137076157CT0.99841.04220.02321.127028369261560.28217
6rs9373173137088444AG0.96831.04290.02361.125286311242220.32439
6rs1028565137083058AG0.97290.95910.02351.118900781610980.32439
6rs11154879137047060AT0.55050.93890.03591.101110344073410.15407
6rs9285484137092247AG1.00071.04140.02321.093664958194910.3099
6rs12529555137092737AG0.97910.96000.02361.078157518594140.38742
6rs9402843137088889CG0.99001.04050.02331.053596866100950.3099
6rs9385772137091048CT0.97430.96070.02351.051538129938720.33689
6rs720345137089954AG0.97350.96080.02351.049099910633610.32439
6rs6570090137086891CT0.97911.04050.02351.043063586155800.2987
6rs9376226137091526AT0.99441.04010.02331.041818502435050.32193
6rs1581713137088173CT0.94710.96040.02391.041388342235120.33693
6rs720344137090135CG0.97290.96110.02351.037962313434990.33689
6rs9402841137071514CT0.99660.96180.02321.026687379547100.27584
6rs7739002137120748AC0.56761.07550.04361.023145853423780.04377
6rs6570091137092589CT0.99840.96200.02321.019088062223160.3099
6rs9389431137089050AC0.99240.96190.02331.018317272628710.3099
6rs9385771137089730AT0.97121.03960.02361.003138231509330.32439
6rs911179137103776AG0.98800.96240.02350.990124366287840.38742
6rs9483945137099066AG1.00060.96350.02320.9629721202442250.32439
6rs6938120137067159CG0.99010.96340.02330.9609826780025880.28217
6rs9321567137067959GT0.99021.03770.02330.9480760839538930.2812
6rs4896214137070593AG0.99451.03750.02330.9457700901366030.29063
6rs9389426137069138CT0.99470.96390.02330.9446216686250.31227
6rs12664803137116796GT0.97201.03770.02350.937042165915490.28619
6rs6941553137093621CT0.97950.96370.02350.936666641048250.32439
6rs9389425137069120CG0.99420.96420.02330.9318141382538380.27753
6rs6570098137113348AG0.98110.96390.02340.9310723883179280.30552
6rs1819155137107482AG0.98110.96410.02340.9262816496538770.31565
6rs1570056137101620CT1.00100.96450.02320.9237237445957820.3099
6rs7761520137094870GT0.99361.03700.02330.9233595563296580.31565
6rs6936533137093164AT0.99310.96440.02330.9233595563296580.3099
6rs10484491137069560AG1.00090.96470.02320.9175736991392280.28217
6rs9784881137097512GT0.99241.03680.02330.9157813132607610.3099
6rs9373172137068475AG0.93011.03790.02410.9125735429637150.24684
6rs4243449137064415AG0.98281.03680.02340.9093892921715930.26482
6rs1570055137101396CT0.98891.03670.02340.9093892921715930.32439
6rs12198737137037480AG0.63241.07250.04690.8690233083943830.23168
6rs11154883137101643AG0.99310.96650.02330.8422411139531360.32439
6rs6925103137117703CT0.97351.03370.02350.79723931260680.28365
6rs4896219137121235AC0.97300.96840.02350.7644715530924510.2422
6rs2237268136994623CT0.95821.03080.02450.6645420993106160.00732
6rs12195309137103256AG0.11401.23770.17800.6363880201078560.01996
6rs9402836136992586CT0.95311.02990.02460.6360121702515090.00613
6rs9483937136996842AC0.93821.02870.02460.6024075659618830.01269
6rs7775356136998333AT0.94491.02860.02460.5992893632267690.01753
6rs12153890137054283AC0.61200.96040.03530.5972229303896530.12693
6rs6912397137004526AG0.77681.03110.02710.5882119954561310.01127
6rs2064205136999357CT0.95301.02670.02450.5508302678347990.01655
6rs3765259137031976CT0.56201.03360.03110.5392524581558030.16719
6rs9389413136976441AC0.45711.18820.16590.5250556645346120.00487
6rs958293136999926AG0.90821.02550.02490.5054280157698010.00934
6rs9385770137004301CT0.84281.02620.02610.4937656403878740.00197
6rs6906871137003910AC0.86601.02570.02560.4917396944876660.00948
6rs6917580137001971CT0.92451.02490.02490.4907974776688970.00732
6rs9376219137005583CT0.51910.96860.03390.4602967610521740.0023
6rs9402835136981494AG0.42371.14180.16410.3778896396387810.00487
6rs9376205136940780AT0.18230.87700.16950.3580304022979410.0057
6rs7755097136942169CT0.94450.97420.03470.3456309090247140.00686
6rs9389405136932767CT0.97161.02560.03360.3449576586687980.01508
6rs9389407136940034AG0.98000.97500.03480.3301254975101970.00333
6rs7767701136933755CT0.93850.97580.03380.3292904047762030.01644
6rs9389406136935506CT0.99031.02480.03460.3192113884933180.00603
6rs4631311136934896AG0.98280.97680.03360.3139897086847140.01106
6rs9385763136931575AG0.92450.97620.03490.3100698959817820.00686
6rs2237262136929027CG0.98431.02320.03360.3056580896358190.01051
6rs9321564136981511AG0.80551.02150.03420.2728655762395110.00275
6rs3799472136910622AG0.98880.98040.03190.2705922030369320.00493
6rs9402824136932511AC0.94540.97950.03370.2686530244540450.01575
6rs9402839137036903AG1.01431.02190.03640.2590060684151140.08907
6rs7748892137044971AG0.98550.96020.06850.2569608451950670.01996
6rs6570084136945928AG0.97781.02010.03370.2554723265274330.01051
6rs6570083136945695AT0.98481.02070.03470.2552377629344220.00365
6rs3903660137161271CT0.97950.98650.02420.2406343783440710.18084
6rs3757165137157712CT0.98851.01340.02400.2364222755333550.16695
6rs9376211136948277CG0.97880.98160.03370.2347786336950190.01051
6rs6912539137150450AG0.99100.98720.02410.2275315969467200.19671
6rs9376221137034072CT0.95181.02370.04380.2270918050287280.05843
6rs9389421137030936AC0.46631.01880.03500.2255560310750350.18565
6rs4524621137153357CG0.99071.01280.02410.2227907418543150.19671
6rs2237263136937159AG0.97580.98220.03430.2214146721370380.00392
6rs9376222137034962CT0.94590.97750.04420.2176707310031630.05843
6rs9321570137137372CG0.98791.01240.02410.2156680519778520.19122
6rs1570054137143419CT0.99311.01230.02410.2123978538176620.20691
6rs2327760137163489CT0.97031.01240.02440.211690187892950.17364
6rs2327742136925861AG0.98531.01660.03300.2087305190897320.01435
6rs9494554137038675CT0.94721.02210.04420.2069783401540170.04943
6rs9483947137147093CT0.99380.98820.02410.2064191326318440.20691
6rs3734552137154326AG0.98910.98820.02410.2060699932273150.18084
6rs9494555137042799AC0.93980.97860.04440.2030789246698310.05928
6rs13195420137030728AG0.44411.01720.03550.2005216011620190.05561
6rs13193586136929885AG0.65260.97250.05830.1990768181867820.0603
6rs9402845137131215AG0.98120.98850.02420.1978422468130380.19122
6rs9494569137146486CG0.99690.98860.02400.197773762308930.19502
6rs6570087137048621AC0.98751.03230.06840.1923973300835050.02024
6rs11755484137164797AG0.51500.97270.06110.1865524557351790.03543
6rs926401136916395CT0.98740.98530.03310.1846879564756410.01508
6rs7761896137048809CT0.98821.03020.06800.1796014772960180.01996
6rs2327743136950935CT0.94210.98780.03290.1494762911210060.02001
6rs9402830136950414CG0.96691.01270.03400.1491700401514690.00729
6rs4351280136919739AG0.98251.01190.03320.1420647352805710.01575
6rs1022690137126989CT0.97511.00850.02390.1413425159091920.12451
6rs9376201136920854CG0.98751.01210.03410.1396020948726870.00643
6rs2237270137008434CT0.99920.98940.03120.1357856695386700.00651
6rs9402846137135070CG0.98021.00810.02380.1346590943754160.12146
6rs7753357137042251AT0.97101.01430.04220.1326503828112080.06626
6rs9389402136915707CT0.98680.98930.03310.1283686954624460.01435
6rs9494552137026937CT0.93410.97840.06690.1279603320267140.00264
6rs3757161136914204CG0.98420.98930.03320.1278437272517070.0273
6rs932589137124831CT0.98761.00780.02380.1274941006540750.13643
6rs760863136951409AG0.96581.01020.03290.1197582241045200.01508
6rs9376200136915612CT0.98971.01050.03410.1189007816109830.00643
6rs11154886137140817CT0.98910.99290.02370.1174185464455490.12451
6rs13203080136926504AG0.54570.98670.04520.1155445039295122e-04
6rs6916746137010692CT0.97741.01960.06550.1150914058373930.00264
6rs9494547137005186CT0.49311.02530.08830.1092996023011250.00264
6rs9494548137005255CT0.48221.02560.08940.1092437480817820.00264
6rs12164028136971628AG0.95711.02790.10000.1062382379420570.00981
6rs2237271137010234AC0.99941.00840.03120.1036942925339190.00651
6rs9376212136960912AT0.93981.03080.11320.1029780439396370.00981
6rs9483938137017663GT0.97910.98300.06590.09952362861074310.00264
6rs9494549137005747AC0.54691.01970.07630.09772507952549830.00017
6rs6910488137016894AT0.98221.01670.06580.09636748391576230.00264
6rs2277100136963812AG0.93671.02900.11580.09420411963213150.00981
6rs760862136951357CT0.97550.99200.03280.0932879430570360.01508
6rs1997703137011546CT0.96601.00750.03140.0909791457888440.00966
6rs9389409136949281CT0.96970.99230.03400.08618614761628330.00643
6rs9402827136949309AG0.96810.99250.03400.08354605145007490.00643
6rs6904753137015976CT0.96551.00670.03140.08034671768963580.01004
6rs2237269137008312CG0.98570.99390.03300.06940751155740170.02784
6rs6914406137022491AG0.92020.98200.10070.06722192993944950.00981
6rs9385764136931912CT0.93881.01760.11650.0552213188764930.01008
6rs3757163136916144CT0.98610.99520.03290.05408848318072660.01508
6rs2076260137019261CT0.95380.99560.03130.05153812993871650.01968
6rs17654215137102706CT0.62271.00780.05860.04871106272232790.02636
6rs17723504136955846CT0.94530.98600.11610.04421607108308860.00981
6rs7773600137026912AG0.88411.00360.03190.04129280891271530.01312
6rs6932836136958382AG0.94191.01330.11610.04129280891271530.00981
6rs17796516136960547CT0.94270.98690.11610.04110180528922830.00981
6rs9402829136950109CG0.92760.98710.11740.03990993209508050.00981
6rs6922031137011307CT1.00551.00330.03410.03526907894637070.01796
6rs6570099137114086AG0.94390.99390.06560.03348282355320810.02517
6rs9385767136967559CT0.92850.98940.11500.03334211579824220.00981
6rs2076262136954910CT0.95841.00990.11430.03086376640328750.00981
6rs6910459137016799CT0.99321.00550.06520.03021146258506110.00264
6rs9376206136944187CG0.93471.00980.11660.02983915696268620.00981
6rs9402838137015009AC0.52851.00270.03320.02863136320857670.10981
6rs9376207136944230AG0.94001.00760.11630.02323747673253940.00981
6rs12530245136926343CT0.95620.99400.11610.01827197463838380.00995
6rs9399187136918132AG0.93890.99450.11610.01668951420588450.00988
6rs9376203136933958CT0.94470.99450.11620.01664438566821170.01008
6rs2272887137021827AG0.97870.99880.03290.01322826573375510.03085
6rs2237264136961671AG0.95291.00360.10970.01153022979012450.00981
6rs9376202136933439AT0.94491.00380.11720.01139645665433610.00995
6rs1011969137020933AC0.99091.00100.03260.01103992960966200.02979
6rs17723721137013261CT1.00260.99920.03420.008419542825660180.01796
6rs9376204136940430AG0.93831.00270.11630.008065450281052170.00995
6rs17796708137016316CT0.97191.00070.03440.007137328610972330.01907
6rs9402826136945615AC0.93501.00240.11630.007049039429553560.00981
6rs9385765136938669AG0.94960.99820.11660.005287014568429780.00981
6rs2282857136957266AG0.58001.00070.11630.002176919254274550.01484
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.