Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT1E

 

BP - Genomewide Association Studies for MT1E


 

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Description

 
Shown here are the results for gene MT1E from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
16rs160412255220801CG0.89771.04890.03520.756713853916554(Index SNP)
16rs182721055224783AC0.86790.95360.03620.7230788679342260.81352
16rs207083655217621CG0.70341.06170.05350.5788898702065660.3245
16rs201870355209552AC0.68781.02840.02800.4974363308926370.17291
16rs90477355209102AC0.70541.03360.03640.4390179444137650.02848
16rs200198555209716AC0.70551.03360.03640.4387793210660560.02869
16rs993674155225286CT0.93451.04410.08510.2130357405642670.22581
16rs478394655208810GT0.89620.98220.03790.1970211446647380.01984
16rs201872455209932AG0.89401.01810.03790.1968161114646580.00388
16rs1293416655207975GT0.95940.98740.03500.1446625955304600.02162
16rs1107615955228328CT0.91400.97760.08560.1018784244588920.22581
16rs227083655225115CT0.66100.99390.03000.07613452481449860.11192
16rs740388155212672CG0.59420.99430.03040.0697643472337150.02621
16rs805572455207138CT0.98060.99540.03230.05256627811294920.00465
16rs478470155228168GT0.83061.00360.02600.0510005459730470.25175
16rs182720855224387CT0.80751.00040.02630.005902910411790010.24894
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.