Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT1H

 

BP - Genomewide Association Studies for MT1H


 

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Description

 
Shown here are the results for gene MT1H from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
16rs206254655261718AT0.82220.93150.05070.791021482723747(Index SNP)
16rs229884655258816AG0.67890.91380.06960.7090754406172460.00274
16rs478470855261415CG0.83001.07150.05470.6836102489268050.00695
16rs385911355257468CT0.51530.93430.05700.6317131150978690.00709
16rs453172955272021CT0.96280.97810.02410.4457531918338890.04047
16rs201118655263370CT0.79621.02210.02660.3865810549654270.08936
16rs1270896355253165CG0.79761.03580.04330.3800722897085320.00671
16rs478395055269059CT0.79740.98310.02670.2824959252357980.0514
16rs719489555254592GT0.94230.98960.02490.1719204094432540.00704
16rs1164779655254052AG0.96930.99050.02470.1546538625885910.00553
16rs1270896255251876AG0.97711.00940.02450.1528593825865940.00626
16rs229884755258795AT0.70820.98930.04260.09620485725896470.50752
16rs1244353555251824CG0.85830.98260.09130.0718090519612430.00272
16rs1244798655253047CT0.92251.01370.08890.0563571172478710.00272
16rs1107616255251731CT0.87351.00970.09160.03815194098167570.00272
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.