Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT1X

 

BP - Genomewide Association Studies for MT1X


 

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Description

 
Shown here are the results for gene MT1X from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
16rs1333693655280073CT0.70310.85110.07741.42864060724616(Index SNP)
16rs718881955282867AG0.50610.85490.08271.235973392307961
16rs1107616555276970AT0.96940.96430.02410.8837244124194560.01865
16rs448227855284375AT0.97411.03660.02400.8709549401120420.01849
16rs1259860055279371CT1.00681.07470.04830.8671002300555170.00162
16rs719539455277779AG0.96970.96510.02400.8541822855081720.01865
16rs1107616355276578GT0.96860.96520.02410.850780887344620.01909
16rs1107616455276905CT0.97221.03590.02400.8483237691529520.01837
16rs806410055282674AG0.87210.96740.02520.7256112044496210.02054
16rs478471455282311AG0.87161.03310.02500.7157949322982060.02455
16rs441149555282376CT0.31801.14250.11600.6003262785189620.00067
16rs453172955272021CT0.96280.97810.02410.4457531918338890.01698
16rs230123455274483GT0.80000.97900.02690.3666325548829930.04522
16rs478471255274299CT0.80040.97980.02690.3481407307530510.04473
16rs478395055269059CT0.79740.98310.02670.2824959252357980.04009
16rs159993355273363AC0.82421.00010.02590.001871492871733610.03678
16rs478395255276658CT0.85561.00010.02540.001087095641214160.01809
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.