Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT2A

 

BP - Genomewide Association Studies for MT2A


 

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Description

 
Shown here are the results for gene MT2A from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
16rs216173755196735AG0.80430.95210.03610.758702612890007(Index SNP)
16rs100876655197301CG0.80461.03000.02640.5790545940780280.35
16rs181132255197206AT0.78920.96260.03720.5155577923575931
16rs201870355209552AC0.68781.02840.02800.4974363308926370.19419
16rs90477355209102AC0.70541.03360.03640.4390179444137650.72176
16rs200198555209716AC0.70551.03360.03640.4387793210660560.7202
16rs1164205555201766AG0.83160.96980.03500.4183916339679420.03846
16rs1063655200844CG0.74511.02330.03000.3540867249661560.08333
16rs805210655192602AG0.87731.01900.02700.3142582613977360.09091
16rs478394655208810GT0.89620.98220.03790.1970211446647380.02552
16rs201872455209932AG0.89401.01810.03790.1968161114646580.0048
16rs1293416655207975GT0.95940.98740.03500.1446625955304600.02778
16rs805572455207138CT0.98060.99540.03230.05256627811294920.03846
16rs158083355202151AC0.79791.00020.02830.003007018109294290.08832
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.