Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: q14.1    Gene: MYO6

 

BP - Genomewide Association Studies for MYO6


 

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Description

 
Shown here are the results for gene MYO6 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
6rs264740476516226AG0.99360.94370.02491.70005709997723(Index SNP)
6rs284254976515098CT0.98681.04370.02521.047401265470230.24051
6rs27669876529791CT0.98591.05660.03380.9871627752948280.32053
6rs274895676521723CG0.96670.95060.03180.9515581964495950.41904
6rs377800576690105CT0.88691.04510.02820.9303319030884040.0761
6rs693834976541000AT0.98460.94850.03380.929592678259880.32011
6rs690661576546494CT0.98601.05390.03360.92664829761310.3446
6rs274895576521022CG0.98221.05000.03190.8999742698921370.37942
6rs1220990376606558CT0.96830.96340.02460.887060023915920.2322
6rs69918676681799CT0.98220.96450.02440.8598063214213690.25274
6rs132116276513067CT0.99450.95400.03180.8588639098792610.40594
6rs1252622776620597CT0.95630.96310.02550.8535618647142250.20289
6rs218124576600098AT1.00471.03610.02410.8520146793161950.25868
6rs72086376664374AG0.98560.96480.02440.849550590539120.24826
6rs72086276664703AT0.98380.96490.02440.8446639625349380.24826
6rs1215396476599731AC0.93501.04870.03260.8419392060633950.3115
6rs1221379576625116AG0.97260.95260.03320.841336019186010.26528
6rs944757976674411AG0.98371.03620.02440.8407336689065060.24853
6rs218124676600038AT0.99350.96430.02490.8374355934769810.20289
6rs1094329276590201AG1.00830.96590.02400.8288588489716180.25868
6rs929400576662966CT0.98421.03560.02440.8215986584662450.24826
6rs128004476579322CT0.98760.95280.03370.821023052706830.34502
6rs690504776554829CT0.99250.95300.03360.8184422261372140.36868
6rs379844776592800CT1.00601.03500.02400.8164454663811380.25868
6rs153550176655624AG0.98601.03530.02430.8127613801685210.24826
6rs284254076555650AG0.99951.03480.02410.8071538848111580.24619
6rs227385976589439AG1.00560.96660.02400.8041003475907660.25868
6rs1080604776577544CG0.99401.04640.03240.7939841232366550.2889
6rs379844876588032AG1.00450.96720.02410.7804154737857450.25868
6rs935060276617218CT0.99750.95630.03230.7775436633207530.2889
6rs1219610576575424AT0.99770.95640.03230.7754669373939140.2889
6rs1221038676610556CT0.99400.95650.03240.7698066211309540.2889
6rs1221173576616629CT0.99110.95670.03240.766242637034490.27467
6rs1094329576611116CT0.99261.04530.03240.7659891824128210.28723
6rs220879876640363AG0.99901.04510.03230.7654827164873130.2889
6rs1094329476610996CT0.99181.04510.03240.7604502791595270.2889
6rs1221651876606957AG0.99480.95690.03240.7599502278873520.28723
6rs935224476628350AG0.99611.04490.03230.7597004179972870.26528
6rs377800876622585CT0.99180.95710.03230.7574585717016160.28808
6rs1221260476602868GT0.99481.04490.03240.7569619513137060.28723
6rs1094328276512109GT0.99371.04410.03180.7564658981679380.3808
6rs203862476617427CT0.98100.95490.03400.7559704109699780.32053
6rs1219799376606545AG0.99560.95710.03240.7554754884299160.2889
6rs379843076660572AG0.99830.95720.03230.754487332185850.32996
6rs1221096376602404CT0.99491.04480.03240.754487332185850.2889
6rs936095076636197CG0.99400.95730.03230.753009300758450.2575
6rs72126476574616AG0.91531.04690.03400.7498240519160750.29648
6rs1220346176607450AG0.99631.04450.03240.7481185454474720.28723
6rs1321139176652354AC0.99781.04440.03230.7476324855401010.2889
6rs935914476644825GT0.99731.04440.03230.7469044141509680.2074
6rs1220249176646931CG0.99760.95750.03230.7464197104378170.2889
6rs379844176609283AG0.99420.95750.03240.745210312602790.2889
6rs203862576617688AG0.98090.95540.03400.745210312602790.30142
6rs1215420276659521GT0.99870.95760.03230.7437634667940770.2889
6rs1319455776635897CT0.99311.04430.03230.7435227937583230.20401
6rs379844276609272CG0.99540.95760.03240.7428015738606550.29662
6rs936094676629692AG0.99771.04400.03230.737548910269570.2889
6rs382295776664000AG0.95141.04640.03420.7330630888408270.34502
6rs645384576633247GT0.97911.04610.03410.7309542903423770.33889
6rs934153576567051CT0.99431.04370.03240.7290883605895190.2889
6rs379843976623454GT0.97840.95630.03410.7230788679342260.32949
6rs935914576644910AG0.99080.94390.04400.7212463990471710.13367
6rs929400476662776CT0.98920.94390.04400.7207894873986050.13367
6rs229593876658712AG0.98980.94400.04400.7207894873986050.13367
6rs645384376615205GT0.99650.94440.04390.7162466166674730.13367
6rs128004776584511AG0.98470.95710.03370.7157949322982060.34502
6rs934153476527262CG0.99360.95830.03270.715569266155480.35616
6rs1321692176640907AG1.00071.04280.03230.7130946470276250.2889
6rs1322041676634752AT0.97841.04380.03310.7101881608823790.26528
6rs1320507376531161GT0.99311.04310.03270.7053133757205570.34238
6rs231293376634385CT0.99451.05790.04390.6989700043360190.13367
6rs379845576538856AG0.99391.04220.03270.6859220082207870.328
6rs1221249976581593AG0.26780.86850.11370.6679657229724820.02041
6rs192358676624674GT0.96100.95230.04130.6247022617826610.23977
6rs132116176510902AG0.98770.96330.03190.6178027896225460.40594
6rs132255076587136AG0.99820.95250.04370.5747919488613440.13367
6rs27669976512768CG0.98561.04760.04770.4816176844546560.21777
6rs1688696376693838CT0.96431.03280.03400.4650858955701330.0033
6rs379844076613339CT0.99410.97020.03230.4584207560534190.28815
6rs1220715976609496CT0.86320.94930.05800.4321505494268930.13367
6rs774647676685732AG1.00130.97390.03090.4066031576997930.09345
6rs1219127076560278AG0.76781.04910.05700.39718065756730.11616
6rs27669376517904AG0.98450.95780.05820.338376590770770.15414
6rs1319499876585158CT0.97580.96570.05120.3046934775681970.0298
6rs1718999076542944AG0.91181.01790.02620.3023348373523250.16141
6rs935914976695670AT0.99301.01990.03080.2829955929594530.10984
6rs691471676683476CT1.00081.01400.02340.2573534100612640.00133
6rs227385776621673AG0.32520.89350.19520.2487208960166580.00263
6rs935914176615100AC0.99200.98660.02350.2482591261890990.00629
6rs936095876695448AG0.97690.98680.02350.2439727870265590.00011
6rs99920976582623AT1.01021.01390.02450.2407099669756960.1302
6rs27669576525835CT0.99641.01370.02460.2371714468109100.14375
6rs934333076692463CT0.97831.01300.02350.2341824846900822e-05
6rs1719130676615837CT0.99290.98660.02470.2338847167785860.10631
6rs128004076572896CT1.00921.01340.02450.2315098948287550.1302
6rs274895776532053CT0.99831.01320.02460.2260673525323550.14375
6rs1175854376629388AG1.00551.01310.02460.2238074852529280.10856
6rs379843576635386GT0.97960.98700.02500.2219211380625450.12362
6rs1779452976615905AC0.99481.01300.02470.2211255279972600.09795
6rs379843876623888AG0.32820.90380.19480.2191068913129210.00389
6rs379843476645282CT1.00471.01270.02450.2166682371125760.11493
6rs936095476666112AG1.00121.01210.02330.2164537177296501e-04
6rs1175570476642123AG1.00200.98800.02450.2053725553354920.11493
6rs934332776663016AT1.00060.98860.02340.2052332020591790.00133
6rs133504376644645AG0.99241.01160.02340.2051635421854390.0043
6rs1719227976659715AG1.01080.98810.02450.2050242559488680.1369
6rs934153976649250AG0.99321.01150.02340.204537105609620.00251
6rs229593676653448CT1.01011.01200.02450.2035644411898260.1369
6rs1719222376656302CT1.01081.01200.02450.2034256667895700.1369
6rs128005076593525AG1.00091.01140.02330.2030096094543140.00372
6rs377800676630951AT0.94860.97650.04910.2023170650851010.16368
6rs1780062576653087CG1.00981.01190.02450.2021786886359760.13946
6rs379842576664270CG1.01241.01190.02450.2021095169416510.1369
6rs1049890476642917AC1.00040.98820.02460.2016256233184390.11493
6rs447679576641512AT0.99380.98880.02340.2012112860487510.00544
6rs1320251976640991CT0.99671.01140.02340.2011422682525140.0055
6rs128005676598282AG0.99901.01130.02340.2005216011620190.00253
6rs379842976661293GT1.00121.01130.02330.2004526928743850.002
6rs379842776661517AG1.00120.98890.02330.1996954224438010.00225
6rs128003876570135CT1.01020.98830.02450.199420378430870.1302
6rs1266404976649924CG1.00391.01180.02450.1990768181867820.11493
6rs91067976596313CT0.98230.98890.02360.1969527895088710.001
6rs379843376645504CT1.00281.01170.02450.1966111750163870.11493
6rs934332576633737AT0.99700.98900.02340.1960651501361580.01265
6rs1260676681461CT1.01081.01160.02450.1949751555701950.1369
6rs693299276630463AG1.00151.01080.02330.1903056412830760.00347
6rs128005876598884CT0.99970.98930.02340.1898347154568500.00253
6rs210420376678877GT1.01021.01130.02450.1894314707835870.1369
6rs377800776630865CT0.99851.01070.02340.1873539837668810.00675
6rs944755476552119AG0.78740.97350.05940.1860855799513970.021
6rs128005276595123AG1.00220.98980.02330.1808510571928660.00307
6rs128005476597708AG1.00351.01030.02330.1797985405143600.00253
6rs128004976593053AC1.00151.01030.02330.1797985405143600.00253
6rs128005376595915AG0.99990.99080.02340.1587657044939590.00178
6rs379845876519431CT0.57081.01340.04590.1121577348926430.01448
6rs691114876548663AG0.12961.02180.14660.05394093961487630.02015
6rs645384876686994CG0.97640.99640.02490.05286048235717090.06418
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.