Metamoodics Gene Information

 

  Chromosome: chr7    Cytoband: p15.3    Gene: NPY

 

BP - Genomewide Association Studies for NPY


 

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Description

 
Shown here are the results for gene NPY from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
7rs1614824288863CT0.97200.94710.02541.49106647394997(Index SNP)
7rs390549724288093CG0.97830.95400.02701.090497458594580.69005
7rs1614224291195AG0.98091.04800.02701.082074577935260.67114
7rs1614324291113CT0.98031.04770.02701.073194689888390.67114
7rs1614924288850AG0.98070.95500.02701.054531414868180.67114
7rs780086124287185AG0.97921.04680.02701.042201225070000.68284
7rs1647824291133AG0.98100.95550.02701.037299268295660.67114
7rs1613824292020CG0.98140.95580.02701.027380660940380.67114
7rs1270052424287939AG0.95950.94720.03251.020679302617980.10471
7rs1270052324287636AG0.95700.94790.03260.9991322784687730.0941
7rs1095100324287171AG0.95331.05500.03260.9965394678904940.1038
7rs1613124296362CT0.97561.04970.03230.8761483590329140.1038
7rs185929124289184AT0.99561.07430.05760.6703987516434810.02256
7rs385772324288352CT0.99551.07410.05750.6691805335041630.01838
7rs385772424288533AG0.99520.93280.05760.6443569497791310.02256
7rs1270052524304910AG0.85530.95960.03470.6300423926539470.016
7rs1610624306626CT0.99341.03610.03080.6050232804454360.02998
7rs302512124291869CT0.83850.91500.07740.5994620106080540.01348
7rs695111024296716CG0.99491.06790.05740.5982549177629370.02256
7rs697770524294340AG0.99501.06760.05750.5924391505136370.02256
7rs697773624294406AG0.99471.06710.05750.5880437620695990.02256
7rs695093724296600CG0.99331.06610.05750.5765902722669070.02256
7rs1611124304676AG0.97430.96920.03090.5055671012736010.04418
7rs1612224298749CG0.99200.94040.06720.4430947309445520.03626
7rs1647524298011AG0.95451.04190.04600.4301581005962380.10987
7rs202389024299272AG0.76760.96430.04430.3858412904908250.00798
7rs302510724307631CT0.74780.97050.03820.3637127479014870.06787
7rs302511824294202GT0.95841.05160.06500.3570411205902090.13763
7rs107331724287626AG0.93511.05040.06510.3467874862246560.08955
7rs1613924291404CT0.94960.95210.06520.3453422453504750.13763
7rs302512024292794CT0.95220.95260.06510.3409399277590620.13763
7rs302511524295397AG0.95240.95340.06510.3338565727084420.13763
7rs1647924288587AG0.93981.04820.06520.3271635458286030.12108
7rs302512424288913AG0.15291.15450.23040.2732727909734280.03308
7rs471976224297375AT0.23320.92370.13500.2541448048262710.00113
7rs1647624296744GT0.95211.01200.02380.2110542729762520.36127
7rs557424295658CT0.98630.99010.02340.1726307269461750.41543
7rs1613524294445AG1.00671.01850.04380.1703103591010290.00183
7rs1647224300594AG0.97931.01770.04430.1600822243213190.04917
7rs1025643224287312AG0.97461.00850.02350.1438755557577000.42463
7rs1610924305894GT0.98251.01030.02870.1422454779405580.36624
7rs1611824303347CG0.97881.00570.02380.09162222756760540.19843
7rs1611624303927AG0.98631.00530.02340.08544530148236640.4262
7rs978502324291534AG0.97871.00410.02350.06484555278383160.3302
7rs1614524290514GT0.97620.99680.02350.04948910701400340.35938
7rs1614724289935CT0.97681.00300.02350.04604711676807690.38986
7rs1612424298324GT0.98921.00140.02330.02154556663477140.34842
7rs1614124291284GT0.88720.99870.02460.01809082990920770.31187
7rs1612924297290AC0.99430.99890.02330.01641881329420930.34842
7rs1611924301455AG0.98360.99950.02340.007888512213050330.34842
7rs1647324300176AT0.98451.00040.02340.005330978174470590.35192
7rs218949524298339AG0.98640.99980.02340.003400777299833230.34237
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.