Metamoodics Gene Information

 

  Chromosome: chr7    Cytoband: q22.1    Gene: RELN

 

BP - Genomewide Association Studies for RELN


 

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Description

 
Shown here are the results for gene RELN from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
7rs17156232103232687GT0.84671.25290.07162.78754603895972(Index SNP)
7rs7792066103350381CT0.91430.92410.02512.775208043507320.00188
7rs7781289103347917AG0.91331.08130.02512.728390698621170.00011
7rs12705149103143298CT0.98770.90870.03162.604324214730060.00228
7rs12705150103143511CT0.99080.91150.03152.479254528480520.01565
7rs12533383103347949AG0.95250.93030.02492.428174750959170.02938
7rs12705167103353610AG0.95530.93040.02492.423543467594380.02979
7rs6960627103359124CT0.93131.07470.02512.382789905442570.03046
7rs11760725103356703AG0.95861.07380.02492.376647318462010.02938
7rs11765701103355404AG0.95730.93150.02492.363512103646630.02979
7rs6978991103359450CT0.94910.93150.02502.343710098808640.02938
7rs12533834103360994CG0.85730.92760.02692.287687091318630.01189
7rs17133096103224721AT0.84701.20780.07032.14062149557440.67883
7rs3808030102945221CG0.98400.85140.06192.030723904511070.02035
7rs362754102969462CT0.97941.17440.06232.008198201155360.02035
7rs362750102968519CT0.97320.85240.06231.986741334716480.02035
7rs3735630103361697CT0.88721.06460.02471.946537395074541e-05
7rs362719102973113AC0.83901.08640.03321.904830648568240.00836
7rs2711881102922667CT0.97650.93920.02521.892450870255310.02309
7rs10266480103362925CT0.88101.06340.02481.880084589742011e-05
7rs3905915103325638AG1.00240.93590.02731.817585347565450.00569
7rs16872658103256105CG0.94840.91880.03491.813326132500250.00591
7rs2528856102930031CT0.96811.06330.02531.810790510417690.00136
7rs4727570102921911AG0.99191.06240.02501.805763251276170.0015
7rs6967257103364235AG0.88300.94220.02481.789413975094841e-05
7rs17149018102899189GT0.85910.87250.05701.778585762157660.01085
7rs6949488103364223GT0.88301.06080.02481.762959208620811e-05
7rs17149266102901195CT0.87680.87360.05681.760700520873110.01085
7rs802788103347852AG0.83861.06260.02571.740167300936520.01029
7rs17347678102896009CT0.98410.87190.05811.738737131207510.00183
7rs3808043102908345CG0.92390.94010.02631.723768042078170.00011
7rs7790872103237509AG0.92280.91590.03751.715794932298210.00591
7rs3735629103361871CT0.87071.06030.02501.714892970433190.00868
7rs13222123103055581AG0.31301.43920.15591.709075440617250.07089
7rs13438060103354742AG0.83881.06120.02571.682145510668530.00972
7rs362787102978675AT0.74581.16090.06471.677367288307780.01468
7rs2299379103160287CT0.98201.05640.02381.675923420260511e-05
7rs10250047103359068AT0.83600.94240.02571.675100502947690.01029
7rs16872603103222843AG0.85981.09020.03751.673254620434680.00652
7rs2906640102894269AT0.94600.87820.05651.668572703479260.00231
7rs362770102976005AG0.83160.86880.06171.646468440922240.01429
7rs262335103193092CG0.99071.20100.08041.644356949779130.32011
7rs736707102917639AG0.96590.93630.02891.643209539648280.01453
7rs2711844102920099GT0.97720.93650.02891.636012170251510.01453
7rs10487174103355110CT0.84011.05990.02571.627640417475680.01029
7rs262337103191516CT0.98611.19820.08061.604324214730060.32011
7rs10233848102909881AG0.93710.94330.02601.602059991327960.0015
7rs362780102977594AG0.84091.14910.06231.590066876668710.01468
7rs10487166103162502CT0.97901.08450.03691.550675906901270.00328
7rs362779102977522CT0.82891.14460.06221.525783735923740.01468
7rs13241499102942751CT0.99560.91220.04281.497982785172850.01074
7rs262378103237813AG0.99640.84530.07851.492144128304170.32011
7rs2965087102899221CT0.90351.05710.02601.490931954982840.0019
7rs39332103238327AG0.95050.94360.02741.465846925814940.00713
7rs17152313102941079CT0.99781.09480.04281.464073258604430.01108
7rs2256670102954911AG0.99101.07820.03561.461677666768560.01956
7rs39337103242253CT0.95141.05940.02741.458171233218690.00674
7rs10215035103352232CG0.86881.05430.02511.456925764966470.02418
7rs1615525103188109CT0.94561.18850.08271.435097327470800.32011
7rs12154738103352968CT0.86830.94920.02511.425505731714670.03
7rs7812099103354289CT0.86881.05330.02511.418164075942350.03
7rs6954835103357837GT0.86890.94950.02501.414877813693180.02664
7rs39336103241189CT0.95341.05820.02731.414088289680570.00674
7rs1978198102896685AT0.92341.05470.02591.399244850360380.0015
7rs2528859102939008AG0.94230.94810.02611.387852161673510.00122
7rs262379103237387CT0.99110.84910.08011.386158178123930.32194
7rs7782669103356638CT0.86900.95020.02501.382580253262820.03198
7rs17355678102930967CT0.96260.89000.05721.378927628856370.00183
7rs636187103164842AG0.85181.07480.03551.373146585333270.0856
7rs10226485103357158AG0.86890.95070.02501.363211310965630.03
7rs2256504102953131CT0.99471.07370.03531.356251314540470.01956
7rs2711846102939733GT0.94120.94880.02611.354872600741610.00082
7rs497536103175234AC0.81340.92820.03711.350665141287860.0956
7rs2256658102954575CT0.98840.93130.03551.346594509335500.01956
7rs10248053102951889CT1.00011.06460.03131.342275045794890.01333
7rs963938103186299AT0.93801.17950.08281.336770365467130.32011
7rs17157216103336023AG0.80261.07700.03741.323306390375130.0094
7rs262368103243408CT0.97850.85230.08071.322484295201240.32011
7rs262360103247035CT0.96361.17450.08151.314168725373940.32011
7rs262369103242856AG0.97460.85320.08061.310158590862500.32011
7rs499998103168876CG0.77720.92760.03841.299296282854980.03433
7rs476736103168659CT0.85160.93320.03531.296880653763920.07642
7rs362746102966831AG1.00220.86120.07651.292941059372400.00136
7rs262336103191779AG0.98940.85620.07961.292174431667770.32011
7rs17133124103298853CT0.99540.93430.03501.286425462227930.00536
7rs491170103165095CT0.85321.07110.03531.285502591350190.07642
7rs588423103169016GT0.84940.93360.03541.284916329305070.07642
7rs6950645103360672AG0.80211.05680.02851.279096829186540.00641
7rs638355103165298AG0.85560.93400.03531.277695213125670.07642
7rs491921103165151CT0.85311.07070.03531.275396484603280.07642
7rs651488103165913CG0.85361.07050.03531.271402756616570.07642
7rs683360103168436CT0.85171.07040.03531.266241164412800.07642
7rs262374103240830CT0.98131.16810.08081.263922362996050.32011
7rs549743103166899CG0.85350.93450.03531.260190400978640.07642
7rs496801103165727CT0.85370.93460.03531.257431965633860.07642
7rs682018103168155CG0.85151.07000.03531.256882374785260.10836
7rs471360103168085CT0.85200.93460.03531.254925208417940.07642
7rs2711845102920016AG0.71680.89390.05861.254534831329270.01449
7rs3898844103329264AC0.98641.04750.02431.248489949729960.01019
7rs6951651103331139CG0.98930.95480.02431.246263777824990.01904
7rs1476928103347089CG0.79370.93160.03731.242072816886670.00894
7rs17269500103345373AG0.79260.93190.03731.234629519708350.03091
7rs1476927103346962AT0.79331.07310.03731.233884716778590.00894
7rs3898845103329296CT0.98630.95530.02431.221776373233900.01904
7rs802787103336960GT0.81981.05150.02671.220475656675210.02275
7rs3808033102941007CT0.97020.94260.03161.213958789757450.01333
7rs3915122103329035CT0.98560.95550.02441.209363038068300.02186
7rs6951845103331297AG0.97170.95520.02461.206139798657330.02599
7rs3808040102927125AC0.84770.87230.07371.194635092533550.02874
7rs6964943103183847CT0.39130.80940.11481.183957659078000.00048
7rs3819477103183899AG0.38620.80830.11581.179338865356409e-04
7rs3819476103183875CT0.38671.23600.11551.176004408844039e-04
7rs9987028103332101AG0.95081.04620.02471.172114017210140.04542
7rs10085736102915319CT0.98060.94610.03031.170824926082910.01397
7rs7808106102912821CT0.97971.05680.03031.167810538931490.01531
7rs3808039102938672CT0.89031.13700.07071.159893905543240.02874
7rs17155576103185904CG0.89441.05860.03141.156518056960040.00925
7rs4140848103190023CT0.98920.94730.03001.151810883008600.00887
7rs3914125103310127AG0.98521.06510.03501.143815073272830.00415
7rs17133142103299637AG0.74370.93530.03721.140981856111110.00179
7rs12538149103271597CG0.85350.95380.02631.139542204576530.00781
7rs11974819103189799AG0.98791.05530.03001.139183036135460.00938
7rs10487171103188408CT0.94761.05540.03001.138943755423130.00994
7rs3779521102946869AG0.90660.87910.07191.134896025358870.02874
7rs4140931102964481GT0.86071.13040.06851.133830852366230.02874
7rs3914124103310228CT0.98491.06440.03501.127261172527330.00591
7rs17348122102911227CT0.84691.10400.05561.124765053549840.0028
7rs6943563102915908CG0.85010.90690.05501.122455892284060.00192
7rs17150781102913034AG0.95751.05880.03221.118273064623580.00241
7rs2214943103190535AT0.97490.94850.02981.115544503929510.01001
7rs1024559102903294AT0.95510.94480.03221.108797172739700.00262
7rs694894103184640AG0.53050.94240.03371.10490910306560.00039
7rs3819489103210000AG0.98051.05390.03011.091890459607450.00958
7rs2247776102986955AG0.92281.06610.03681.085445301482370.02367
7rs2528861102939547AT0.93200.94930.03031.063486257521110.00482
7rs4125503103326211AT0.96881.04420.02541.056208801070700.01949
7rs10233291103324992GT0.92810.95830.02491.055714779311250.04769
7rs2711849102939169AC0.93091.05300.03041.051391450123560
7rs1510858103280144AG0.99361.04830.02781.050902874887080.00883
7rs6465945103336194AT0.75410.93990.03641.050854047580060.06508
7rs2528858102938847AG0.86520.90740.05731.045130628933520.01488
7rs39386103271457GT0.34561.23640.12581.038009712559940.00231
7rs2283029103185455CT1.00431.05420.03131.036968124946100.00866
7rs39397103277165AC0.96971.04060.02371.028770552723760.00029
7rs362644103039099AC0.98351.04050.02371.028770552723764e-04
7rs2237636103199720CT0.99000.95150.02981.019951154935040.01033
7rs262334103198081CT0.95701.04740.02791.012244383261480.0309
7rs39407103288399CT0.97111.04320.02561.004101676353560.0015
7rs39342103249811CT0.96961.04820.02861.004101676353560.00422
7rs264369103253403CT0.91121.04100.02450.9991322784687730.03564
7rs10487160102962491GT0.92901.07750.04550.996108833763090.01488
7rs264372103253294CT0.91350.96110.02440.9800533183211580.03498
7rs362806102996101CT0.97530.94290.03630.9767475403662890.02367
7rs17152161102928939CT0.95831.05300.03200.9698052146432490.00262
7rs650974103183919AC0.45780.94590.03460.967381239149280.00863
7rs1860686103079680CT0.99380.94860.03290.9645702618154520.08647
7rs39395103276965AG0.99501.03810.02340.9582126810282486e-05
7rs362642103037107CT1.01440.96360.02330.9546770212133430.00064
7rs661492103185277CT0.59270.93990.03900.953114809162290.01128
7rs13235135102928673AG0.95610.95020.03210.952725132615820.00925
7rs13232021102928383AG0.95700.95040.03210.9461535731477470.00262
7rs7804453102929687AT0.95611.05200.03210.9411945133240930.00014
7rs4729931103226078CT0.98931.04620.02860.9408153823686290.01546
7rs4446675103184569CG0.78601.08740.05320.9389246763702080.0028
7rs39338103243277AC0.96741.04600.02860.934047019686130.00437
7rs39341103248509AG0.96850.95610.02860.9336740746379620.00422
7rs2711861102941273GT0.99511.05450.03390.9314431049276370.00038
7rs2299348103047299AG0.99441.05300.03290.9307019878844710.0856
7rs2528873102923338AC0.80801.05360.03340.9273825234547630.01531
7rs2528875102923757AT0.98251.04810.03030.9190129530891130.01531
7rs13239318102929780CG0.77601.05700.03580.9164973801697330.00262
7rs7797395103342506CT0.74990.94540.03630.9150664250632840.0613
7rs39398103277178CT0.99411.03730.02370.9143527117031430.00179
7rs720078103070249CT0.99510.95040.03290.9132843360551170.08647
7rs2299401103340521CT0.75000.94560.03630.9090369234042680.05965
7rs2711835102931270CT0.80961.09590.05950.9065783148377650.01468
7rs264370103253369CT0.90900.96310.02450.9058784041594390.03282
7rs3808034102940903AG0.83621.12050.07400.90517961964520.02874
7rs39339103247171GT0.97171.04490.02860.9034375616258650.02284
7rs3914126103292911AC0.99600.96230.02520.8968807464542860.00124
7rs39399103277228AG0.99391.03670.02370.8944898152300260.00059
7rs264371103253312AT0.91041.03780.02450.887730231582730.03498
7rs10272697103345054GT0.75510.94670.03620.8863908489269720.04917
7rs39387103273157CT0.99040.96470.02380.8853890157678270.00015
7rs10231405103343886CT0.74970.94660.03630.8837244124194560.0613
7rs39396103277111CT0.99481.03630.02360.8804142250382160.00165
7rs17286505103113482CG0.97591.03610.02360.8777841217271730.00192
7rs2299403103343150GT0.75021.05610.03630.8771290771355650.0613
7rs2058504103341238AG0.74950.94720.03630.8712777156615730.0613
7rs2711843102944922AG0.99260.96250.02560.8680607047895750.00771
7rs39400103281118AG0.99311.03580.02370.8620132672764680.00165
7rs2382688102891644AG0.99491.04310.02850.8569851997459050.00665
7rs17155063103163402AC0.98310.91920.05710.852942328971640.00332
7rs10487169103184694CT0.83701.08980.05830.852942328971640.00136
7rs39406103287735CT0.99230.96570.02370.8517059025652540.00165
7rs264376103251493AG0.93350.96530.02400.849243560139690.04546
7rs13236934103181009CT0.86000.91470.06090.8431480989299890.00231
7rs2157748103122021AT1.00070.94860.03640.8326826652518240.0013
7rs17154829103152714CT0.98641.05420.03650.830619504688050.00024
7rs10245317103344010AG0.69921.05460.03670.830619504688050.04247
7rs997447103052612CT0.97281.04870.03290.829151796356690.03071
7rs496907103149720CT1.00250.96440.02510.827397068790148e-05
7rs10215599103324394AT0.94311.03680.02510.823619307756730.00603
7rs10240865103126474AT0.99870.94900.03640.8221750281353180.00015
7rs39384103268880CT0.99600.96660.02360.8207355356609750.00165
7rs10435342103192753CT0.96661.04650.03170.819014419213270.06511
7rs262372103242367CT0.93391.03510.02400.8187282284405380.04481
7rs17154372103122764AC0.99970.94940.03640.8141746403870380.00024
7rs2106173103121792CT1.00781.05330.03640.8130436645345880.00024
7rs262366103244188CT0.93381.03490.02400.8124792791635370.04481
7rs17290575103188857AG0.90201.04720.03230.8121973612815810.00168
7rs17151768102921523AG1.00381.04890.03350.8105096863006320.00206
7rs7797700102919907AT0.98540.95290.03400.8082696066371443e-05
7rs262365103245053AG0.93571.03470.02400.8074325466634540.04481
7rs2075044102968252CT0.79550.89790.07590.8074325466634540.02874
7rs2299367103119946GT1.00461.05290.03640.8043770564130630.00024
7rs10281066103120346AC1.00250.94980.03640.8032712773767130.00024
7rs262361103245773CT0.93370.96660.02400.8029952719769540.04481
7rs362771102976124CT0.98820.89450.07890.8018930011265980.00137
7rs10250273103125361AG0.99821.05280.03650.799970733446230.00037
7rs2106172103121724CT1.00170.95000.03640.7977842241988690.0036
7rs39381103266826AT0.34691.19360.12580.7975116829399060.00231
7rs39385103270043AC0.99481.03380.02360.7964232250220270.00175
7rs2711883102924580CT0.95780.96060.02860.79560866808070.01028
7rs3213612103155588CT0.98530.95000.03650.7953374882517810.00024
7rs12540676103326287CT0.93700.96660.02430.7915586435614330.01169
7rs155333103226350CT0.92460.96120.02830.7894139750948430.02632
7rs1404431103223839CT0.98841.04070.02870.7819899570156370.01472
7rs3808028103048826CT0.97220.91610.06320.7812020018882620.00282
7rs10953394103308149AT0.99120.96230.02780.7772835288524170.00883
7rs2299371103146156AC0.98780.95100.03640.7752080435073190.00853
7rs17153784103052589AG0.95731.08890.06180.7749493038619510.00299
7rs10487164103109108AG0.98071.04690.03330.7731424297112760.08647
7rs10279900103125291AG0.99920.95110.03640.7721132953863260.00024
7rs6951931103195522CT0.92441.04380.03130.7682756166714830.00053
7rs3808025103050981AC0.96861.09040.06320.766242637034490.0028
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7rs955319103256439CT0.99950.99700.03170.03461012978487770.00431
7rs7807465103279465CT1.00321.00250.02640.03428102975577910.03863
7rs9791408103299253AG0.99991.00290.03170.03240522732811020.00468
7rs17313716103388618AG0.97150.99790.02360.03198428600635820.07441
7rs6951875103419411AG0.91840.99780.02460.03165716904105450.00387
7rs722277103382888CT0.96820.99800.02360.03086376640328750.03143
7rs7803462103303296CT0.99750.99730.03170.03030458888152670.00468
7rs13241576103303910CT0.99711.00260.03170.02881695914383860.00468
7rs12536415102950788AC0.98861.00210.02630.02807505081580860.00223
7rs362635103028869AG0.99590.99810.02480.02714944415276990.03388
7rs7809688103291814CT1.00091.00230.03160.02631808149601630.00468
7rs4460306103408368AC0.99300.99840.02330.02525809549904980.05367
7rs2237642103307259CT1.00831.00250.03480.02512002699306950.00832
7rs886804103210071AC0.95081.00180.02600.02479803774214760.01855
7rs10251365103207855AG0.94900.99820.02590.02475205875931890.01937
7rs10280683103207991AG0.95001.00170.02590.02291687968414730.019
7rs17156468103259249CT1.00011.00200.03170.02273378757270730.00468
7rs2283033103305167AG0.94491.00200.03190.02255077261765880.00228
7rs39351103254945AC0.97111.00190.03040.02218497391681330.00028
7rs2075040102950083CT0.98800.99840.02630.02159120737696070.00223
7rs13232645103283932AG1.00041.00190.03170.02154556663477140.00468
7rs7788125103279248AG1.00240.99840.02640.02127182286150820.07043
7rs722613103123251AC0.95911.00150.02440.02118061326715770.00136
7rs4727582103386042AG1.01191.00140.02330.02072485240897680.04511
7rs6952315103413558CT0.92110.99860.02450.02026956933771450.00287
7rs6465938103279579CT0.98770.99850.02680.02022406727031440.03511
7rs13239553103291279AG1.00001.00180.03170.02017856996977480.00468
7rs9649266103291122AG1.00011.00180.03170.02008758966528310.00468
7rs7777395103297784GT0.99930.99820.03170.01999662841625370.00468
7rs17157128103325569AG0.99271.00240.04290.01999662841625370.054
7rs13223714103277656CT1.00390.99850.02640.01990568621470610.03998
7rs2299392103298456AG0.99940.99830.03170.01931502563668530.00457
7rs6979719103288782AG0.99990.99830.03170.01881586260164570.00457
7rs2299387103295985GT0.99950.99830.03170.01881586260164570.00468
7rs3886301103297299AC0.99960.99840.03170.01836257534423090.01035
7rs6465944103320636AC1.00791.00150.02850.01831727262871460.01545
7rs2237639103295725AG1.00001.00160.03170.01822668137225280.00468
7rs7794946103298027AG0.99970.99840.03170.01768353030793470.00435
7rs2299388103296144CT0.99970.99840.03170.01750263080228750.00457
7rs645260103145707AC0.97540.99870.02670.01736700560515040.03042
7rs3886302103297320AC0.99970.99840.03170.01732180661651580.00446
7rs2299391103296611CT1.00011.00150.03170.01677978535189710.00468
7rs2299389103296468AT0.99921.00140.03170.01574279829458390.00468
7rs362631103020561AG0.99671.00130.02950.01565274241413620.13595
7rs10255733103209097AG0.94910.99890.02600.01520274291070720.01855
7rs11766205103368036CT0.51220.99780.05330.01461843976800310.00034
7rs10251700103386490AG0.95490.99820.04600.01416951014160780.00431
7rs12705172103388220GT1.00561.00090.02340.01291497037587800.04511
7rs17156834103293991AG1.00011.00110.03170.01251249386690710.00468
7rs7800597103293702AG0.99971.00110.03170.01228905686969410.00468
7rs6465947103402828AC0.99141.00080.02330.01211039000225470.01701
7rs3914132103314605CT1.00811.00090.02850.01063918622375264e-05
7rs362722102980006CG0.22110.99830.06550.009306039320248420.00433
7rs10230806103403586CT0.99140.99940.02330.008773924307505140.0093
7rs4270893103399075CT0.98950.99940.02330.008375265465994640.01776
7rs663302103185721AC0.82480.99940.02650.008153946355103320.01757
7rs2299394103299179AG1.00270.99930.03160.008065450281052170.00468
7rs745538103209715CT0.94951.00060.02600.007932739972333250.01855
7rs6943822103385907CT1.01300.99950.02330.007402303897961750.04511
7rs4727583103386180AG1.01201.00050.02330.006872514894289870.04511
7rs2283034103305285CT0.99750.99940.03160.006299305179649760.00468
7rs2073551103069595GT0.98351.00040.02500.005638848091998980.03438
7rs6950391103390766CT0.98821.00040.02330.005243055412371880.01707
7rs6976337103392020CT0.98850.99970.02330.005067263269958210.01636
7rs13243480103292380AG1.00051.00040.03170.004847623108546190.00468
7rs10254112103308957CG1.00611.00040.02860.004628093971837590.01563
7rs7791481103292082CG1.00010.99970.03170.003444550366634710.00826
7rs17133113103266887AT1.00051.00030.03170.002788417167495030.00468
7rs11761756103319019AT1.00890.99990.02850.00156628113553110.01545
7rs4489256103414605AT0.99731.00000.02430.0006084382809090680.0153
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.