Metamoodics Gene Information

 

  Chromosome: chr9    Cytoband: p13.2-p13.1    Gene: SHB

 

BP - Genomewide Association Studies for SHB


 

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Description

 
Shown here are the results for gene SHB from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
9rs1081463937999663AG1.01241.07270.02312.61636413163812(Index SNP)
9rs487873438000085AT1.01251.07200.02312.574955125448611
9rs77601637931745CT0.91151.08290.02672.546070407942270.47653
9rs1097363837995435CT1.01040.93370.02322.518844129171961
9rs432356037993803CT0.95591.07290.02382.513427849481640.84031
9rs1073235837944913AG1.00901.07100.02322.507658746745030.93311
9rs1075846337942230CT1.00940.93380.02322.501413791182480.93534
9rs386100337942631AG1.00930.93390.02322.495801081460550.93534
9rs702802037997747AG1.01091.06990.02322.452225294612181
9rs1075846737960485AG0.95531.07170.02382.449038247701820.92895
9rs703737138006247CT1.01050.93490.02322.437231456983481
9rs702580138007681AG1.00991.06930.02322.421017157297211
9rs704806337947229AG1.01230.93520.02322.417368560510360.93534
9rs704387037946373AG1.01040.93570.02322.381219975493790.93534
9rs704406037946271AG1.00981.06870.02322.376543951930070.93311
9rs487873538002492AG1.01410.93610.02312.370284667352870.96716
9rs224376237981170CT1.00910.93600.02322.36693572730851
9rs1073349137946724CT1.01070.93620.02322.353302268700670.93534
9rs1011431937950393AG1.01271.06790.02322.343135508451080.93534
9rs786213037956970AG1.00931.06790.02322.339134521996130.93534
9rs94393837973770CT1.01270.93670.02312.334512819217191
9rs77602237924780CT0.97850.93110.02532.328549445787510.50153
9rs703435138009458AG1.01031.06750.02322.322758154053351
9rs704450137937601CT1.00831.06750.02322.310424784240060.90451
9rs224388137980397CT1.01090.93750.02312.279014255846261
9rs704349537951922CT0.95170.93610.02392.247567390738530.86434
9rs1011434837950693AC1.01511.06570.02312.224389551993640.93534
9rs703651637999406CT0.97481.06620.02362.176330186731860.90451
9rs647666637953047CT0.97600.93810.02362.173148052179360.90451
9rs487873037988754AG1.01581.06450.02312.164436248330900.93534
9rs224400637978647CT1.01191.06460.02322.160647671104580.93479
9rs487873338000025CT1.01231.06430.02322.148069321359730.93534
9rs218312838004322CT1.01040.93960.02322.142004504439080.93534
9rs77600837911959CG0.97950.93900.02352.126040345256650.90451
9rs224420737976978AG1.01221.06380.02312.124417895672110.93534
9rs1081463737984334AG1.01141.06360.02322.105850153232080.93534
9rs1097363437985845CT1.01190.94030.02322.101768615486900.93534
9rs192823237979697AG1.01221.06310.02322.085181019552530.93534
9rs224432237976109GT1.01191.06310.02312.083967389811430.93534
9rs224340137967990CT1.01340.94070.02312.082914809359430.93534
9rs113837437964743CT1.01481.06270.02312.072167867133420.93534
9rs1233850937982582CT1.01021.06290.02322.068033885271830.92233
9rs224448137974731CG1.01200.94110.02312.058538260652670.93534
9rs87041037968583CT1.01300.94120.02312.057347188306790.93534
9rs1081464238005037CT1.01170.94110.02322.056802369931070.93534
9rs393509737967559AC1.01291.06250.02312.055961719945580.93534
9rs1081463837987787AG1.01061.06230.02322.039576792922170.93534
9rs77601037919838CT0.98940.94010.02382.028584976615000.7114
9rs1234793537991073CT1.00450.94170.02332.007181479933320.90451
9rs224378237980693CT1.01270.94200.02322.004408675747650.93534
9rs1693470837990647CT1.00531.06160.02321.995678626217360.90451
9rs77600937918488AG0.98961.06300.02381.992252221999260.69144
9rs380241238005729GT1.01150.94230.02321.988006885340740.93534
9rs380241437964481GT1.01360.94250.02311.983384452442820.93534
9rs224389337979893AG1.01200.94260.02321.972242795309450.93534
9rs1081464338008690CT1.01010.94320.02321.935167780261430.93534
9rs1028380338009145CT1.01060.94370.02321.906578314837760.93072
9rs376363838027852GT0.91421.06280.02441.905528871358360.90451
9rs77601537932152AC0.96410.94200.02391.901702463505300.65936
9rs224473137972916CT1.01120.94430.02321.875821944525320.93534
9rs73574137934489AG1.01920.94450.02311.875169850586140.75719
9rs77601937929673GT0.99601.06020.02361.873868592738020.69144
9rs1081463337950202CT1.00800.94480.02341.815592514587680.69144
9rs787310238031142GT0.99040.94420.02381.801068130067790.65936
9rs77602037928387CG0.99511.05860.02371.793174123968150.69144
9rs702607338030672CT0.98781.05870.02381.783042792638900.69615
9rs704268138030828CT0.98830.94470.02381.775466937393910.65936
9rs787309438001047CT1.00630.94530.02361.768530409569320.69144
9rs785031138050968CT0.98460.94520.02381.745210312602790.65936
9rs110577337969220AG1.00781.05720.02351.743282254022510.69144
9rs487874338048424CT0.96951.06440.02641.739690054205080.308
9rs94393737973657CT1.00530.94590.02361.738737131207510.69144
9rs1238089037992256AG0.99351.05720.02371.725149679983340.65902
9rs487873738010544GT0.99200.93960.02661.721017883134560.34018
9rs1081464638021030AG1.00861.05680.02361.713992877920530.69144
9rs192824638053869AT0.92201.06480.02691.712422190921290.42261
9rs77602337924140CT1.00070.94710.02331.7084091743420.35403
9rs110577437969378AT1.00840.94670.02351.705313375720560.69144
9rs1097364638022374CT1.00830.94650.02361.701146923590290.69144
9rs214954737980801AG1.00651.05620.02361.692290076595190.68913
9rs702530338030095CT0.99801.05630.02361.686554629573590.6872
9rs1081464838028431CG1.00120.94690.02371.670398751643480.7114
9rs192824538053602CG0.95770.94090.02671.644740094472620.2936
9rs132046438009801AC1.00390.94330.02561.641113795594130.44016
9rs1075846938020982AC1.00910.94780.02361.639974910810600.69144
9rs647667338013587CG1.00790.94780.02361.639595945270060.69144
9rs487817838027086CT1.00761.05520.02361.638083381331360.69144
9rs384992738045128AG0.96891.06220.02671.628009088535090.308
9rs1743971738012953AG1.00801.05480.02361.625068446021810.69144
9rs289078338014458AG0.99590.94370.02661.536256278752940.34018
9rs487874238024181AT1.00790.94990.02361.529883646849000.69144
9rs487873938011686CT1.00530.94650.02561.499626285646630.4242
9rs785679038013500AG1.00690.94660.02561.495121540589780.44016
9rs108286537922314CT0.97550.94440.02671.493494967595130.33309
9rs192824338025665AC0.99520.94560.02661.453704164878560.34018
9rs703816738015898CG1.00280.94750.02561.450138811528060.44016
9rs785673638013653CT1.00481.05510.02561.442372511573170.44016
9rs77602137926464AC0.97500.94560.02671.439734602137290.34018
9rs238177538014812AG1.00790.94870.02561.405939098729580.44016
9rs289078438014523AG1.00551.05360.02561.384365531122580.44016
9rs785277537984142GT0.30171.35370.15241.328827157284920.00973
9rs1097365738053401CT0.77780.84730.08821.220475656675210.01727
9rs77601837930439CT0.97390.95210.02661.186886245992100.34018
9rs1097364338016801CT0.81460.87580.08500.9255492810454090.02524
9rs1178944137983303GT0.91810.93940.04270.8446639625349380.0772
9rs1097362737961389CG0.87840.94880.03620.8332739444199480.14392
9rs1178947337944424GT0.98341.05060.03900.6878226435602210.09441
9rs1751677937945265CT0.98320.95270.03900.6687752189792680.09441
9rs197693637945433AG0.98211.04910.03910.6587633767613080.09441
9rs1693466237941354AC0.98170.95350.03910.6520848134983090.09441
9rs210324137940936CT0.98640.95420.03910.6382721639824070.09534
9rs374754737906408CT0.95281.04800.03930.6335770427740270.10394
9rs704795238005646CG0.87181.05000.04150.6196078399429730.11366
9rs1200022637910230AG0.99301.14280.11710.5946536398242910.01812
9rs702701437933571CT0.82321.04700.04250.5542401635113690.08738
9rs1751697337958915CT0.98130.95860.03910.5540845860488770.09441
9rs1178806537915826CG0.95561.04040.03910.5069604116823490.10394
9rs374754537906164CT0.93060.96120.03980.4948500216800940.10584
9rs376363738027956AT0.91511.03950.03930.4887852988636120.10394
9rs1743950938006419AC0.98640.96260.03900.4835968515525970.09441
9rs703409037898832CG0.12320.78710.25240.4648325148850560.01844
9rs238177437994509CT0.82701.03820.03990.4587953093167420.0404
9rs94393638017644CT1.00190.97230.03000.4559319556497240.0342
9rs1179267838010036AG0.98580.96470.03900.4461169733561260.08927
9rs704705138010944AC1.01300.97420.02890.4355706730020170.25347
9rs386100237925948AG0.97221.03040.03340.4312117876846530.17598
9rs1329845137977297AG0.87621.03510.03930.4199878874705760.13364
9rs1097360537896722CG0.85120.95850.04870.4162346317150.0161
9rs1178906137940230AG0.98710.96860.03820.3942641061232530.05282
9rs382751837938432AG0.99411.02930.03770.3528127021040110.05778
9rs786451237939638AG0.96471.02900.03800.3457271729022890.03895
9rs1693465837940543AC0.98701.02920.03820.3453422453504750.05282
9rs702375637936629AG0.98190.97330.03770.3256901110585230.05778
9rs1097364238015982CG0.99750.97990.02950.3074174377250910.22675
9rs1693463937933092CT0.97811.02580.03760.3025962767995120.05778
9rs209141537941176CT0.98821.02260.03760.2579822528598620.05282
9rs1179010638037710AG0.95881.02280.03850.2526658903840950.07119
9rs1234588537993567CT0.86331.01520.02940.2165967188774370.09518
9rs192824438048665AG0.99681.01590.03290.1997642106726460.17598
9rs1179055037925319CT0.97810.98300.03750.1889614913957840.05778
9rs1751680637946128GT0.77100.98540.03380.1775703762206430.14091
9rs1237791837977408CT0.86671.01860.05090.1439965460027790.04648
9rs1097362237949693CT0.98011.01150.03160.1439360466669000.16284
9rs73574037934427AG0.97661.01340.03780.1396619934290060.00723
9rs702090137983696CT0.99010.98920.03250.1322968667299020.17598
9rs1081464538017524GT0.96690.98960.03480.116508909811070.14392
9rs238177037993513AG0.71420.98750.04450.1096907831000520.10299
9rs1097363537986724GT0.98980.99180.03250.09631326826349750.17598
9rs702722737919809CG0.97121.00770.03730.07758597585436570.05778
9rs376167237898658AG0.96150.99550.02380.07134815334630540.04607
9rs1097360837902608CG1.00870.99660.03120.04005278429150140.16779
9rs1097360737901531CT1.00490.99870.03130.01479814163542820.16446
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.