Metamoodics Gene Information

 

  Chromosome: chr17    Cytoband: q11.2    Gene: SLC6A4

 

BP - Genomewide Association Studies for SLC6A4


 

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Description

 
Shown here are the results for gene SLC6A4 from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
17rs458330625562841AG0.96600.93380.02412.35546294222159(Index SNP)
17rs14070125562658CT0.96970.93400.02402.354872600741610.93333
17rs205484725556139AG0.96471.07070.02412.341988603342891
17rs379480825555919CT0.95900.93390.02412.337336590425960.96503
17rs425141725575984CT0.59110.88220.04502.273761953197360.19811
17rs202093925574858AG0.97601.06300.02391.973058372040971
17rs432562225550601CT0.97871.06170.02371.945770090136600.80867
17rs104217325549137AC0.97950.94300.02361.883392256011750.80867
17rs381303425548930AC0.97840.94320.02371.872247484167030.80575
17rs1108012125552968CT0.96761.06030.02381.860435733824150.84076
17rs930362825551354CT0.97691.05980.02361.851089006890640.69901
17rs190645125539605AG0.98060.94490.02361.780939667551140.80867
17rs722419925547852GT0.97700.94670.02371.687822643560220.75038
17rs202094225571040CT0.98251.05680.02411.658367664221950.41441
17rs206671325575791AG0.97990.94790.02421.570086302236250.41441
17rs807158325555152AT0.77301.17600.09001.143996546002780.00568
17rs439211925589489CT0.76551.17300.09011.116168286670550.01126
17rs1294504225596054CT0.99381.04460.02501.090123182009610.20653
17rs148797125596879CT0.99121.04060.02420.9991322784687730.26093
17rs721499125596486AG0.98861.04040.02420.9905491042013060.25965
17rs1165753625553368AG0.63840.91800.06580.7137681459714470.04162
17rs1696562825579551CG0.63151.05230.06060.3981572102179020.01294
17rs2552825574104GT0.93420.97640.03290.3299397825268660.14966
17rs202093325585881AT0.66830.95970.06260.2916640973177370.03509
17rs14070025567515CT0.89211.02340.04140.2390500485891030.081
17rs807600525571336AG0.98431.01650.02960.2367217889810210.1844
17rs635425574024GT0.95620.98440.03000.2216316566441260.17544
17rs202093025590167CT0.85120.96730.06520.2146701649892330.02299
17rs989550025560713CG0.99830.96580.07020.2074682380986920.0113
17rs1108012225571461CT0.98901.01330.02980.1811804924524640.16667
17rs807166725576899CT0.98411.01090.03000.1439965460027790.16667
17rs202093625574940AG0.98531.01010.03000.1322379753497990.16667
17rs1215021425575014CG0.95330.99080.03010.1201016756699900.18868
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.