Metamoodics Gene Information

 

  Chromosome: chr9    Cytoband: p21.2    Gene: TEK

 

BP - Genomewide Association Studies for TEK


 

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Description

 
Shown here are the results for gene TEK from a mega-analysis of bipolar disorder carried out by the Psychiatric GWAS Consortium (PGC) of 11 GWAS studies. The total sample included 7,481 cases of bipolar disorder and 9,250 controls all of European ancestry with data on ~2.5M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
9rs1329520627170747GT0.84431.11640.04411.90170246350530(Index SNP)
9rs59089427174755CG0.97540.94040.02891.475344287642220.13433
9rs647596827130731CT0.95970.95200.02381.409715596281840.021
9rs704785627169075AG0.96190.94900.02541.406935568341280.01427
9rs787117827138475AG0.99501.04930.02341.404503778174430.02146
9rs785584827143055AT0.98840.94700.02651.401647290130720.01631
9rs647595927121053CT0.94221.05060.02411.397505931192720.02078
9rs787301927126577AC0.99040.95330.02341.386686838544540.02238
9rs647596627126393CT0.99050.95350.02341.377371573870670.02238
9rs784728027127122CG0.99001.04860.02341.36936875597950.02228
9rs787316127126654CT0.99131.04840.02341.361311113309880.02238
9rs1328598427142682AT0.99631.05950.02861.360712774089760.02737
9rs202712427129252AG0.99231.04830.02341.358129454523690.02238
9rs785326227146574AG0.97921.06000.02891.357634419155030.02737
9rs424269827114745AC0.93481.05310.02571.357139947415510.00858
9rs787332927126890AC0.99071.04820.02341.352128234693770.02275
9rs1691108327127654GT0.99041.04810.02341.349206960348070.02238
9rs311763827168697CT0.94521.06080.02961.335170058856910.14391
9rs1255448527127253AC0.99091.04760.02341.329290404776200.02238
9rs373718727203772CT0.91570.95130.02521.323580768281640.01488
9rs647596327123052AG0.97961.04760.02361.317764643097440.02238
9rs1178813627125276CT0.98171.04760.02351.315873074386920.02275
9rs1235260327123611CT0.98011.04760.02351.315334135974140.02275
9rs1769505727146297CG0.98021.05860.02891.311936303053660.02737
9rs53867927142724AC1.00970.95510.02331.311847244408430.0297
9rs1235263127123522AG0.98010.95470.02351.310158590862500.02238
9rs1233916227123561CT0.98010.95470.02351.309449538489640.02238
9rs71667627145016GT0.98941.05820.02881.306624848974810.09637
9rs136077227192296AT0.98390.95530.02341.296021174991610.02428
9rs703750927124793AG0.96151.04750.02371.294649537114290.02275
9rs136077327192284GT0.98381.04660.02341.287687091318630.02428
9rs69294627191830AG0.98551.04650.02341.286761538454340.02428
9rs65539227191574AG0.98371.04650.02341.28399665636520.02428
9rs704484227122514CT0.97970.95540.02361.277201603129090.02135
9rs55889727191745AT0.98371.04630.02341.276544327964810.02428
9rs215206627178862GT0.99160.95450.02451.240558802866300.01527
9rs66446127142308CT1.01430.95730.02321.219178824146530.0297
9rs1200538827134863AG0.99741.04480.02341.219106891312920.03119
9rs222453027166886CT0.85450.94560.02991.212823007529450.11807
9rs1233973727115056AG0.82741.05330.02791.204606665068710.0109
9rs192333227192482AC0.98970.95810.02331.176395371644840.02717
9rs1769483727125798CT0.93670.95330.02611.17353645090720.01225
9rs703281727123385CT0.96911.04490.02421.161402747183340.0042
9rs1051179927124868AG0.96410.95440.02591.141522958186660.01514
9rs275690027193625CT0.99090.95360.02651.139302725947960.07643
9rs1178988527128898CT0.97631.04420.02411.138824164486970.0042
9rs63820327193134AG0.99331.04260.02331.135370275454490.02717
9rs58172427177422GT0.99761.04280.02341.132414673452960.03225
9rs1255228027124951CT0.96480.95470.02591.132414673452960.01514
9rs55072227192726AT0.99011.04260.02331.132296866729900.02717
9rs408128627128783CT0.97430.95780.02411.132061349109220.0042
9rs786204727192727CT0.99000.95920.02331.129596094720970.02818
9rs188953927128872AG0.97441.04380.02411.123147352398660.0042
9rs702424327128618AG0.97510.95840.02411.110138278741810.0042
9rs63922527192870AG0.99051.04200.02331.109970413836580.02717
9rs65588027191459AC0.98101.04240.02361.104246057926270.01984
9rs60634227187673GT0.98661.04160.02331.094258072608400.02617
9rs53829427195551AG0.98450.96020.02341.086398050270840.02428
9rs1255298527126705CT0.97070.95610.02581.084441884588480.01514
9rs59530327194441AG0.98821.04700.02651.081393084855020.07745
9rs56649027194798AG0.98760.95520.02651.07691148455760.07643
9rs54106527195235AT0.98720.95520.02651.07623803917130.07643
9rs60841627193837CT0.98851.04680.02651.075720713938120.07643
9rs57411827193943CG0.98780.95540.02651.071501731876310.07643
9rs59494927194469CT0.98731.04670.02651.070836616794940.07537
9rs48945127193428AG0.98551.04660.02651.067019178076800.07643
9rs60765027193973CT0.98771.04660.02651.066613958096950.07537
9rs60976627193511CT0.98820.95650.02651.030770520137360.07807
9rs1329305127122073GT0.95090.96080.02391.026733563891470.03113
9rs54291327195021AG0.95240.95670.02671.010950843561780.07537
9rs67135327190266AG0.98631.03930.02331.007755855953230.02617
9rs1096773127129817AG1.01401.04060.02460.9767475403662890.01346
9rs111178227202966CT0.89991.04390.02650.9763360818022070.01003
9rs786221727141645AG0.95890.95640.02810.9484616094846730.02484
9rs1051180427142102AC0.99741.04450.02760.9408153823686290.02484
9rs1255360627193764CT0.97771.06210.03870.9226320947158440.00225
9rs66944127127242CT1.00741.03870.02460.9100948885606020.01347
9rs1255187727132888CT0.75331.05240.03320.9069286936239370.03981
9rs57832727183847AG0.98411.04300.02750.8979094744881630.09903
9rs133481027200225AG0.91630.96370.02430.8910968723326870.02252
9rs56055127198252GT0.98710.96570.02340.8687022034023770.02717
9rs65201027113225AG0.91391.05320.03520.8520146793161950.00473
9rs68625627195922CT0.98340.96630.02360.8374355934769810.01984
9rs63390327186119GT0.99840.96200.02680.8253588073395520.08442
9rs1255472327106823CT0.90870.96070.02790.8244881866365520.00313
9rs60308527113260AG0.92220.95230.03500.7878123955960420.00473
9rs460142527142292CT1.01321.03390.02410.7775436633207530.04264
9rs51010127196307AC0.98211.03290.02360.7715996412969950.01984
9rs1255479927163704AG0.94880.95080.03710.7587026128900070.00423
9rs48934727177216CG0.99331.03380.02480.7418418066592060.00023
9rs58644127111906CT0.82401.05180.03810.7321245806811020.00372
9rs1255222827163693CT0.94370.95180.03760.7235381958267560.00414
9rs1096775627162438CT0.50020.86160.11470.7121982700697740.00109
9rs60266927113202AG0.91271.04690.03530.7117507744280140.00494
9rs203856927177306CG0.99601.04450.03430.6873995607387410.00521
9rs58780027207012CG0.77740.95720.03500.6757175447023070.01387
9rs48862427205792CT0.81671.04500.03560.6641410886801820.00144
9rs785674727147034AG0.93521.03070.02490.6501399178076690.04105
9rs132205227169244CT0.95751.03220.02620.6441655041150640.00899
9rs207731727149526CG0.89101.04340.03540.637140697041320.00479
9rs220863727166554CT0.99491.04100.03440.6149302236680650.00521
9rs703459127141692AG0.96851.03110.02660.6027554189896140.00028
9rs381828227180949CT0.99061.03020.02590.6010189333418690.00778
9rs227372227196825GT0.90941.04070.03490.5958507507903050.20788
9rs60211227144182CT0.99101.05230.04480.5941416006823630.00283
9rs424267027190738AC0.89091.03470.02990.5941416006823630.0048
9rs141382527151811AG0.81351.03110.02690.5938005763366870.01778
9rs62576727125713CT0.98141.02740.02380.5914208745913330.00359
9rs48072327144419AG0.99261.05180.04470.5867002359187480.00283
9rs1783481127175762GT0.98841.02950.02590.5816987086802550.00778
9rs60072827143866CT0.99380.95190.04480.5663901566762820.00283
9rs1179129427166229GT0.99321.03830.03440.5609832716124870.00521
9rs703502127141706AG1.00040.97180.02630.5597207867644120.00093
9rs59823227151420CT0.69871.06860.06190.5469876088785450.00082
9rs50494727146995CG0.97740.95330.04470.5457651042517350.00283
9rs52123927176051AG0.98330.97130.02740.5409092103994140.00923
9rs53412927204719AG0.95441.02580.02440.5288550348393670.04484
9rs49189227183541CT0.97710.97590.02360.5224446678010190.03352
9rs53607827204972CT0.95770.96310.03680.5138530031934270.0028
9rs51158627179946AC0.99040.97260.02730.5103227083363010.00019
9rs487814927139669CT0.93381.02830.02750.5089185865768130.0089
9rs57372227184389AG0.97621.02390.02360.5007254181077830.03352
9rs215206527178831AG0.99060.97440.02590.5004503740948510.00778
9rs55098227207992GT1.02160.97190.02890.4906630419823560.00144
9rs57391827208178CT1.00501.02910.02930.4859838195993510.0016
9rs703450527141394AG0.99761.02300.02320.4853194558750180.02794
9rs50668527153395AG0.84971.02760.02790.4816176844546560.01305
9rs215206727207062GT0.94791.02860.02980.4640732586044310.00063
9rs1235064927164170AT0.99561.03290.03430.4621809049267260.0049
9rs62887327145544CT0.98881.04280.04460.459170185888920.00283
9rs48129427180890CT0.99051.02550.02740.4467239538629010.00923
9rs57403327208221CT1.00580.97360.02920.4440595621814890.00144
9rs68170727207851CG1.01110.97360.02930.4424927980943420.00144
9rs381828327159124AG0.90280.97300.03030.4349790716547060.00456
9rs1096774027145789AG0.89861.02430.02690.4300411819034060.01121
9rs55019027207947CT1.00830.97440.02920.4265481779645150.00144
9rs1081253227187282GT0.98090.96560.03950.4249276742861880.00204
9rs1096776027172825AG0.99030.97670.02780.4020855287974720.00674
9rs132204827222748CT1.00250.97950.02450.3994627056355310.01274
9rs227372027199469AC1.00090.95610.05370.3944794765625310.00163
9rs67902627110780AG1.00790.97640.02850.3939412505896860.00189
9rs99493427160308CT0.99730.97740.02770.3888079391315660.00955
9rs59183127188644AT0.89121.03220.03900.3809066693732570.00235
9rs1096776627189144AC0.97831.03280.03970.3799681048737030.00318
9rs62178627108807AG0.90510.97990.02560.3694704285731760.01327
9rs1051180227158315AG0.90581.02370.03030.3575354797578790.0064
9rs1075764127202360CT0.86230.97830.02930.3429441471428960.00756
9rs785514027222588CG0.95541.02850.03790.3384712598680170.00423
9rs703724627219544CG1.00710.97880.02910.3359224098149250.00144
9rs85727219786AG1.01231.02140.02910.3309621991148440.00248
9rs378031727180992CT0.85820.97510.03530.3226668485800980.00454
9rs787111027138155AG0.97260.96430.05110.3212085656337560.00137
9rs386101527093414AG0.95020.97310.03870.3175841383226410.00248
9rs704226727125962CT0.93560.98350.02400.3109576609718280.00092
9rs222452927182036AG0.98731.01700.02450.3075055924969160.01451
9rs101404927218503CT0.99360.98390.02380.3055703090429170.01859
9rs220863427227399CT0.97831.02390.03480.3025962767995120.09046
9rs61553227094709AG0.95721.02640.03870.2999889376778880.00248
9rs117825827176828AT0.87850.97480.03830.296278840072980.00058
9rs133480927116415GT0.94460.97640.03590.2959353205914330.00405
9rs65442227171761AT0.87020.97480.03850.2941362877160810.00112
9rs1769523627229343AG0.99071.01920.02890.2927705806727060.00144
9rs1096779327223737GT1.00290.98110.02920.2894595520667030.00244
9rs1096775327158704CT0.94511.01560.02390.2860896458710450.03319
9rs62223227108707AG0.92541.01520.02470.2654401784205240.01541
9rs702278327228850AG0.96530.97980.03380.2617745518574950.0887
9rs386101427093332AG0.95021.02280.03820.2553159367231140.00177
9rs1096779527224132CG1.00521.01720.02910.2542227821102410.00144
9rs487836827223367AG0.99110.98280.02950.2532879774833400.1145
9rs56558627160934CT0.99120.98400.02780.2508823376436780.00944
9rs1237695027228272CG0.95151.01770.03020.2506502394025230.00339
9rs141382927191968AG0.98531.01570.02720.2459576132145640.01019
9rs1776140327113348CG0.82540.97670.04230.2382224624918220.01124
9rs65786727098975CT0.99601.01620.02900.2379970306248850.01724
9rs487836927223523CT0.99111.01870.03400.2326214758858190.09186
9rs132205327169132CT0.84861.03300.05970.2321765019924830.00136
9rs68263227173463AC0.65311.03860.07160.2241711855353880.00108
9rs62162927186587AG0.64500.96370.07230.2152401053359950.0011
9rs786537627142034AC0.97070.97420.05130.2146701649892330.00135
9rs68118227104726AG1.00871.01460.02850.2144566300434070.01465
9rs487837027223556AC0.98800.98520.02960.2121854329369770.1145
9rs1096772427108323AC0.80520.97110.05850.2107013888405590.00107
9rs447559827224300AG0.98450.98530.02980.2087305190897320.1145
9rs704086627190929AG0.98320.98670.02730.2055816691258590.01019
9rs1081252927161373GT0.99851.01520.03100.2041894753325920.00747
9rs704211927125831CT0.98171.01260.02700.1917214904172320.00188
9rs703984927190358CT0.98631.01270.02720.1914514487595950.01019
9rs1073876327105768CT1.01371.01290.02790.1896330463183750.01479
9rs702798427189373AG0.99450.98720.02820.1889614913957840.00209
9rs58628427142977CT0.99711.01270.02800.1855526214775120.00455
9rs133481127180655AG0.98131.02720.05960.1855526214775120.00108
9rs785404827137976CT0.98670.98580.03200.1839576590780030.02181
9rs1096771527096614AG0.98550.98710.02910.1839576590780030.01607
9rs50744127143874AG0.99220.98770.02810.1810486883598270.00455
9rs1775666727134483AG0.98801.01420.03200.1805218716378770.0246
9rs1775659927126031CT0.98631.01420.03200.1803244800057070.023
9rs59931227143536AG0.99211.01230.02810.1780281823579570.00524
9rs110777427154846CT0.94630.98920.02510.1764605663431410.0035
9rs702764727189387AG0.99581.01220.02820.1761998462501220.00732
9rs64184827198857GT0.95901.01090.02530.1752885565352660.00592
9rs1096771627097349CT0.96150.98750.02990.1717913855320550.02017
9rs988673227220509AG0.94510.98630.03320.1689625143599750.00506
9rs58445127142524CT0.99401.01170.02810.1676827300777380.00455
9rs373681927209058AG0.92841.01810.04390.1660246287200940.0025
9rs787602427192663AG0.92830.98840.02870.1653885792773130.00089
9rs378031527186290AG0.98661.01050.02570.1646265475299910.01321
9rs51464327143078AG0.99620.98880.02800.1620329816313450.00455
9rs67753427105526CT0.94140.98830.02940.161969917014680.01716
9rs68073927104804AT1.00840.98870.02850.1607105439938530.01465
9rs1775668527134681CT0.98721.01280.03200.1602706247936120.023
9rs1096771927098810GT0.99081.02300.05740.1595802222635140.00133
9rs61898727109400CG0.98090.99020.02510.1576404266693250.0057
9rs192332727225404CT0.98781.01150.02980.1539104196420160.12231
9rs66681227110369GT0.97911.00960.02510.1536010269653250.0057
9rs1096775027156159CT0.95490.99060.02540.1489251947711130.00964
9rs785872227223157CT0.98871.00870.02350.1467886654966830.02865
9rs1081254027218564AG0.90441.01750.04760.1455724942121390.00378
9rs66451327142343CT0.99321.01030.02810.1445414196139640.00455
9rs63002327098800AG0.99710.98960.02890.1445414196139640.01724
9rs440948527224184AT0.98821.01070.02980.1430295665175080.1145
9rs1691113627174714AG0.97421.02170.05980.1425468829647330.00108
9rs787451427209640AC0.94840.98940.03010.1411020427679970.0273
9rs1691109227132444AG0.96931.01370.03970.1358450439979740.00319
9rs59031027109803AT0.97991.00850.02510.1325325121409490.00541
9rs99493327160402CG0.94281.00860.02540.1322968667299020.00656
9rs703559227224029AG0.99171.00830.02470.1318847946727830.04917
9rs373718827203580CT0.94480.99090.02880.1247071746289920.13819
9rs988685727220388AG0.99131.01050.03310.1236666709136200.00565
9rs67950427110920AG0.93791.00770.02480.1215356546585310.00411
9rs998781727220152AG0.99281.01030.03310.1213058996038920.00565
9rs703674327154220AG0.82221.00840.02790.1171340802783710.00899
9rs227371527219141CT0.99341.00990.03300.1165657063169910.00565
9rs1769479627124636AG0.97511.00950.03210.1144691668119080.023
9rs61537527102311GT1.00131.00790.02700.1135092748275180.00908
9rs1234050027124683GT0.97480.99090.03210.1100823165637940.023
9rs192332827225164AT0.98680.99310.02480.1082953237608170.04917
9rs1769502627145031CT1.00621.00900.03280.1053516962064830.02647
9rs132205127175101CT0.98270.98410.05920.1044669605159300.00108
9rs228223027193487CG0.98401.00770.02850.1036942925339190.00732
9rs1233786027122605GT0.97280.99150.03210.1021530684204280.023
9rs59642727089244AG0.95281.01030.03900.1012199867101740.00401
9rs159025527223968GT0.98911.01050.04160.09636748391576230.0028
9rs61733327205039AC0.82001.00920.03630.09604229147682950.00376
9rs1691104727123016AC0.98621.00990.04020.09312646527792960.00287
9rs378030727196274CT0.98401.00670.02750.09285746899685950.01019
9rs487836727223272CG0.98941.00580.02480.08841629901892420.04917
9rs140730027220196CT1.00301.01220.05420.08433639649422680.01124
9rs1178815427125336AC0.99000.99130.04010.0821795180063030.00287
9rs61798627109674CT0.94191.00530.02470.08128833461767880.00329
9rs1096776727193799CT0.98771.00600.02850.07857365898473458e-05
9rs159025427224089AT0.85641.01230.06240.07360609973031780.01512
9rs746869527224521AG0.98770.99210.04160.07088774334533940.00286
9rs487925027183503CT0.99670.99520.02560.07083661679493560.01101
9rs1051180327144617AG1.01030.99380.03270.07083661679493560.02647
9rs703957927128062CT0.99090.99250.04010.06991736660762880.00287
9rs1233986727224049CT0.99161.00610.03300.0691528083175030.00571
9rs133480827116340CT0.89380.98820.06460.06869471857832680.00107
9rs66647827163180CT0.70580.99500.02780.06757697362326120.0292
9rs373954227162838AC0.72351.00550.03040.06717123309915340.01212
9rs66954527172887CT0.97861.00300.02400.04488976902944820.02201
9rs382441027163062GT0.87321.00370.03060.04402377775167460.00698
9rs227371927210066AG0.97141.00390.03300.04287180232318690.00527
9rs66910227172802CT0.97831.00270.02400.04048162302700170.02201
9rs702484627216947GT0.98460.99740.02350.04014804520039470.03905
9rs1096779727225123CT0.99031.00350.03300.03824678581321740.00565
9rs67180427155030AG1.01840.99730.02960.03263926003405030.00866
9rs141382827194175CT0.98840.99800.02860.02502800570193100.0068
9rs1223705027154940AG0.72091.00950.13770.02456819149073718e-04
9rs155545427218754CT0.94850.99810.03050.02163685291611710.03863
9rs1234983227158433AG0.84781.00150.02750.01890657685407020.00069
9rs1096771727098433AG0.97270.99790.05840.01237841787451620.00133
9rs1775699727229130CT0.97870.99820.05590.01144104312138450.01124
9rs214592627183311AG0.98130.99940.02410.008818242332126820.02036
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18;43(10):977-83. doi: 10.1038/ng.943. PubMed PMID: 21926972.