Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q21.2    Gene: ANK3

 

BP - Genomewide Linkage Studies for ANK3


 

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Description

 
Shown here are the results for gene ANK3 from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs7909028chr10:1653080.062   0.10.0340.0390.05900.080.0090.0190.0490.79500
rs2496275chr10:2505440.2719ZMYND11
0.0980.0320.0370.05700.0770.0070.0170.0470.78900
rs2018975chr10:3075010.4375   0.0960.0310.0360.05600.0740.0060.0160.0450.78300
rs6560842chr10:4824830.9238DIP2C
0.090.0260.0310.05100.0660.0010.0110.0420.76800
rs816570chr10:6704751.4022DIP2C
0.0760.0190.0260.04200.05400.0060.0320.69400
rs1057304chr10:8431061.8061   0.0620.0130.0220.03400.04200.0020.0220.62300
rs1029182chr10:19559373.7232   0.0540.0180.0270.0300.0760.0070.0070.0050.200
rs10751879chr10:25171774.7645   0.120.0210.0610.0610.0020.1120.0330.0410.0080.1970.0080.008
rs729260chr10:25211744.7749   0.1210.0210.0610.0610.0020.1120.0330.0410.0080.1980.0080.008
rs7902082chr10:27853665.597   0.180.0310.0940.0940.0160.1790.0520.0680.010.3540.0340.04
rs3814595chr10:31916797.4114PITRM1
0.1790.0340.0980.1120.0090.1930.0320.04800.4130.0560.066
rs735155chr10:33641788.2963   0.1310.010.080.09700.1230.020.0300.2830.050.06
rs705466chr10:36360509.7582   0.0510.0020.080.0900.0850.0280.03800.1010.0420.06
rs3750858chr10:379141310.5485   0.0170.0010.0640.07400.0710.0250.03500.0390.0290.044
rs2031573chr10:399189711.644   000.0370.05400.0560.0070.01700.0030.0070.017
rs313476chr10:457630213.3865   00.0030.0380.07500.05400.010000.01
rs2167703chr10:486526214.1047AKR1E2
00.0080.0540.10400.0590.0010.012000.0010.012
rs1993181chr10:488116814.1406   00.0080.0560.10600.0590.0010.013000.0010.013
rs4750217chr10:574590616.0987ASB13
00.0120.1450.18600.040.0210.052000.0320.053
rs713588chr10:592696816.6656   00.0160.1730.2200.0460.0270.063000.0430.07
rs591510chr10:598195916.818FBXO18
00.0170.1810.22900.0480.0280.066000.0460.075
rs1887027chr10:615378817.3391   00.020.2170.26700.0380.0330.073000.0530.087
rs2031220chr10:642700318.1567   00.0210.2780.33100.0120.0450.088000.0660.111
rs11597105chr10:655258718.5012PRKCQ
00.0160.2950.35500.0070.0550.105000.080.135
rs1041226chr10:668385718.8073   00.0120.310.37700.0030.0640.12000.0920.157
rs2439903chr10:687186619.269LOC100507127
00.0070.3120.37400.0010.0810.138000.1130.183
rs942432chr10:720257019.8679   00.0010.2940.33800.0020.1050.156000.1430.213
rs1969825chr10:726132619.9925SFMBT2
000.290.3300.0020.110.16000.150.22
rs942434chr10:727701320.0268SFMBT2
0.0010.0020.2960.33600.0020.1120.162000.1560.226
rs1537626chr10:769313020.7098ITIH5
0.0220.0520.4390.47900.0030.1530.21000.2990.376
rs3858256chr10:781022820.9237ITIH2
0.0290.0670.4840.52400.0030.1650.225000.3440.423
rs1244459chr10:796824621.3211TAF3
0.0350.1220.5350.57500.0190.1920.249000.4020.479
rs2671303chr10:811458321.7308   0.0410.1850.580.6200.040.2210.274000.4550.528
rs516769chr10:825217422.0707   0.0440.2320.6050.64600.0580.2390.291000.490.561
rs1663691chr10:906373824.2101   0.0170.3680.4410.48700.180.1840.27400.0340.4470.562
rs2589569chr10:911197424.3107   0.0180.3620.4320.47600.180.1810.27100.0350.4410.558
rs1033912chr10:963252725.069   0.0220.3150.370.40100.1810.160.25300.0540.3960.533
rs867221chr10:1089530326.2645   0.0010.1740.3570.39700.1480.1650.31100.1840.3430.591
rs1535976chr10:1189013827.8556   00.020.2690.30900.0350.1970.34900.1310.3590.701
rs1892302chr10:1248657829.3059CAMK1D
0.0020.0040.260.31300.0040.1520.31200.0550.2960.653
rs1111060chr10:1261681829.6704CAMK1D
0.0050.0030.260.31700.0020.130.2900.0320.2660.61
rs652029chr10:1310441331.1082   0.1520.0040.3250.38600.0020.110.28200.0050.2350.58
rs7899305chr10:1323961731.5382   0.2140.0050.3470.41200.0040.110.29100.0070.2570.618
rs4615920chr10:1338266031.9995   0.280.0050.370.4400.0060.110.300.0090.280.66
rs1890876chr10:1352273732.4488BEND7
0.310.0040.3610.42700.010.0970.27800.0070.2580.624
rs13005chr10:1372577233.0802FRMD4A
0.3460.0030.350.4100.0160.0790.24800.0040.230.575
rs1001201chr10:1408345834.1083FRMD4A
0.3450.0090.3510.4100.0130.0720.223000.230.517
rs873849chr10:1454981335.3393   0.3350.0090.3460.3900.0150.0930.24700.0010.230.47
rs2298033chr10:1568971637.6721ITGA8
0.3930.0480.250.2330.0140.0580.1130.2100.0390.2270.34
rs1341106chr10:1574128437.7748ITGA8
0.3960.050.2470.2290.0160.0610.1150.2100.0420.2280.337
rs1341100chr10:1579384337.8593ITGA8
0.3990.0520.2440.2260.0170.0630.1170.2100.0440.2290.334
rs780838chr10:1696137640.3919CUBN
0.5090.1160.5220.5060.0850.0840.3080.3940.0110.0760.3120.402
rs1810205chr10:1700523340.4804CUBN
0.5040.1110.5240.5090.0850.0780.310.3950.0110.0730.310.4
rs1276709chr10:1707814440.6267CUBN
0.4980.1030.5290.5150.0860.0690.3130.3960.010.0680.3070.397
rs359327chr10:1743887641.3012ST8SIA6
0.410.070.510.5090.070.0330.2960.3730.0050.0410.2790.366
rs729245chr10:1878180042.9254CACNB2
0.0670.0510.3570.4040.0030.0030.1840.23600.0010.1740.245
rs10740828chr10:1936087143.436   0.0450.0640.3240.3780.0010.0030.180.23000.1610.24
rs949857chr10:2056574344.3644PLXDC2
0.0280.0710.2170.270.0150.0030.1580.1900.0010.1240.196
rs4748722chr10:2111352744.7506NEBL
0.0210.0630.140.1850.0310.0010.1350.147000.0970.15
rs10828183chr10:2139355744.9474NEBL
0.0170.0590.1010.1420.03900.1230.126000.0840.126
rs8341chr10:2286513945.9502PIP4K2A
0.0080.0480.0610.1010.05700.1010.101000.080.101
rs927751chr10:2354653546.5007   0.0060.0670.0550.0950.05300.0950.100.0010.0650.095
rs442463chr10:2465456347.8051KIAA1217
0.0020.2120.0260.0580.0330.0020.0660.08400.0050.0260.066
rs1928365chr10:2582277049.1753GPR158
0.0020.4290.0020.020.0140.0260.0420.05700.01500.032
rs1339812chr10:2635816749.8042MYO3A
0.0090.4670.0080.020.0170.0710.0480.08200.0200.038
rs1521034chr10:2644283749.9235MYO3A
0.010.4740.0090.020.0180.0790.0490.08700.0200.039
rs1935484chr10:2649449649.9927MYO3A
0.0110.4790.010.020.0180.0840.050.0900.02100.04
rs1999240chr10:2650313650.0042MYO3A
0.0110.4790.010.020.0180.0850.050.0900.02100.04
rs994502chr10:2654017250.0533MYO3A
0.0110.4780.010.0210.0170.0850.050.0900.0200.04
rs638324chr10:2777026751.7191   0.0150.4550.010.0300.090.050.09700.00100.033
rs1979720chr10:2791489551.801   0.0150.4550.010.0300.0920.050.0980000.032
rs1494201chr10:2792982451.8045   0.0150.4550.010.0300.0920.050.0980000.032
rs997750chr10:2795993751.8114   0.0150.4550.010.0300.0920.050.0980000.032
rs1494199chr10:2796860551.8128   0.0150.4550.010.0300.0920.050.0980000.032
rs332136chr10:2889858452.5645WAC
0.0270.4450.010.0300.1140.0390.08900.0100.024
rs788065chr10:2929257153.309   0.0320.4030.0070.02400.1050.0210.06500.014-0.0030.017
rs1889735chr10:2940573653.5909   0.0290.3720.0040.01800.0840.0120.0500.011-0.0060.014
rs950000chr10:2946041153.7349   0.0270.3560.0030.01500.0720.0080.04300.009-0.0070.013
rs913034chr10:2980724754.682SVIL
0.020.26900.0100.03100.02300.004-0.0030.017
rs1328327chr10:2990437654.9324SVIL
0.0180.24800.0100.02300.02100.003-0.0010.019
rs959629chr10:3065688056.754MTPAP
0.0090.2130.0180.05300.0810.0250.08800.0110.0080.06
rs793096chr10:3142545558.1974   0.0020.10.0440.10800.2280.0760.21800.1140.0460.188
rs1272045chr10:3146985658.2612   0.0020.0980.0450.1100.2310.0780.2200.1230.0480.194
rs727345chr10:3193907958.6738   0.0040.0870.0530.12700.2480.090.23700.1810.060.231
rs10508775chr10:3290473659.1232C10orf68
0.0110.0820.060.14100.2630.0980.24900.2530.0710.262
rs11009089chr10:3313456559.2413C10orf68
0.0170.0850.060.14200.2640.0950.24800.2770.0720.265
rs1360456chr10:3354693459.5418NRP1
0.0310.0920.060.14500.2680.0890.24500.340.0750.271
rs927099chr10:3356584259.5647NRP1
0.0320.0930.060.14600.2680.0890.24400.3450.0760.271
rs1441027chr10:3462370360.4116PARD3
0.050.1270.0760.17500.2860.0760.23600.5460.0840.28
rs1345561chr10:3581062861.3949CCNY
0.0430.1850.10.2100.3450.0620.21400.7880.090.272
rs913167chr10:3627916261.7779   0.0420.2090.10.2100.3860.0540.19900.8710.090.264
rs1892143chr10:3864651163.1359   0.0540.3870.1850.31400.5180.0680.21501.1450.0840.241
rs2505822chr10:4216169763.2709LOC441666
0.0610.380.20.32700.5140.0760.22101.1490.0880.243
rs624804chr10:4257359363.2959   0.0620.3780.2030.3300.5130.0780.22201.150.0890.243
rs2819021chr10:4324080863.5746   0.0760.3630.2330.35700.5030.0940.23301.1580.0970.246
rs1009769chr10:4368135863.798LOC100506835
0.0880.350.2580.3800.4960.1080.24201.1650.1040.248
rs77839chr10:4415853664.0908   0.1030.330.2970.4250.0040.4790.1350.26901.1480.120.264
rs11596854chr10:4717157665.3616   0.1550.1880.4810.6880.0770.3320.3120.48200.7940.2340.418
rs4922532chr10:4817014565.972   0.1580.0990.4990.7190.1330.2440.3480.51800.5890.2590.449
rs1822861chr10:4950433266.8988ARHGAP22
0.1620.1580.4460.630.2040.2660.3590.50200.6480.2240.378
rs1917810chr10:5054007767.5858CHAT
0.1610.2390.4750.6610.180.2710.3420.47100.570.1970.311
rs1268722chr10:5062121667.6461OGDHL
0.1610.2460.4790.6650.1770.2710.3410.46800.5610.1940.305
rs1203406chr10:5186802268.2818SGMS1
0.1660.2930.5060.6930.1470.2520.3160.4300.440.1770.259
rs4935215chr10:5249202268.497PRKG1
0.1690.2940.510.6950.1390.2370.3050.41500.3870.1750.25
rs1912607chr10:5405043570.2086   0.1420.1750.4150.5410.0040.0630.1420.2100.0650.1160.164
rs1000218chr10:5411255770.3184   0.1430.1690.4080.5310.0030.0620.1370.20400.0640.1140.16
rs10824792chr10:5419621270.4378MBL2
0.1440.1640.3990.5210.0030.0610.1320.19800.0620.1110.157
rs1900423chr10:5535314471.8075PCDH15
0.1230.1270.2710.37300.0970.0940.13800.0790.0760.116
rs996320chr10:5567108472.11PCDH15
0.1180.1280.2540.35700.1220.0930.13900.0920.0710.114
rs1338799chr10:5729968573.4219   0.1260.150.2940.41800.2680.1280.23100.1450.0880.163
rs1904764chr10:5881410174.157   0.1240.1420.2950.42200.2770.1310.24600.1410.0980.175
rs1427209chr10:5993293175.042   0.0820.0940.2720.38400.1610.0820.17100.1180.0930.152
rs10740731chr10:6001889275.1209BICC1
0.0820.0950.2750.39100.160.0850.17400.120.0970.156
rs1897620chr10:6056627175.6737   0.0850.10.2970.44100.1530.1070.1900.1330.130.184
rs284642chr10:6075171975.8764FAM13C
0.0860.1020.3050.45900.1510.1150.19600.1380.1430.194
rs1999668chr10:6075508875.8798FAM13C
0.0860.1020.3050.45900.1510.1150.19600.1380.1430.194
rs10826283chr10:6081769475.9472   0.0860.1030.3080.46500.150.1180.19800.140.1470.197
- chr10:61458164 ANK3            
rs1906455chr10:6260312977.9003   0.0130.1530.2340.35600.2320.1010.12400.1160.0920.085
rs1906457chr10:6260842477.9048   0.0130.1530.2340.35600.2320.1010.12400.1160.0920.085
rs224136chr10:6414068179.0008   0.0160.1510.270.350.0020.2570.160.100.1420.140.07
rs377859chr10:6418607179.0313   0.0160.150.2690.3480.0020.2550.160.09900.1410.1390.069
rs911610chr10:6429004879.0942   0.0150.1470.2660.3440.0020.2510.1590.09800.1380.1360.067
rs907chr10:6460668579.3164JMJD1C
0.0130.1380.2570.3310.0020.2360.1570.09400.1280.1270.061
rs1866311chr10:6549379579.8847   0.0060.1140.2350.2970.0010.1980.1510.08200.1040.1050.043
rs1925622chr10:6843964483.1183CTNNA3
LRRTM3
00.0050.0740.07500.0080.028000.0320.0580
rs1904645chr10:6863149883.4169CTNNA3
00.0030.0590.06300.0050.022000.0240.0520
rs10998021chr10:6963819583.7666MYPN
00.0010.0420.04900.0020.015000.0150.0450
rs1227938chr10:7082827485.2618HK1
000.010.02000000.0020.03-0.003
rs736594chr10:7089679685.4074TSPAN15
000.010.02000000.0020.03-0.004
rs16927648chr10:7187786687.8443   000.020.02000000.0040.012-0.018
rs10999657chr10:7249446289.7143   000.00300000000.01-0.013
rs877783chr10:7298594690.9317CDH23
000.0090.009000.0190000.038-0.001
rs1867998chr10:7300504890.9693CDH23
000.010.01000.0190000.0390
rs2394829chr10:7301538690.9897CDH23
000.010.01000.020000.040
rs3000976chr10:7407280892.608   000.0340.03000.0540.02000.0480.004
rs7095447chr10:7478990592.6986   000.0330.03000.0530.02000.0460.003
rs2688610chr10:7532493792.7387   000.0330.03000.0530.02000.0450.003
rs2227551chr10:7533919692.74   000.0330.03000.0530.02000.0450.003
rs4065chr10:7534647092.7407C10orf55
PLAU
000.0330.03000.0530.02000.0450.003
rs2675666chr10:7535265792.7413   000.0330.03000.0530.02000.0450.003
rs12254441chr10:7628786392.9481KAT6B
000.0310.03000.0510.02000.0410.001
rs9415126chr10:7731655993.9354C10orf11
000.0580.058000.0220.02000.0210
rs1040934chr10:7773626694.4881C10orf11
000.0650.065000.0350.03000.0250.005
rs1907308chr10:7796965794.8174C10orf11
000.0680.068000.0450.036000.0280.008
rs158421chr10:7885204095.9782KCNMA1
000.050.05000.050.04000.030
rs1655630chr10:8007154097.3422   000.120.104000.070.073000.040.01
rs703990chr10:8060044598.1621ZMIZ1
0.00200.1450.133000.070.08000.0420.01
rs1892498chr10:8077386898.4125   0.00500.1520.138000.070.08000.0440.01
rs720262chr10:82462543100.3545   0.0300.160.144000.0570.0570.02600.0570.004
rs1360953chr10:82803782100.7118   0.03100.160.147000.0640.0640.03900.0640.007
rs1336439chr10:82822237100.7315   0.03100.160.147000.0650.0650.0400.0650.007
rs11192313chr10:83801929101.8912NRG3
0.06700.2310.2120.00500.1320.1320.09600.1410.046
rs2475793chr10:84629629102.7492NRG3
0.1590.0010.270.2270.01900.1550.1550.18200.2020.08
rs489466chr10:84638946102.7587NRG3
0.1610.0010.270.2280.01900.1550.1550.18300.2030.08
rs1188786chr10:86313194104.3929   0.15800.30.230.11200.2440.240.28700.2460.128
rs11201444chr10:86944161104.9326   0.11600.30.230.16200.2760.2670.28900.2410.139
rs1880382chr10:87506325105.3732GRID1
0.07100.270.2230.15500.2760.2810.2740.0060.2550.17
rs10887577chr10:88069347105.7721GRID1
0.02800.2380.2150.14200.2720.2930.2590.0120.2710.202
rs10887683chr10:88706557106.2409MMRN2
0.00300.210.2030.1160.0020.2510.2830.2170.0120.2560.206
rs4869chr10:88720292106.2499C10orf116
0.00300.210.2030.1160.0020.250.2830.2150.0120.2550.205
rs2039305chr10:89977163107.1833   000.1710.1730.0560.010.1810.2170.0980.0010.1650.144
rs1556611chr10:91193194108.4847SLC16A12
000.1150.1210.0280.0230.1210.1310.03400.0810.046
rs1001065chr10:92080546109.532   000.0790.0730.0370.0220.0840.0730.03800.0490.015
rs7094359chr10:92294890109.7652   000.0690.0620.0420.0190.0770.0620.04300.0450.012
rs1857586chr10:92460757109.9377   000.0620.0530.0460.0180.0720.0530.04700.0410.011
rs7475251chr10:93389110110.6262   000.0290.0250.0510.0160.0450.0250.05100.0270.004
rs1111875chr10:94452862111.4167   000.0180.0140.0540.0230.030.010.04500.020
rs787652chr10:95026565112.2726   000.0330.0230.0670.0460.0350.010.02600.0170
rs701873chr10:95180558112.496MYOF
000.0350.0250.0770.0560.040.010.01800.0150
rs1547173chr10:95417271112.8409   000.0380.0280.0930.070.0470.010.00600.0120
rs2298037chr10:96736068113.9716CYP2C9
000.040.030.2210.1850.050.010.01600.010
rs1536556chr10:97127095114.1732SORBS1
000.040.0320.2230.1960.0530.0130.01700.010
rs9093chr10:98269043115.2555TM9SF3
000.0430.0450.2040.240.0730.0330.02100.0150
rs713251chr10:98278056115.267TM9SF3
000.0430.0450.2030.2410.0730.0330.02100.0150
rs531676chr10:99627568117.2986CRTAC1
00.0060.0510.0680.1340.2550.0810.0440.02100.0670.017
rs489062chr10:99705734117.4075CRTAC1
00.0060.0480.0640.1320.2590.0780.0420.01900.0660.016
rs1998756chr10:100219522118.0478HPSE2
00.0060.0290.0390.1190.280.060.030.00900.060.01
rs1889974chr10:100258510118.0904HPSE2
00.0060.0280.0380.1190.2830.060.030.00900.060.01
rs2862928chr10:101788336119.4449   00.0010.0060.0160.1050.3960.0640.0340.00800.060.014
rs1410079chr10:101836163119.4793   00.0010.0050.0150.1050.40.0650.0350.00800.060.015
rs1045232chr10:103305791120.7751BTRC
0000.010.1130.5490.1010.0630.00300.0680.028
rs749694chr10:103509774120.9316   0000.010.1140.5660.1070.0680.00200.0690.029
rs6580chr10:105196864121.6255CALHM2
000.0060.0160.0940.5210.1160.0890.00800.1080.061
rs276219chr10:106077502122.1415ITPRIP
000.010.020.0790.4930.1230.1040.01400.1380.087
rs1361800chr10:106802106122.572SORCS3
000.010.020.0740.5060.1310.1170.0240.0010.1640.109
rs1034178chr10:106889411122.6076SORCS3
000.010.020.0740.5070.1320.1180.0240.0010.1660.11
rs17121613chr10:108553106123.883SORCS1
000.010.0290.0420.5570.1310.1390.0450.0120.1720.139
rs1887984chr10:110103015125.5891   00.0250.0420.0680.0410.7790.1520.1980.1430.0550.1760.162
rs1324288chr10:110989897126.1982   00.0380.0540.0840.0960.8590.160.2140.2480.10.1940.188
rs884587chr10:112364292127.6308   00.070.070.1060.4041.2580.1730.2550.6720.4380.3260.348
rs11195400chr10:112753375127.9143SHOC2
00.0790.070.1090.471.3770.1780.2670.760.5380.360.388
rs618120chr10:113660106128.5992   00.1650.1180.170.6391.860.2640.3540.9280.8350.4660.484
rs1408817chr10:114488135129.9504VTI1A
0.0280.3180.2170.2770.9752.7110.3770.4581.1411.3070.6060.597
rs1891760chr10:115249096131.6075   0.1110.3920.3710.4571.172.6720.4860.5731.0191.3920.6360.658
rs932652chr10:115334779131.7901HABP2
0.1230.3990.3890.4771.1822.6530.4970.5850.9971.3890.6380.664
rs151603chr10:115719971132.6048   0.1760.4290.4280.531.0242.5010.5220.6360.7331.3050.5860.658
rs180922chr10:115726087132.615   0.1770.4290.4280.5311.0222.4980.5220.6370.7291.3040.5850.658
rs765173chr10:116591665133.565FAM160B1
0.2610.5160.4910.6290.6422.3130.5640.7390.3281.2130.5270.661
rs1157117chr10:117522381134.6196ATRNL1
0.390.5860.5860.7640.4842.1770.6580.8930.1661.1720.5660.713
rs1900500chr10:118438068136.1758HSPA12A
0.5280.4410.6140.8010.5361.7520.6820.9290.2541.0120.6640.737
rs1638432chr10:118451929136.1989HSPA12A
0.5280.4410.6120.7980.5341.750.680.9260.2521.0110.6620.734
rs758367chr10:118475191136.2376HSPA12A
0.5270.440.6090.7940.531.7470.6760.9210.2491.0090.6590.729
rs703422chr10:119818167139.218CASC2
0.4140.3590.280.3860.2091.3890.3180.4940.0220.7090.2890.272
rs915272chr10:120882532141.0335FAM45A
FAM45B
0.2610.1710.1390.2090.0530.9640.1490.28900.3360.0690.069
rs1467813chr10:121271597141.4781RGS10
0.2560.1550.130.20.0481.0760.140.2800.4670.0560.056
rs1041517chr10:121893964142.4399   0.2330.110.1070.1720.0321.090.1170.24800.4450.0310.031
rs934321chr10:122704274144.0524MIR5694
0.1680.0570.0680.1180.0030.9130.0890.18800.2290.0190.019
rs1696837chr10:123417632145.821   0.1070.0520.0240.05501.0210.0540.14400.270.010.002
rs2901297chr10:123511474146.028ATE1
0.0980.0520.020.04901.0250.050.13900.2730.010
rs911788chr10:123931788146.8218TACC2
0.0440.0640.0120.0340.0020.9160.050.11500.270.010.008
rs1571423chr10:125239972148.7362   0.0010.04600.00300.7860.0430.07500.1930.020.01
rs870577chr10:125654250149.3303   00.038-0.003000.7210.0370.06700.1880.0270.01
rs10899chr10:125758210149.5363CHST15
00.036-0.005000.6970.0350.06500.190.0310.01
rs2949368chr10:126716070151.7155CTBP2
00.037-0.03-0.010.0070.5570.030.040.1360.3670.1160.037
rs1152690chr10:126786372151.8878CTBP2
00.04-0.03-0.010.0090.5620.030.040.1620.4020.1240.039
rs7919596chr10:126889636152.1399   00.046-0.03-0.010.0090.5510.0290.0370.1810.4310.130.04
rs4962480chr10:127378272153.4494LOC283038
00.079-0.026-0.010.0020.4220.0160.0160.1880.4650.1260.036
rs1278305chr10:127801415154.5319ADAM12
00.102-0.015-0.0100.3360.010.010.180.4510.1310.041
rs728104chr10:127970593154.9395ADAM12
00.111-0.011-0.0100.3120.010.010.180.4470.1390.049
rs873957chr10:127993139154.9933ADAM12
00.112-0.01-0.0100.3080.010.010.180.4460.140.05
rs10901726chr10:128531665156.2474   0.0010.08900.0020.0030.2810.0270.0250.2260.3880.1620.072
rs1926143chr10:129464867158.1532   0.0350.070.0280.0380.0630.2680.1150.0940.5090.5160.4220.215
rs1255135chr10:130007627159.8457   0.110.0540.1210.1390.1650.3110.2930.2711.0450.6780.9980.502
rs765934chr10:130634338162.4893   0.220.0250.2350.2550.1490.0240.3450.3450.840.3181.0160.58
rs1869251chr10:130702545162.8132   0.2260.0170.2380.2580.1390.010.3360.3420.7920.2740.9810.574
rs7072831chr10:130881856163.6333   0.1970.0050.1960.2220.12500.3110.340.6990.210.8710.557
rs1861860chr10:130916682163.7909   0.1890.0030.1850.2130.12400.3060.340.6820.2010.8490.554
rs570967chr10:131311320165.4074MGMT
0.13900.1080.1380.17500.2540.3030.4520.1150.4830.449
rs6482747chr10:131384247165.7074MGMT
0.14400.1140.1440.1990.0010.2720.3270.4050.1140.4560.47
rs1980849chr10:131429387165.9035MGMT
0.14700.1180.1480.2140.0010.2840.3420.3730.1130.4390.483
rs1036268chr10:132580441169.2699   0.080.0230.3760.4660.2980.2120.8441.0340.6470.4991.2671.429
rs893509chr10:132903432170.0983TCERG1L
0.0810.0540.4160.5090.3040.3760.9091.1030.7210.6871.4181.593
rs754575chr10:132926048170.1586TCERG1L
0.0780.0560.4140.5080.2990.3820.9081.1050.7210.6921.4171.595
rs1530064chr10:132938782170.1925TCERG1L
0.0760.0580.4120.5080.2960.3860.9081.1060.7210.6951.4161.596
rs10159746chr10:133592667171.727   0.0090.1230.3440.4850.170.4970.8641.1150.6770.7531.3421.584
rs1888120chr10:133714136171.9797   0.0030.1330.3310.480.150.5050.8511.110.6610.7511.3221.571
rs12570033chr10:133984693172.5018   0.0030.1240.3050.4450.1760.4960.841.0850.710.731.2851.5
rs3793670chr10:134389701173.2015INPP5A
0.0030.1070.2760.4040.2140.4940.8341.0620.7750.7311.2541.428
rs4463779chr10:134642616173.579   0.0040.0950.2680.3930.2340.5070.8421.0660.8020.7721.2621.424
rs761774chr10:134778129173.7539GPR123
0.0050.0890.2650.3870.2420.5130.8451.0680.8150.791.2651.422
rs880340chr10:134903113173.9152VENTX
0.0050.0840.2620.3830.2510.5180.8481.0690.8270.8081.2681.421

Table Legend: Tabular display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow row marks the location of the selected gene, and the whitened rows correspond to 20 Mb
around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

References

 

Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry. 2012 Jul;17(8):818-26. doi: 10.1038/mp.2011.89. Epub 2011 Jul 19. PubMed PMID: 21769101