Metamoodics Gene Information

 

  Chromosome: chr13    Cytoband: q33.2    Gene: DAOA

 

BP - Genomewide Linkage Studies for DAOA


 

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Description

 
Shown here are the results for gene DAOA from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs1334958chr13:184399100.0627   00-0.037-0.0470.1020.060.0440.0840.42700.0660.055
rs1334961chr13:184487750.0749   00-0.037-0.0470.1030.0590.0450.0850.42800.0670.056
rs1572372chr13:197380041.0074   000-0.010.1520.0390.110.150.44700.150.13
rs3847993chr13:201931941.7154IL17D
0.00100-0.010.160.0460.0960.1290.43400.1290.109
rs509012chr13:211926634.0091   00-0.03-0.050.0620.0540.010.010.42200.090.06
rs765244chr13:213493714.5378LINC00424
00-0.025-0.0450.0520.0610.0050.0050.40600.090.055
rs8000805chr13:215152655.0413   00-0.019-0.0390.0440.066000.39300.0950.053
rs292476chr13:219311206.2384   000-0.0080.0410.0460.0120.010.36300.1950.118
rs4132778chr13:219915836.409   0.00100-0.0060.040.0440.0140.010.34400.1920.116
rs6490738chr13:220636496.6117   0.00100-0.0040.0380.0410.0160.010.32100.1880.114
rs475992chr13:227721508.6121SGCG
0.00200-0.010.0250.009000.1300.0430.012
rs1008812chr13:228641458.8689SACS
0.00200-0.010.0260.006000.11200.0280.004
rs9318302chr13:2354778110.3146   0.01500-0.010.0370.0110-0.0030.0230-0.003-0.016
rs8000533chr13:2408722411.3515   0.02300-0.010.050.0090-0.0060.0010-0.01-0.034
rs6490970chr13:2413273811.4536   0.02300-0.010.0520.0090-0.0050.0010-0.01-0.035
rs977655chr13:2520256914.1231ATP8A2
0.0060000.0890.0120.01000-0.01-0.04
rs306395chr13:2534856414.5048ATP8A2
0.0050000.0940.0070.01000-0.01-0.04
rs1886204chr13:2707234118.9547LNX2
0.00600.0100.21800.050.01000-0.03
rs535534chr13:2710732319.0419POLR1D
0.00600.0100.22100.0490.01000-0.031
rs2491218chr13:2750204120.0582FLT3
0.00400-0.0010.2500.02900.0070-0.01-0.052
rs1572881chr13:2811390421.7311   0.11500-0.010.41100.013-0.0070.1570-0.017-0.119
rs1617234chr13:2820706921.9398   0.13500-0.010.42700.011-0.0090.1820-0.019-0.128
rs954108chr13:2826670622.0923   0.14800-0.010.43100.01-0.010.1910-0.02-0.128
rs720083chr13:2924723723.4873UBL3
0.22600-0.0150.35800.005-0.020.1920-0.035-0.134
rs604269chr13:2950772724.0836   0.2200-0.0190.27200-0.0290.1580-0.05-0.156
rs478410chr13:2955408124.2326   0.19700-0.0180.23800-0.0280.1440-0.05-0.148
rs717651chr13:3007059425.7846   0.01900-0.0020.01300-0.0120.0280-0.042-0.079
rs1125434chr13:3032525926.5688   0.00100-0.006000-0.0040.0220-0.04-0.064
rs1854950chr13:3043951026.9141TEX26
000-0.009000-0.0010.0260-0.04-0.061
rs567972chr13:3095028628.1905   000-0.008000.00200.0620-0.024-0.034
rs436227chr13:3153242429.3924FRY
000.0040000.0140.0040.07900-0.006
rs390704chr13:3153686629.4015FRY
000.0040000.0140.0040.07900-0.006
rs1329344chr13:3299623231.6184STARD13
000.0220.006000.0390.0320.11700.0060
rs912675chr13:3316920531.8322   000.0270.008000.0450.0370.1200.0080
rs2321566chr13:3316941831.8325   000.0270.008000.0450.0370.1200.0080
rs4142811chr13:3362426632.336   000.050.0270.01300.0840.0670.13600.0230.01
rs12429306chr13:3406087832.8719LINC00457
0.00100.0820.0540.03300.1370.110.15900.0450.026
rs4943303chr13:3495072634.0148MIR548F5
NBEA
0.01600.1210.0910.05100.1610.1310.1900.060.04
rs20411chr13:3512948834.2755MIR548F5
NBEA
0.02500.1370.1070.05800.1770.1490.21500.0680.048
rs1517894chr13:3600026735.6263   0.1220.0030.2680.2440.110.0010.2890.2690.34600.1280.101
rs9469chr13:3648183136.405FAM48A
0.2220.0350.3890.3730.1560.0160.3790.3710.40200.1780.152
rs1781670chr13:3658522136.5836   0.2470.0480.4190.4050.1670.0220.40.3980.41100.1910.167
rs668103chr13:3765275038.4644   0.3320.1160.5180.5180.2350.0370.5420.5610.48400.2730.263
rs980285chr13:3793793238.9428   0.3370.140.5470.5470.2580.0450.5850.6140.51700.3060.296
rs737645chr13:3893169340.5562LHFP
0.230.1670.5980.6120.350.1090.8270.8570.7070.0060.570.522
rs732390chr13:3942698141.3543   0.1960.1470.6310.6370.3490.0970.8840.9030.7450.0090.6610.576
rs2004000chr13:4028151542.5872SLC25A15
TPTE2P5
0.1460.0870.6680.6680.3150.0590.890.890.6750.0040.6980.588
rs7799chr13:4043105242.8108ELF1
0.1380.0780.6740.6740.3120.0550.890.890.6590.0040.7040.594
rs912875chr13:4157523843.7186DGKH
0.1170.0730.7160.7450.3540.0510.9690.9690.7060.0020.8320.744
rs994856chr13:4160645143.739DGKH
0.1170.0730.7170.7470.3550.0510.9710.9710.7080.0020.8360.748
rs238349chr13:4170358843.817   0.1150.0730.7210.7540.360.0510.980.980.7140.0010.8490.763
rs1169791chr13:4216851744.4935   0.0990.0580.750.7950.3990.0711.0841.0840.8250.0010.9840.889
rs1544295chr13:4239668944.9074EPSTI1
0.0880.0450.7660.8150.4220.0871.1541.1540.9050.0021.0710.963
rs299344chr13:4316158946.499ENOX1
0.0640.0180.7050.750.5950.1711.2651.221.0650.0061.21.105
rs1408875chr13:4391405847.5961TSC22D1
0.0490.0040.6080.6370.6180.1531.1631.1071.0790.0021.1621.084
rs2050638chr13:4423983447.8019   0.0460.0020.5840.6080.6120.1441.1261.0681.0740.0011.1461.072
rs4941527chr13:4488370548.3093SLC25A30
0.04300.5320.5460.6060.1411.0530.991.07101.1391.072
rs2985981chr13:4499266348.4473COG3
0.04300.520.5310.6050.1441.0360.9721.07101.1431.078
rs1886040chr13:4562159549.5424LCP1
0.03900.4810.4810.6070.160.9750.8891.0420.0011.221.16
rs625052chr13:4570066949.7045   0.03800.4840.4840.6090.1620.9770.8861.0320.0011.2371.177
rs720277chr13:4643127651.3001   0.04600.5330.5320.5560.1320.8970.8120.9640.0041.251.214
rs973908chr13:4661401951.623   0.04400.5360.5450.5370.1390.8940.8250.9260.0081.251.24
rs912278chr13:4818148852.5616CYSLTR2
0.0300.4730.4810.4620.1670.8110.7730.7740.0431.2111.276
rs1427167chr13:4835769852.5873   0.0300.470.4780.4590.1680.8080.770.7690.0441.2091.276
rs7446chr13:4917351653.0644KPNA3
0.02100.4160.4150.4170.1840.7470.7170.6860.0691.1851.286
rs1407441chr13:4918899153.0789KPNA3
0.02100.4150.4140.4170.1840.7470.7170.6850.071.1861.288
rs1239684chr13:5006272053.8873   0.01800.3670.3490.3920.1960.7150.6850.6270.0991.2421.369
rs675305chr13:5022018954.026DLEU7
0.01800.3620.3420.3860.1970.7080.680.6140.1041.2451.377
rs1014934chr13:5096705854.5166   0.0180.0010.3910.3760.3310.1790.6790.6750.5230.1261.1471.313
rs1058142chr13:5124020754.6214DHRS12
0.0180.0010.3970.3830.3190.1750.6730.6740.5040.131.1261.299
rs2274202chr13:5162079954.7165NEK3
0.0180.0010.4030.390.3090.1710.6670.6730.4860.1351.1071.287
rs1322938chr13:5262975855.1271   0.0160.0010.3640.3550.240.140.5630.5810.3760.1270.911.083
rs1573217chr13:5337982355.4811   0.00900.2090.2040.1380.080.3230.3330.2150.0730.5210.621
rs1361026chr13:5392333555.699   0.00600.3310.3450.1740.0720.4730.5160.2830.1690.8111.019
rs1340580chr13:5401951555.7292   0.00600.3480.3640.1790.0710.4940.5420.2930.1820.8511.075
rs1336229chr13:5405652055.7392   0.00500.3540.3710.1810.0710.50.550.2960.1860.8641.093
rs1382461chr13:5406365155.7411   0.00500.3550.3720.1810.070.5020.5520.2960.1870.8661.096
rs641385chr13:5477102655.8744   0.00400.4290.4590.2030.0660.5940.6640.3380.2461.0431.34
rs1936318chr13:5603011455.9188   0.00300.4540.4870.210.0640.6240.7020.3520.2651.1021.421
rs1409239chr13:5687932355.9522   0.00300.4730.5090.2160.0630.6470.730.3620.281.1471.483
rs9569695chr13:5693846055.9562   0.00300.4750.5120.2170.0630.650.7330.3630.2821.1521.49
rs717256chr13:5732442856.0639   0.00200.4840.5250.2290.0570.670.7580.3930.2911.1981.549
rs901510chr13:5877360756.8639   000.2840.3330.2870.0090.550.6140.5880.1641.0461.285
rs340210chr13:5933191457.2615DIAPH3
000.2530.30.2670.0010.5380.590.6030.130.9961.203
rs300320chr13:6034173257.965   000.260.30.1850.0010.5590.590.5550.0970.9331.105
rs310935chr13:6193178258.6738   000.3680.3740.1410.0080.6480.6570.4060.0990.931.107
rs1553161chr13:6204507158.722   000.3760.3790.1380.0090.6540.6620.3960.0990.931.107
rs1335686chr13:6238563058.8653   000.3980.3950.130.0110.6720.6770.3640.10.931.109
rs188481chr13:6271039258.9934   000.4190.4090.1220.0120.6890.6890.3360.1010.931.11
rs1545963chr13:6375154359.3911   0.00200.510.4840.1240.0350.7410.7330.3640.130.9461.11
rs7330384chr13:6445641459.7945   0.00500.6030.5610.1270.060.7930.7770.3930.160.9621.11
rs1831972chr13:6583772360.5747PCDH9
0.01500.6840.6230.1540.0660.8430.8290.4640.1381.0391.173
rs1547143chr13:6653076460.9036PCDH9
0.0200.7040.6360.1690.0620.8560.8450.4970.1161.0781.209
rs735600chr13:6790029161.4957   0.01100.690.630.1320.0470.8350.840.4970.1141.1591.294
rs1340745chr13:6841421561.761MIR548H4
0.00500.680.6250.110.040.8220.8350.4920.1161.1971.334
rs768826chr13:7066864263.9177   000.6320.5720.0520.0090.7430.7820.2820.0761.241.399
rs7990251chr13:7067830463.9291   000.6320.5720.0510.0090.7430.7820.280.0761.241.399
rs2706411chr13:7151752665.2579   0.00900.7250.6630.05900.810.8480.3240.0481.3981.561
rs9564928chr13:7234329966.9744PIBF1
0.06200.7890.7190.11900.8590.870.3450.0391.4691.649
rs1023102chr13:7272301767.5719   0.0650.0220.7960.7310.1790.0050.9170.9040.4190.071.5391.684
rs1331769chr13:7374136269.348   0.0410.2380.7240.6940.3910.1341.151.0330.7020.2511.7331.722
rs1318725chr13:7376077369.3866   0.040.2370.7170.6870.3930.1351.151.0310.7060.2531.7341.719
rs2038946chr13:7401920369.9397   0.0320.2230.6110.5810.4270.151.151.0030.7640.2811.7391.675
rs1011026chr13:7463200871.1535   0.0130.140.3830.3650.2750.0860.7070.620.60.271.3511.303
rs9573506chr13:7471956671.2922   0.0170.1360.3680.3510.2940.0850.6680.5840.6570.2751.3241.27
rs1560540chr13:7478049671.3944TBC1D4
0.020.1330.3570.3410.3090.0840.640.5570.6990.2781.3051.245
rs9565166chr13:7495138571.6522TBC1D4
0.0280.1250.3280.3150.3450.0810.5670.490.8060.2871.2561.183
rs1394695chr13:7582962672.6252   0.0670.1030.3030.2860.4270.0590.4450.3621.0530.2811.2211.106
rs1886037chr13:7706175373.3829SCEL
0.0860.0840.3060.2820.4410.0380.4190.3251.120.2491.2251.083
rs5351chr13:7737331473.6496EDNRB
0.0880.0760.3040.2770.4380.0310.4110.3141.1240.2341.2141.065
rs9530845chr13:7847594374.7007MIR548A2
0.0920.070.3280.2980.4250.0210.4350.3421.1480.2151.271.103
rs9545158chr13:7909090775.4037   0.0680.0750.3160.2940.3370.0170.4220.341.0350.1961.2761.134
rs1892096chr13:8004479576.3633   0.020.0790.2580.2550.1450.0110.3360.2850.7660.1591.2151.122
rs1176270chr13:8021851776.5179   0.0150.0780.2490.2490.1160.010.3180.2740.7270.1551.2041.114
rs768218chr13:8115716477.2838   00.0850.1920.2020.0180.0160.220.2030.5810.1541.1051.016
rs984518chr13:8158113177.5679   00.0920.1630.1730.0110.0230.180.1660.5550.1641.0390.942
rs1334857chr13:8341548378.4154   00.1460.0870.09700.060.0910.0850.4620.2080.8820.759
rs722952chr13:8512891479.3494   00.2040.030.03600.110.0360.0360.3530.2790.7620.625
rs407218chr13:8534462579.4864   00.2020.0250.03100.1140.0310.0310.3410.2920.7460.611
rs1034052chr13:8534605579.4872   00.2020.0250.03100.1140.0310.0310.3410.2920.7460.611
rs979969chr13:8709510280.3653MIR4500HG
00.1730.0060.00600.120.0060.0060.2960.3670.6610.534
rs9582993chr13:8762319880.7565   00.1460.0020.00200.1080.0020.0020.2980.3970.6290.507
rs4424782chr13:8767842280.8013   00.1430.0020.00200.1060.0020.0020.2980.4010.6260.504
rs2044348chr13:8870043881.6436   00.1150.006000.077000.3230.5150.5780.458
rs9301665chr13:8971580182.5124   00.1290.020.0100.060.0050.0050.3430.6520.5750.466
rs1332470chr13:9021519182.954   00.1470.0290.01900.0560.010.010.3480.7240.5890.488
rs9523070chr13:9021781082.9559   00.1470.0290.01900.0560.010.010.3480.7240.5890.488
rs898271chr13:9053992283.2424   00.1710.0420.03200.0670.0220.020.3490.7330.6140.517
rs1411316chr13:9075518283.456   00.190.0530.04300.0770.0330.0280.3490.7350.6360.54
rs319541chr13:9256335985.3114   00.210.1290.12900.0830.080.0760.2250.3790.5410.454
rs1408209chr13:9280557585.6671GPC6
00.2060.140.1400.0880.080.0830.2020.3590.520.437
rs719223chr13:9353293787.1057GPC6
00.1530.130.1400.0560.0710.0820.1370.3070.4880.382
rs766606chr13:9445216889.081   00.0220.1210.13000.1030.1330.2270.190.6470.423