Metamoodics Gene Information

 

  Chromosome: chr11    Cytoband: q23.1-q23.2    Gene: DRD2

 

BP - Genomewide Linkage Studies for DRD2


 

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Description

 
Shown here are the results for gene DRD2 from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs741737chr11:2785050.1363   0.8230.1940.0910.021.7610.1360.2350.0310.070.1990.1140.073
rs7481525chr11:3681880.45B4GALNT4
0.8360.1970.0950.021.8040.140.2480.0340.0830.2090.1240.079
rs885454chr11:11999673.2695   0.8820.230.1070.032.1550.1850.350.060.2360.3520.220.153
rs2029463chr11:16184814.6249MOB2
0.8750.2550.0940.032.1530.1980.3380.0540.2360.4330.220.166
rs1004446chr11:21267196.1907IGF2
INS-IGF2
0.8090.3230.090.0321.9220.2350.290.0480.2060.4890.2120.166
rs451041chr11:30173018.8643CARS
0.7710.3910.090.051.4370.2360.1450.0110.0920.3980.0950.094
rs956453chr11:33641059.8445LOC650368
0.8430.4370.1070.0671.390.2440.1570.0270.0490.3920.0650.09
rs879114chr11:360035410.2958   0.8660.4620.1220.0821.3980.260.1870.0420.0420.4720.0690.099
rs1451724chr11:381324410.5955RHOG
0.8740.4790.1340.0941.410.2740.2140.0540.0420.5520.0780.108
rs2231963chr11:458159611.5751TRIM68
0.8870.4530.1670.1221.4540.2480.2730.0820.0540.6250.090.114
rs1609812chr11:520371712.9752HBB
0.7950.2840.1510.1011.5550.1110.290.080.0690.4370.080.09
rs892336chr11:555925513.8409OR52B6
0.7190.1250.1160.0661.6640.0290.2480.0630.1020.2930.0720.065
rs906895chr11:623682415.3497   0.5540.0230.050.0231.6580.0010.1590.0430.20.1820.050.053
rs10500688chr11:724794516.991SYT9
0.37900.0101.36700.090.020.1490.10.010.02
rs2200650chr11:728277117.0588SYT9
0.3700.009-0.0011.37200.0880.0190.1530.1020.0090.019
rs2280726chr11:803930518.5288TUB
0.1850-0.011-0.0211.34200.0340.0050.210.13200.005
rs905290chr11:871030519.7486ST5
0.1030-0.027-0.0370.98100.00500.1830.10400
rs10279chr11:892588520.0093TMEM9B
0.0930-0.031-0.0410.8980000.1750.09400
rs1425151chr11:1064479321.225MRVI1
0.0630-0.11-0.1080.6240-0.01-0.040.0770.009-0.032-0.024
rs16908224chr11:1069337521.3113   0.0650-0.11-0.1070.6220-0.01-0.040.0730.009-0.033-0.026
rs4910014chr11:1152471223.2216GALNTL4
0.1540-0.059-0.0510.6550.001-0.008-0.0260.0020.034-0.043-0.033
rs7484014chr11:1161184423.4728   0.1760-0.046-0.0410.670.002-0.005-0.0210.0010.056-0.036-0.026
rs1365406chr11:1251929625.6767   0.2280.14200.0070.5190.1760000.53500.007
rs730414chr11:1341543026.9838BTBD10
0.1280.17400.030.2110.23300.0100.82900.02
rs7484197chr11:1424023027.523SPON1
0.1130.270.0160.0560.140.31600.0201.04700.02
rs10832503chr11:1566103828.8235   0.1120.3790.0380.1050.0660.4670.0080.04601.35300.028
rs722317chr11:1588013829.062   0.1150.3830.0420.1140.0640.4890.0110.05201.3820.0010.032
rs214101chr11:1724593030.649   0.1510.3910.0960.2020.090.5880.0430.11601.4170.0230.089
rs4757574chr11:1768295031.1829   0.1610.3920.1080.220.1070.570.050.12601.3120.030.1
rs4348874chr11:1874876032.7214PTPN5
0.160.4020.0930.2130.1770.4210.0430.10300.5770.0230.093
rs1470251chr11:2007816837.101NAV2
0.0610.6470.1030.2530.2030.7810.060.14900.629-0.0010.029
rs961746chr11:2011754137.2363   0.060.6380.1070.2570.1980.7750.060.14800.617-0.0020.028
rs4278510chr11:2166859541.0572   00.3130.0880.1860.0080.2900.02900.157-0.073-0.012
rs1009807chr11:2181775441.3364   00.3120.0770.1660.0060.27900.02300.135-0.09-0.02
rs2593688chr11:2234560742.3344SLC17A6
00.2950.0470.1170.0020.24100.0100.062-0.147-0.05
rs7117792chr11:2265419942.8658GAS2
00.2730.0410.11100.21900.0100.027-0.173-0.066
rs4486627chr11:2284875043.1754   00.250.0380.10500.206-0.0020.00800.015-0.184-0.074
rs4584574chr11:2303239943.4557   00.2220.0350.09600.192-0.0050.00500.011-0.189-0.079
rs731365chr11:2429063345.3663   00.090.010.0400.127-0.016000-0.209-0.113
rs1596854chr11:2502087346.3796LUZP2
00.0670.0140.04400.102-0.0060.00400-0.167-0.081
rs1389423chr11:2574842247.1938   00.0580.0180.0500.08500.01200-0.12-0.046
rs7480892chr11:2636716347.7117ANO3
00.0510.0130.0500.08400.01700-0.094-0.036
rs1461382chr11:2636863647.7126ANO3
00.0510.0130.0500.08400.01700-0.094-0.036
rs1157659chr11:2771419848.9004   00.0240.010.0500.08100.02900-0.053-0.012
rs1491846chr11:2785559049.0263   00.0210.010.0500.0800.0300-0.049-0.01
rs1564745chr11:2824813149.3454METTL15
00.0190.0130.05300.06900.0300-0.04-0.007
rs1032091chr11:2824865449.3458METTL15
00.0190.0130.05300.06900.0300-0.04-0.007
rs973556chr11:2881529049.6949   00.0180.0170.05700.05700.0300-0.029-0.003
rs524373chr11:2998365050.3446   00.0160.0170.0570.0010.03500.02700-0.02-0.003
rs509628chr11:3149193151.2994ELP4
00.0190.0130.0560.0030.0100.01700-0.023-0.013
rs1003715chr11:3197692051.6024   00.0230.0160.0620.0030.0100.01400-0.026-0.016
rs373499chr11:3310271552.4546CSTF3
00.0390.020.0790.0010.0100.0100-0.039-0.025
rs10734415chr11:3327137452.7042HIPK3
00.0440.020.0840.0010.01100.0100-0.044-0.027
rs750780chr11:3387417053.7795   00.070.020.0900.01400.0100-0.058-0.03
rs910090chr11:3439411754.9083   00.1080.0110.06300.006-0.0090.00100-0.06-0.039
rs1530966chr11:3455218455.265   00.1010.0070.05200.004-0.018-0.00300-0.065-0.045
rs2045040chr11:3457533255.3165   00.10.0070.05100.003-0.019-0.00300-0.066-0.046
rs666110chr11:3581907257.7407   00.045-0.0070.0100-0.13-0.05200-0.1-0.07
rs1499511chr11:3604442958.1587LDLRAD3
00.049-0.0070.01500-0.135-0.05700-0.095-0.064
rs179801chr11:3706711159.8803   0.0110.0930.0360.07500-0.092-0.03100-0.061-0.021
rs1026833chr11:3852300061.0034   0.0340.05400.0200-0.25-0.1500-0.17-0.1
rs1488943chr11:3917540761.1258   0.0320.05100.01900-0.268-0.16100-0.186-0.111
rs2035693chr11:3919360861.1364   0.0320.0500.01900-0.269-0.16200-0.188-0.112
rs920443chr11:4037966862.2288LRRC4C
0.0280.0300.01200-0.383-0.23500-0.311-0.199
rs1027388chr11:4057640462.4276LRRC4C
0.0330.03200.01400-0.377-0.23100-0.321-0.207
rs1462224chr11:4101631662.9295LRRC4C
0.0450.03600.01900-0.362-0.22100-0.346-0.227
rs1488618chr11:4216281663.9103   0.1240.0460.0180.03800-0.287-0.17400-0.323-0.23
rs975104chr11:4294909664.121   0.1280.0420.0190.03900-0.285-0.17500-0.322-0.234
rs4755782chr11:4412457265.4726EXT2
0.0720.0020.0050.02100-0.344-0.22400-0.349-0.274
rs4755809chr11:4427976965.8649ALX4
0.0510.0010.0010.01300-0.363-0.23600-0.357-0.286
rs919445chr11:4458953066.5073CD82
0.022000.00500-0.375-0.2400-0.33-0.26
rs1487718chr11:4511803667.4934PRDM11
000000-0.355-0.2200-0.275-0.2
rs11988chr11:4721783668.7854ACP2
00.00100.00800-0.259-0.12900-0.203-0.131
rs3886262chr11:4777358668.8178NUP160
00.00100.00800-0.256-0.12600-0.201-0.129
rs1917309chr11:4940263068.9377   00.00100.00900-0.246-0.11600-0.194-0.123
rs1532421chr11:5013450668.9538   00.00100.0100-0.244-0.11400-0.193-0.122
rs10792360chr11:5536098869.0269   00.00100.00900-0.222-0.10200-0.175-0.111
rs10750788chr11:5572164069.0327   00.00100.00900-0.219-0.100-0.173-0.11
rs1397050chr11:5612833369.0406OR8U8
00.00100.00900-0.217-0.09900-0.172-0.108
rs764855chr11:5636698869.0462   00.00100.00900-0.217-0.100-0.172-0.109
rs490358chr11:5691398169.0743PRG2
00.00100.00900-0.22-0.10200-0.175-0.111
rs1447168chr11:5764118769.2116OR9Q1
00.00100.00700-0.235-0.11200-0.189-0.119
rs1451327chr11:5774766969.2362   00.00100.00700-0.238-0.11400-0.192-0.121
rs1009171chr11:5817847969.3517   00.00100.00600-0.25-0.12200-0.204-0.128
rs1941968chr11:5817912369.3519   00.00100.00600-0.25-0.12200-0.204-0.128
rs11607526chr11:5892297869.5383   0000.00400-0.27-0.13600-0.223-0.14
rs487641chr11:5929187369.7557STX3
0000.00200-0.294-0.15200-0.245-0.154
rs1530354chr11:5995702270.4598MS4A5
0000.00500-0.288-0.13800-0.206-0.115
rs612415chr11:6061646271.3189   00-0.0030.0100-0.25-0.10.0030-0.117-0.04
rs1675090chr11:6169668272.7642   00-0.0250.00200-0.25-0.10.0220-0.075-0.012
rs630759chr11:6293328573.8136MIR3680-1
MIR3680-2
SLC22A9
00-0.03000-0.217-0.0840.0150-0.054-0.002
rs626333chr11:6334843774.143C11orf84
00-0.029000-0.201-0.0760.010-0.0460
rs728919chr11:6346515074.2397NAA40
00-0.028000-0.196-0.0730.0090-0.0430
rs562865chr11:6353284174.301MACROD1
00-0.027000-0.192-0.0710.0080-0.0410
rs1783811chr11:6408987274.787SLC22A11
00-0.022000-0.163-0.0560.0030-0.0260
rs633727chr11:6441600075.0792   00-0.022000-0.149-0.0500-0.020
rs931127chr11:6516187675.7463   00-0.035000-0.143-0.0500-0.020
rs1530891chr11:6647500776.8196PC
00-0.024000-0.091-0.03400-0.020
rs614080chr11:6710386377.0664   00-0.019000-0.081-0.0300-0.020
rs1695chr11:6710926577.0679GSTP1
00-0.019000-0.081-0.0300-0.020
rs7124513chr11:6715229077.0758NUDT8
00-0.019000-0.081-0.0300-0.020
rs4255548chr11:6873054678.4775   00-0.0050.00500-0.09-0.0350.0040-0.020
rs7122786chr11:6878578678.5512   00-0.0040.00600-0.09-0.0360.0050-0.020
rs749811chr11:7061161681.6341SHANK2
00-0.006000-0.116-0.0760.060-0.036-0.033
rs514933chr11:7160785583.0487FOLR2
00-0.02000-0.119-0.090.1150-0.039-0.058
rs593753chr11:7236908883.5566FCHSD2
00-0.014000-0.109-0.0840.1030-0.029-0.038
rs591804chr11:7304085883.9676PLEKHB1
00-0.01000-0.101-0.080.0940-0.021-0.021
rs539343chr11:7383243884.4248   00-0.014000-0.113-0.1010.0880-0.016-0.02
rs4456280chr11:7445877284.898   00-0.019000-0.127-0.1250.0830-0.011-0.02
rs540461chr11:7507766085.4449   00-0.038-0.01300-0.139-0.1520.0780-0.019-0.033
rs7103372chr11:7556205386.0115   00-0.061-0.0300-0.15-0.180.0730-0.03-0.05
rs589149chr11:7556373186.0137   00-0.061-0.0300-0.15-0.180.0730-0.03-0.05
rs1945085chr11:7641489387.0465   00-0.122-0.05100-0.183-0.1730.0910-0.021-0.041
rs1945465chr11:7803414688.537   00-0.165-0.07500-0.277-0.2510.0710-0.051-0.071
rs1783953chr11:7813177388.6798ODZ4
00-0.167-0.07700-0.284-0.2570.0690-0.054-0.074
rs7102569chr11:7886254789.7753   00-0.17-0.0800-0.316-0.2780.0590-0.076-0.088
rs12272787chr11:7964020491.3705   00-0.276-0.15500-0.426-0.3590.0190-0.191-0.193
rs1459937chr11:8120336192.8221   00-0.361-0.21300-0.503-0.40600-0.367-0.332
rs1945906chr11:8123872592.8519   00-0.363-0.21400-0.504-0.40700-0.371-0.335
rs1459952chr11:8126038792.8694   00-0.363-0.21500-0.505-0.40700-0.373-0.337
rs7932435chr11:8203222193.381   00-0.412-0.2500-0.54-0.42900-0.424-0.392
rs1278402chr11:8264974593.8012   00-0.458-0.28400-0.574-0.4500-0.462-0.438
rs561646chr11:8542368595.491PICALM
00-0.455-0.2700-0.551-0.40600-0.48-0.47
rs1986778chr11:8689839296.7053   00-0.381-0.21500.003-0.464-0.31400-0.435-0.425
rs1880116chr11:8696802096.7832   00-0.375-0.21100.003-0.457-0.30700-0.431-0.421
rs160195chr11:8793262197.7481GRM5
00-0.345-0.200.008-0.433-0.27500-0.398-0.395
rs496972chr11:8887379998.2978NOX4
00-0.367-0.22400.006-0.46-0.300-0.408-0.426
rs1404524chr11:9017329598.5481   00-0.389-0.24400.004-0.485-0.32500-0.423-0.456
rs1388472chr11:9127895299.1072   00-0.422-0.27700-0.526-0.36900-0.454-0.521
rs1027454chr11:9147389499.2252   00-0.414-0.27300-0.521-0.36800-0.459-0.533
rs543704chr11:9186964699.4677FAT3
00-0.397-0.26600-0.511-0.36500-0.469-0.557
rs536417chr11:9190998799.4938FAT3
00-0.395-0.26500-0.51-0.36500-0.47-0.559
rs586699chr11:9192938299.5064FAT3
00-0.395-0.26500-0.51-0.36500-0.47-0.561
rs1944108chr11:93103823100.1667SNORA32
00-0.362-0.25500-0.498-0.36800-0.515-0.638
rs584109chr11:93652402100.5417   00-0.365-0.26600-0.517-0.38700-0.571-0.702
rs541821chr11:94801223102.0737   00-0.416-0.32600-0.604-0.46200-0.81-0.949
rs1255182chr11:95112039102.6381   00-0.388-0.29800-0.632-0.47900-0.889-1.017
rs483884chr11:95551040103.3936MAML2
00-0.354-0.27200-0.63-0.48200-0.893-1.017
rs2919032chr11:96132850104.3292   00-0.31-0.24400-0.567-0.43400-0.777-0.897
rs921562chr11:96806939105.1034   00-0.26-0.20100-0.481-0.34600-0.672-0.771
rs723513chr11:97588753105.9228   00-0.178-0.12700-0.334-0.23100-0.533-0.624
rs2848479chr11:97592809105.9269   00-0.177-0.12700-0.333-0.2300-0.532-0.623
rs17561441chr11:98336227106.5524   00-0.142-0.09200.004-0.292-0.19800-0.492-0.555
rs12807115chr11:99120957107.1438CNTN5
00-0.144-0.09200.007-0.306-0.2100-0.516-0.546
rs7119230chr11:99550452107.5288CNTN5
00-0.21-0.14900.004-0.402-0.29100-0.639-0.642
rs1002122chr11:99566587107.5487CNTN5
00-0.213-0.15200.004-0.407-0.29500-0.646-0.647
rs622675chr11:100165933108.3653ARHGAP42
00-0.308-0.23800.001-0.549-0.41200-0.819-0.775
rs618291chr11:100186421108.3954ARHGAP42
00-0.31-0.2400.001-0.552-0.41400-0.822-0.776
rs4121835chr11:100600051109.043   00-0.342-0.27100.002-0.6-0.4500-0.866-0.795
rs948734chr11:101434119109.7445C11orf70
00-0.377-0.28500.001-0.607-0.44300-0.796-0.718
rs1711399chr11:101965987109.9329MMP20
00-0.387-0.28900-0.609-0.44100-0.777-0.697
rs1276257chr11:102041624109.9628   00-0.388-0.28900-0.61-0.4400-0.774-0.694
rs536107chr11:102404003110.147   00-0.38-0.27800-0.597-0.42700-0.748-0.668
rs601535chr11:102605727110.26DYNC2H1
00-0.372-0.26900.001-0.587-0.41700-0.731-0.651
rs559345chr11:102802726110.3858DYNC2H1
00-0.363-0.25900.001-0.575-0.40500-0.712-0.632
rs623114chr11:104333317111.0286CASP4
00-0.318-0.20900.003-0.521-0.35100-0.619-0.539
rs1483025chr11:104511146111.0932   00-0.313-0.20600.003-0.522-0.35300-0.616-0.538
rs1822982chr11:105025351111.3505GRIA4
00-0.295-0.19600.002-0.527-0.36100-0.606-0.533
rs1938961chr11:105118319111.4086GRIA4
00-0.291-0.19400.002-0.528-0.36200-0.604-0.532
rs2000633chr11:105370044111.5782   00-0.28-0.18700.001-0.532-0.36700-0.597-0.528
rs17105704chr11:105788910111.8684   00-0.259-0.17500-0.537-0.37600-0.585-0.523
rs4754240chr11:107014042112.5785ELMOD1
00-0.273-0.19300-0.598-0.43800-0.615-0.578
rs1504747chr11:107348812112.7467   00-0.28-0.200-0.615-0.45500-0.625-0.595
rs627418chr11:107636435112.8883ATM
00-0.286-0.20600-0.629-0.46900-0.633-0.609
rs592955chr11:107661683112.9007ATM
00-0.286-0.20600-0.63-0.4700-0.634-0.61
rs884444chr11:108534007113.3309   00-0.267-0.19300-0.627-0.4700-0.64-0.646
rs11213210chr11:109323040114.0085   00-0.219-0.15900-0.599-0.44900-0.639-0.699
rs12420766chr11:109709110114.4991   00-0.19-0.12500-0.52-0.3700-0.58-0.62
rs882524chr11:109711028114.5014   00-0.19-0.12500-0.52-0.3700-0.58-0.62
rs1469170chr11:110246224115.2047   00-0.142-0.07800-0.403-0.26300-0.487-0.505
rs7937151chr11:112340234117.5897NCAM1
00-0.0040.00600.013-0.089-0.03600-0.151-0.151
rs2011505chr11:112493446117.788NCAM1
00-0.0020.00800.016-0.075-0.02800-0.131-0.131
- chr11:112785526 DRD2            
rs869451chr11:113258222119.2005   000.0040.02800.031-0.0160.00400.001-0.058-0.058
rs766783chr11:113774555120.2343C11orf71
00.0040.0290.07600.1110.0070.03900.01-0.008-0.008
rs1013583chr11:114740016121.6423CADM1
0.0220.0780.1110.20100.4290.0690.17100.1910.0130.013
rs1009746chr11:115624122122.9948   0.2720.3530.3090.41900.9750.2090.36900.6850.090.07
rs2174876chr11:115944894123.6552   0.3310.3660.2770.36800.8920.1580.29100.6010.0570.044
rs609177chr11:116275727124.421SIK3
0.3890.3570.2770.3570.0020.7460.1340.24600.5130.040.026
rs236919chr11:116600571125.1439PCSK7
0.4540.320.3230.3990.0290.570.1590.2490.0020.4380.0490.024
rs947889chr11:117379741126.1754   0.5470.2060.4550.5080.1790.2980.2770.30.0190.3030.1040.05
rs7389chr11:118033676126.9108PHLDB1
0.270.1120.4330.5010.2110.0960.3060.30.0480.0950.1180.05
rs547345chr11:118503079127.3834HINFP
0.1680.0680.3840.4580.2560.0440.2790.2650.0520.0430.0970.038
rs644252chr11:118548710127.4352NLRX1
0.1590.0640.3780.4520.2620.0410.2750.2610.0520.040.0940.037
rs1073634chr11:119477852128.7152   0.0360.0040.260.340.39400.2230.1960.05900.0530.013
rs481703chr11:120560950130.6984TECTA
000.1050.1710.33600.1280.1150.02300.0160
rs665035chr11:120589022130.7522   000.1020.1670.33200.1250.1120.02200.0150
rs575030chr11:120597608130.7688   000.1020.1660.33100.1240.1120.02200.0150
rs596437chr11:120875233131.2962SORL1
000.0840.1410.25900.0920.0820.01100.007-0.006
rs617847chr11:120907853131.3542SORL1
000.0830.1390.24800.0890.0790.0100.006-0.007
rs676943chr11:121553535132.4423MIR100HG
000.070.1240.10100.0460.04000-0.024
rs668183chr11:121771915132.9037   000.070.1290.07500.0410.040.00100-0.029
rs1894078chr11:122104161133.6905UBASH3B
000.070.1230.10500.0540.0470.01900-0.023
rs930983chr11:122339624134.3321   000.0630.1170.11600.0570.0530.02900-0.023
rs485345chr11:122580125135.0392   000.0480.1060.10300.0480.0580.0320-0.001-0.034
rs1148109chr11:123010309136.1108SCN3B
0000.0190.05700.0090.0090.0040-0.032-0.136
rs6590016chr11:123261797136.6978   0000.0130.0500.0030.0030.0010-0.044-0.165
rs11219543chr11:123639117137.4921OR8G1
00-0.0050.0050.04100000-0.06-0.2
rs1893702chr11:123791429137.7511   00-0.0080.0020.03800000-0.065-0.21
rs4936975chr11:124426176138.5552   00-0.043-0.0220.0250-0.017-0.01700-0.114-0.287
rs593290chr11:124583710138.7275PKNOX2
00-0.054-0.0290.0210-0.022-0.02200-0.128-0.307
rs3740892chr11:124760925138.904PKNOX2
00-0.064-0.0360.0180-0.027-0.02700-0.142-0.328
rs4627097chr11:124957523139.0571EI24
00-0.072-0.0420.0160-0.029-0.02900-0.151-0.341
rs1425842chr11:125116850139.2557   00-0.08-0.050.0170-0.027-0.02700-0.153-0.345
rs528638chr11:125382285139.7205CDON
00-0.099-0.0690.0170-0.023-0.02300-0.157-0.354
rs586566chr11:125704828140.4345DCPS
00-0.119-0.0930.0210-0.02-0.0200-0.169-0.369
rs2156449chr11:126038959141.3222KIRREL3
00-0.124-0.1070.0310-0.017-0.0170.0010-0.177-0.38
rs1944819chr11:126558227142.6232   00-0.098-0.0940.050-0.004-0.010.0030-0.164-0.374
rs670163chr11:128159454144.9685FLI1
00-0.06-0.0610.00100000-0.17-0.37
rs1027323chr11:128729876146.0512   00-0.029-0.039000.001000-0.159-0.318
rs923811chr11:128920427146.4601   00-0.025-0.035000.005000-0.151-0.302
rs1043654chr11:129275136147.2543PRDM10
00-0.017-0.027000.01000-0.127-0.262
rs2001625chr11:130103423149.4199   0000000.0280.0100-0.036-0.122
rs1944142chr11:130222650149.8668   0000000.0370.0100-0.031-0.113
rs6590576chr11:130833679152.1791NTM
000.0470.047000.1370.089000.004-0.008
rs965493chr11:131145305153.2571NTM
000.1010.098000.180.14000.0230
rs3345chr11:131346779153.8995NTM
000.1520.143000.2060.166000.0290
rs2044727chr11:131644201154.8362NTM
000.2350.2250.00300.2520.2120.0400.0470
rs570969chr11:132496973157.0995OPCML
000.2460.2150.03600.1760.1660.23500.0430
rs475056chr11:132548468157.2899OPCML
000.2380.2060.03500.1680.1580.24400.0490
rs930176chr11:132598789157.4711OPCML
000.2310.1960.03400.1610.1510.25200.0540
rs470982chr11:133472588159.9567JAM3
000.0430.0130.06700.0420.0220.47800.050
rs893953chr11:133754531160.4273B3GAT1
000.0270.0060.0700.0310.0160.48900.037-0.004
rs7116815chr11:134177246160.9519   000.01100.07200.0210.010.49600.021-0.01
rs1508540chr11:134237573160.9972   000.0100.07200.020.010.49700.02-0.01
rs1824832chr11:134313007161.0573   000.01100.07200.020.010.49600.02-0.01

Table Legend: Tabular display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow row marks the location of the selected gene, and the whitened rows correspond to 20 Mb
around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

References

 

Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry. 2012 Jul;17(8):818-26. doi: 10.1038/mp.2011.89. Epub 2011 Jul 19. PubMed PMID: 21769101