Metamoodics Gene Information

 

  Chromosome: chr11    Cytoband: q23.1-q23.2    Gene: DRD2

 

BP - Genomewide Linkage Studies for DRD2


 

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Description

 
Shown here are the results for gene DRD2 from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs741737chr11:2785050.1363   0.8230.1940.0910.021.7610.1360.2350.0310.070.1990.1140.073
rs7481525chr11:3681880.45B4GALNT4
0.8360.1970.0950.021.8040.140.2480.0340.0830.2090.1240.079
rs885454chr11:11999673.2695   0.8820.230.1070.032.1550.1850.350.060.2360.3520.220.153
rs2029463chr11:16184814.6249MOB2
0.8750.2550.0940.032.1530.1980.3380.0540.2360.4330.220.166
rs1004446chr11:21267196.1907IGF2
INS-IGF2
0.8090.3230.090.0321.9220.2350.290.0480.2060.4890.2120.166
rs451041chr11:30173018.8643CARS
0.7710.3910.090.051.4370.2360.1450.0110.0920.3980.0950.094
rs956453chr11:33641059.8445LOC650368
0.8430.4370.1070.0671.390.2440.1570.0270.0490.3920.0650.09
rs879114chr11:360035410.2958   0.8660.4620.1220.0821.3980.260.1870.0420.0420.4720.0690.099
rs1451724chr11:381324410.5955RHOG
0.8740.4790.1340.0941.410.2740.2140.0540.0420.5520.0780.108
rs2231963chr11:458159611.5751TRIM68
0.8870.4530.1670.1221.4540.2480.2730.0820.0540.6250.090.114
rs1609812chr11:520371712.9752HBB
0.7950.2840.1510.1011.5550.1110.290.080.0690.4370.080.09
rs892336chr11:555925513.8409OR52B6
0.7190.1250.1160.0661.6640.0290.2480.0630.1020.2930.0720.065
rs906895chr11:623682415.3497   0.5540.0230.050.0231.6580.0010.1590.0430.20.1820.050.053
rs10500688chr11:724794516.991SYT9
0.37900.0101.36700.090.020.1490.10.010.02
rs2200650chr11:728277117.0588SYT9
0.3700.009-0.0011.37200.0880.0190.1530.1020.0090.019
rs2280726chr11:803930518.5288TUB
0.1850-0.011-0.0211.34200.0340.0050.210.13200.005
rs905290chr11:871030519.7486ST5
0.1030-0.027-0.0370.98100.00500.1830.10400
rs10279chr11:892588520.0093TMEM9B
0.0930-0.031-0.0410.8980000.1750.09400
rs1425151chr11:1064479321.225MRVI1
0.0630-0.11-0.1080.6240-0.01-0.040.0770.009-0.032-0.024
rs16908224chr11:1069337521.3113   0.0650-0.11-0.1070.6220-0.01-0.040.0730.009-0.033-0.026
rs4910014chr11:1152471223.2216GALNTL4
0.1540-0.059-0.0510.6550.001-0.008-0.0260.0020.034-0.043-0.033
rs7484014chr11:1161184423.4728   0.1760-0.046-0.0410.670.002-0.005-0.0210.0010.056-0.036-0.026
rs1365406chr11:1251929625.6767   0.2280.14200.0070.5190.1760000.53500.007
rs730414chr11:1341543026.9838BTBD10
0.1280.17400.030.2110.23300.0100.82900.02
rs7484197chr11:1424023027.523SPON1
0.1130.270.0160.0560.140.31600.0201.04700.02
rs10832503chr11:1566103828.8235   0.1120.3790.0380.1050.0660.4670.0080.04601.35300.028
rs722317chr11:1588013829.062   0.1150.3830.0420.1140.0640.4890.0110.05201.3820.0010.032
rs214101chr11:1724593030.649   0.1510.3910.0960.2020.090.5880.0430.11601.4170.0230.089
rs4757574chr11:1768295031.1829   0.1610.3920.1080.220.1070.570.050.12601.3120.030.1
rs4348874chr11:1874876032.7214PTPN5
0.160.4020.0930.2130.1770.4210.0430.10300.5770.0230.093
rs1470251chr11:2007816837.101NAV2
0.0610.6470.1030.2530.2030.7810.060.14900.629-0.0010.029
rs961746chr11:2011754137.2363   0.060.6380.1070.2570.1980.7750.060.14800.617-0.0020.028
rs4278510chr11:2166859541.0572   00.3130.0880.1860.0080.2900.02900.157-0.073-0.012
rs1009807chr11:2181775441.3364   00.3120.0770.1660.0060.27900.02300.135-0.09-0.02
rs2593688chr11:2234560742.3344SLC17A6
00.2950.0470.1170.0020.24100.0100.062-0.147-0.05
rs7117792chr11:2265419942.8658GAS2
00.2730.0410.11100.21900.0100.027-0.173-0.066
rs4486627chr11:2284875043.1754   00.250.0380.10500.206-0.0020.00800.015-0.184-0.074
rs4584574chr11:2303239943.4557   00.2220.0350.09600.192-0.0050.00500.011-0.189-0.079
rs731365chr11:2429063345.3663   00.090.010.0400.127-0.016000-0.209-0.113
rs1596854chr11:2502087346.3796LUZP2
00.0670.0140.04400.102-0.0060.00400-0.167-0.081
rs1389423chr11:2574842247.1938   00.0580.0180.0500.08500.01200-0.12-0.046
rs7480892chr11:2636716347.7117ANO3
00.0510.0130.0500.08400.01700-0.094-0.036
rs1461382chr11:2636863647.7126ANO3
00.0510.0130.0500.08400.01700-0.094-0.036
rs1157659chr11:2771419848.9004   00.0240.010.0500.08100.02900-0.053-0.012
rs1491846chr11:2785559049.0263   00.0210.010.0500.0800.0300-0.049-0.01
rs1564745chr11:2824813149.3454METTL15
00.0190.0130.05300.06900.0300-0.04-0.007
rs1032091chr11:2824865449.3458METTL15
00.0190.0130.05300.06900.0300-0.04-0.007
rs973556chr11:2881529049.6949   00.0180.0170.05700.05700.0300-0.029-0.003
rs524373chr11:2998365050.3446   00.0160.0170.0570.0010.03500.02700-0.02-0.003
rs509628chr11:3149193151.2994ELP4
00.0190.0130.0560.0030.0100.01700-0.023-0.013
rs1003715chr11:3197692051.6024   00.0230.0160.0620.0030.0100.01400-0.026-0.016
rs373499chr11:3310271552.4546CSTF3
00.0390.020.0790.0010.0100.0100-0.039-0.025
rs10734415chr11:3327137452.7042HIPK3
00.0440.020.0840.0010.01100.0100-0.044-0.027
rs750780chr11:3387417053.7795   00.070.020.0900.01400.0100-0.058-0.03
rs910090chr11:3439411754.9083   00.1080.0110.06300.006-0.0090.00100-0.06-0.039
rs1530966chr11:3455218455.265   00.1010.0070.05200.004-0.018-0.00300-0.065-0.045
rs2045040chr11:3457533255.3165   00.10.0070.05100.003-0.019-0.00300-0.066-0.046
rs666110chr11:3581907257.7407   00.045-0.0070.0100-0.13-0.05200-0.1-0.07
rs1499511chr11:3604442958.1587LDLRAD3
00.049-0.0070.01500-0.135-0.05700-0.095-0.064
rs179801chr11:3706711159.8803   0.0110.0930.0360.07500-0.092-0.03100-0.061-0.021
rs1026833chr11:3852300061.0034   0.0340.05400.0200-0.25-0.1500-0.17-0.1
rs1488943chr11:3917540761.1258   0.0320.05100.01900-0.268-0.16100-0.186-0.111
rs2035693chr11:3919360861.1364   0.0320.0500.01900-0.269-0.16200-0.188-0.112
rs920443chr11:4037966862.2288LRRC4C
0.0280.0300.01200-0.383-0.23500-0.311-0.199
rs1027388chr11:4057640462.4276LRRC4C
0.0330.03200.01400-0.377-0.23100-0.321-0.207
rs1462224chr11:4101631662.9295LRRC4C
0.0450.03600.01900-0.362-0.22100-0.346-0.227
rs1488618chr11:4216281663.9103   0.1240.0460.0180.03800-0.287-0.17400-0.323-0.23
rs975104chr11:4294909664.121   0.1280.0420.0190.03900-0.285-0.17500-0.322-0.234
rs4755782chr11:4412457265.4726EXT2
0.0720.0020.0050.02100-0.344-0.22400-0.349-0.274
rs4755809chr11:4427976965.8649ALX4
0.0510.0010.0010.01300-0.363-0.23600-0.357-0.286
rs919445chr11:4458953066.5073CD82
0.022000.00500-0.375-0.2400-0.33-0.26
rs1487718chr11:4511803667.4934PRDM11
000000-0.355-0.2200-0.275-0.2
rs11988chr11:4721783668.7854ACP2
00.00100.00800-0.259-0.12900-0.203-0.131