Metamoodics Gene Information

 

  Chromosome: chr3    Cytoband: q27.1    Gene: DVL3

 

BP - Genomewide Linkage Studies for DVL3


 

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Description

 
Shown here are the results for gene DVL3 from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs1516337chr3:1662450.0308   0.050.4980.3480.4780.0260.4690.4080.5480.3190.1560.6170.796
rs1516350chr3:1696140.0346   0.0490.4980.3480.4780.0260.4690.4080.5480.3190.1560.6170.795
rs1516348chr3:1770340.0429   0.0490.4980.3470.4770.0260.4690.4080.5470.3180.1550.6160.794
rs1850264chr3:2010670.0729   0.0490.4970.3460.4760.0260.470.4060.5450.3160.1540.6130.79
rs902118chr3:11616872.0935CNTN6
0.0230.4420.2350.3650.0170.4580.3010.4110.1710.0770.4190.515
rs1551995chr3:13750962.6224CNTN6
0.0180.3720.2090.3390.0110.3420.2480.3580.1330.0380.3550.43
rs968057chr3:23676445.6023CNTN4
0.0020.1920.1020.18200.0260.0620.1360.01700.1260.12
rs1024147chr3:27092076.974CNTN4
00.1710.10.18900.0040.0310.101000.110.1
rs1391931chr3:29100837.9132CNTN4
00.2220.2190.35400.0040.0670.146000.1650.164
rs2290610chr3:31149578.9143IL5RA
00.1980.2030.33300.0020.070.141000.1970.225
rs1153459chr3:31334859.0015   00.1950.20.3300.0020.070.14000.20.23
rs1508729chr3:352268510.7929   00.0370.1360.23000.0160.03000.1120.097
rs1488403chr3:365924611.2749   00.0180.1220.209000.0070.017000.0890.075
rs795734chr3:408470012.6705   00.0010.080.1530000.01000.0530.053
rs902982chr3:456818814.0901ITPR1
000.0470.09600-0.001-0.001000.0370.037
rs11130180chr3:493073515.0655   000.0190.05700-0.011-0.011000.0090.009
rs1435359chr3:577694417.4907   000000-0.055-0.05500-0.05-0.055
rs2470486chr3:577776317.4928   000000-0.055-0.05500-0.05-0.055
rs1504034chr3:610983618.4403   00-0.004-0.00400-0.073-0.06900-0.092-0.092
rs465152chr3:689407920.1704GRM7
00-0.033-0.04500-0.153-0.14500-0.26-0.239
rs11716647chr3:759941021.4943GRM7
00-0.055-0.08500-0.16-0.1700-0.32-0.285
rs463659chr3:818881022.9868   00-0.08-0.120.0070-0.12-0.1400-0.3-0.27
rs164466chr3:872417124.6538   00-0.083-0.130.0020-0.107-0.13300-0.29-0.24
rs11131150chr3:887045325.1336   00-0.085-0.1350.0020-0.108-0.13800-0.281-0.233
rs2251166chr3:941673726.5909SETD5
00-0.144-0.200-0.195-0.2200-0.308-0.274
rs749477chr3:1063182328.3446   00-0.163-0.21300-0.253-0.24700-0.37-0.293
rs892605chr3:1068286128.4367   00-0.161-0.21100-0.254-0.24600-0.37-0.291
rs1039202chr3:1170605930.3141VGLL4
00-0.124-0.1800-0.236-0.21600-0.308-0.221
rs299630chr3:1254342531.2119TSEN2
00-0.108-0.17800-0.237-0.22200-0.249-0.176
rs299629chr3:1255184631.2159   00-0.108-0.17800-0.237-0.22100-0.249-0.176
rs904453chr3:1267989431.3401RAF1
00-0.107-0.17700-0.23-0.21600-0.243-0.173
rs357116chr3:1329685232.0722   00-0.099-0.16800-0.185-0.18400-0.21-0.158
rs729639chr3:1380185532.9399   00-0.081-0.14200-0.124-0.10500-0.21-0.132
rs353087chr3:1516559135.3664   00-0.259-0.26600-0.304-0.18600-0.395-0.186
rs826423chr3:1531660535.5789SH3BP5
00-0.276-0.28100-0.329-0.20100-0.427-0.201
rs905946chr3:1623389536.8743GALNTL2
00-0.406-0.39700-0.459-0.300-0.639-0.317
rs895941chr3:1682122037.5223   00-0.394-0.38400-0.402-0.26300-0.629-0.299
rs1441035chr3:1697624037.6996PLCL2
00-0.385-0.37500-0.379-0.24700-0.618-0.288
rs1375818chr3:1724590437.9082TBC1D5
00-0.375-0.36500-0.352-0.22800-0.606-0.276
rs1374197chr3:1736961938.0041TBC1D5
00-0.37-0.3600-0.34-0.2200-0.6-0.27
rs717939chr3:1860174638.6253   00-0.314-0.29100-0.309-0.17600-0.587-0.22
rs336610chr3:1862501938.6308   00-0.313-0.29100-0.308-0.17600-0.587-0.22
rs396506chr3:1983724339.4666   00-0.28-0.24100-0.271-0.13600-0.552-0.171
rs12632924chr3:1989515139.5422   00-0.28-0.23900-0.268-0.13400-0.547-0.168
rs1679208chr3:2190994643.2243   00-0.323-0.26100-0.236-0.13600-0.383-0.116
rs1117chr3:2206081343.4752   00-0.316-0.25100-0.23-0.1300-0.376-0.11
rs1494225chr3:2244184644.1442   00-0.304-0.23300-0.22-0.12100-0.372-0.104
rs11129071chr3:2252491044.2544   00-0.308-0.23500-0.22-0.12300-0.38-0.108
rs680930chr3:2300189244.9466   00-0.328-0.24900-0.22-0.12900-0.436-0.128
rs1473379chr3:2384860645.8895UBE2E1
00-0.366-0.27700-0.3-0.18300-0.529-0.183
rs1865712chr3:2444935746.4512THRB
00-0.433-0.33900-0.378-0.24900-0.599-0.249
rs892940chr3:2451384246.5146LOC644990
00-0.442-0.34700-0.387-0.25700-0.607-0.257
rs2076993chr3:2462529846.6442   00-0.46-0.36400-0.407-0.27400-0.624-0.274
rs1872143chr3:2529098147.4971   00-0.545-0.44500-0.5-0.35500-0.715-0.37
rs922943chr3:2538375247.6482   00-0.555-0.45500-0.512-0.36500-0.728-0.385
rs6768396chr3:2539671147.6684   00-0.557-0.45700-0.513-0.36700-0.73-0.387
rs1502377chr3:2639645449.1068   00-0.588-0.5100-0.536-0.40800-0.831-0.509
rs7616789chr3:2699916249.8973   00-0.572-0.5100-0.504-0.39200-0.839-0.572
rs1445111chr3:2722897550.1685   00-0.592-0.53400-0.508-0.39700-0.86-0.6
rs669607chr3:2804644850.8943   00-0.686-0.63500-0.545-0.42600-0.947-0.687
rs966029chr3:2824079751.0567   00-0.694-0.64800-0.547-0.42900-0.962-0.703
rs1463535chr3:2864928551.4305LOC645206
00-0.657-0.63300-0.528-0.42100-0.977-0.726
rs736357chr3:2932293752.2362RBMS3
00-0.586-0.60100-0.491-0.40100-1.024-0.774
rs1506297chr3:3004731153.3971   00-0.488-0.52600-0.416-0.33400-1.044-0.76
rs304838chr3:3078167854.5419GADL1
00-0.34-0.39500.006-0.29-0.23700-0.857-0.578
rs12629588chr3:3176839756.0649OSBPL10
00-0.165-0.22400.032-0.147-0.10700.002-0.604-0.345
rs4796chr3:3249878157.4493CMTM6
00-0.072-0.10800.051-0.082-0.05100.005-0.507-0.261
rs1127732chr3:3388057059.1072PDCD6IP
0.0010-0.027-0.05500.054-0.036-0.02700.001-0.477-0.252
rs1406568chr3:3441431859.3631   0.0040-0.019-0.04200.056-0.025-0.01900.002-0.446-0.235
rs1976146chr3:3479697059.5503   0.0060.001-0.013-0.03200.058-0.018-0.01300.003-0.424-0.221
rs12639495chr3:3505083559.7089   0.0070.001-0.009-0.02500.059-0.012-0.00900.004-0.405-0.21
rs713144chr3:3505997159.717   0.0070.001-0.008-0.02400.059-0.011-0.00800.004-0.404-0.21
rs1455326chr3:3541712659.9858   0.010.0010-0.01100.062-0.001000.005-0.372-0.191
rs967672chr3:3680159560.9342   0.04200-0.010.0110.0060-0.00900-0.407-0.293
rs1392748chr3:3724031761.1506   0.04400-0.0130.0110.002-0.002-0.01500-0.427-0.321
rs883523chr3:3728609661.1815GOLGA4
0.04400-0.0140.010.002-0.002-0.01500-0.43-0.325
rs267538chr3:3756074361.3717ITGA9
0.04400-0.0170.0090.001-0.004-0.02100-0.451-0.352
rs2226462chr3:3804376261.7129PLCD1
0.04500-0.0240.0060.001-0.007-0.03100-0.488-0.4
rs762318chr3:3849137362.0689ACVR2B
0.0430-0.001-0.0330.0030-0.012-0.04400-0.519-0.441
rs1405796chr3:3966977363.0398   0.010-0.019-0.07800-0.039-0.09800-0.495-0.454
rs1405793chr3:3973152063.0886   0.0110-0.018-0.07500-0.037-0.09500-0.488-0.448
rs1996562chr3:4011075063.4091MYRIP
0.0170-0.012-0.0550.0020-0.028-0.07500-0.447-0.403
rs749932chr3:4135362564.6123ULK4
0.03800.006-0.0080.0120-0.004-0.02200-0.327-0.277
rs1495704chr3:4147831664.7309ULK4
0.0400.007-0.0050.0140-0.003-0.01800-0.319-0.269
rs477078chr3:4234559865.4901   0.05700.005-0.0050.02300-0.0100-0.236-0.196
rs13061576chr3:4280798365.863HIGD1A
0.06700.001-0.0090.0270.0010-0.0100-0.188-0.155
rs1351631chr3:4349317166.3906ANO10
0.07900-0.0140.0320.0010-0.01400-0.166-0.128
rs737516chr3:4353308966.4212ANO10
0.07900-0.0140.0320.0010-0.01400-0.166-0.127
rs1013758chr3:4360137966.4604ANO10
0.0800-0.0150.0330.0010-0.01500-0.165-0.126
rs954282chr3:4472836767.3588   0.100-0.0160.05700-0.01300-0.142-0.096
rs2056321chr3:4505813767.607   0.10600-0.0140.0700-0.00800-0.13-0.086
rs1860264chr3:4589808968.1586   0.10200-0.0120.09100000-0.123-0.078
rs737452chr3:4600241468.2216FYCO1
0.09700-0.0120.0900000-0.128-0.081
rs1520483chr3:4648521368.5062   0.07500-0.0150.08700000-0.15-0.095
rs1402152chr3:4654942268.5428LRRC2
0.07200-0.0150.08700000-0.153-0.097
rs1014228chr3:4762764369.0844SMARCC1
0.02900-0.0160.06800000-0.157-0.099
rs319682chr3:4789012269.1856MAP4
0.02500-0.0140.05900000-0.134-0.085
rs1865741chr3:4933789669.436USP4
0.02400-0.0130.05700000-0.142-0.086
rs1049256chr3:4973834269.446IP6K1
0.02400-0.0130.05600000-0.142-0.086
rs7061chr3:5008951969.4529RBM6
0.02400-0.0130.05600000-0.143-0.086
rs2188151chr3:5017692869.4542SEMA3F
0.02400-0.0130.05600000-0.143-0.086
rs2236947chr3:5034643669.4574RASSF1
0.02400-0.0130.05600000-0.143-0.086
rs7433217chr3:5096223469.4678DOCK3
0.02400-0.0130.05600000-0.143-0.086
rs11720298chr3:5155654969.4798RAD54L2
0.02400-0.0130.05600000-0.143-0.087
rs3617chr3:5280884569.7865ITIH3
0.02400-0.0110.05400000-0.153-0.089
rs2101397chr3:5347398270.3682   0.0300-0.010.04800-0.00400-0.171-0.101
rs893367chr3:5388477170.9345ACTR8
0.0400-0.010.04100-0.00900-0.188-0.118
rs9864433chr3:5457071872.1936CACNA2D3
0.00300-0.02600-0.01-0.02200-0.204-0.124
rs920891chr3:5524627673.5825   000-0.00400-0.01-0.02400-0.145-0.077
rs1392702chr3:5680901975.8415ARHGEF3
000.0270.008000-0.0100-0.025-0.013
rs536036chr3:5730192376.1797   0.0130.0290.0350.01200.0230-0.0100-0.022-0.012
rs1444185chr3:5866201777.0321   0.0730.1610.060.0200.1270-0.0100-0.029-0.02
rs1472653chr3:5956063278.1745   0.0750.1720.0860.0400.1340-0.00800-0.008-0.008
rs1447971chr3:6044031979.9081FHIT
0.2340.0820.2690.18100.010.0180.0090000
rs7649991chr3:6104843580.9608FHIT
0.3110.0170.290.19000.030.010000
rs6763822chr3:6145135881.5257   0.2990.0190.290.190.00200.0350.010000
rs1320173chr3:6149315681.5861   0.2970.020.290.190.00200.0360.010000
rs624755chr3:6170900281.926PTPRG
0.2870.0220.290.190.00300.0390.010000
rs1528198chr3:6237987683.0367CADPS
0.3780.0240.4360.3050.00700.0840.022000.0120.011
rs1534724chr3:6240462483.0872CADPS
0.3830.0240.4430.3110.00900.0890.024000.0150.013
rs1374679chr3:6305030784.3915   0.5290.0410.6350.4810.0600.2350.105000.0860.066
rs1874925chr3:6316654184.6172   0.5590.0480.6660.510.07100.2660.126000.0950.075
rs935794chr3:6340719285.1049SYNPR
SYNPR-AS1
0.6040.0580.7120.5530.08600.320.161000.1080.089
rs1376478chr3:6341766285.1268SYNPR
SYNPR-AS1
0.6040.0570.710.5510.08600.320.161000.1070.089
rs6790592chr3:6343310385.1592SYNPR
SYNPR-AS1
0.6020.0560.7070.5490.08500.320.162000.1070.088
rs1390436chr3:6353892285.3678SYNPR
0.5930.050.6910.5340.0800.320.164000.1030.086
rs853276chr3:6426939986.9029   0.4860.0090.5050.3730.03700.2210.107000.0450.035
rs894741chr3:6440214287.1355   0.4760.0050.4870.360.03700.2110.1000.0360.026
rs877523chr3:6480986787.738ADAMTS9-AS2
MIR548AN
0.4720.0020.4750.360.04900.2170.1000.0180.008
rs1983357chr3:6496933587.9524ADAMTS9-AS2
0.4700.4710.360.05400.220.1000.0110.001
rs782728chr3:6640899290.4205SLC25A26
0.51300.5880.4210.23100.3990.147000.0260.006
rs332364chr3:6647452790.5289SLC25A26
0.49300.5770.4130.22500.3940.144000.0250.005
rs1490265chr3:6753473391.877SUCLG2
0.17300.3460.2570.09800.2380.069000.0020
rs11706848chr3:6774370292.1385SUCLG2
0.13900.3260.2460.08200.2260.068000.0010
rs935734chr3:6778206192.1798SUCLG2
0.13900.3270.2470.08100.2270.071000.0020
rs262180chr3:6850062992.9277FAM19A1
0.13500.3570.2770.06900.2570.116000.0090
rs1463957chr3:6917668793.457TMF1
0.11400.3050.2340.07200.2190.083000.0050
rs1121758chr3:6970449093.7962   0.09800.2640.20.07500.1880.056000.0020
rs1427434chr3:6983106493.8811   0.09400.2540.1920.07600.1810.05000.0010
rs1996818chr3:7039547494.2497   0.0800.260.1950.07400.180.047000.0070.002
rs1008411chr3:7052866794.3609   0.07700.2690.2020.07200.1840.051000.0110.004
rs1024889chr3:7054602094.3821   0.07600.2710.2030.07200.1850.051000.0110.004
rs1491607chr3:7066107594.4982   0.07300.280.210.07100.190.055000.0150.005
rs1002201chr3:7095382194.8837   0.06100.3110.2330.06600.2050.067000.0270.009
rs17108chr3:7160889596.0715FOXP1
0.10700.5740.4840.11200.3850.1750.00200.1370.097
rs2102313chr3:7210951697.3094   0.1400.7560.6720.10800.4530.2460.02300.2390.202
rs1024008chr3:7276171399.0392   0.09700.7030.6440.10300.4260.2470.05700.2380.228
rs3821379chr3:7309966499.857GXYLT2
0.06800.5640.5210.11600.3360.1810.10700.1890.179
rs7064chr3:73514520100.888PDZRN3
0.07700.4870.4380.14400.2670.1260.21700.1980.152
rs1441443chr3:74005900101.8386   0.03400.4210.380.0900.2260.1030.28500.2340.158
rs36003chr3:74336368102.3596   0.0250.0030.4240.3950.09800.220.10.36600.2540.167
rs35981chr3:74360878102.3962   0.0250.0040.4260.3980.100.220.10.37300.2560.168
rs12488229chr3:75317481103.4092   0.0310.0160.4540.4650.1800.2320.1080.55900.2760.184
rs7636341chr3:76304369104.1388   0.0370.0220.4490.4890.23900.2430.1170.64500.2620.186
rs2037190chr3:76307730104.1426   0.0370.0220.4490.4890.23800.2430.1170.64500.2610.186
rs1562499chr3:76685084104.4957   0.0330.0150.420.460.2100.2250.110.62300.240.175
rs1470569chr3:77614616105.4899ROBO2
0.0460.0030.3410.3760.1300.1710.080.5300.1760.131
rs876675chr3:77758328105.626ROBO2
0.0510.0020.330.3640.11900.1620.0750.51300.1660.122
rs4680983chr3:78522584106.3166   0.0810.0010.2810.3050.09700.1210.0470.500.1210.081
rs1383407chr3:78990861106.6094ROBO1
0.0950.0020.2630.2810.10500.1030.0360.5300.1030.063
rs328049chr3:79068495106.6513ROBO1
0.0980.0030.2610.2780.10600.1010.0340.53500.1010.061
rs2895959chr3:80088716107.1272   0.1260.0040.230.2390.11100.0720.0170.54800.0720.035
rs2061719chr3:81336030107.4142   0.1510.0040.2070.2130.10100.0550.0120.49700.0550.023
rs820273chr3:81630656107.4752GBE1
0.1560.0040.2020.2070.09800.0510.010.48600.0510.021
rs17114chr3:82296326107.6398   0.1710.0030.1890.1920.09300.0420.0070.45700.0420.014
rs936035chr3:82784640107.7658   0.1820.0030.1790.1810.08800.0340.0050.43500.0340.009
rs349148chr3:83466890107.9065   0.1940.0030.1670.1680.08300.0260.0020.4100.0260.004
rs1524793chr3:83795169107.9579   0.1980.0030.1630.1640.08100.0230.0010.400.0230.002
rs1524783chr3:83883488107.9713   0.20.0030.1620.1630.08100.0220.0010.39800.0220.001
rs1385654chr3:84626971108.1125   0.1950.0030.1560.1570.07200.01900.35100.0180
rs1470797chr3:85404030108.3041CADM2
0.1840.0020.1480.1510.05700.01700.27900.0140
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rs1545866chr3:177503856182.9872   0.2460.8690.160.0600.3960000.428-0.04-0.05
rs6799767chr3:177512790182.9998   0.2470.8710.160.0600.3960000.425-0.04-0.05
rs1483635chr3:177530837183.0227   0.250.8690.1610.0600.3940000.424-0.041-0.05
rs936034chr3:177723338183.2628   0.2790.8510.1710.06500.3780000.416-0.048-0.055
rs1377826chr3:177803719183.3626   0.2920.8440.1750.06700.3720000.412-0.051-0.057
rs1490054chr3:177954026183.5648   0.3160.8290.1830.07100.3580000.405-0.057-0.061
rs4857696chr3:178689724184.4611LINC00578
0.4020.850.2510.1120.0030.3280000.408-0.056-0.061
rs7626381chr3:178693283184.4653LINC00578
0.4030.8510.2510.1130.0030.3280000.408-0.056-0.061
rs7628308chr3:179308741185.1794   0.4450.9590.3210.1610.0090.3450.002000.426-0.042-0.05
rs6443567chr3:179910410185.7543KCNMB2
0.461.1050.3550.1950.0140.4040.008000.415-0.048-0.05
rs1468924chr3:180465663186.2089KCNMB3
0.4621.2440.3490.20.0190.4740.008000.424-0.06-0.056
rs2049769chr3:181136696186.6585PEX5L
0.4551.410.3040.1770.0250.5720.003000.452-0.083-0.07
rs1401974chr3:182055425187.0517   0.4451.5410.2650.1560.0290.649-0.002-0.00200.475-0.106-0.085
rs13094706chr3:183076477187.7685   0.3871.6110.1930.1060.0080.695-0.031-0.02300.492-0.185-0.157
rs492310chr3:184078509189.4711ATP11B
0.1671.5970.0460.02600.76-0.099-0.04900.477-0.265-0.219
rs1973738chr3:184727004190.7864KLHL6
0.0661.5320.0120.00200.779-0.128-0.06800.448-0.254-0.222
rs2054172chr3:184861195191.0462KLHL24
0.0521.5150.01000.774-0.138-0.07500.441-0.257-0.226
rs262958chr3:184975682191.2667YEATS2
0.0411.4910.007000.738-0.178-0.09700.431-0.29-0.255
rs869417chr3:185171832191.6497ABCC5
0.0231.450.004000.677-0.247-0.13500.414-0.347-0.304
rs10937158chr3:185191133191.686ABCC5
0.0211.4470.003000.671-0.253-0.13900.413-0.353-0.309
- chr3:185355977 DVL3            
rs3892035chr3:185685725192.5831   0.0031.282-0.047-0.04100.585-0.432-0.25700.446-0.505-0.437
rs4686705chr3:185839049192.8424   0.0011.223-0.067-0.05900.57-0.487-0.29600.466-0.552-0.476
rs2377104chr3:185942570192.9899   01.19-0.079-0.06900.561-0.518-0.31800.478-0.578-0.498
rs4432622chr3:186038158193.1374VPS8
01.182-0.08-0.06900.556-0.516-0.31700.481-0.575-0.5
rs3332chr3:186253074193.4415VPS8
01.168-0.08-0.06600.546-0.507-0.31100.484-0.562-0.5
rs13074297chr3:186327401193.5224C3orf70
01.164-0.08-0.06500.544-0.504-0.3100.485-0.559-0.5
rs1837882chr3:186714863194.1188LIPH
01.151-0.075-0.05600.534-0.476-0.2900.495-0.529-0.49
rs6808013chr3:187432923195.8471DGKG
01.28-0.015-0.01300.609-0.277-0.16100.576-0.374-0.352
rs713484chr3:187772367196.872DNAJB11
01.405-0.001-0.00100.701-0.182-0.10600.658-0.299-0.279
rs266759chr3:187991006197.5541RFC4
01.3710000.714-0.17-0.10600.697-0.312-0.292
rs1568302chr3:188583214199.5645   01.239-0.006-0.0100.725-0.243-0.18300.789-0.481-0.434
rs1157840chr3:189103221201.0821   01.3720-0.00900.755-0.293-0.21500.825-0.548-0.451
rs2030033chr3:189172982201.2572   01.40-0.00700.759-0.279-0.20500.814-0.521-0.432
rs2030525chr3:189557134202.2778LPP
01.4270000.709-0.209-0.15200.698-0.396-0.344
rs2049218chr3:189605672202.386LPP
01.3920000.683-0.205-0.14800.671-0.391-0.342
rs4686963chr3:189681874202.6001LPP
01.3220000.63-0.196-0.14200.618-0.38-0.338
rs10937369chr3:190015503203.4559LPP
00.9540000.397-0.194-0.14400.409-0.369-0.344
rs1515504chr3:191130783206.0004   00.470000.108-0.21-0.1700.065-0.29-0.32
rs538338chr3:191367347206.5744   00.3650000.081-0.181-0.15300.047-0.261-0.274
rs532616chr3:191426960206.722   00.3390000.074-0.174-0.14800.042-0.254-0.262
rs3864005chr3:191505497206.9157   00.3030000.065-0.164-0.14300.036-0.244-0.247
rs1559018chr3:191779777207.5791IL1RAP
00.230.0060.00600.041-0.148-0.12300.023-0.199-0.199
rs955441chr3:192828266210.0274   0.1160.2510.080.050.0180.004-0.091-0.0710.0490-0.111-0.121
rs975121chr3:193379912211.1821FGF12
0.1350.2620.0660.0360.0220.005-0.149-0.1210.0630.002-0.137-0.161
rs2986chr3:194013896212.5251MB21D2
0.1720.20.0550.020.0320-0.179-0.170.0590-0.165-0.205
rs769592chr3:194130457212.7882   0.1780.1990.0580.020.0340-0.174-0.170.0590-0.162-0.202
rs7627589chr3:195326068216.1018   0.0980.2070.0390.0100-0.167-0.1680.0040-0.222-0.261
rs8513chr3:195557506216.8337LRRC15
0.0590.2140.0320.0100-0.145-0.1530.0010-0.237-0.268
rs711995chr3:195842216217.7341   0.0130.2050.0150.0100-0.155-0.14300-0.255-0.248
rs1075870chr3:196162571218.7419   00.1710.0030.00300-0.249-0.21400-0.356-0.314
rs823507chr3:196742938219.785PPP1R2
00.1550000.003-0.335-0.28700-0.437-0.371
rs903196chr3:197057721220.2556   00.1570000.003-0.342-0.29500-0.435-0.365
rs9844652chr3:197070986220.2784   00.1570000.003-0.342-0.29400-0.433-0.363
rs9343chr3:197444622220.9429OSTalpha
00.1650000.002-0.322-0.28100-0.393-0.323
rs338180chr3:198496361222.8034DLG1
00.1130000-0.308-0.29600-0.362-0.246
rs338217chr3:198511324222.8265DLG1-AS1
00.1120000-0.308-0.29700-0.362-0.245
rs718501chr3:198568120222.9267   00.1070000-0.309-0.29900-0.361-0.242
rs6788537chr3:198646246223.0693   00.1020000-0.309-0.300-0.361-0.241
rs2686085chr3:198707095223.1717   00.10000-0.308-0.300-0.363-0.242
rs1030576chr3:198790909223.3264   00.0960000-0.307-0.300-0.367-0.243

Table Legend: Tabular display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow row marks the location of the selected gene, and the whitened rows correspond to 20 Mb
around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

References

 

Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry. 2012 Jul;17(8):818-26. doi: 10.1038/mp.2011.89. Epub 2011 Jul 19. PubMed PMID: 21769101