Metamoodics Gene Information

 

  Chromosome: chr9    Cytoband: p21.3    Gene: ELAVL2

 

BP - Genomewide Linkage Studies for ELAVL2


 

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Description

 
Shown here are the results for gene ELAVL2 from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs1532310chr9:5929860.7779KANK1
0.010-0.048-0.0600-0.098-0.0980.0010-0.14-0.098
rs1532309chr9:5931920.7784KANK1
0.010-0.048-0.0600-0.098-0.0980.0010-0.14-0.098
rs999924chr9:13222572.9652   00-0.148-0.13900-0.188-0.18800-0.199-0.149
rs10810061chr9:13957323.2098   00-0.165-0.15700-0.209-0.21100-0.202-0.154
rs10114417chr9:14496633.3885   00-0.177-0.17100-0.225-0.22900-0.204-0.158
rs1535842chr9:22025466.0195   00-0.319-0.32900-0.39-0.430.0010-0.18-0.2
rs1331829chr9:23729526.711   00-0.299-0.30900-0.376-0.430.0040-0.173-0.207
rs729367chr9:25902537.4899FLJ35024
00-0.3-0.3100-0.39-0.450.0080-0.17-0.22
rs2124210chr9:379131610.3395   00-0.37-0.36600-0.53-0.610.0190-0.183-0.253
rs4131424chr9:432566812.0314   00-0.231-0.2200-0.38-0.450.0510-0.08-0.13
rs7851353chr9:440138312.2943   00-0.236-0.2200-0.383-0.4530.0480-0.077-0.127
rs10758654chr9:479806913.8877RCL1
00-0.277-0.22900-0.426-0.4780.0220-0.07-0.111
rs10758703chr9:572152715.8603KIAA1432
00-0.26-0.19300-0.404-0.3970.0010-0.079-0.091
rs1028702chr9:577685015.874ERMP1
00-0.26-0.19300-0.404-0.3960.0010-0.079-0.091
rs695013chr9:608156515.9482   00-0.26-0.19100-0.402-0.39300-0.079-0.091
rs1407862chr9:702277616.7584KDM4C
00-0.26-0.19800-0.385-0.39800-0.072-0.082
rs4740874chr9:725717617.1704   00-0.265-0.20300-0.389-0.40700-0.075-0.082
rs10976528chr9:771781818.6028   00-0.29-0.2200-0.442-0.44600-0.106-0.09
rs1156793chr9:836866220.388PTPRD
00-0.25-0.200-0.41-0.4300.001-0.076-0.06
rs765800chr9:878477521.7413PTPRD
00-0.25-0.20700-0.417-0.4300-0.07-0.06
rs833403chr9:1051333425.8541PTPRD
00-0.106-0.08400-0.269-0.22900.005-0.023-0.011
rs901986chr9:1118601626.7489   00.002-0.063-0.0500-0.193-0.1600.006-0.005-0.003
rs4548275chr9:1281911028.762   00.037-0.002000.009-0.032-0.01700.0160.0730.083
rs1854908chr9:1313407829.2542MPDZ
00.0450000.015-0.017-0.00700.0130.1030.108
rs7866589chr9:1423778831.4634NFIB
00.0620.0190.01500.0470.0050.005000.2260.182
rs1556031chr9:1442759332.1252   0.0040.0690.0510.03900.0730.030.0260.00100.3150.248
rs1143025chr9:1460218832.6714ZDHHC21
0.0220.090.1440.12100.0920.1170.0970.00500.4680.368
rs1215120chr9:1527452734.4359TTC39B
0.0570.0450.3880.37200.0550.440.3850.02100.8750.697
rs1328273chr9:1601346935.4517   0.0870.0240.4730.47200.0280.5530.5060.02300.9420.761
rs2151065chr9:1623571635.8459   0.1040.0190.4920.49900.0210.5720.5380.01800.9260.753
rs1888952chr9:1624811835.8654   0.1050.0190.4930.50100.020.5730.5390.01800.9250.753
rs263580chr9:1702931237.4515   0.1840.0470.6040.6190.1720.0620.8340.7550.16101.1650.917
rs960232chr9:1815611239.5017   0.3810.0060.550.560.4580.0450.9350.8350.30401.240.965
rs748530chr9:1962971341.8431SLC24A2
0.21400.3530.3730.3130.0580.7740.7290.24601.0660.869
rs717081chr9:2027713943.1749   0.19400.3720.3830.230.0520.8040.8130.19601.0050.87
rs1332184chr9:2149420344.4735MIR31HG
0.17500.4650.5040.2210.0690.9881.0570.24501.0460.922
rs720974chr9:2150990444.4865MIR31HG
0.17600.4680.5070.2210.070.9921.0610.24701.0480.924
rs1414237chr9:2172291244.6844   0.18200.5030.5510.2210.0781.0411.1180.27401.0760.945
rs1360590chr9:2203144345.1075CDKN2B-AS1
0.200.5840.6430.2140.0841.141.2370.30401.1140.984
rs10757309chr9:2233578945.4834   0.22900.6660.7220.1870.0631.2121.3310.25501.0910.999
rs702223chr9:2380384047.3653ELAVL2
0.26100.9010.9570.10.0081.421.5930.12301.0211.075
rs1332677chr9:2466160248.266   0.24400.8880.9350.08401.3881.5430.09600.9170.989
rs2169325chr9:2490186848.5587   0.22900.8530.8970.0801.3531.5020.08700.8580.921
rs1128953chr9:2566734949.8229TUSC1
0.14400.7010.7740.04901.1441.3170.04600.5560.581
rs757099chr9:2572756749.9187   0.13600.690.7670.04601.1251.3020.04300.5310.554
rs1220087chr9:2577872149.9975   0.1300.680.760.04401.111.290.0400.5110.531
rs666478chr9:2716318051.8643TEK
0.08400.5950.6670.04500.8490.9360.02200.3890.352
rs9103chr9:2753682853.2441C9orf72
0.0800.6080.6730.04200.7010.7410.00600.3130.26
rs1452357chr9:2809084654.9574LINGO2
0.08600.5810.6210.02700.5050.554000.2610.192
rs560764chr9:2958283655.8815   0.1800.7210.7520.04900.4740.506000.2420.19
rs1018254chr9:3013323056.1765   0.18900.7220.7560.04900.4470.477000.2310.178
rs17179086chr9:3089798056.6169   0.17900.6780.7210.04300.390.420.00100.2090.147
rs1412340chr9:3160933457.1707   0.18100.6570.7070.05100.3590.3850.00200.1990.127
rs288886chr9:3173200757.2828   0.18800.6680.7180.0600.3710.3950.00200.2040.131
rs471371chr9:3386084459.2217UBE2R2
0.30500.8860.9040.29100.6370.6030.03100.3420.218
rs11789226chr9:3496550860.0021KIAA1045
0.33600.870.850.37100.660.580.05200.350.21
rs944700chr9:3509994960.0603FAM214B
0.33700.8790.860.37300.6690.590.05500.3610.218
rs7847459chr9:3610644060.501RECK
0.34400.9450.930.38700.7350.660.07500.4450.28
rs954779chr9:3640952960.7218   0.34800.9780.9650.39400.7680.6950.08400.4870.311
rs735741chr9:3793448962.3576SHB
0.2601.0161.0170.32900.8660.7760.12500.7640.529
rs1138374chr9:3796474362.4038SHB
0.25601.0161.0180.32300.8640.7740.12400.7710.534
rs10122815chr9:3831935263.0083   0.19301.011.030.24900.840.750.12200.860.601
rs1004604chr9:3835217163.0649   0.190.0011.0121.0310.24600.8430.7530.12100.8640.605
rs987187chr9:3836521563.0874   0.190.0021.0131.0320.24400.8430.7530.1200.8650.607
rs10814685chr9:3837163963.099   0.1890.0021.0131.0320.24400.8440.7540.1200.8660.608
rs10868856chr9:7026175366.9329PGM5
0.0460.1020.8450.8360.0930.0020.7930.6830.1010.1710.9980.787
rs923784chr9:7030709966.973PGM5
0.0450.1030.8420.8320.0930.0020.7910.6810.1020.1730.9990.789
rs2026349chr9:7038343567.0488   0.0420.1040.8440.8340.090.0020.790.6790.10.180.9970.786
rs1414944chr9:7064620067.2331PIP5K1B
0.0360.1050.8610.8490.0810.0020.7880.6750.0950.1970.9860.771
rs1889915chr9:7235453268.3003TRPM3
0.020.1461.0171.0060.0680.0260.8670.7320.0940.3231.0630.818
rs1074670chr9:7320659368.7405   0.0350.2041.1451.1470.1040.0610.9950.8380.1280.41.2440.977
rs10869076chr9:7379697169.1541   0.0420.261.2661.2850.1130.0821.0810.9120.1290.4451.351.081
rs4745340chr9:7635382670.6401RORB
0.0220.4421.6291.7120.0160.0521.1020.9610.0080.3831.3051.121
rs2031197chr9:7635856870.6465RORB
0.0220.4421.631.7130.0160.0511.1010.9610.0080.3831.3051.121
rs1333342chr9:7669198071.1632TRPM6
0.0170.4871.7321.82200.0311.1090.98600.3421.2981.125
rs891370chr9:7725654672.2534   0.0330.562.0082.10100.0361.3161.23100.2821.421.238
rs927632chr9:7834981374.8687   0.1490.5252.5912.6440.0020.0381.8541.79400.0551.7071.623
rs1891835chr9:7861570975.4846PRUNE2
0.1940.5722.7122.7770.0140.0671.9871.9410.0020.0611.7441.693
rs2839899chr9:7954081976.8958GNAQ
0.2980.7712.8372.9260.0820.2242.2072.1860.0230.1351.7431.75
rs1887773chr9:7961875576.9621GNAQ
0.3030.7812.8392.9280.0860.2342.2152.1950.0240.1391.7411.75
rs722642chr9:8048573977.995   0.6281.0153.2883.3980.2270.4272.4592.4390.0340.261.781.869
rs713478chr9:8050194078.0214   0.6311.0143.2843.3920.2270.4272.4522.4310.0340.2611.7761.863
rs735914chr9:8100612178.9648   0.6950.933.023.0240.180.392.0842.0250.0190.2541.5771.542
rs1417080chr9:8132068179.5434   0.6520.8222.9452.9830.1570.3371.9721.9280.0090.2141.4561.459
rs4527956chr9:8288075981.0423   0.4840.3922.4962.6960.0860.1251.5261.56500.0431.0911.151
rs870713chr9:8341697882.1822TLE1
0.3480.3172.1372.3280.0470.0381.1671.18600.0050.8570.914
rs2378592chr9:8368504782.6681   0.3120.3282.052.2160.0420.0371.081.0700.0060.770.816
rs485522chr9:8453482683.5498   0.260.3541.8862.0190.0610.0540.9210.85300.0210.6390.646
rs7846911chr9:8495724984.0229   0.2420.371.8011.9190.0810.0680.8390.73800.0320.5790.558
rs10746699chr9:8504593084.1768   0.2660.3861.8051.9110.0910.0680.8310.72800.0290.5730.546
rs1359168chr9:8510406384.2957FRMD3
0.2850.3981.8091.9050.0980.0680.8250.71900.0260.5680.536
rs944947chr9:8548988484.7421UBQLN1
0.3570.4441.8221.8830.1250.0690.8030.68800.0150.550.501
rs918223chr9:8560166084.7875GKAP1
0.3640.4491.8241.8810.1280.0690.8010.68500.0140.5490.497
rs1187337chr9:8650585785.2615NTRK2
0.4150.4571.7521.7860.1580.0570.7460.62300.0070.5220.459
rs1778970chr9:8658563085.3805NTRK2
0.4230.4511.7161.7480.1660.0510.7250.60200.0060.5130.45
rs675837chr9:8745976786.8409AGTPBP1
0.4580.3731.3621.3730.2180.0140.5110.4060.00200.4110.35
rs88644chr9:8829584088.404   0.4820.3561.21.2160.2930.0230.460.3620.01900.3860.322
rs912067chr9:8915159690.2765   0.4270.3380.9340.9290.3960.0420.420.2980.04500.3150.243
rs729958chr9:8947700791.0222DAPK1
0.3640.2950.7580.7690.4090.0410.3390.240.02900.250.2
rs560019chr9:8977334191.6296CDK20
0.3390.2580.710.7390.3680.0330.3210.2340.02700.2440.2
rs4077800chr9:9148798894.9876UNQ6494
0.1250.0140.3510.4410.05100.1010.090.00400.1010.11
rs7046597chr9:9224655796.5767   0.1130.0540.2510.3310.02500.0530.0480.00100.0580.068
rs2780701chr9:9260710297.1899SYK
0.1140.0710.2260.3010.01900.0380.0360.00100.0420.052
rs17577532chr9:9283459497.5117   0.1230.0690.220.2840.01800.0350.03000.030.04
rs4744070chr9:9340894198.0689   0.1370.0630.2050.2540.01700.0290.019000.0090.019
rs1316268chr9:9377438398.3844   0.1310.0550.1830.2290.01900.0260.016000.0060.016
rs3780346chr9:9401400998.5607IARS
0.1280.050.1710.2150.01900.0240.014000.0040.014
rs715846chr9:9431283498.7572CENPP
ECM2
0.1250.0450.1570.1990.0200.0220.012000.0020.012
rs4744136chr9:9431484598.7584CENPP
ECM2
0.1250.0450.1570.1990.0200.0220.012000.0020.012
rs4534181chr9:9513374599.2256C9orf129
0.1260.0430.1330.1750.02700.0220.015000.0050.015
rs10761323chr9:9599096699.7099MIRLET7DHG
0.1350.050.1190.1660.04100.0270.0240.00100.0140.024
rs2945802chr9:96360274100.0176   0.1410.0550.110.1610.04900.0310.0310.00200.0210.031
rs1048510chr9:96360948100.0183FBP2
0.1410.0550.110.1610.04900.0310.0310.00200.0210.031
rs1335049chr9:97487704101.3931   0.1650.0730.1160.1860.070.0020.060.0640.04800.0660.056
rs700962chr9:97617869101.5253LINC00476
0.170.0720.1150.1850.0740.0020.060.0650.0500.0650.055
rs10819780chr9:97866190101.7957   0.180.070.1120.1820.0820.0030.060.0680.05500.0620.052
rs1020884chr9:99197873102.3443LOC286359
0.1470.0790.0960.1660.0690.0020.0460.060.05900.0530.043
rs952765chr9:99407127102.3695TSTD2
0.1440.0790.0950.1650.0680.0020.0450.0590.05900.0530.043
rs6478437chr9:99647318102.4562   0.1340.0820.0920.1620.0630.0020.0420.0560.05900.0510.041
rs814027chr9:99951492102.7427CORO2A
0.1010.0910.080.150.0470.0010.030.0480.05900.0450.035
rs1167768chr9:100371213103.3843GABBR2
0.0590.1480.0930.1980.0460.010.0470.090.09600.0590.061
rs1555519chr9:100605466103.6774   0.0490.1850.1110.2420.0560.0180.0670.1280.12300.0740.084
rs1529191chr9:101885729104.7958ERP44
0.0180.2820.1140.2980.0830.0520.090.2020.13900.0820.118
rs1338121chr9:102054839104.8514INVS
0.0170.2860.1130.2990.0840.0540.090.2040.13800.0810.119
rs1930243chr9:102155993104.9063   0.0150.2890.1120.2990.0850.0560.090.2060.13700.0810.119
rs2026999chr9:102179978104.924   0.0150.2910.1120.2990.0850.0560.090.2070.13600.0810.119
rs1338740chr9:102659418105.3732   0.0110.2880.0950.2810.0820.0560.0790.1950.11300.0650.109
rs1329088chr9:102920305105.725LPPR1
0.0090.280.0810.2640.0780.0540.0680.1810.09300.0510.098
rs1323421chr9:103457375106.4584GRIN3A
0.0060.2310.0610.2320.0720.0350.0510.1470.05700.0260.072
rs2000182chr9:103832631106.9037   0.0040.190.0520.2140.0690.0180.0420.1250.03700.0130.054
rs884416chr9:104362414107.3999   0.0350.2480.070.2380.1080.040.0480.1280.03300.0180.062
rs363717chr9:106584521109.1689ABCA1
0.3130.5670.2250.4540.3480.2350.140.2290.0560.0150.1070.2
rs1463983chr9:107466605110.007   0.490.5690.3510.5710.5080.270.240.320.0860.0220.1910.3
rs1961970chr9:107721604110.0712   0.4980.5690.3590.5810.510.2650.2430.3210.090.0210.1960.304
rs1516882chr9:107952732110.1972   0.5140.570.3760.60.5140.2530.2480.3240.0980.020.2060.312
rs1017890chr9:108113522110.3679   0.5360.570.3980.6250.5180.2380.2550.3270.1080.0190.2190.322
rs1491100chr9:108394648110.7891   0.5910.5720.4530.6880.530.1990.2720.3360.1330.0150.2530.347
rs1819730chr9:109271684112.7083   0.8520.6990.6710.9650.6510.1720.3240.3530.2270.0140.3140.37
rs940287chr9:109476996113.2185   0.9220.7520.7481.0590.6750.1830.3470.3720.2740.0180.3370.383
rs1407850chr9:110104622114.8352   1.1111.0261.121.5120.7070.290.5190.5670.5080.0540.50.514
rs1407392chr9:111428280116.3728   0.9331.0641.21.5770.6090.3080.6260.650.6140.1450.6590.618
rs1923433chr9:111440086116.3937   0.9281.0621.1971.5730.6060.3070.6250.6490.6120.1460.6580.616
rs1327532chr9:112166135117.4872   0.6590.9771.0031.3680.4160.2410.4920.5320.5090.1590.5620.507
rs984071chr9:112178851117.5027SVEP1
0.6550.9760.9991.3640.4140.240.490.530.5070.1580.560.505
rs2254168chr9:112229034117.5667SVEP1
0.640.970.9871.3510.4030.2350.4790.5210.4980.1570.5490.495
rs1043836chr9:115176019120.7152HDHD3
0.1360.5610.6410.1290.0280.2290.2790.0530.0320.160.194
rs1871692chr9:115541098121.5334   0.090.530.6411.0120.1130.0180.2360.3020.0220.020.140.191
rs1000709chr9:116277575123.2964DFNB31
0.1110.6590.7951.1850.120.0470.3140.4170.0160.0160.1470.223
rs726657chr9:116736157123.9827   0.2720.8761.0141.4040.2250.1030.4170.5270.050.0330.2080.298
rs1060545chr9:116861439124.1553TNC
0.3310.9191.0291.3960.2730.1370.4280.5250.0660.0470.2070.288
rs1757096chr9:116889462124.1911TNC
0.3440.9271.0311.3930.2830.1440.430.5240.070.050.2060.285
rs1250019chr9:116896139124.1996TNC
0.3470.931.0321.3920.2850.1460.430.5240.0710.050.2060.284
rs1250288chr9:117047253124.39211-Dec
0.4160.9761.0441.3750.3410.1860.440.5180.090.0670.2020.269
rs1405chr9:117994445125.7286PAPPA
0.6081.1090.9851.2030.4580.3190.4190.4420.1440.1860.1750.191
rs1334071chr9:118855800126.7416ASTN2
0.3450.9960.8681.1160.1980.180.3330.3980.0650.190.1920.21
rs1572306chr9:119111369127.0121ASTN2
0.2550.9610.841.10.1150.1320.310.390.0380.1850.20.22
rs734096chr9:119759172127.7252   0.2251.1360.8251.0780.1060.2020.310.390.0170.2760.2150.249
rs724975chr9:120828533129.253   0.0881.5180.6920.9090.0570.3210.290.3300.4390.1820.237
rs230146chr9:120916787129.4015   0.0771.4980.670.880.0490.3070.2780.31200.4260.1720.224
rs1013324chr9:122051509131.3832   00.90.3440.45900.0580.0830.07300.1480.0450.055
rs769012chr9:123273842132.3343GGTA1P
00.6640.2270.3100.0110.0270.0200.0740.010.02
rs1757319chr9:123372593132.4133DAB2IP
00.6460.2160.29800.010.0230.01800.0690.0080.018
rs4679chr9:123954434133.0056NDUFA8
00.510.140.21000000.033-0.010
rs1571586chr9:123997346133.0672MORN5
00.5060.1420.213000000.033-0.0110
rs10818768chr9:124749144134.0406RABGAP1
00.4480.1680.24800.0020000.033-0.020
rs12115650chr9:125407526134.9374DENND1A
00.2950.1330.213000000.012-0.0290
rs3780683chr9:125829029135.4317LHX2
00.30.1560.24900.0010000.014-0.0260
rs917783chr9:125830428135.4332LHX2
00.30.1560.24900.0010000.014-0.0260
rs2148742chr9:125910873135.5118   00.3020.1610.25600.0010000.015-0.0250
rs12009chr9:127037124136.3253HSPA5
00.330.2060.31600.0030000.018-0.020
rs1055352chr9:127950240137.1117   00.3480.2410.35200.0040000.017-0.020
rs2275241chr9:128410397137.674   00.330.2470.36300.0040000.009-0.020
rs624903chr9:128687043138.0759ZBTB34
00.3240.2560.37500.0050.0020.00200.004-0.0190
rs947626chr9:129814190139.3151   0.0010.4040.380.4900.0420.0390.05500-0.0070.009
rs751340chr9:130729182140.8232PHYHD1
0.0120.5880.6460.75600.1930.1620.21700.0030.0160.079
rs913275chr9:130950465141.302PPP2R4
0.0210.6460.7250.8320.0010.2750.2160.28800.0130.0320.117
rs1220789chr9:131297604142.1089LOC100506190
0.0390.7160.8390.9330.0080.4140.3090.40700.0360.0640.185
rs1054879chr9:132035589144.1888NCS1
0.1090.5440.9520.9320.1630.4630.4610.48800.0570.1510.258
rs6597676chr9:132955010146.3736LAMC3
0.3840.530.910.7960.3440.7530.5430.4450.0590.2320.2390.208
rs818051chr9:132959999146.3843   0.3850.5290.9090.7950.3440.7530.5420.4450.0590.2320.2380.207
rs735107chr9:133186227146.9007   0.3950.5110.8680.7490.3470.7730.5320.4240.0560.2540.2230.176
rs10901140chr9:134099855147.865NTNG2
0.4360.40.7650.6360.520.6280.5390.3940.080.240.2460.161
rs565325chr9:134341499148.2821C9orf171
0.4470.3740.7530.620.5570.5980.5650.4040.0940.2320.2670.166
rs456396chr9:134552621148.7281GTF3C4
0.4560.3590.7570.620.5720.5870.6060.4260.110.2230.2940.175
rs215156chr9:134653342148.9677AK8
0.460.3510.760.620.580.5810.6270.4380.1190.2190.3080.179
rs886017chr9:134963921149.7242RALGDS
0.5470.4610.8030.6710.6530.6840.7310.5410.1060.2880.3320.231
rs12335chr9:135187655150.2699SURF6
0.6130.6140.8630.7330.6830.8290.7830.6040.080.3630.3530.28
rs2797851chr9:135494401151.1149DBH
0.7050.9450.9650.8350.6711.1370.8030.6560.0230.4970.3850.358
rs886112chr9:135760666151.7468VAV2
0.7081.1050.8830.7530.5721.2440.7080.580.0070.5160.360.345
rs7023064chr9:136236772153.4847   0.7371.3340.8010.6760.621.4950.6360.5010.0040.7280.4040.355
rs877954chr9:136466229155.003RXRA
0.751.3590.6990.580.6971.4380.510.380.0761.0170.460.34
rs3132332chr9:136515594155.3175   0.7211.2710.6430.5320.671.3920.4590.3390.07410.4220.308
rs2989726chr9:136949195158.3432FCN1
0.2760.5030.1390.1130.3920.9180.080.0430.0150.7830.1030.077
rs4641145chr9:137059312158.973   0.2290.4440.1020.0810.3660.8920.0610.0310.0110.7870.0910.07
rs914400chr9:137433029160.8008   0.2580.3760.0840.0720.3830.8510.060.040.010.8780.1080.106
rs783768chr9:137607587161.6128LOC100130954
0.2570.2880.0680.0580.3790.7350.060.040.0040.7660.1160.116
rs945383chr9:138738659164.9875FAM69B
0.2440.0410.030.010.3590.1910.050.0300.1780.090.08
rs908831chr9:138942363165.4491   0.2270.0310.0210.0060.3320.1520.0410.02600.1420.0810.071
rs1018330chr9:139100206165.7616LOC100289341
0.2160.0260.0150.0020.3130.1260.0350.02200.1180.0750.065
rs7028989chr9:140031491167.114CACNA1B
0.1310.004-0.011-0.0210.2020.0210-0.0100.0140.0090
rs7860423chr9:140075368167.1665CACNA1B
0.130.004-0.012-0.0220.2010.0210-0.0100.0140.0080
rs7357733chr9:140123767167.2243CACNA1B
0.1290.003-0.012-0.0220.20.020-0.0100.0130.0080

Table Legend: Tabular display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow row marks the location of the selected gene, and the whitened rows correspond to 20 Mb
around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

References

 

Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry. 2012 Jul;17(8):818-26. doi: 10.1038/mp.2011.89. Epub 2011 Jul 19. PubMed PMID: 21769101