Metamoodics Gene Information

 

  Chromosome: chr12    Cytoband: p13.31    Gene: GNB3

 

BP - Genomewide Linkage Studies for GNB3


 

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Description

 
Shown here are the results for gene GNB3 from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs633159chr12:1648050   0.010-0.21-0.260.0070-0.34-0.270.0010-0.29-0.34
rs476646chr12:2073950.0567SLC6A13
0.0110-0.211-0.2610.0070-0.343-0.2720.0010-0.293-0.343
rs1563619chr12:7031861.2253   0.0270-0.215-0.2650.0170-0.379-0.30100-0.357-0.409
rs2107614chr12:7733401.3798WNK1
0.0310-0.212-0.2620.0190-0.371-0.29500-0.361-0.415
rs1005394chr12:13113982.7406ERC1
0.0570-0.207-0.2570.0340-0.318-0.2700-0.417-0.477
rs766956chr12:13253672.7797ERC1
0.0580-0.208-0.2580.0350-0.317-0.2700-0.419-0.479
rs2270037chr12:16201023.5735WNT5B
0.0740-0.193-0.2430.0540-0.27-0.24700-0.407-0.461
rs2238070chr12:23263765.5052CACNA1C
0.1440-0.12-0.160.1840-0.13-0.1450.0030-0.245-0.305
rs216025chr12:26188616.3014CACNA1C
0.1660-0.094-0.1340.2570-0.097-0.120.0150-0.207-0.27
rs537938chr12:32643598.2013TSPAN9
0.1760-0.086-0.1360.4010-0.088-0.1380.0880-0.198-0.278
rs990949chr12:33568438.5506   0.1730-0.097-0.1470.420-0.084-0.1340.10-0.194-0.274
rs887358chr12:34525968.9003PRMT8
0.170-0.107-0.1570.4390-0.081-0.1310.1130-0.191-0.271
rs9300302chr12:373773210.0265   0.140-0.14-0.20.4180-0.059-0.0890.0920-0.149-0.189
rs4766200chr12:401981011.2332   0.1410-0.135-0.2050.4140-0.042-0.0620.1190-0.122-0.145
rs1860345chr12:478107313.9096   0.1230-0.198-0.2680.3030-0.097-0.1360.1070-0.168-0.216
rs2109423chr12:488661314.1353   0.1170-0.211-0.2810.2760-0.118-0.1580.0960-0.188-0.242
rs248881chr12:508102214.5792   0.1020-0.246-0.3160.2080-0.175-0.2150.0680-0.245-0.313
rs617022chr12:517382314.8003   0.0940-0.264-0.3340.1740-0.204-0.2440.0540-0.274-0.348
rs1558776chr12:558382515.6917ANO2
0.0510-0.204-0.2530.0760-0.216-0.2220.0560-0.217-0.29
rs1558507chr12:561808315.7723ANO2
0.0470-0.195-0.2420.0680-0.215-0.2160.0570-0.207-0.28
rs417664chr12:566085615.8691ANO2
0.0420-0.184-0.2280.0590-0.213-0.2090.0590-0.196-0.267
rs917857chr12:595208516.5478VWF
0.0420-0.17-0.210.040-0.205-0.1950.0570-0.164-0.223
rs216889chr12:596971416.5904VWF
0.0420-0.17-0.210.040-0.204-0.1940.0560-0.162-0.22
rs216896chr12:597105716.5937VWF
0.0420-0.17-0.210.0390-0.204-0.1940.0560-0.162-0.22
rs216293chr12:602392016.7224VWF
0.0440-0.17-0.210.0380-0.203-0.1930.0550-0.158-0.214
rs797773chr12:617782717.0966   0.0480.002-0.171-0.2120.0350-0.204-0.1940.050-0.151-0.201
rs740839chr12:620889817.1641CD9
0.0490.003-0.172-0.2130.0350-0.207-0.1970.0490-0.152-0.202
rs2365567chr12:671410818.385   0.0450.011-0.188-0.2420.0290-0.248-0.2380.0290-0.152-0.195
- chr12:6819635 GNB3            
rs1349411chr12:728392519.6945   0.0080-0.207-0.260.0120-0.253-0.2430.0210-0.112-0.135
rs4883148chr12:850550522.849CLEC6A
0.0110.004-0.036-0.0580.0690-0.048-0.0480.060.003-0.012-0.013
rs4883169chr12:861669323.1039   0.0140.007-0.028-0.0470.0740-0.037-0.0370.0570.005-0.009-0.009
rs226386chr12:915399424.2383A2M
0.0280.019-0.01-0.0250.0890-0.01-0.0120.0210.01100
rs226376chr12:916497824.2518   0.0280.019-0.01-0.0250.090-0.01-0.0130.0210.0100
rs1560011chr12:971421924.9838CLEC2D
0.0280.01-0.01-0.040.1060-0.01-0.020.0120.00900
rs1870194chr12:1066425025.5397STYK1
0.0250.005-0.021-0.0560.1010-0.015-0.0310.0060.007-0.011-0.011
rs1063193chr12:1089104725.7412PRH1-PRR4
PRR4
0.0240.003-0.025-0.0620.0990-0.017-0.0350.0030.006-0.015-0.015
rs916041chr12:1170359727.2283ETV6
0.0370-0.018-0.0630.0960-0.008-0.02500.005-0.008-0.008
rs732868chr12:1185897727.6867ETV6
0.0480-0.013-0.0490.0970-0.003-0.01600.004-0.003-0.003
rs4763797chr12:1233820029.4632   0.10900-0.0250.06400-0.00500.00500
rs714480chr12:1244364929.8759LOH12CR1
0.11300-0.0210.03200-0.00900.00700
rs1548837chr12:1294558431.7172GPRC5A
0.10300-0.0030.00900000.03400
rs1895056chr12:1402930233.9903   0.043000000000.0090.010.01
rs2900333chr12:1454513434.4029   0.0310.00200000000.0050.0060.01
rs993123chr12:1546890235.7222PTPRO
0.0250.0320.00700.017000.007000.0070.01
rs1861577chr12:1645524037.4077   0.1870.1430.0280.0120.3820.010.0320.022000.0120.018
rs993694chr12:1649225137.4573   0.1890.1430.0260.0110.3870.010.0310.021000.0110.016
rs992690chr12:1654142837.5244   0.190.1430.0240.010.3930.0110.030.02000.010.014
rs1488080chr12:1683827637.8918   0.1990.1420.0130.0020.4290.0140.0220.012000.0020.003
rs1447410chr12:1853380438.926PIK3C2G
0.0960.09-0.018-0.0190.3450.0130.001-0.00900-0.028-0.009
rs751082chr12:1942326440.0881   0.0750.149-0.00100.2930.051-0.002-0.00200.003-0.036-0.013
rs1875467chr12:1951361240.2356AEBP2
0.070.145-0.00200.2840.05-0.005-0.00500.002-0.046-0.017
rs1427979chr12:2023272541.5447   0.0330.108-0.01-0.0050.2150.038-0.036-0.04200-0.149-0.073
rs1366chr12:2156029443.8817GOLT1B
0.0190.095-0.00100.180.037-0.06-0.07800-0.275-0.184
rs2009625chr12:2221651244.781   0.0140.067-0.008-0.0080.1680.021-0.083-0.10300-0.303-0.221
rs6487356chr12:2373178046.7202SOX5
0.0080.066-0.034-0.0270.1490.011-0.142-0.16900-0.327-0.292
rs575608chr12:2439242747.7117SOX5
0.0140.055-0.061-0.0660.1460.012-0.157-0.20100-0.316-0.314
rs1396208chr12:2444958747.8016SOX5
0.0150.053-0.064-0.070.1460.012-0.158-0.20400-0.314-0.316
rs1381802chr12:2575313450.1325   0.0130.011-0.083-0.1130.0720.006-0.167-0.24700-0.286-0.326
rs875295chr12:2623215550.9589   0.0050.007-0.099-0.1290.0470.006-0.151-0.23100-0.261-0.301
rs1151048chr12:2697655451.936ASUN
0.0040.018-0.044-0.0830.0230.04-0.066-0.11800-0.204-0.206
rs841603chr12:2720274952.1462   0.0030.017-0.039-0.0770.0180.036-0.067-0.11300-0.204-0.203
rs7973582chr12:2770249152.5758PPFIBP1
0.0020.012-0.034-0.0680.0090.019-0.089-0.12200-0.217-0.212
rs10506029chr12:2836450252.9485CCDC91
00.007-0.031-0.0610.0010.004-0.107-0.12900-0.228-0.219
rs4931123chr12:2903601053.9709   00.012-0.011-0.02100-0.081-0.07200-0.211-0.181
rs10843425chr12:2951294054.8611OVCH1
00.008-0.01-0.01100-0.08-0.0700-0.167-0.137
rs2043623chr12:2951928354.8702OVCH1
00.008-0.01-0.01100-0.08-0.0700-0.166-0.136
rs759890chr12:2972099055.1982TMTC1
00.009-0.01-0.0100-0.076-0.06400-0.154-0.124
rs1909160chr12:3003727955.6696   00.012-0.01-0.0100-0.067-0.0500-0.14-0.11
rs581642chr12:3090285856.4405   00.019-0.01-0.0100-0.047-0.03100-0.104-0.087
rs256722chr12:3091462556.454   00.02-0.01-0.0100-0.046-0.03100-0.103-0.086
rs1666228chr12:3192251557.4892   00.013-0.03-0.03400-0.03-0.02500-0.075-0.08
rs325437chr12:3241351657.8844BICD1
00.003-0.045-0.05400-0.03-0.02900-0.079-0.088
rs904582chr12:3262650358.0139FGD4
00-0.05-0.0600-0.03-0.0300-0.079-0.089
rs1473652chr12:3269523958.0533   00-0.05-0.05900-0.031-0.0300-0.078-0.087
rs1353933chr12:3303560458.216   00-0.05-0.05800-0.034-0.0300-0.071-0.079
rs1705748chr12:3402443858.3853   00-0.05-0.05600-0.038-0.0300-0.065-0.071
rs1705772chr12:3406602358.3874   00-0.05-0.05600-0.038-0.0300-0.065-0.071
rs2068119chr12:3465085058.4175   00-0.05-0.05600-0.038-0.0300-0.063-0.069
rs10880624chr12:3681258358.5286   00-0.05-0.05500-0.041-0.0300-0.059-0.064
rs1906260chr12:3688728058.5326   00-0.05-0.05500-0.041-0.0300-0.059-0.063
rs956066chr12:3858300759.001SLC2A13
00-0.05-0.0500-0.05-0.0300-0.04-0.04
rs1820545chr12:3909686059.2655   00-0.053-0.05300-0.066-0.04600-0.045-0.045
rs872168chr12:4044578460.0801   00-0.059-0.05900-0.111-0.09100.001-0.058-0.059
rs2061192chr12:4096153660.495   00-0.055-0.05500-0.115-0.09500.005-0.045-0.055
rs1224438chr12:4368430862.277   00-0.022-0.02400-0.109-0.08900.098-0.007-0.022
rs1495042chr12:4372065362.3065DBX2
00-0.021-0.02400-0.108-0.08800.1-0.007-0.021
rs965125chr12:4400848962.5464ANO6
00-0.014-0.01900-0.098-0.07800.117-0.005-0.014
rs1012642chr12:4463954663.1012SCAF11
00-0.002-0.01100-0.083-0.06400.140-0.001
rs1444588chr12:4475068463.2104   00-0.004-0.01200-0.086-0.06800.1310-0.002
rs1978161chr12:4675398864.9794SENP1
00-0.059-0.06900-0.159-0.16900.012-0.02-0.049
rs1542707chr12:4692144465.1236   00-0.066-0.07600-0.161-0.16800.01-0.02-0.05
rs1107654chr12:4696736465.1637   00-0.068-0.07800-0.162-0.16700.01-0.02-0.05
rs1471998chr12:4699826965.1903   00-0.07-0.0800-0.162-0.16600.01-0.02-0.05
rs10783285chr12:4754359565.6802RND1
00-0.094-0.10400-0.167-0.15600.007-0.02-0.05
rs296736chr12:4862797466.1488   00-0.101-0.10800-0.158-0.13800.006-0.017-0.044
rs7532chr12:4881023166.2309CERS5
00-0.096-0.10200-0.152-0.13200.007-0.015-0.041
rs1521516chr12:4934197566.4411DIP2B
00-0.084-0.0850.0010-0.135-0.11500.009-0.011-0.032
rs868884chr12:5015536567.342SLC4A8
00-0.036-0.0260.0020.002-0.073-0.05600.0140-0.007
rs2641530chr12:5067107868.3601ACVR1B
00-0.00600.0010.006-0.044-0.03400.0100
rs644524chr12:5121773469.5066   00-0.005-0.00500.005-0.075-0.0600.0010-0.005
rs894734chr12:5260599471.5016   00-0.02-0.0200.001-0.2-0.16500-0.005-0.035
rs1867299chr12:5261624271.5199HOXC-AS5
00-0.02-0.0200.001-0.201-0.16600-0.005-0.035
rs2279400chr12:5286758171.9507SMUG1
00-0.02-0.0200.001-0.227-0.18800-0.01-0.04
rs774033chr12:5511157874.8615TIMELESS
00-0.086-0.09600-0.536-0.48600.02-0.077-0.154
rs10122chr12:5663689875.7459XRCC6BP1
00-0.142-0.14500-0.647-0.56700.067-0.073-0.123
rs1848125chr12:5680607875.8594   00-0.15-0.15200-0.662-0.57700.074-0.071-0.117
rs990372chr12:5684089575.8803   00-0.152-0.15300-0.664-0.57900.076-0.071-0.116
rs1174596chr12:5704760376.0017   00-0.16-0.1600-0.679-0.58900.083-0.07-0.11
rs187991chr12:5824857276.8355   0.0090-0.051-0.0600-0.388-0.31400.119-0.012-0.026
rs1000708chr12:5836975576.8916SLC16A7
0.010-0.044-0.05300-0.368-0.29600.121-0.008-0.021
rs1504464chr12:5902944677.1465   0.0160-0.026-0.03400-0.315-0.24800.120.001-0.009
rs1393988chr12:5927363077.211   0.0180-0.024-0.03200-0.309-0.24300.1170.002-0.008
rs1503578chr12:5927798377.2122   0.0180-0.024-0.03200-0.309-0.24300.1170.002-0.008
rs1506918chr12:5989256477.4615   0.0270-0.016-0.02200-0.284-0.22300.1070.005-0.005
rs2048822chr12:6005989277.5632   0.030-0.013-0.01700-0.274-0.21500.1030.006-0.004
rs337514chr12:6153845879.1924PPM1H
0.0470-0.01-0.0200-0.256-0.19800.0090.010
rs1695105chr12:6288384680.405C12orf66
0.050-0.01-0.0200-0.228-0.17400.040.0140
rs1344945chr12:6396189581.2037MSRB3
0.0510-0.01-0.0200.006-0.194-0.13600.0970.0220.002
rs997188chr12:6411614981.3126MSRB3
0.0520.001-0.01-0.0200.009-0.185-0.12800.1130.0230.003
rs1816562chr12:6496460482.4942   0.060.028-0.005-0.0100.078-0.105-0.0600.2580.030.01
rs961049chr12:6504885882.6297GRIP1
0.0620.035-0.004-0.00700.092-0.099-0.05500.2710.030.01
rs1493492chr12:6523064182.9263GRIP1
0.0650.05-0.001-0.00100.121-0.084-0.04300.2970.030.01
rs1480027chr12:6541102883.2347   0.0640.048-0.007-0.00700.106-0.101-0.05600.2660.0230.008
rs1252269chr12:6554903983.4979   0.0620.041-0.015-0.01500.082-0.125-0.07500.2230.0150.005
rs11832437chr12:6566825983.7406   0.060.034-0.022-0.02200.06-0.147-0.09200.1830.0080.003
rs1871566chr12:6641777985.2109   0.0570.014-0.05-0.0400.021-0.271-0.19300.074-0.031-0.043
rs717078chr12:6641794385.2111   0.0570.014-0.05-0.0400.021-0.271-0.19300.074-0.031-0.043
rs1195817chr12:6761719986.7583CPM
0.0630.001-0.065-0.04800-0.441-0.30800.003-0.153-0.158
rs472197chr12:6821297187.2659FRS2
0.0650.001-0.07-0.0500-0.475-0.34100-0.207-0.207
rs1057617chr12:6850042787.4636RAB3IP
0.0670.001-0.07-0.0500-0.479-0.34900-0.226-0.226
rs1240267chr12:6857039587.5037   0.0680.001-0.07-0.0500-0.48-0.3500-0.23-0.23
rs1796337chr12:6982635388.5307TSPAN8
0.0990.03-0.043-0.02900-0.426-0.32800-0.28-0.296
rs1149006chr12:7031651988.9154ZFC3H1
0.1190.051-0.024-0.01300-0.38-0.29700-0.28-0.307
rs1149007chr12:7031881588.9169ZFC3H1
0.1190.051-0.024-0.01300-0.38-0.29700-0.28-0.308
rs1149014chr12:7032704188.9222ZFC3H1
0.1190.051-0.024-0.01300-0.379-0.29600-0.28-0.308
rs1149018chr12:7033272588.9259ZFC3H1
0.1190.051-0.024-0.01300-0.379-0.29600-0.28-0.308
rs1484828chr12:7090638989.2205   0.1170.056-0.022-0.01400-0.392-0.30300-0.304-0.336
rs1433251chr12:7136229889.381   0.1130.057-0.024-0.01800-0.408-0.31300-0.322-0.356
rs1400142chr12:7172876289.5046   0.110.058-0.025-0.0200-0.42-0.3200-0.336-0.371
rs7305820chr12:7283704989.7332LOC100507377
0.1050.059-0.027-0.02500-0.443-0.33400-0.361-0.398
rs1493829chr12:7327102589.8101   0.1030.059-0.028-0.02600-0.451-0.33900-0.369-0.407
rs1396226chr12:7358611289.9472   0.0990.06-0.029-0.02900-0.465-0.34700-0.384-0.424
rs11833439chr12:7358788789.948   0.0990.06-0.029-0.02900-0.465-0.34700-0.384-0.424
rs6582285chr12:7397705490.1887CAPS2
0.1050.068-0.024-0.02400-0.438-0.32200-0.371-0.402
rs11180636chr12:7437475790.6375   0.120.088-0.011-0.01100-0.362-0.25400.001-0.326-0.334
rs11104254chr12:7515126291.721   0.1370.165000.0250.009-0.257-0.16400.005-0.304-0.244
rs7963830chr12:7533830291.9617OSBPL8
0.1390.186000.0330.012-0.242-0.15200.006-0.309-0.232
rs1565728chr12:7595208292.7572E2F7
0.1420.122000.2710.003-0.164-0.13500.001-0.272-0.207
rs1915356chr12:7611078792.9065   0.1430.109000.3180.001-0.149-0.13200.001-0.265-0.203
rs10506765chr12:7692040793.9184NAV3
0.1370.033-0.009-0.0090.3760-0.112-0.12100-0.297-0.209
rs1007729chr12:7692121393.9195NAV3
0.1370.033-0.009-0.0090.3760-0.112-0.12100-0.297-0.209
rs770124chr12:7694599893.9521NAV3
0.1360.031-0.01-0.010.3770-0.111-0.1200-0.298-0.21
rs300510chr12:7710868594.1939NAV3
0.1390.033-0.008-0.0080.3940-0.096-0.10800-0.288-0.2
rs1245775chr12:7828493196.1435SYT1
0.1520.0920.0130.0130.4970-0.009-0.01900.001-0.186-0.116
rs1163016chr12:7957648497.3032PTPRQ
0.1710.1450.0330.0330.49800-0.0100.007-0.148-0.084
rs11114842chr12:8030065297.6267PPFIA2
0.1830.1560.0360.0360.50600-0.0100.01-0.135-0.077
rs12825792chr12:8102018698.0903   0.1960.1810.0390.0390.51600-0.0100.023-0.125-0.076
rs12146872chr12:8173225698.6678TMTC2
0.190.2560.0330.0330.5240.0030-0.0100.086-0.153-0.117
rs2063239chr12:8179837298.7342TMTC2
0.1890.2650.0330.0330.5250.0030-0.0100.093-0.157-0.121
rs1517815chr12:8211543698.9974   0.1860.30.030.030.5280.0040-0.0100.122-0.17-0.14
rs1517814chr12:8211689198.9985   0.1860.30.030.030.5280.0040-0.0100.122-0.17-0.14
rs11116110chr12:8282631899.4682   0.2350.3350.0580.0630.5520.0030-0.00500.094-0.118-0.098
rs11612337chr12:8403513699.963LRRIQ1
0.2860.3710.0880.0970.5780.001000.0010.064-0.064-0.053
rs1507213chr12:8404827199.9669LRRIQ1
0.2870.3720.0880.0980.5780.001000.0010.064-0.064-0.053
rs2404772chr12:8406856099.9729LRRIQ1
0.2870.3720.0880.0980.5790.001000.0010.064-0.063-0.052
rs1489347chr12:85779093100.3776   0.2660.3290.0710.0810.5590.0010-0.0040.1360.058-0.049-0.039
rs730538chr12:85811637100.388   0.2660.3280.0710.0810.5590.0010-0.0040.140.058-0.048-0.038
rs2061589chr12:86818614100.7156   0.2450.2890.0540.0640.54100-0.0070.2560.055-0.039-0.029
rs1019206chr12:87915163101.3709   0.2230.2580.0360.050.5590.0050.004-0.0060.5610.089-0.015-0.013
rs1689419chr12:88318519101.6618   0.2190.2610.0330.050.5860.0090.007-0.0030.7190.118-0.004-0.007
rs1401982chr12:88513730101.7979ATP2B1
0.2170.2620.0320.050.5980.010.008-0.0020.7940.1310.002-0.004
rs2051713chr12:89501262102.5645   0.3310.3460.0360.050.780.0530.01600.9820.1930.0210.006
rs2034954chr12:90372269103.2589   0.4110.3790.030.040.9080.0730.01501.0310.1930.0250.007
rs1489895chr12:90536332103.4049   0.4060.3610.0240.0340.9090.0660.01201.0240.1750.0220.006
rs337663chr12:91229335104.2017   0.430.27300.0080.9210.0320-0.0040.9990.0940.0080
rs930248chr12:92228091105.4655LOC643339
0.6480.174000.9800-0.021.080.0600
rs1520724chr12:93389608107.4032   0.6450.045001.0800-0.011.4090.0350.0240
rs2128894chr12:93407377107.4424   0.6420.043001.0800-0.011.4130.0350.0240
rs6538609chr12:94072604109.1772FGD6
0.48500-0.0080.99200.014-0.0081.4920.0620.0570.002
rs17290272chr12:94731047110.2497   0.4520.0020.0050.0020.98400.0450.0021.460.1420.110.017
rs10860029chr12:95301537110.5612CDK17
0.4350.0010.0110.0060.97200.0640.0061.4480.1690.1350.027
rs7296534chr12:95327242110.5708   0.4340.0010.0110.0060.97200.0640.0061.4480.170.1360.027
rs1012315chr12:96163275111.1864   0.39100.0270.0160.94400.1090.0211.4180.2290.1910.051
rs20508chr12:96606718111.9186   0.31200.0570.0380.900.1820.0651.3660.3120.2710.095
rs2063508chr12:98448682114.3279ANKS1B
0.2450.0010.3030.2731.47200.6320.3431.7230.6540.6690.366
rs3205421chr12:100632476116.4535CHPT1
0.100.5280.5041.45400.9380.5871.2510.4760.9250.679
rs10823chr12:100841272116.7178DRAM1
0.07300.5390.5121.34900.9490.6031.060.4230.9270.713
rs6539055chr12:101669816117.6768   0.03800.570.5471.25601.0410.6940.7840.3240.9910.831
rs703618chr12:102545393118.9249STAB2
0.02200.5980.5971.2070.0011.20.850.4880.241.020.898
rs1000295chr12:102827376119.3943GNN
0.01300.5880.5881.1230.0011.2530.9070.3430.1740.9810.904
rs1165678chr12:102846314119.4226GNN
0.01300.5870.5871.1170.0011.2560.9110.3340.1690.9780.904
rs9143chr12:104091741120.929APPL2
000.5980.6160.8650.0011.5061.1840.0980.1191.0591.049
rs1862032chr12:104901578122.2025   000.6440.6621.0350.021.6921.3520.1470.1921.0921.05
rs4964186chr12:105604365123.6147LOC100287944
RFX4
000.4420.4520.9810.0061.5621.2340.1320.1690.9340.89
rs2044304chr12:105708493123.776RIC8B
000.4160.4260.9620.0041.5361.2110.1260.1650.9110.869
rs1037013chr12:105743438123.8286RIC8B
000.4070.4170.9550.0041.5271.2040.1240.1640.9040.862
rs1863527chr12:106732681124.9125   000.280.2710.98201.2810.9790.1640.1530.7520.712
rs10492252chr12:107489014125.8593   000.1330.1231.15300.9160.6760.4030.1260.5850.528
rs246079chr12:108031443126.722UNG
000.0810.0640.98300.7160.5290.3330.0890.5020.471
rs1642031chr12:108046618126.7457   000.080.0630.97600.7110.5260.330.0880.50.47
rs741402chr12:108068738126.7798ACACB
000.0790.0610.96700.7040.5210.3250.0860.4980.469
rs2053242chr12:108238411127.0362   000.0680.0480.90100.6490.4810.290.0760.4730.455
rs2058804chr12:108393394127.2431KCTD10
000.0550.0380.86900.5870.4320.2770.0740.4310.426
rs1477136chr12:108547774127.4241   000.0450.0290.84100.5330.3880.2670.0720.3950.401
rs1861809chr12:108729971127.6184TRPV4
000.0330.0190.81100.4740.3420.2550.070.3560.373
rs1476470chr12:109751414128.2847   000.00700.73900.3490.2410.2390.0740.2890.329
rs737280chr12:110679359128.3912   000.00600.73400.3440.2380.2420.0770.2920.332
rs233722chr12:111515857129.0165   00000.69800.320.220.2540.0940.3110.351
rs1863534chr12:112472905130.3304   00000.1940.0130.280.2230.0070.2120.360.427
rs1920586chr12:113051507131.3952   000.0120.0120.0190.0740.2760.2500.3930.4120.503
rs2555016chr12:113155046131.5977   000.0180.0180.0210.0940.2840.2600.4570.4280.526
rs2287570chr12:113940471133.2365   000.1170.1190.0820.3640.3920.3870.0011.060.6260.813
rs2141693chr12:114265278133.9656   00.0020.1390.1490.0910.3960.4280.4380.0061.1110.7060.944
rs2008370chr12:114814120135.0289   00.0020.1710.1810.0690.4390.4430.4520.0081.0380.7871.077
rs4145166chr12:115105568135.4583MED13L
00.0010.1840.1940.1440.4110.4860.4770.0560.9740.891.185
rs2657297chr12:115424590136.0876   000.1930.2040.2320.370.5270.4990.1130.8820.9991.302
rs903770chr12:115776340136.9617   000.1230.1430.1720.3120.3960.3850.0780.7760.7891.128
rs2393111chr12:115866673137.2262FBXW8
000.1110.1290.2210.2970.3850.3660.0670.7460.7531.084
rs885487chr12:116024317137.66   000.0940.1070.3210.2730.3770.340.050.6970.7011.014
rs1995257chr12:116341442138.5448   000.0470.0520.4650.1920.3430.2760.020.5360.5840.862
rs1530541chr12:116714114139.4981KSR2
000.0250.0250.4630.130.3250.2450.0030.3330.530.78
rs714323chr12:116851383139.7804KSR2
000.0280.0280.4320.1240.3280.2480.0010.2760.5360.78
rs4590911chr12:117047140140.2265   000.0280.0280.3940.1190.330.24800.1980.5490.782
rs461499chr12:117234181140.6444TAOK3
000.0240.0240.370.1160.330.24400.1370.5660.786
rs7295288chr12:117340196140.8226SUDS3
000.0220.0220.360.1150.330.24200.110.5730.788
rs1520780chr12:117524108141.1951   000.0180.0180.3370.1140.320.22800.1040.5880.784
rs2730753chr12:117656357141.4584   000.0150.0150.320.1140.3070.21200.1320.5980.776
rs1016203chr12:117907925141.9086SRRM4
000.0110.0110.290.1140.2850.18500.1780.6160.763
rs2422chr12:119049571143.4623GCN1L1
000.0150.0150.1430.0280.2410.1800.1670.640.8
rs610694chr12:119789209144.1277SPPL3
000.0210.0210.1120.0090.2240.17400.1470.6270.774
rs1179992chr12:119979815144.2425   000.0220.0220.110.0120.2180.16800.1470.6160.751
rs17434647chr12:120063407144.2855P2RX7
000.0230.0230.110.0140.2160.16600.1460.6110.743
rs1473553chr12:121551010144.9728ZCCHC8
000.030.030.0990.0340.1810.13100.1450.5430.605
rs1790094chr12:122152641145.0668PITPNM2
000.0320.0320.1180.0370.1880.13400.1480.5450.601
rs989892chr12:123853169147.5931SCARB1
00.0020.1640.1420.8920.120.4970.2860.2740.2170.670.603
rs4765621chr12:123886668147.6994SCARB1
00.0030.1680.1440.9210.1190.5060.2870.2910.2080.6650.594
rs7132145chr12:124066676148.2601BRI3BP
00.0060.1850.1471.0370.120.5350.280.3420.1690.6420.56
rs922873chr12:124092880148.3437   00.0060.1870.1471.0480.1210.5370.2760.3430.1640.640.556
rs2197777chr12:124397172149.2974TMEM132B
00.020.2030.1461.0750.1620.5380.2620.3370.1960.6380.566
rs6489020chr12:124866956150.639   00.0730.2040.1790.7170.3160.4840.3280.2620.4950.7120.733
rs225553chr12:125000215150.9125   00.0870.2010.1870.6230.350.4740.3450.2420.5560.7260.769
rs4765360chr12:125444263151.8888   00.1510.2530.2520.5010.4290.550.4480.150.4680.8190.922
rs2058290chr12:125641100152.3874   00.1680.2720.2750.3840.4680.5680.4870.0960.4430.8490.979
rs7133178chr12:125782861152.7847LOC387895
00.1770.2840.2910.2760.4990.5760.5150.0530.4310.8691.018
rs6489151chr12:126136173153.996   00.2580.370.410.0020.6790.640.67900.5111.0491.259
rs2712530chr12:126267725154.4574   00.290.3930.4280.0070.6920.6860.71700.5631.1191.338
rs1910780chr12:126441395155.089   00.3230.4110.440.0140.6970.7250.74600.6271.181.418
rs12231982chr12:126694001156.1375   00.2660.3160.3360.0010.5930.5560.58800.6440.9521.286
rs3924902chr12:127099565158.1512   00.2480.2570.28800.4580.3750.41400.6120.7021.066
rs952093chr12:127410524159.9008TMEM132C
00.3310.2220.25300.6020.3140.32600.650.5970.882
rs897978chr12:127553400160.6596TMEM132C
00.370.1870.2100.6320.2570.26700.6060.5370.771
rs7963526chr12:127799941161.9426   00.40.1040.13300.7560.1830.17400.6380.4440.607
rs1465727chr12:127972538162.8499GLT1D1
00.3080.0660.07900.6740.1380.10200.8640.330.439
rs490127chr12:128113078163.5982   00.2830.0660.0700.7020.1540.10201.0290.3160.434
rs1486629chr12:128226509164.2453TMEM132D
00.2860.0750.07500.7670.180.11701.1480.3370.472
rs7134835chr12:128476623165.5459TMEM132D
00.3380.0950.09500.9320.2260.15601.2660.4230.567
rs1543045chr12:128644233166.3813TMEM132D
00.4050.0920.09601.0590.2360.1701.2140.4420.571
rs896511chr12:128771155166.9558TMEM132D
00.4760.0810.0901.1770.230.1701.1240.4310.542
rs2047709chr12:128922645167.6401TMEM132D
00.4140.0480.06401.1090.1850.14400.9560.4110.495
rs826716chr12:129102507168.4846   00.2390.020.0400.8560.1650.140.0030.7790.4340.509
rs4760075chr12:129189897168.8709   00.130.0130.03300.690.1690.1470.0060.7090.4610.54
rs428715chr12:129301997169.3391   00.0970.020.0370.0070.5890.190.160.0580.6430.5210.584
rs6486532chr12:129302572169.3414   00.0970.020.0370.0070.5890.190.160.0590.6430.5210.584
rs1487602chr12:129669296170.8234   0.0010.1480.0480.0580.0330.4150.2460.180.2640.3010.6860.675
rs1195569chr12:129791424171.2855   0.0010.1680.0440.0570.0310.3940.2410.1740.280.2040.6770.654
rs1545610chr12:130741437173.9073   00.1940.0010.00200.280.0860.0640.1020.0520.2950.294
rs737434chr12:130787012173.9882SFSWAP
00.1940000.2760.0810.060.0950.050.2820.282
rs1278602chr12:132009011175.7835ZNF605
00.135-0.041-0.02400.1650.0040.0020.0020.0410.0970.097
rs1278601chr12:132009554175.7839ZNF605
00.135-0.041-0.02400.1650.0040.0020.0020.0410.0970.097
rs4758930chr12:132088232175.844ZNF26
00.133-0.044-0.02500.1620.0030.0020.0010.0410.0920.092
rs937538chr12:132120315175.8659   00.132-0.045-0.02600.1610.0030.0010.0010.0410.0910.091
rs595241chr12:132164652175.8902   00.131-0.046-0.02700.1590.0020.0010.0010.040.0890.089
rs632610chr12:132170791175.8936ZNF140
00.131-0.046-0.02700.1590.0020.0010.0010.040.0890.089
rs10870584chr12:132223994175.9269ZNF10
00.13-0.047-0.02800.1570.0010.0010.0010.040.0860.086
rs2270928chr12:132238673175.9392ZNF10
00.13-0.048-0.02800.1560.0010.00100.040.0850.085
rs7960480chr12:132288239176.0051ZNF268
00.128-0.05-0.0300.1530000.040.080.08

Table Legend: Tabular display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow row marks the location of the selected gene, and the whitened rows correspond to 20 Mb
around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

References

 

Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry. 2012 Jul;17(8):818-26. doi: 10.1038/mp.2011.89. Epub 2011 Jul 19. PubMed PMID: 21769101