Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT1E

 

BP - Genomewide Linkage Studies for MT1E


 

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Description

 
Shown here are the results for gene MT1E from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs8466chr16:373540.0047POLR3K
01.039-0.41-0.210.0121.932-0.24-0.1401.001-0.48-0.2
rs1211375chr16:1802810.4499LUC7L
01.057-0.383-0.1920.0151.988-0.218-0.12701.044-0.467-0.191
rs1203957chr16:1812110.4537LUC7L
01.057-0.383-0.1920.0151.988-0.217-0.12601.044-0.466-0.191
rs1203974chr16:2174590.6016LUC7L
01.062-0.374-0.1860.0162.007-0.21-0.12201.058-0.462-0.188
rs926694chr16:4679621.6025RAB11FIP3
01.105-0.302-0.1460.0232.153-0.142-0.0801.163-0.402-0.156
rs2038227chr16:4791411.6465RAB11FIP3
01.106-0.298-0.1440.0232.16-0.138-0.07801.168-0.398-0.154
rs763053chr16:6759222.3981WDR24
01.127-0.262-0.130.0162.242-0.102-0.05201.242-0.362-0.144
rs2072042chr16:9766413.4851SOX8
01.197-0.24-0.1250.0012.329-0.085-0.0401.357-0.316-0.145
rs2745165chr16:11953914.2309CACNA1H
01.297-0.218-0.11502.382-0.075-0.03801.426-0.268-0.138
rs8045185chr16:14413765.0142CLCN7
01.407-0.181-0.10102.383-0.061-0.0301.43-0.231-0.131
rs3178656chr16:16535145.6715CRAMP1L
01.204-0.22-0.12702.086-0.087-0.0501.17-0.27-0.164
rs757107chr16:28560957.9596   00.521-0.289-0.17900.867-0.169-0.09900.281-0.329-0.258
rs2075852chr16:32226068.5176ZNF200
00.399-0.326-0.21100.606-0.201-0.12600.179-0.377-0.312
rs859302chr16:472026310.5201ANKS3
00.149-0.376-0.27600.218-0.22-0.17500.077-0.43-0.39
rs1012259chr16:589291013.8414   00.011-0.463-0.37200.032-0.166-0.1350.0030.002-0.27-0.26
rs2043631chr16:590636313.9099   00.01-0.462-0.37100.029-0.164-0.1330.0030.001-0.265-0.255
rs1035564chr16:605054814.6295RBFOX1
00.009-0.347-0.28800.012-0.103-0.0990.0010-0.197-0.193
rs12930199chr16:622332215.4886RBFOX1
00.008-0.275-0.2400.004-0.07-0.08500-0.15-0.16
rs716508chr16:627691315.7819RBFOX1
00.007-0.272-0.2400.003-0.07-0.08800-0.144-0.16
rs7195006chr16:693920418.1029RBFOX1
00.049-0.168-0.14800.203-0.03-0.0300-0.088-0.088
rs1019141chr16:765828819.5047RBFOX1
00.099-0.145-0.12500.377-0.035-0.0300.001-0.075-0.07
rs763649chr16:766914619.5342RBFOX1
00.099-0.145-0.12500.381-0.035-0.0300.001-0.075-0.07
rs1507038chr16:797577620.5293   00.085-0.124-0.10400.489-0.051-0.0300.02-0.091-0.081
rs997097chr16:815913221.1837   00.073-0.101-0.08300.546-0.058-0.02800.06-0.093-0.083
rs933488chr16:860387922.604   00.089-0.042-0.03200.577-0.044-0.01400.244-0.048-0.038
rs1420040chr16:975789825.0715GRIN2A
00.0810000.335-0.038-0.00900.399-0.029-0.029
rs10153114chr16:1032037326.4097   00.0860.0080.00800.177-0.006000.433-0.006-0.006
rs10221chr16:1048479626.7978ATF7IP2
00.0810.0160.01600.149-0.002000.432-0.002-0.002
rs887864chr16:1106638628.1078CLEC16A
00.0680.0650.07500.1380.0010.02200.4330.0220.012
rs741175chr16:1106718628.1098CLEC16A
00.0680.0650.07500.1380.0010.02200.4330.0220.012
rs1035579chr16:1243866030.6444SNX29
0.0130.020.1990.21900.0320.0430.09600.1970.0890.086
rs8044488chr16:1333985533.6363   00.0590.3850.42500.0370.1580.26100.2210.2610.334
rs734826chr16:1339788133.7487   00.0620.3920.43200.0380.1650.2700.220.270.345
rs756983chr16:1344876633.8479   00.0640.3990.43900.0390.1710.27800.2190.2780.355
rs1547405chr16:1350285233.9423   00.0660.4060.44600.040.1770.28500.2180.2850.364
rs1158123chr16:1361636634.1703   00.0840.3950.44100.0480.1650.27600.2360.2590.344
rs30222chr16:1431715934.5395   00.1210.3610.42300.0630.1310.24700.2760.1930.289
rs2384933chr16:1572364735.4758MYH11
NDE1
00.2060.2960.38600.10.0660.18100.3240.0720.163
rs212087chr16:1613779136.2169ABCC1
00.240.2590.35900.1150.0360.13900.3040.0260.091
rs1472426chr16:1709993538.0553   0.0020.110.1690.24900.03200.05800.18600.039
rs936347chr16:1717829638.173XYLT1
0.0020.1090.1680.24700.03100.05500.17800.037
rs1457907chr16:1725373738.2917XYLT1
0.0020.1080.1670.24400.0300.05100.17100.034
rs1379652chr16:1730409938.3653XYLT1
0.0020.1070.1660.24300.0300.04900.16600.033
rs757189chr16:1789580439.3357   0.0020.090.1430.2100.019-0.0030.02300.09800.017
rs2925508chr16:1876748241.2829SMG1
00.0170.0430.07200-0.045-0.00800-0.03-0.006
rs1544357chr16:1911711142.0374SYT17
000000-0.111-0.03100-0.079-0.02
rs724307chr16:1917348242.1284SYT17
000000-0.114-0.03400-0.077-0.02
rs2106671chr16:1917812142.1364SYT17
000000-0.114-0.03400-0.077-0.02
rs2023762chr16:1918409842.1467SYT17
000000-0.114-0.03400-0.077-0.02
rs179209chr16:1921463142.1993CLEC19A
000000-0.116-0.03600-0.076-0.02
rs179219chr16:1922087342.2101CLEC19A
000000-0.116-0.03600-0.076-0.02
rs875648chr16:1957077042.6437C16orf62
000000-0.129-0.04900-0.067-0.02
rs227761chr16:1976880642.882IQCK
000000-0.136-0.05600-0.062-0.02
rs727590chr16:1995316943.1313GPR139
000000-0.141-0.06100-0.056-0.019
rs2031077chr16:2114523744.9227   000000-0.141-0.06100-0.012-0.001
rs741720chr16:2114797944.927   000000-0.141-0.06100-0.011-0.001
rs208965chr16:2276983646.8988HS3ST2
000.0550.05500-0.025-0.002000.0270.037
rs1858799chr16:2302288547.3027USP31
000.0660.06300-0.0170000.030.04
rs152733chr16:2327017947.7247SCNN1B
000.0740.06700-0.0130000.030.04
rs194790chr16:2369965848.4654   000.080.0700-0.010000.0210.035
rs2239340chr16:2413818149.2833PRKCB
000.080.07300-0.010000.010.03
rs11865135chr16:2420301749.4115CACNG3
000.080.07400-0.010000.010.03
rs1011078chr16:2480117850.6001SLC5A11
000.0740.06200-0.010000.0040.018
rs874562chr16:2501002150.9465   000.0710.05200-0.010000.0010.011
rs2157857chr16:2542074851.7028   000.0980.07100-0.00300000.01
rs6497875chr16:2543292651.7261   000.0990.07200-0.00300000.01
rs205162chr16:2550413851.863   000.1050.07600-0.00100000.01
rs173147chr16:2651038754.132   0.02300.3550.288000.0450.065000.0260.026
rs10220980chr16:2652967054.1846   0.02100.350.283000.0430.063000.0240.024
rs237131chr16:2654790754.2344   0.0200.3440.279000.0410.061000.0230.023
rs2057768chr16:2722959655.8668   000.1470.13200.0030.0010.00400-0.035-0.009
rs8832chr16:2728328855.9768IL4R
000.1330.12200.00400.00100-0.039-0.01
rs11150577chr16:2989402658.4396TAOK2
0.0070.0640.3430.35200.1340.0090.04300.026-0.04-0.006
rs889551chr16:3116792359.1202   0.0080.0810.340.35700.1390.0170.0500.011-0.0330
rs13143chr16:3139653459.2184TGFB1I1
0.0070.0680.2840.29700.1160.0140.04200.009-0.0280
rs1534507chr16:3156792859.2864   0.0060.0580.2440.25600.10.0120.03600.008-0.0240
rs12931636chr16:3411730659.5892   0.0030.0280.1190.12400.0480.0060.01700.004-0.0120
rs189378chr16:3466336059.6009   0.0030.0270.1140.1200.0470.0060.01700.004-0.0110
rs4887606chr16:3480272859.6033   0.0030.0280.1160.12200.0470.0060.01700.004-0.0110
rs17734120chr16:4520585959.7068SHCBP1
0.0050.0520.2030.22100.0560.0090.03100.003-0.0190
rs700582chr16:4527203059.7077VPS35
0.0050.0520.2040.22200.0560.0090.03100.003-0.0190
rs36471chr16:4534149059.7086   0.0050.0530.2050.22200.0560.0090.03100.003-0.0190
rs40355chr16:4535038259.7087   0.0050.0530.2050.22300.0560.0090.03100.003-0.0190
rs1978320chr16:4544591259.7102   0.0050.0530.2060.22400.0560.010.03100.003-0.0190
rs1566467chr16:4707048259.8742   0.0090.0910.3440.3800.0710.0150.05300.001-0.0310
rs1224chr16:4713031859.9189N4BP1
0.010.1020.3820.42300.0750.0170.05900.001-0.0340
rs1861659chr16:4812276261.1557ZNF423
00.1220.3410.40900.0770.0080.04700.005-0.058-0.01
rs1064448chr16:4890838462.5115ADCY7
00.1390.270.31900.07400.0200.063-0.05-0.01
rs11640716chr16:4922259063.1522NKD1
00.1430.2440.28100.07200.00800.09-0.052-0.012
rs2063099chr16:5001837264.9063   00.1050.1740.18500.015-0.009000.076-0.069-0.029
rs1420533chr16:5112112766.8258TOX3
00.0810.1070.11500.004-0.01000.077-0.033-0.012
rs1990637chr16:5159517667.543   00.0690.0840.09400.003-0.01000.056-0.019-0.005
rs1946155chr16:5219179668.4468RPGRIP1L
00.0510.0610.07100.002-0.01000.025-0.010
rs1543921chr16:5291455270.4333   00.0520.030.0400.023-0.01-0.0100.004-0.0060
rs8060118chr16:5364964272.653   00.1510.0670.07300.106-0.003000.00400
rs837529chr16:5404379573.4153   00.1480.0620.07200.1330000.00400.004
rs1203490chr16:5475579574.6349LOC283856
00.0790.0440.05400.120000.0010.0060.023
rs1809348chr16:5484084974.7578GNAO1
00.0710.0420.05200.11600000.0080.025
- chr16:55217085 MT1E            
rs735144chr16:5544142575.8981   00.080.0580.05900.15500000.0190.03
rs41383chr16:5566850376.3801NLRC5
00.1080.060.06400.16100000.0240.038
rs1982395chr16:5622625777.297GPR56
00.1630.0660.08200.15600.0060.00100.0330.059
rs247041chr16:5643514177.6221   00.1780.0720.09500.14900.0120.00100.0360.069
rs37358chr16:5675242778.0811CSNK2A2
00.1930.0810.11100.13900.0210.00700.0410.082
rs1862802chr16:5703487678.4624   00.1810.0850.11500.13400.0250.02800.0450.089
rs6993chr16:5729886878.824GOT2
00.170.0880.11800.12800.0280.04900.0480.096
rs990813chr16:5762811779.3174   0.0030.1490.080.10700.1200.0330.09700.050.1
rs1482258chr16:5806859280.0005   0.0090.1160.060.0800.10600.040.1800.050.1
rs768462chr16:5862734980.8352   0.0220.2050.0930.130.0030.1740.0170.0650.18600.050.108
rs715262chr16:5938414781.8432   0.0110.2440.0580.0980.0010.1680.0030.0450.15900.0160.059
rs17822576chr16:6010584182.6548   0.0140.2410.050.090.0020.19400.040.15600.0030.037
rs1027277chr16:6124249783.3048   0.0140.2020.0410.0780.0030.18700.0310.157000.024
rs1424032chr16:6152465483.4609   0.0120.1840.0360.0720.0030.17500.0260.157000.021
rs30882chr16:6155697483.485   0.0120.1810.0350.0710.0030.17400.0250.157000.02
rs918703chr16:6209066783.8892   0.0080.1340.0230.0540.0040.14400.0130.158000.012
rs717293chr16:6211602183.9113   0.0080.1310.0230.0540.0040.14200.0130.158000.012
rs1903014chr16:6284477584.6139   0.0080.0580.0080.0320.0230.075-0.0060.0040.176000.016
rs973200chr16:6356531385.3284CDH11
0.0140.0250.0070.030.0520.042-0.0070.0070.197000.023
rs1423832chr16:6411006585.8403LOC283867
0.0240.0350.0170.0450.0790.05-0.0020.0170.21000.028
rs1359839chr16:6425285285.981   0.0270.0380.020.0490.0860.05300.020.214000.03
rs461785chr16:6436654586.0866   0.0290.0420.0220.0530.0870.0530.0010.0230.2200.0020.034
rs149156chr16:6547020786.9936   0.0490.0810.040.080.0880.0570.010.050.28500.020.08
rs9033chr16:6573950087.155C16orf70
0.0550.0930.0550.1020.0960.0760.0190.0690.2900.0260.094
rs1541979chr16:6788264387.7462SNTB2
0.0760.1380.1150.1840.1250.150.0550.140.3100.050.147
rs153053chr16:6800382087.795   0.0780.1420.1190.1910.1280.1560.0580.1450.31100.0520.152
rs244415chr16:6822418487.8917NFAT5
0.0810.150.1290.2050.1330.1680.0640.1570.31400.0560.16
rs722579chr16:6908572588.2862COG4
0.0670.1830.140.2310.1160.2250.070.1760.2960.0050.0630.181
rs235987chr16:6980684788.6463HYDIN
0.0440.2160.140.2460.0890.280.070.1830.2680.0120.0660.196
rs1018910chr16:6983596988.6614   0.0430.2170.140.2460.0880.2820.070.1830.2670.0120.0670.196
rs310334chr16:7013104888.8227   0.0330.2310.140.2530.0750.3060.070.1860.2550.0150.0680.203
rs719353chr16:7160005290.0821ZFHX3
0.0020.170.0970.2070.0110.2450.0230.1050.1770.0080.0340.146
rs328384chr16:7239729791.4293   0.0190.4110.2140.3160.0110.460.0770.1770.160.1170.0930.223
rs7200946chr16:7280629092.1631   0.0290.5470.2670.3570.0080.5670.10.20.1260.1840.110.242
rs10500587chr16:7305541292.5321GLG1
0.0370.5750.2810.3710.010.5830.10.20.1180.2010.110.245
rs9932977chr16:7329264992.8862   0.0440.6010.2950.3850.0110.60.10.20.110.2170.110.249
rs7187229chr16:7330123792.8987   0.0440.6020.2960.3860.0110.60.10.20.1090.2170.110.249
rs11149780chr16:7349786793.1646WDR59
0.0630.620.3160.4050.0140.5930.0950.1920.1060.2160.1070.25
rs8062565chr16:7382322093.5019BCAR1
0.0980.640.350.4350.020.5690.0850.1750.1040.2040.10.25
rs1549660chr16:7492468794.2862CNTNAP4
0.1560.6290.40.480.0330.5140.070.1440.1040.1650.0870.244
rs1506819chr16:7502960094.3714CNTNAP4
0.1570.6170.40.480.0340.5080.070.1430.1050.1590.0860.243
rs1002077chr16:7505590494.3924CNTNAP4
0.1580.6140.40.480.0340.5070.070.1420.1060.1580.0860.242
rs1948719chr16:7595558295.332ADAMTS18
0.1580.5050.3670.4530.030.420.050.1030.0860.1030.0570.19
rs1922604chr16:7664967996.303   0.1280.4620.30.40.0040.3020.0070.0380.0240.0850.0070.092
rs1074964chr16:7672775996.4573WWOX
0.1250.4640.30.40.0040.2890.0050.0320.020.0870.0050.083
rs1125671chr16:7724878797.6828WWOX
0.1060.4740.320.4070.0010.20100.0030.0050.11200.036
rs1079635chr16:7742111698.7795WWOX
0.0920.420.3070.37900.125-0.00800.0080.12600.03
rs1079638chr16:7746749799.0726WWOX
0.0890.3960.3010.37100.105-0.00900.010.12900.03
rs1018159chr16:7751295999.3746WWOX
0.0890.3650.3040.37400.088-0.00600.0160.13200.03
rs1424110chr16:77725446101.0363WWOX
0.0820.1420.280.3400.008000.0560.1290.010.041
rs424074chr16:77792088101.6745WWOX
0.0750.1420.2870.34700.008000.0790.1690.0170.067
rs728929chr16:78227825104.0147   0.0880.1830.3510.41100.01500.020.1480.3370.090.23
rs1424234chr16:78240204104.0531   0.0890.1850.3530.41300.01500.020.1490.3380.0910.231
rs1125733chr16:79009741105.3419   0.0880.2240.3970.4600.03100.020.180.3860.1170.271
rs1037973chr16:79957577108.0878GAN
0.0020.0640.2830.38100.1450.0110.0410.3070.3550.3210.497
rs2012502chr16:80285582109.1603CMIP
00.0140.2040.28200.1260.020.050.3870.2610.330.47
rs11443chr16:80588949110.1846SDR42E1
000.1610.23100.0830.020.0480.4960.1070.3320.47
rs967955chr16:80707794110.5626   000.1420.21200.0810.020.0440.510.1020.3360.47
rs2967305chr16:80877154111.1479   000.1210.19100.0760.020.040.530.10.3440.477
rs725514chr16:81412395112.5551CDH13
0.00100.1690.2440.0010.0510.0370.0620.5830.140.4370.592
rs7190151chr16:81671174113.146CDH13
0.00800.2220.3020.0120.0420.0690.0980.6380.1670.5220.673
rs1424189chr16:81888111113.7831CDH13
0.03900.3170.3970.0580.0480.1520.1740.7450.2090.6620.775
rs723919chr16:81899735113.8201CDH13
0.04100.3230.4030.0610.0480.1570.1780.7520.2110.670.781
rs1387370chr16:82085523114.3991CDH13
0.06300.3660.4340.1020.0550.2080.2240.8080.2290.7420.826
rs41103chr16:82398662115.4901   0.09200.40.4450.1650.0710.2790.2850.8770.2120.8240.879
rs39552chr16:82811885117.2322   0.13900.430.4450.2250.1140.3450.3110.9620.120.9280.948
rs922450chr16:82990535118.2914ATP2C2
0.1470.0060.4330.430.2350.1190.3420.2890.8910.0590.9170.913
rs247892chr16:83037774118.5695ATP2C2
0.1540.010.4360.430.2420.1280.3530.2970.8440.060.9140.916
rs6564047chr16:83093567118.8549KIAA1609
0.1610.0140.4390.430.250.1370.3640.3060.7970.0610.9110.919
rs2052904chr16:83195691119.3731COTL1
0.1850.0120.410.3930.2860.1140.3960.3170.7080.0690.8840.89
rs7184873chr16:83253886119.6927   0.2020.0080.3850.3610.3140.0890.4180.3240.6530.0760.8620.865
rs889613chr16:83256645119.7083   0.2030.0080.3830.3590.3150.0880.420.3240.650.0760.860.863
rs1874014chr16:83413017120.4896CRISPLD2
0.1710.0030.340.3150.2930.0380.4350.320.5380.0840.830.825
rs751339chr16:83562169121.2786   0.09600.3060.2920.2070.0070.4130.310.4170.0970.8060.818
rs3751750chr16:83672780121.7782KIAA0513
0.05400.2810.2770.1410.0030.3830.310.3160.1140.7810.833
rs998624chr16:83921939122.4939   0.02800.250.260.0940.0040.350.3050.2260.1590.740.825
rs12930771chr16:84594272125.027   0.06700.3390.3380.1490.120.4680.4080.2270.4670.7470.807
rs276990chr16:84778717125.7735   0.07800.3090.2940.1230.1220.4080.340.1810.4930.6730.717
rs889593chr16:85072700127.0566FOXF1-AS1
0.12900.3080.2590.1160.0790.3560.2770.1390.490.60.621
rs8052199chr16:85348497128.102   0.09700.2720.2420.0740.0770.2830.2260.080.5380.4330.464
rs2076962chr16:85717982129.3033   0.1100.3020.2780.0320.0890.2110.1840.1250.6660.3550.392
rs3794668chr16:86301992130.6302KLHDC4
0.07500.3360.3450.0080.0410.1710.1640.1130.480.2820.325
rs11076696chr16:87267489131.899MGC23284
0.0060.0010.2770.31500.0340.0970.1060.0180.180.170.265
rs750740chr16:87334839131.9929PIEZO1
00.0010.270.3100.0350.090.10.0110.1580.1610.26
rs463701chr16:88126261133.0958SPG7
0.0040.050.3390.37900.1310.1290.1490.0080.2420.2070.361
rs452176chr16:88180533133.1705CPNE7
0.0050.070.3540.39400.1550.1350.1550.0080.2480.2120.37
rs1006547chr16:88371730133.429FANCA
0.0090.1380.4060.44600.2390.1590.1790.0080.2710.230.401
rs1800330chr16:88385465133.4472FANCA
0.0090.1430.4090.44900.2450.160.180.0080.2730.2310.404
rs8577chr16:88638780133.7921GAS8
LOC100130015
0.0150.2330.4780.51800.3570.1910.2110.0070.3030.2550.445
rs869048chr16:88640449133.7946LOC100130015
0.0150.2340.4790.51900.3580.1920.2120.0070.3040.2560.445

Table Legend: Tabular display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow row marks the location of the selected gene, and the whitened rows correspond to 20 Mb
around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

References

 

Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry. 2012 Jul;17(8):818-26. doi: 10.1038/mp.2011.89. Epub 2011 Jul 19. PubMed PMID: 21769101