Metamoodics Gene Information

 

  Chromosome: chr7    Cytoband: q22.1    Gene: RELN

 

BP - Genomewide Linkage Studies for RELN


 

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Description

 
Shown here are the results for gene RELN from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs1127460chr7:8452930.6639SUN1
0.0110.4040.010.0100.043-0.003-0.0100.1780.0870.15
rs7785205chr7:8915580.7189GET4
0.0110.4070.010.0100.043-0.003-0.0100.1780.0870.15
rs1057558chr7:10288920.8853C7orf50
0.0120.4160.010.0100.046-0.001-0.0100.1790.0890.15
rs4236375chr7:11110530.9871C7orf50
0.0120.4210.010.0100.0470-0.0100.1790.090.15
rs1543985chr7:11796531.0894   0.0130.4320.010.0100.0490-0.00900.1730.0880.148
rs1362136chr7:24720932.8324   0.030.5630.010.0100.0660-0.00800.0580.0450.097
rs798485chr7:27700363.2866GNA12
0.030.5280.0070.00700.051-0.006-0.01600.0350.0310.073
rs1044701chr7:42723605.972SDK1
0.0230.112-0.029-0.01900-0.099-0.12800-0.0190
rs1553960chr7:48666217.1573PAPOLB
RADIL
0.0320.09-0.02-0.020.0030-0.047-0.0750000
rs852432chr7:55292668.473   0.0350.083-0.02-0.0150.0040-0.025-0.0410000.005
rs1468996chr7:57009838.815RNF216
0.0350.089-0.02-0.0120.0050-0.022-0.0340000.008
rs4560chr7:60298099.5086AIMP2
EIF2AK1
0.0410.117-0.01-0.0050.0070-0.01-0.02000.0050.015
rs13438509chr7:714283211.1924   0.0870.2080.0280.040.02200.0040.002000.0520.052
rs1299548chr7:726881811.3974   0.0940.210.0360.050.02600.0080.004000.0640.064
rs2042545chr7:784197012.8448LOC729852
0.1390.2030.1020.1310.06300.0620.0440.01400.1680.159
rs37995chr7:799565913.2601GLCCI1
0.1490.2360.1180.1480.0740.0030.0830.0660.01900.1880.175
rs1558557chr7:827551814.0277   0.1650.3430.1390.1690.0940.0130.120.110.02600.2090.189
rs6463843chr7:880524215.6917   0.1530.5080.1060.1260.2030.0690.120.0930.0100.1660.149
rs1032873chr7:961880517.577   0.1270.4430.0840.10.1040.0610.0940.070.00800.1380.134
rs1013719chr7:1052127518.8563   0.1230.4060.0890.10.0750.0740.090.0790.00200.1040.104
rs1012123chr7:1065245619.0171   0.1230.4030.0910.1010.0740.0760.0910.080.00100.10.1
rs12666416chr7:1200894220.8037   0.1060.460.1540.1640.0440.1180.1540.124000.1180.1
rs769111chr7:1202633120.8266   0.1060.4610.1550.1650.0440.1190.1550.125000.1180.1
rs6460985chr7:1289008122.2108   0.0250.5850.1420.1620.0070.210.1920.162000.1180.11
rs2051930chr7:1380252823.8075   0.0010.5620.070.09800.2820.20.186000.1020.102
rs1367781chr7:1452957025.0815DGKB
00.2690.0310.05200.1720.2130.214000.10.112
rs917440chr7:1569027826.9811MEOX2
00.3560.050.090.0020.3460.2890.299000.10.15
rs726395chr7:1570124026.9955   00.3570.050.090.0020.3480.290.3000.10.15
rs2030972chr7:1602570527.4294   00.3480.0590.090.0070.3470.3110.309000.1130.163
rs957960chr7:1884393330.7635HDAC9
00.4140.1630.1650.0450.4120.4980.441000.3510.401
rs714392chr7:1957767431.7934   00.330.1620.1620.0540.3870.5020.442000.4020.42
rs206198chr7:2033828333.0227ITGB8
00.0590.070.090.0610.1830.3990.3490.00800.4490.349
rs1858941chr7:2060300433.4975   00.0410.0650.0850.0640.1640.3850.3350.00800.420.32
rs2906667chr7:2173352135.6788DNAH11
000.060.070.0620.0790.370.3540.00500.360.274
rs1859805chr7:2215054336.3844RAPGEF5
000.060.070.0580.0450.3920.3850.00500.360.284
rs1419756chr7:2216350636.4047RAPGEF5
000.060.070.0580.0440.3920.3860.00500.360.284
rs740295chr7:2243981336.8344STEAP1B
000.060.070.0530.0210.4050.4030.00600.360.288
rs858239chr7:2325284037.8301   000.0430.0530.0420.0030.3520.3680.01200.310.24
rs798646chr7:2358625938.1114   000.040.050.0390.0010.3380.3560.01400.2940.223
rs1469000chr7:2377713038.2655STK31
000.040.050.0380.0010.3350.3490.01500.2870.214
rs39453chr7:2510037439.5945   000.0460.0440.0200.2960.2780.02900.220.128
rs766838chr7:2599669140.6894   000.050.0330.00300.2460.1950.03900.1790.072
rs1404282chr7:2755197641.8816HIBADH
000.0410.021000.1680.1260.01400.1170.034
rs1860759chr7:2836498543.1151CREB5
000.0290.018000.0840.045000.054-0.001
rs7313chr7:2903673444.6111CPVL
000.0140000.0220.004000.004-0.022
rs1568658chr7:2910808344.7748CPVL
000.0120000.0170.002000.002-0.025
rs245906chr7:2916639444.9084   000.0110000.0130.001000.001-0.028
rs13834chr7:2992698746.6584SCRN1
000.0170.01000.0270.01000-0.003
rs255139chr7:3071906648.2816   000.0360.028000.0330.01600.0190.0030
rs763486chr7:3162000949.6848CCDC129
000.0710.077000.0540.05100.0360.0170
rs2049758chr7:3304121651.048NT5C3
000.1080.108000.0980.09800.0020.0290.01
rs724291chr7:3376566251.6665   000.0770.083000.0670.07300.0010.0170.003
rs731844chr7:3411678952.0077BMPER
000.060.07000.050.06000.010
rs342990chr7:3543557053.3428   000.0930.113000.040.0500.0060.0270.017
rs2041632chr7:3643256854.6631ANLN
000.0930.113000.0130.017000.0070.003
rs2058675chr7:3674485755.1556   000.0870.11000.010.0120000.002
rs918980chr7:3756842356.6699   000.0630.11000.010.0130000.01
rs2007664chr7:3799036557.4046   000.0520.098000.0060.0060000.006
rs722336chr7:3847143058.1095AMPH
000.0420.0830000.0010000
rs2043786chr7:3849709358.1512AMPH
000.0430.0850000.0020000
rs1949880chr7:3906291358.803POU6F2
000.0560.1040000.0080000
rs715283chr7:3955475759.1349   000.0630.1150000.0110000.001
rs887447chr7:4018255059.5633C7orf10
000.0710.1330000.0160000.006
rs756328chr7:4024578759.6178C7orf10
000.0720.1350000.0160000.006
rs722790chr7:4100056260.465   000.1030.173000.0090.0340.01100.0140.015
rs963779chr7:4101611460.4856   000.1040.174000.010.0350.01200.0150.015
rs1548630chr7:4103430660.5096   000.1050.175000.010.0350.01200.0150.015
rs37262chr7:4129941960.8812   000.1240.194000.0180.0460.02100.0260.019
rs273093chr7:4138974961.019   000.1320.201000.020.0510.02400.0310.021
rs273196chr7:4140454661.0428   000.1340.203000.0210.0510.02400.0330.023
rs2007475chr7:4171308261.587INHBA-AS1
000.1830.241000.0320.0680.02400.0650.061
rs2024031chr7:4185777161.8483   000.2060.259000.0370.0750.02400.0810.079
rs7781467chr7:4190343361.9298   000.2140.265000.0390.0780.02400.0860.085
rs757911chr7:4196136262.0271   000.2210.271000.040.080.02300.0890.09
rs846284chr7:4203677762.1315GLI3
00.0010.2230.277000.0390.080.02100.0850.089
rs699491chr7:4205079862.153GLI3
00.0010.2230.278000.0380.080.02100.0840.088
rs846263chr7:4205891762.1654GLI3
00.0010.2230.278000.0380.080.02100.0830.088
rs3823723chr7:4210598962.2364GLI3
00.0020.2250.282000.0380.080.01900.0810.088
rs1012033chr7:4309504963.4062   00.0130.2080.296000.0220.0640.00200.0340.06
rs1029482chr7:4322113563.5378HECW1
00.0140.1970.288000.0190.0580.00200.0280.053
rs740094chr7:4463622365.4321OGDH
00.0150.0870.16300-0.0040.0060000
rs1852210chr7:4596078167.1804   00.0310.0570.12400-0.028000.003-0.018-0.01
rs2054789chr7:4621805767.4442   00.0620.0680.12900-0.026000.008-0.016-0.01
rs1486155chr7:4626224267.485   00.0670.0690.1300-0.025000.009-0.015-0.01
rs723149chr7:4654358167.7513   00.0980.080.13500-0.022000.014-0.012-0.01
rs2013523chr7:4708566068.2052   00.1580.1190.15800.002-0.01600.0030.026-0.008-0.008
rs921630chr7:4776158368.8379   00.2530.2070.21500.008-0.00300.0110.047-0.002-0.002
rs1474283chr7:4791438868.9733PKD1L1
00.2730.2260.22800.01-0.00100.0130.05200
rs1529867chr7:4878557369.7271   00.3260.3460.33200.0110.0150.0220.0560.0360.0440.022
rs1529590chr7:4933270770.2472   00.3650.4050.3800.0150.0250.0350.0750.030.070.035
rs2043731chr7:5113750672.4669COBL
0.0150.6070.510.4600.1310.070.080.0870.0450.1450.095
rs616185chr7:5180467173.2845   0.0260.7250.5560.50800.2240.0870.0970.0730.050.1630.113
rs169902chr7:5262024073.9486   0.0430.8640.6620.62100.3370.1270.1370.0650.0620.2160.166
rs2877132chr7:5342309774.3821   0.0580.860.6660.62200.3780.1260.1360.0660.0760.2350.181
rs1524395chr7:5416599574.7779   0.0720.8440.6620.61400.4110.1220.1320.0670.0890.2510.193
rs2049410chr7:5417405074.7828   0.0720.8440.6620.61400.4120.1220.1320.0670.0890.2510.193
rs11238298chr7:5418670174.7906   0.0720.8430.6620.61400.4120.1220.1320.0670.0890.2520.194
rs12538489chr7:5506733075.3559EGFR
0.0580.7420.5920.54200.4070.0950.1050.0670.1050.2490.186
rs13222366chr7:5596719675.9532ZNF713
0.0210.5860.4790.42900.3690.0530.0630.0640.1210.2310.162
rs1532084chr7:5655924676.3144   0.0190.5680.4670.4200.360.050.0570.0670.120.2240.157
rs1532083chr7:5656095076.3152   0.0190.5680.4670.4200.360.050.0570.0670.120.2240.157
rs6460119chr7:6323197077.3214   0.0220.5640.4540.41700.3420.050.050.0760.1160.2070.147
rs517258chr7:6438061877.7102   0.0230.5750.4460.41300.3370.050.050.0790.1160.2030.143
rs13536chr7:6565662578.1858LOC493754
0.0270.5930.4470.41200.3410.0570.0570.0910.1260.2190.153
rs801193chr7:6566804778.1908LOC493754
0.0270.5940.4480.41200.3410.0580.0580.0910.1270.2190.153
rs956523chr7:6646986178.6233   0.0350.6150.4650.41600.360.0750.0750.1110.1530.2620.184
rs1874243chr7:6746601779.3165   0.0360.5940.4550.39800.3660.0870.0870.1140.2050.3090.219
rs1468588chr7:6874359280.5229AUTS2
0.0170.4810.3840.32900.3440.080.080.0570.3160.3460.261
rs2533440chr7:6874720280.5272AUTS2
0.0170.4810.3840.32900.3440.080.080.0570.3170.3460.261
rs3094901chr7:6957588681.5229AUTS2
0.010.4270.3540.29400.3390.080.080.0250.4610.3550.296
rs10266560chr7:7040322782.4577WBSCR17
0.0110.3820.3130.25300.3770.0710.0710.0120.6830.3230.292
rs678798chr7:7082704882.8949   0.0120.3630.2860.22600.4170.0620.0620.0090.8090.2960.274
rs2960920chr7:7172168383.716TYW1B
0.0350.380.2940.23400.5140.0670.0670.0070.9040.2830.27
rs11764572chr7:7281637184.64   0.0180.3510.2420.18200.5850.0570.0570.0030.9870.2610.251
rs7810996chr7:7326255184.9829LAT2
0.0040.3310.2120.15200.6050.050.050.0011.0170.2510.241
rs3135677chr7:7329306785.009RFC2
0.0030.330.210.1500.6070.0510.0510.0011.0210.2510.241
rs2527367chr7:7373707485.3387GTF2I
0.0030.3320.2240.16400.6540.0770.0840.011.0770.2910.294
rs757364chr7:7512534686.4592HIP1
0.0010.3320.250.19500.7810.1530.1820.0321.2240.3980.437
rs1859293chr7:7521091586.5383   0.0010.3310.250.19500.7860.1570.1880.0331.230.4020.443
rs917424chr7:7582246887.0991YWHAG
00.3190.2410.19100.8120.1730.2140.0371.2450.4220.472
rs10224066chr7:7584264587.1176   00.3170.2390.18900.8110.1720.2130.0371.2420.4210.471
rs740158chr7:7689377288.212   00.2370.1490.09900.7220.0990.1430.0251.0490.3180.368
rs798332chr7:7774686489.1728MAGI2
00.2070.1030.05500.6340.0550.0730.0070.90.1760.222
rs714438chr7:7782024189.2627MAGI2
RPL13AP17
00.2050.0990.05200.6270.0520.0690.0070.8830.1630.208
rs1034699chr7:7954485891.5719   00.1660.0290.01400.4440.0040.00400.462-0.0060.004
rs1468242chr7:7963656091.7085GNAI1
00.1640.0260.01300.4350.0030.00300.442-0.0070.003
rs2030711chr7:8005787892.2297   00.1540.0290.0170.0050.4190.0050.00500.388-0.0080
rs1029847chr7:8143115694.0036CACNA2D1
0.0040.110.120.080.1660.420.070.060.0090.3060.010.01
rs258651chr7:8155944994.2087CACNA2D1
0.0030.0990.1240.0880.1650.3730.0740.0620.0140.2960.0120.012
rs28156chr7:8248414695.7167PCLO
00.0310.1830.1630.1530.0760.1120.0920.0410.1880.0340.027
rs42002chr7:8309902196.6056SEMA3E
00.0080.230.2220.1710.0120.1440.1180.0320.0690.040.03
rs917089chr7:8356838597.1119SEMA3A
000.2470.2480.18300.1560.1270.0220.0080.0390.03
rs473880chr7:8374701697.2689   000.2420.2450.1800.1490.1220.020.0070.0370.03
rs612774chr7:8382012297.3384   000.240.2430.17900.1460.120.0190.0060.0370.03
rs764077chr7:8460233097.8585   000.2240.2330.16900.1260.1040.0130.0010.0310.03
rs1024516chr7:8611913498.347GRM3
000.1710.1780.13900.0820.0650.00700.020.016
rs4148738chr7:8700098598.6975ABCB1
000.1220.1250.11100.0430.030.00300.0090.002
rs1202169chr7:8703378698.713ABCB1
000.120.1230.1100.0420.0290.00300.0090.001
rs1637503chr7:8743057998.9366ADAM22
000.0890.090.09200.0170.0060.00100.002-0.007
rs1688886chr7:8744167998.944ADAM22
000.0880.0880.09100.0160.0060.00100.002-0.008
rs1637489chr7:8745149798.9506ADAM22
000.0870.0870.09100.0150.0050.00100.001-0.008
rs1468121chr7:8818580599.4116   000.0640.0640.07400.010000-0.01
rs717474chr7:8862923399.7374ZNF804B
000.0510.0510.06400.010000-0.01
rs1023564chr7:8867965099.774ZNF804B
000.0490.0490.06300.010000-0.01
rs194506chr7:89680566100.6385STEAP2
000.040.0460.0570.0060.0160.006000-0.004
rs194518chr7:89691085100.6476STEAP2
000.040.0460.0570.0060.0160.006000-0.004
rs42611chr7:89787996100.732   000.040.0470.0570.0070.0170.007000-0.003
rs758706chr7:90332855101.1866CDK14
000.040.0480.0680.0170.0180.010.0050.00200
rs10234074chr7:91358055102.0169   000.040.040.1170.0530.010.010.0250.0100
rs722263chr7:92724748103.3137CCDC132
000.0530.0530.1060.092000.0370.01300
rs1326152chr7:94273042105.1228   000.0650.0550.0730.102000.0620.0440.010.01
rs854731chr7:94471624105.2894PPP1R9A
000.0580.0480.0720.096000.060.0430.010.01
rs1859121chr7:94814903105.5757   000.0470.0370.0710.086000.0560.0420.010.01
rs1053275chr7:94839491105.5918PON3
000.0460.0360.0710.085000.0560.0420.010.01
rs1917486chr7:96079539106.4096   000.0220.0120.0440.059-0.00400.0320.0330.0060.006
rs1229540chr7:97261330107.78   00.0010.0100.0010.028-0.0100.0010.0110.0080.008
rs1047035chr7:98282223109.0256TMEM130
00.0140.0320.02100.0450.0010.0010.0060.0210.0430.044
rs219826chr7:98485075109.2046SMURF1
0.0010.0190.0420.0280.0010.0480.0060.0080.0090.0290.0670.069
rs219798chr7:98488035109.2075SMURF1
0.0010.0190.0420.0280.0010.0480.0060.0080.0090.030.0670.069
rs4727439chr7:99348170109.7689TRIM4
0.0050.0350.0760.0510.0030.060.0230.0310.0210.0550.140.148
rs1617640chr7:100155234110.1408   0.0090.0410.0940.0640.0070.0690.0380.0470.0370.0870.1810.191
rs11178chr7:100567804110.3439SERPINE1
0.0110.040.10.070.0120.0750.0510.0570.0540.1160.1980.208
rs201492chr7:101540858110.9188CUX1
0.0190.0360.1180.0880.0240.0930.0850.0860.10.20.2440.254
rs727708chr7:103118180112.0594RELN
0.0280.080.1510.1110.0270.1090.0910.0810.1390.310.2920.292
rs1010340chr7:104617931113.3429SRPK2
0.0130.0270.150.1230.0170.0780.090.090.1570.2530.3230.31
rs234chr7:105348371114.5269   0.0020.0010.1190.1050.0030.0350.0540.0650.1580.0970.3210.301
rs41261chr7:105399068114.6341CDHR3
0.0010.0010.1170.1040.0030.0320.0510.0640.1580.0810.3230.303
rs176481chr7:105515161114.8859   000.1120.1010.0010.0250.0430.0610.160.0440.3280.308
rs887882chr7:105622519115.1071   000.1030.09300.0210.0370.0550.1680.0240.3260.301
rs1024761chr7:105875514115.5836   000.0690.05900.0140.0220.0310.1970.0110.3070.263
rs1476878chr7:106485904116.661PRKAR2B
000.0140.01700.0090.0030.0030.22300.2570.217
rs257376chr7:106587233116.8171PRKAR2B
000.0070.01400.0090.0020.0020.22400.2490.214
rs2028030chr7:107147241117.5913   00.00200.00400.037000.1420.0060.1990.192
rs441534chr7:107616772118.0797NRCAM
00.003-0.002-0.00100.056-0.005-0.0020.0790.0120.160.173
rs10234165chr7:108674847119.0679   00-0.026-0.01400.051-0.069-0.02500.0340.0470.085
rs1013920chr7:109655311119.901   00-0.101-0.06400.023-0.177-0.08300.0370.0050.018
rs719530chr7:109678201119.9196   00-0.103-0.06500.023-0.18-0.08400.0370.0040.016
rs214459chr7:110637675120.6354IMMP2L
00-0.116-0.0700.009-0.139-0.06500.02900.004
rs214468chr7:110649119120.6439IMMP2L
00-0.116-0.0700.009-0.138-0.06400.02900.004
rs37742chr7:110700856120.6825IMMP2L
00-0.117-0.0700.008-0.135-0.06300.02900.003
rs1476517chr7:111285062121.0905DOCK4
00-0.129-0.07800.004-0.113-0.05300.024-0.0010
rs2966478chr7:112048462121.5901   00-0.179-0.12300.01-0.128-0.06800.02-0.0060
rs2940339chr7:112973745122.0711   00-0.221-0.16100.014-0.142-0.08100.016-0.010
rs1123065chr7:114452015123.0392   00-0.234-0.16500.001-0.165-0.08700.006-0.0090.003
rs2040587chr7:114462759123.0479   00-0.232-0.16400.001-0.164-0.08700.006-0.0090.003
rs2056865chr7:116007768124.2782   00.007-0.058-0.03600-0.029-0.01400.0950.0390.098
rs41736chr7:116223004124.4433MET
00.011-0.045-0.02800-0.022-0.01100.1060.0510.114
rs885993chr7:116916640124.9231CFTR
00.022-0.006-0.00400.001-0.003-0.00200.1380.0850.162
rs213950chr7:116986769124.9694CFTR
00.023-0.002-0.00200.001-0.001-0.00100.1410.0880.167
rs38831chr7:117507112125.2713   00.0360000.0010000.1630.0950.173
rs846427chr7:119280806125.6306   00.0530000.0020000.190.1030.176
rs868053chr7:120567521126.2115CPED1
00.062-0.004-0.00200.002-0.002000.2050.1020.165
rs12217chr7:121501889126.9818AASS
00.034-0.02-0.0100-0.01000.1580.0710.111
rs1320393chr7:122558943127.7784SLC13A1
00.01-0.051-0.02600-0.057-0.03100.0990.0310.056
rs1880180chr7:122626098127.8198SLC13A1
00.008-0.053-0.02600-0.059-0.03300.0960.0290.053
rs1121030chr7:123495485128.49   00.005-0.075-0.0400-0.09-0.05500.060.010.025
rs1860487chr7:123502372128.4974   00.005-0.075-0.0400-0.09-0.05500.060.010.025
rs1833083chr7:125007189129.648   00.03-0.077-0.0500-0.11-0.07600.01700.004
rs996867chr7:125034557129.6529   00.031-0.077-0.0500-0.11-0.07700.01700.003
rs1419607chr7:125178881129.675   00.031-0.077-0.0500-0.11-0.07700.01600.003
rs719319chr7:125499973129.7423   00.034-0.075-0.0500-0.11-0.07700.01400.003
rs766240chr7:125922975129.9104GRM8
00.04-0.072-0.0500-0.11-0.07900.00900.001
rs1419438chr7:126416116130.1053GRM8
00.045-0.066-0.04700-0.113-0.08200.009-0.0010
rs1419437chr7:126447341130.1182GRM8
00.045-0.065-0.04600-0.114-0.08200.009-0.0010
rs322812chr7:127532023130.6381   00.056-0.044-0.03100-0.129-0.09300.021-0.0060
rs587499chr7:128864767131.6969FAM40B
00.046-0.023-0.01300-0.126-0.09300.044-0.010
rs1464890chr7:129451548132.5132ZC3HC1
00.022-0.035-0.0200-0.156-0.12100.047-0.010
rs2030974chr7:129693119132.9551   00.007-0.049-0.02900-0.187-0.14700.045-0.010
rs729332chr7:129704366132.9767CPA2
00.006-0.049-0.0300-0.188-0.14900.045-0.010
rs1809627chr7:129758424133.0851   00.006-0.047-0.02800-0.181-0.1420.0010.044-0.0090
rs1990790chr7:129820866133.2007CEP41
00.008-0.042-0.02600-0.168-0.1320.0020.044-0.0080
rs969827chr7:130291151134.2539FLJ43663
00.019-0.007-0.00700-0.067-0.050.0150.0390.0030.003
rs15956chr7:130831458135.8728MKLN1
00.0050.0090.00900-0.013-0.0110.0180.0320.0270.027
rs4728251chr7:131478876137.6703PLXNA4
00.050.017000.046000.0430.0460.0430.03
rs10223934chr7:132042784138.813FLJ40288
00.1010.012000.110-0.0080.0690.040.0580.022
rs1468974chr7:132230234139.0992CHCHD3
00.1090.01000.119-0.001-0.010.0710.0420.060.02
rs889826chr7:133246411139.6191EXOC4
00.1090.01000.111-0.006-0.010.0610.0630.060.02
rs1646656chr7:133681457139.8553   00.1090.01000.107-0.009-0.010.0560.0720.060.02
rs1962522chr7:134436889140.4575AGBL3
00.1630.0150.00500.149-0.005-0.0050.0620.1490.060.025
rs1559534chr7:134692033140.7224   00.1940.0170.00700.174-0.003-0.0030.0670.190.060.027
rs1863005chr7:134704002140.7341CNOT4
00.1950.0170.00700.175-0.003-0.0030.0670.1920.060.027
rs1582634chr7:134817061140.8723CNOT4
00.2110.0190.00900.189-0.001-0.0010.070.2130.060.029
rs959520chr7:135922473141.9112   00.3030.0110.00100.299000.0280.2830.0330.012
rs10488598chr7:136238383142.2073CHRM2
LOC349160
00.3080.0120.00200.328000.0310.310.0380.016
rs748260chr7:137136608143.8973DGKI
00.2590.0290.0100.4410.0090.0090.1060.4110.1150.076
rs273954chr7:137254086144.1369CREB3L2
00.2740.0330.01300.4660.0140.0150.1040.4290.1230.083
rs1424376chr7:137338529144.3212   00.30.0360.01600.4930.020.0230.0940.4520.1260.086
rs1371463chr7:137933620145.7823SVOPL
00.5280.0660.05300.7380.0480.0730.160.6290.1560.123
rs1015343chr7:138003727145.9521SVOPL
00.5570.0690.05900.7690.050.0790.1820.650.1590.129
rs3778931chr7:138753030147.6728C7orf55-LUC7L2
LOC100129148
LUC7L2
0.0040.50.0870.0700.7090.050.10.120.6230.0930.11
rs1464798chr7:138982540148.1734HIPK2
0.0130.470.0920.07200.6560.050.10.1080.5710.0750.095
rs880290chr7:139567990149.1391   0.0440.3380.0970.07900.5290.0510.1040.1110.4280.0530.076
rs1476640chr7:141058779150.8496FLJ40852
WEE2
0.0060.210.0720.06200.4660.0680.1470.140.3040.0870.135
rs768055chr7:141059520150.8506FLJ40852
WEE2
0.0060.210.0710.06100.4660.0690.1470.140.3040.0870.136
rs1859646chr7:141142073150.955   0.0040.2030.070.0600.4630.070.1490.1410.2970.0890.139
rs928916chr7:141954283151.966   00.1750.0410.03100.5660.0410.1020.0920.2450.0510.101
rs940864chr7:142749433153.0055CLCN1
00.1040.030.0200.5820.030.080.090.1510.040.07
rs727714chr7:143729925154.153NOBOX
00.0360.0080.00800.5150.0520.0820.1410.1250.0980.132
rs969356chr7:143804256154.2217TPK1
00.0350.0080.00800.4960.0490.0790.1370.1270.0980.132
rs2056553chr7:144893341155.1253   00.0240000.2720.0130.0440.0920.1380.0950.146
rs850545chr7:145027074155.2444   00.0230000.2580.0150.0470.0930.1380.10.152
rs1860482chr7:145049320155.2651   00.0230000.2560.0150.0480.0930.1380.1010.153
rs802200chr7:145736404155.9658CNTNAP2
00.0160000.1770.0290.0690.1030.1340.1290.188
rs700273chr7:145807313156.0609CNTNAP2
00.0160.0020.00400.1770.040.0830.1060.1330.1370.198
rs1524341chr7:146337622156.7506CNTNAP2
00.0140.030.04500.2220.1580.2350.1370.1180.2130.288
rs1024676chr7:146346794156.7659CNTNAP2
00.0140.0310.04600.2230.160.2380.1370.1180.2140.29
rs10240438chr7:146513587157.0447CNTNAP2
00.0150.0420.06200.2430.2050.2960.1460.1180.2440.325
rs1496542chr7:146534867157.0765CNTNAP2
00.0150.0430.06400.2460.2080.3010.1440.1210.2460.328
rs4431523chr7:147228099158.2558CNTNAP2
00.0250.080.110.0030.3550.3180.4350.0740.2440.310.425
rs963314chr7:147493565158.7213CNTNAP2
MIR548T
00.0230.080.110.0070.3830.3320.4440.0390.2860.2910.416
rs243491chr7:148077106159.703CUL1
00.0670.150.1730.0180.5270.3820.5060.0050.3630.280.431
rs740136chr7:149052143161.3875KRBA1
00.1830.2120.23200.740.3350.48600.4490.1830.347
rs1104881chr7:149772742162.8756LOC285972
00.2970.2480.28500.8670.2750.46200.4150.0870.275
rs1547958chr7:150271218164.0196   00.2560.250.27900.8080.2380.42700.4060.0690.258
rs875588chr7:150799763165.3429RHEB
00.220.2370.23700.6110.1370.2900.50.0430.187
rs2536077chr7:151040039165.9686PRKAG2
00.210.2490.2300.5520.130.27100.5650.050.199
rs10235893chr7:151809888168.063   0.0010.1090.2660.27600.2980.1130.30400.4530.0720.243
rs880310chr7:151832710168.1299   0.0010.110.2730.28300.3020.1150.30800.4460.0740.245
rs6951978chr7:152518421170.2697   0.0380.1290.4450.46500.410.180.39500.2070.150.297
rs1735093chr7:152628820170.6412   0.0430.120.4370.45700.3950.180.38700.1550.150.294
rs38993chr7:153207190172.5198   0.0520.0210.2680.2780.1160.150.1140.24400.0040.1040.204
rs1073088chr7:153725713174.1522DPP6
0.0610.0010.1870.1980.2650.0660.0960.175000.0730.142
rs7800754chr7:154009264175.133DPP6
0.06400.1750.1970.3480.060.1420.2110.00200.0950.155
rs10266693chr7:154080711175.3838DPP6
0.07500.1850.2090.3760.0630.1650.2310.00500.1050.165
rs306278chr7:154419731176.6481PAXIP1
0.13500.2490.2850.5110.0810.2850.3380.03900.1620.222
rs1657290chr7:154589637177.3476   0.17800.2910.3340.5850.1080.3650.4190.07900.2080.278
rs10279206chr7:154906561178.5909   0.2610.0030.360.4040.7090.1810.550.6050.23900.3190.409
rs6953751chr7:155070191179.2232   0.2860.0070.3890.4290.6580.2030.580.6630.33800.360.441
rs1920454chr7:155196211179.6885RBM33
0.2880.0130.4080.4480.4720.1960.4960.6490.38800.360.422
rs1343750chr7:155214887179.7597RBM33
0.2880.0130.410.450.4430.1950.4830.6470.39600.360.42
rs1531381chr7:155383699180.396   0.2790.020.4520.4760.210.2070.4040.620.44300.3760.41
rs10949794chr7:155503432180.792   0.270.0230.4830.4920.0720.2220.3690.60.46400.3920.41
rs1389240chr7:155745559181.6225   0.2460.0310.5120.500.260.3690.5960.5170.0060.4810.466
rs1182378chr7:156741083183.915UBE3C
0.1460.0250.4340.37600.2650.3520.5530.4890.0290.540.482
rs1182414chr7:156751124183.9356UBE3C
0.1450.0250.4330.37500.2650.3510.5530.4880.0290.540.481
rs917740chr7:156945610184.3208   0.1290.020.4010.34100.2050.3180.5050.4390.0270.4980.448
rs7455229chr7:157525204185.3914PTPRN2
0.0960.0050.3360.2800.0590.2420.4060.3240.0260.4020.372
rs10772chr7:158116888186.32NCAPG2
0.0900.3490.29600.0260.2360.410.3010.0350.3960.363
rs455030chr7:158710965187.1367   0.09900.390.33100.0260.2510.430.2970.0420.410.37

Table Legend: Tabular display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow row marks the location of the selected gene, and the whitened rows correspond to 20 Mb
around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

References

 

Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry. 2012 Jul;17(8):818-26. doi: 10.1038/mp.2011.89. Epub 2011 Jul 19. PubMed PMID: 21769101