Metamoodics Gene Information

 

  Chromosome: chr17    Cytoband: q11.2    Gene: SLC6A4

 

BP - Genomewide Linkage Studies for SLC6A4


 

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Description

 
Shown here are the results for gene SLC6A4 from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs1045491chr17:5947382.6128GEMIN4
000.0240.0240.020.2320.4950.59500.1830.1840.224
rs7813chr17:5949362.6137GEMIN4
000.0240.0240.020.2320.4950.59500.1830.1840.224
rs910924chr17:6026702.6507DBIL5P
000.0230.0230.020.2310.4940.59400.1830.1830.223
rs592294chr17:6477482.8641   000.0210.0210.0180.2240.4850.58500.1810.1810.221
rs12939286chr17:11437914.8985TUSC5
000.0010.00100.0690.2610.33300.1360.1520.211
rs11062chr17:16297626.3838SMYD4
000000.0130.1720.20800.1180.1160.18
rs216219chr17:20940417.5002SMG6
000000.0130.1550.17500.1270.10.175
rs1984749chr17:21966547.7185SGSM2
000000.0140.1530.16800.130.0960.173
rs405923chr17:318539110.3763   00-0.004-0.01400.0830.0690.07500.270.0290.081
rs1068692chr17:321703410.4603   00-0.005-0.01500.0860.0660.07200.2690.0260.077
rs395357chr17:338283010.893TRPV3
00-0.009-0.01900.1050.0530.05400.2650.0130.055
rs149245chr17:352640111.2669P2RX5
P2RX5-TAX1BP3
00-0.007-0.01700.1180.0580.05800.2540.010.05
rs884250chr17:429838913.0549SPNS3
000.001000.1590.1230.12200.2110.020.06
rs886361chr17:523348614.9872NUP88
0.00200.0200.0270.2080.2190.1800.1890.030.06
rs7221818chr17:574205516.3522LOC339166
0.01400.0440.020.0240.2390.2430.2100.1960.0260.04
rs2309555chr17:610552517.51   0.02500.040.0150.0220.1720.2050.19500.1380.0150.03
rs12746chr17:629505518.0832FAM64A
0.02900.0290.0090.0210.1210.1780.17800.0980.010.02
rs1443417chr17:643392218.5442KIAA0753
0.0300.0250.0050.0150.0960.1640.16400.0780.010.02
rs222836chr17:707388620.5611DVL2
0.0050-0.006-0.01600.0050.0330.03300.007-0.0060
rs9217chr17:730381221.1203ZBTB4
0.0060-0.009-0.019000.0190.0200-0.010
rs858526chr17:744010721.3584FXR2
0.0120-0.006-0.016000.0160.0200-0.010
rs1565816chr17:770821321.7229   0.020-0.003-0.013000.0130.0200-0.010
rs11650137chr17:831792622.4504   0.03900-0.005000.0150.02500-0.010
rs422173chr17:841390722.6444MYH10
0.04400-0.004000.0160.02600-0.010
rs869019chr17:892562724.1476NTN1
0.078000000.0310.04300-0.0090
rs726598chr17:900021324.427NTN1
0.077000000.0340.04900-0.0060
rs2240739chr17:976086628.2844GAS7
0.20400.010.010.15600.1460.136000.0230.02
rs2904912chr17:1001047029.66GAS7
0.21400.0030.0030.23600.1670.150.00700.0370.027
rs1266160chr17:1040240131.4428   0.1430000.19700.170.1440.02500.0440.03
rs995362chr17:1042164031.5014   0.1410000.1940.0010.170.1450.02600.0450.03
rs1860300chr17:1107541232.8608   0.116000.0090.1220.0040.170.1670.01800.0670.047
rs205060chr17:1123323633.1813SHISA6
0.12400.0050.0140.1150.0040.1810.1850.02600.0790.059
rs2193112chr17:1137548933.6346SHISA6
0.14800.0190.0230.1180.0030.2080.2210.04800.1020.082
rs2240519chr17:1171608534.6227DNAH9
0.21700.0670.0670.1470.0090.280.3060.11700.1510.125
rs1984661chr17:1259150236.7638MYOCD
0.54400.310.310.3270.1190.5520.5370.35400.2760.201
rs2215054chr17:1277973437.1654ARHGAP44
0.62600.3980.40.3660.1610.6330.6150.3670.0050.2950.217
rs1468191chr17:1307682137.7842   0.75800.5770.5850.420.2460.7940.7820.3230.0250.3140.241
rs12943188chr17:1341653438.6548HS3ST3A1
0.8430.0010.7640.7550.3750.2040.8430.7940.1730.0390.2610.204
rs1558120chr17:1374808940.0241   0.89400.8060.7660.3110.0550.7030.6340.0790.0480.1810.131
rs983424chr17:1409427941.9035   1.15901.2211.2370.3430.0250.9110.9450.090.0440.2660.234
rs886862chr17:1415616142.2431HS3ST3B1
1.13701.2351.2620.3240.0210.9220.9670.0810.0590.2750.25
rs917310chr17:1419150342.4383   1.11101.2311.2640.310.0190.9240.9730.0730.0710.2790.258
rs530664chr17:1434935343.334   0.97401.2131.2730.2280.020.910.9870.0390.1320.2870.29
rs917541chr17:1486179046.1802   0.34801.021.16800.0670.6320.84700.320.2190.326
rs231018chr17:1510630647.1299PMP22
0.14600.7730.91200.0320.450.63400.2910.1690.257
rs1045599chr17:1582063548.079ZSWIM7
0.05500.6690.79900.0210.3840.53200.2860.1620.243
rs178815chr17:1603365448.1245NCOR1
0.05600.6740.80400.0210.3860.53400.2870.1640.245
rs1869771chr17:1750181949.6715   0.10400.8770.99400.0610.4840.600.3040.210.314
rs1037037chr17:1870574650.6976PRPSAP2
0.2110.0171.1251.19300.1590.6150.70400.2780.2830.386
rs17668529chr17:1984038051.3408   0.3090.081.3091.32800.3440.7150.7810.0030.2440.3440.43
rs7222302chr17:2046953451.7727   0.3840.151.4341.41500.5310.7840.8330.0070.2150.3870.456
rs1564296chr17:2165439052.4333   0.4450.2871.5391.5030.020.8470.8850.9210.0710.1530.4450.487
rs1521563chr17:2240004852.7927   0.4630.3691.5711.5390.0361.0280.9390.9710.1220.1150.4730.502
rs1402726chr17:2241989752.8022   0.4630.3721.5721.540.0371.0330.940.9720.1240.1140.4740.502
rs1060618chr17:2266420852.9217WSB1
0.4690.3991.5831.5520.0421.0930.9580.9890.1410.1010.4840.507
rs3751921chr17:2266644252.9228   0.4690.3991.5831.5520.0421.0930.9580.9890.1410.1010.4840.507
rs2611757chr17:2354284853.4081NLK
0.4320.4311.5781.5520.0421.1890.9861.0240.1170.1760.4410.473
rs1472081chr17:2442001653.8923   0.3830.4481.5631.5420.0381.2561.0061.0540.0750.2740.3830.43
rs727999chr17:2457075653.9575   0.3760.4511.5611.5410.0371.2651.0081.0570.070.2870.3750.424
rs602056chr17:2489627354.1061TAOK1
0.3610.4211.5391.5290.0371.2441.011.0660.0680.2860.3870.431
- chr17:25549031 SLC6A4            
rs1057993chr17:2579522354.372CPD
0.3350.3451.4861.5030.0381.1761.011.0820.0720.2620.430.457
rs739632chr17:2689546254.9208   0.280.1871.3761.4480.0411.0351.011.1150.0810.2120.5170.512
rs757288chr17:2714809055.2058   0.2790.1551.3761.4730.0440.9881.0431.1570.0950.1920.5650.545
rs894723chr17:2760813055.8515   0.2990.1271.4281.5760.0550.9031.1461.2730.1370.1520.6750.622
rs10853153chr17:2810697656.74MYO1D
0.30.0731.3811.5780.0770.741.1481.2850.2140.120.7220.625
rs2052412chr17:2814327556.8118MYO1D
0.30.0681.3751.5760.0790.7261.1461.2840.220.1180.7240.624
rs6505380chr17:2915840759.5088ASIC2
0.2620.0381.0791.2690.0760.5231.0651.250.4130.3130.7710.686
rs2017167chr17:2955482860.6498   0.2710.0311.0341.1940.0710.3631.1021.2690.520.4320.9560.834
rs1860199chr17:3015403962.1384   0.3770.0491.0321.1480.1070.3161.1541.2980.5350.6011.1671.023
rs225284chr17:3095711963.2457AP2B1
0.380.0260.9211.0010.1880.2451.0611.1540.5290.6641.1510.986
rs226426chr17:3107528963.3765AP2B1
0.3590.0220.890.9650.1870.2371.031.1180.5120.6611.120.957
rs1005552chr17:3202371164.4285DHRS11
0.210.0130.7010.7470.1530.2710.8370.9110.3490.7530.8930.777
rs1859212chr17:3310695765.8097   0.1190.1350.7310.7790.0640.5430.8450.9570.1121.0990.7660.785
rs9916617chr17:3411134867.2687   0.1280.2830.9050.9770.0030.8560.9991.1930.0940.9940.8960.984
rs16523chr17:3457068267.7748ARL5C
0.130.2760.8950.9720.0010.8630.9791.1980.1060.7910.850.954
rs2941506chr17:3508656168.1579PGAP3
0.1240.2620.8580.93800.8490.9451.1720.1170.6820.8130.915
rs1008723chr17:3531979368.3006GSDMB
0.1180.2530.830.9100.8330.9221.1460.1210.6650.7970.892
rs1526601chr17:3608866268.9053   0.0920.2110.7090.78900.7660.8251.0370.1380.5920.730.795
rs4890140chr17:3630168869.1129   0.0820.2050.6760.75500.7450.7981.0050.1360.5790.7060.768
rs1008753chr17:3697757369.8459KRT9
0.040.2060.5880.6600.6710.7170.910.1060.5660.6180.687
rs7217728chr17:3770092770.4163STAT5A
0.0310.2260.5950.66500.6150.7120.8860.0740.5550.6330.737
rs8076790chr17:3840812670.7917RPL27
0.0310.2430.6180.68800.5780.7240.8820.0510.5480.6630.797
rs13851chr17:3872737071.0083   0.0310.2540.6310.70100.5570.730.880.0380.5430.6810.831
rs739769chr17:3909064671.2228MEOX1
0.0440.2720.650.71600.5590.7370.880.0470.5170.7090.87
rs744281chr17:4036541272.0364KIF18B
0.090.3450.7230.7740.0020.5740.7680.8910.0780.4350.8171.02
rs8070376chr17:4037922672.0444KIF18B
0.090.3460.7240.7750.0020.5760.770.8930.0780.4380.8181.022
rs1230101chr17:4083955772.2432ARHGAP27
0.0870.3750.7420.7990.0060.6150.8160.9530.0730.5050.8541.076
rs1078830chr17:4130190172.4321MAPT-AS1
0.0840.4020.7590.8220.010.6520.8591.010.0680.5690.8881.127
rs111769chr17:4222715172.9204WNT3
0.0750.4720.8030.880.020.7470.9721.1560.0560.7330.9761.259
rs736604chr17:4237980873.0018   0.0740.4830.810.890.0220.7630.991.180.0540.760.991.28
rs2051821chr17:4349851473.5263   0.0780.4810.8730.9370.0260.7571.0321.2220.0450.8450.9791.306
rs962272chr17:4433328274.1328   0.0820.4810.9450.9970.0350.7581.0971.2850.0390.940.9821.347
rs1063647chr17:4554288376.2132PDK2
0.1010.5171.1581.270.1420.8291.461.6180.0971.1741.1391.551
rs4794304chr17:4720420778.8328CA10
0.3080.7651.4031.5070.5231.4411.7331.8350.1851.3461.2621.682
rs1526189chr17:4721184478.8412CA10
0.3080.7661.4041.5070.5241.4431.7341.8350.1851.3461.2621.682
rs792786chr17:4843929980.0243   0.2560.9221.2991.4290.5351.641.5971.7270.1781.2921.1161.514
rs1508966chr17:4905848380.4616   0.3010.9391.2771.4070.6071.6691.5351.6650.1691.2211.0421.405
rs2045418chr17:4945823080.7684MIR548AJ2
0.3340.951.2621.3920.6571.691.4921.6220.1631.1710.9891.328
rs1025905chr17:5005931181.3616   0.3960.9181.2721.3870.6811.6851.421.5360.1061.1720.8521.172
rs244340chr17:5055434481.9577STXBP4
0.4580.8511.3071.3990.6591.651.3551.4460.0211.2350.6911.011
rs2033108chr17:5117887182.8803   0.5010.8871.5561.6380.6461.631.5171.5810.0091.2850.7681.114
rs759109chr17:5176380184.1829ANKFN1
0.5190.9031.7261.7630.571.5011.5761.6360.011.2570.871.198
rs11079247chr17:5203872184.884   0.50.9251.7121.7350.5161.4511.4851.5450.0051.2470.7931.114
rs929648chr17:5294011987.372MSI2
0.2820.4651.1121.1570.3240.7620.8830.94700.9040.3990.679
rs1024819chr17:5296227087.4189MSI2
0.2790.4551.1021.1490.3210.7490.8750.93900.8950.3940.674
rs888115chr17:5301646987.5326MSI2
0.2710.431.0781.1290.3130.7180.8540.91900.8740.3810.661
rs2680712chr17:5386486489.2618HSF5
0.1540.0620.7420.8570.2210.2550.6170.7300.4950.2250.545
rs12944948chr17:5430625689.5907PPM1E
0.1390.0370.7190.8540.2060.2110.60.7300.4560.2180.552
rs7224035chr17:5472788089.6678   0.1350.0310.7130.8530.2020.20.5970.7300.4470.2170.553
rs1881441chr17:5505380289.7689CLTC
0.130.0230.7060.8520.1980.1860.5920.7300.4350.2150.555
rs1874548chr17:5519613989.8544VMP1
0.1260.0160.70.8510.1940.1750.5870.7300.4240.2130.557
rs12162165chr17:5593732090.4038APPBP2
0.1170.0090.7060.8740.1870.1640.60.7500.4560.2380.612
rs3826417chr17:5665475791.1189BCAS3
0.1070.0130.7240.9050.1710.1740.6190.77300.5210.2860.697
rs12952542chr17:5696011391.4587   0.0820.0080.7070.8920.1290.1620.5890.75200.50.3030.718
rs1860414chr17:5699756791.4992   0.080.0080.7050.890.1240.1610.5850.7500.4980.3050.72
rs7214703chr17:5713984291.6559BRIP1
0.0680.0060.6970.8840.1050.1550.5710.74100.4890.3130.729
rs11654606chr17:5714367791.6603BRIP1
0.0680.0060.6970.8840.1040.1550.5710.7400.4880.3130.73
rs12451501chr17:5760250992.1509   0.0570.0050.6950.8850.0880.1520.5450.7200.4840.3330.748
rs6504112chr17:5803420092.6144TLK2
0.0970.0130.7410.9310.1680.1810.5580.7200.5330.3420.744
rs4329chr17:5891719093.4741ACE
0.1310.0260.7610.9370.2210.1980.5370.66800.6670.3310.693
rs4353chr17:5892415493.4805ACE
0.1310.0260.7610.9360.2210.1980.5360.66700.6680.3310.692
rs9207chr17:5917763193.6846CCDC47
0.130.0290.7530.9220.2140.1950.5220.64500.7080.3230.672
rs9891018chr17:5918158893.6883CCDC47
0.130.0290.7520.9220.2140.1950.5220.64400.7090.3220.671
rs1874087chr17:5953949693.9537ERN1
0.130.0320.7420.9030.2060.1910.5030.61500.7610.3120.645
rs17650301chr17:5990973594.2469POLG2
0.160.070.8240.9940.1990.2310.5070.6350.0030.9080.3420.66
rs2869825chr17:6071472394.9024   0.2380.1681.0471.2430.1840.3390.5270.70.0121.2750.4270.712
rs11867417chr17:6096836095.1AXIN2
0.260.2011.1061.3060.180.3670.5350.7180.0151.3230.4480.727
rs2107654chr17:6106353595.1862CEP112
0.2690.2161.1281.3280.1790.3780.5390.7250.0161.3170.4550.733
rs10512513chr17:6196560096.3515PRKCA
0.3690.4081.411.610.170.5130.6080.8220.0291.2070.5340.801
rs721429chr17:6212236796.6044PRKCA
0.3810.4431.4611.6610.1730.5390.6280.8440.031.170.5440.808
rs740558chr17:6245067497.1367CACNG4
0.4140.51.5691.7670.1890.5910.6820.9030.0321.1060.5640.824
rs2046323chr17:6328038998.5945BPTF
0.5350.5021.8272.0110.2970.720.9211.1690.0541.0460.6320.886
rs755424chr17:64291990100.1884   0.6570.5432.0422.2320.4570.9321.2821.5640.1151.0620.8711.084
rs2364310chr17:64478082100.4635   0.6780.5482.0892.2790.470.9711.3291.6130.1441.0790.9321.12
rs9302908chr17:65397462102.1469   0.790.4952.1282.3350.3771.0291.4081.6790.2640.8271.0731.159
rs411602chr17:66051172103.1972   0.9580.5532.3392.5150.5251.1731.6711.8740.4710.5451.3731.365
rs1431454chr17:66090535103.2584   0.9710.5592.3552.5270.5381.1871.6841.8810.4830.5461.391.377
rs1981647chr17:66132788103.3247   0.9850.5652.3712.5380.5521.2021.6981.8890.4950.5481.4081.388
rs11867765chr17:66824701104.3317   1.1280.5762.482.580.6951.1911.7941.90.6260.4861.5731.483
rs6501514chr17:67490204105.2608   1.140.4492.3422.3780.7170.7971.691.7260.6310.311.5141.396
rs759563chr17:67882483106.0485   1.1920.3932.2972.2660.7810.611.671.6350.6020.2281.4471.304
rs903107chr17:68573529108.2494SLC39A11
1.250.4592.5672.5070.9080.5292.061.8450.5770.241.7271.45
rs17781597chr17:68734433108.9215FAM104A
1.2820.5332.6952.6620.9210.5592.1671.9390.5530.2861.7751.477
rs1872076chr17:68999734110.0869SDK2
1.290.5072.6422.6750.9940.582.2942.1140.5940.3031.8431.59
rs1872085chr17:69039675110.2823SDK2
1.2820.5172.6252.6630.9930.5922.3042.1240.5730.2951.8061.569
rs1872087chr17:69048320110.3249SDK2
1.280.5192.6212.6610.9930.5942.3062.1260.5680.2941.7981.564
rs450433chr17:69514118112.1816   1.1640.6092.3762.4370.9230.7112.242.0860.3260.2021.3331.215
rs4563067chr17:69700141112.6924   1.1140.5512.2222.2890.8710.6732.0721.9320.2850.1581.1441.031
rs690046chr17:70363771114.0753GRIN2C
1.1130.5352.0082.1080.7650.6291.7031.5720.2520.10.9530.801
rs1000821chr17:71945598116.3923UBE2O
1.010.5191.8871.9770.7080.3981.4831.3180.2840.0021.0520.816
rs717571chr17:72132418116.9478   0.9830.5151.8261.9160.7020.4031.4441.3020.29501.0680.838
rs1117059chr17:72154569117.0103   0.980.5161.821.9090.7020.4041.4391.2990.29501.0690.839
rs4289018chr17:72461996117.9122   0.9810.6041.7841.8190.7480.5041.3581.2090.2510.0030.9880.794
rs387601chr17:72858526119.13849-Sep
0.9440.8121.721.6980.8440.8041.3941.1880.2670.0380.9810.789
rs9915090chr17:73652728121.7155   0.9911.2761.8361.7931.0280.9981.7641.4970.3770.0751.3591.159
rs938350chr17:73911147122.6424PGS1
0.9561.2231.8041.8031.0470.8921.8351.5780.4240.0431.4291.235
rs894976chr17:73997256123.0167DNAH17
0.941.1731.7881.8081.0540.8321.8581.610.4450.0271.4491.261
rs938283chr17:74980093127.8431RBFOX3
0.2550.5530.8580.960.3550.4951.1071.180.1430.0570.9191.131
rs7216806chr17:75050112128.1712   0.2190.5240.8320.9350.3170.4711.0771.160.1220.0560.8881.111
rs1696754chr17:75560132130.5255TBC1D16
0.1240.4280.8561.0010.1980.351.0191.140.0170.0260.7240.984
rs3829611chr17:75776410131.342CARD14
0.1070.4470.8871.0470.1710.3251.0171.1570.0020.020.7070.987
rs10931chr17:76055642132.3085NPTX1
0.110.5440.9451.1280.1420.3581.0361.20500.0240.7141.02
rs1564868chr17:76299771133.0939RPTOR
0.1520.6281.0221.210.120.4081.061.24900.0310.7071.031
rs734338chr17:76396935133.3832RPTOR
0.1790.6141.0881.270.1160.3981.0921.27800.030.7271.066
rs868432chr17:76492330133.6019RPTOR
0.20.6041.1381.3160.1130.391.1161.300.0290.7421.092
rs1062935chr17:76554452133.7811RPTOR
0.2170.5951.181.3540.1110.3841.1361.31800.0290.7551.114
rs6565575chr17:77076237135.0994   0.1960.5151.1821.3320.1310.2611.171.32600.0040.7921.082
rs4969481chr17:77586501136.1018   0.1330.3741.0991.2480.1370.1381.1591.2720.00100.7960.986
rs1387545chr17:78138144136.855FOXK2
0.1150.2621.0161.1570.1390.0621.0761.136000.690.805
rs1046875chr17:78278715136.992FN3KRP
0.1120.2421.0011.1410.1390.0481.0611.111000.6710.772
rs1046896chr17:78278822136.9921FN3KRP
0.1120.2421.0011.1410.1390.0481.0611.111000.6710.772
rs599314chr17:78321361137.0292TBCD
0.1120.2410.9991.1390.1390.0471.0591.109000.6690.769
rs733342chr17:78415369137.1091TBCD
0.1130.240.9981.1370.1390.0471.0581.107000.6680.768
rs3785513chr17:78480037137.157TBCD
0.1130.2390.9971.1350.1390.0471.0571.105000.6670.767

Table Legend: Tabular display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow row marks the location of the selected gene, and the whitened rows correspond to 20 Mb
around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

References

 

Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry. 2012 Jul;17(8):818-26. doi: 10.1038/mp.2011.89. Epub 2011 Jul 19. PubMed PMID: 21769101