Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: q25.1-q25.2    Gene: SYNE1

 

BP - Genomewide Linkage Studies for SYNE1


 

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Description

 
Shown here are the results for gene SYNE1 from a genomewide linkage mega-analysis of bipolar disorder carried out with 972 informative pedigrees of European ancestry pooled from eight research groups in North America and the United Kingdom and genotyped on the Illumina Linkage Panel 12 consisting of 6090 SNPs.
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

 

Results Table

 

 


Marker pos_bp (hg18) pos_cM Gene(s) ASMI ASMII ASMIII      
Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs Dom_H Rec_H Exp Pairs
rs719065chr6:1106320.0267   0.0390.0490.0810.04100.02-0.079-0.05900.029-0.289-0.209
rs1986818chr6:1339690.0323   0.0390.0490.0810.04100.02-0.079-0.05900.029-0.288-0.209
rs727056chr6:1700440.041   0.0390.0490.0810.04100.02-0.079-0.05900.029-0.288-0.209
rs6922081chr6:1993370.0844   0.0410.050.0820.04200.021-0.077-0.05700.029-0.286-0.207
rs4960355chr6:7752932.228   0.1370.0550.1420.0800.035-0.018-0.01800.025-0.18-0.132
rs1055368chr6:8525502.4979   0.1440.0540.1450.0800.038-0.015-0.01500.025-0.18-0.135
rs10793833chr6:12353883.8432   0.1860.0390.1670.08800.049-0.002-0.00200.018-0.18-0.148
rs1013303chr6:16949275.3767GMDS
0.2540.0560.260.15600.0940.0110.01100.022-0.125-0.115
rs234915chr6:21545766.8263GMDS
0.3260.1010.3840.28300.1390.0470.05500.038-0.067-0.057
rs9328112chr6:25969868.1242   0.3090.1070.4230.32800.1280.0540.06300.071-0.066-0.057
rs7775474chr6:341322310.306   0.0540.0220.0580.03100.07-0.003-0.0100.096-0.177-0.18
rs190129chr6:366336011.0243   0.030.0250.0290.0100.079-0.01-0.0100.111-0.17-0.18
rs2025267chr6:410352112.2675   0.0140.0370000.093-0.017-0.02700.127-0.152-0.185
rs1411653chr6:437438113.0379   0.0150.0430000.09-0.01-0.0200.127-0.128-0.169
rs429909chr6:461013413.6515   0.0220.0330.007000.063-0.003-0.0200.108-0.097-0.15
rs2032985chr6:535429015.562FARS2
0.0330.0010.0100.0050.0020-0.0300.048-0.028-0.098
rs6597161chr6:568020616.3338FARS2
0.03400.01700.0100-0.0300.024-0.007-0.073
rs4960147chr6:589759016.9005   0.0300.02800.01100-0.0300.016-0.001-0.062
rs3823193chr6:611421717.4434F13A1
0.02500.03400.00600-0.03400.020-0.056
rs1902944chr6:630448917.8686LY86-AS1
0.02100.03900.00100-0.03900.0250-0.051
rs1892512chr6:692363219.4375   0.01300.0440.004000-0.04400.027-0.014-0.064
rs2763122chr6:742692720.6004   0.01800.0680.016000-0.0500.021-0.02-0.076
rs2815155chr6:801022921.8249EEF1E1-MUTED
0.03600.1050.028000-0.03400.01-0.02-0.088
rs505567chr6:822380422.2561   0.03800.1070.027000-0.03300.006-0.023-0.098
rs1410766chr6:847035922.7494LOC100506207
0.03500.1030.023000-0.03700.002-0.027-0.112
rs6597349chr6:869995823.1946LOC100506207
0.02700.0860.01600-0.002-0.05200-0.038-0.13
rs2876143chr6:892862323.6415   0.01200.0550.00700-0.006-0.07800-0.056-0.152
rs767022chr6:908465223.94   0.00200.0340.00100-0.009-0.09600-0.068-0.167
rs761116chr6:956631524.8951   00.0020.012000-0.019-0.11800-0.106-0.17
rs1328132chr6:987907725.4944   00.0020.005-0.00500-0.05-0.15500-0.145-0.195
rs6925615chr6:1014704426.0025   00.0010-0.0100-0.08-0.1900-0.18-0.22
rs760892chr6:1016679726.0411   00.0010-0.01100-0.08-0.18800-0.176-0.215
rs560194chr6:1063678026.9323GCNT2
000-0.02900-0.071-0.15300-0.087-0.108
rs1225732chr6:1104255627.617SYCP2L
000-0.01800-0.045-0.10700-0.043-0.063
rs561332chr6:1171856728.9946   000000-0.01-0.05000-0.01
rs6926835chr6:1233553130.3541   000.0170.004000-0.0060000
rs1953088chr6:1303392231.823PHACTR1
000.0550.018000.00800000
rs1150613chr6:1328835032.2656PHACTR1
000.0630.023000.0130000.0030
rs1863995chr6:1356559632.6846GFOD1
000.0670.027000.0170000.0070
rs707816chr6:1374296132.8742RANBP9
000.0690.029000.0190000.0090
rs1555020chr6:1457470734.1436   000.1760.114000.1170.044000.1140.043
rs1891284chr6:1476014734.5539   000.1920.127000.1380.057000.1270.051
rs1259078chr6:1512328635.3574   000.2210.144000.1920.088000.1690.078
rs752861chr6:1538123135.8579JARID2
000.2360.149000.2370.113000.2090.103
rs74111chr6:1589458136.6095   000.240.15000.2620.132000.2630.14
rs6900454chr6:1665363637.8025ATXN1
000.2240.134000.2620.124000.290.16
rs6901750chr6:1712740538.9284   000.1460.065000.1760.074000.1970.095
rs10949418chr6:1746939039.7831   000.1240.052000.1620.062000.1670.082
rs214527chr6:1839932941.3795   000.1660.0800.0160.2080.09000.160.072
rs2008687chr6:1928367342.1083   000.1610.08200.0220.2310.098000.170.07
rs1011119chr6:1997214442.7584   000.1680.09500.0240.2960.1430.00200.2280.128
rs965037chr6:2009895142.9123   000.1690.09800.0240.3110.1540.00200.2420.142
rs911361chr6:2052303243.4893E2F3
000.1550.09500.0150.30.160.00500.2550.16
rs1498426chr6:2111613244.2377CDKAL1
000.140.0900.0040.2780.160.00700.2480.168
rs2180419chr6:2183629645.4801LINC00340
000.140.085000.2460.136000.1760.131
rs6456488chr6:2255777546.9866   000.130.07000.1510.061000.0610.041
rs11754333chr6:2330103348.2028   000.1640.0980.03900.1780.068000.0620.052
rs197987chr6:2370119748.7252   000.1480.0930.0400.1730.063000.0670.057
rs1355460chr6:2399985349.1919   000.1530.1030.03700.1760.066000.0780.07
rs1402405chr6:2419847649.5254   000.1770.1270.0320.0010.1860.076000.0910.086
rs159988chr6:2518946651.3319CMAHP
000.2870.2630.0160.0260.2330.137000.1470.17
rs13161chr6:2622268152.6126   000.2630.2650.0130.0490.1970.125000.1350.178
rs198809chr6:2623674552.6229   000.2630.2650.0130.0490.1960.125000.1350.178
rs9379827chr6:2626131452.6407   000.2620.2640.0120.0490.1950.124000.1340.177
rs9295730chr6:2723678553.014   000.2390.2490.0110.0540.170.11000.120.17
rs451774chr6:2861052953.0848GPX5
000.2340.2440.010.0570.1680.108000.1180.167
rs377392chr6:2889272053.097   000.2330.2430.010.0570.1680.108000.1180.167
rs429369chr6:2895988753.0994   000.2330.2430.010.0570.1680.108000.1180.167
rs209122chr6:2898348153.1002TRIM27
000.2330.2430.010.0570.1680.108000.1180.167
rs1264451chr6:3064921653.1576ABCF1
000.2290.2390.0090.0590.1670.107000.1170.165
rs485502chr6:3305132354.838BRD2
000.1360.16300.1460.1250.07300.0430.0830.132
rs11908chr6:3305272454.8394BRD2
000.1360.16300.1460.1250.07300.0430.0830.132
rs1003979chr6:3322214955.0077   000.130.15900.1570.120.0700.0520.080.13
rs2495990chr6:3406858955.8353   000.080.1020.0010.1610.070.03700.1230.0470.08
rs6457796chr6:3493653156.5652UHRF1BP1
000.0470.0560.0030.1560.0490.02400.130.0290.047
rs2395626chr6:3553073257.005FANCE
000.030.030.0050.1530.040.0200.1250.020.03
rs1016146chr6:3555349457.025TEAD3
000.030.030.0050.1550.0410.02100.1270.0220.032
rs2213661chr6:3623462857.7339   000.0370.0450.0120.2280.0840.0420.0010.1690.0710.089
rs1046279chr6:3704054958.7581PI16
00.0030.040.0420.0040.30.130.080.0090.2190.1660.178
rs804859chr6:3772244059.6392MDGA1
00.0070.0340.03400.3330.1270.090.0190.270.2090.2
rs910516chr6:3867292660.5408BTBD9
00.0120.030.0300.3420.0930.0680.0140.310.1880.168
rs1738240chr6:3887171160.7503DNAH8
00.0140.030.0300.3420.0820.060.010.3180.1750.155
rs1885615chr6:3944641361.5528KIF6
00.0180.030.03600.3380.0530.0390.0030.3120.1430.112
rs9471302chr6:4039546163.3332   00.0260.0530.06300.3310.0530.0400.150.1470.097
rs736794chr6:4110581164.817UNC5CL
00.0350.0680.08600.3090.0680.04800.0170.1240.082
rs629832chr6:4139423165.4624   00.0750.0930.12200.360.0930.07800.0130.1430.112
rs1011101chr6:4175136466.2257   00.1290.1220.16200.4320.1220.11200.0460.1750.157
rs722269chr6:4230289467.3295TRERF1
00.1960.1230.16300.5070.1230.11700.1910.190.177
rs1537638chr6:4320417769.1166PTK7
00.3930.10.13900.7330.090.08900.5240.1770.169
rs1563788chr6:4341634169.6599ZNF318
00.4010.10.13300.7630.090.08300.5580.160.163
rs945131chr6:4382397270.7403   00.380.0780.11500.7610.0750.07300.5430.120.13
rs3734693chr6:4407314371.3379   00.3870.0730.1200.6750.080.0900.4740.110.13
rs4714772chr6:4431509571.8931   00.4140.0790.13700.5460.0970.12400.3810.110.147
rs1322669chr6:4458715472.5124   00.4290.0850.15500.5230.120.150.0050.4260.1250.165
rs227850chr6:4480704673.0027   00.4390.090.1700.5240.140.170.010.4850.140.18
rs1293457chr6:4486607673.1315   00.4310.0850.16200.5130.1330.1650.0090.4790.1290.169
rs3778507chr6:4500478173.4728SUPT3H
00.4090.0710.14200.4840.1160.1510.0050.4650.1020.142
rs1284999chr6:4520241773.9552SUPT3H
00.3780.0520.11300.4440.0920.13200.4440.0640.104
rs1928533chr6:4561780274.6359RUNX2
00.3770.0250.06500.4660.0520.08500.4140.0220.049
rs995564chr6:4619076975.384   00.3910.0060.02800.5090.0180.04800.42300.012
rs716493chr6:4641590175.6182RCAN2
00.3990.0040.02100.5270.0110.04100.43800.008
rs1372567chr6:4643736375.6405RCAN2
00.40.0040.02100.5280.0110.04100.4400.007
rs953887chr6:4647003775.6745RCAN2
00.4010.0030.0200.5310.010.0400.44200.007
rs993612chr6:4735175776.4022TNFRSF21
00.44400.0100.55300.02600.46300.004
rs12525548chr6:4737380076.4168TNFRSF21
00.44500.0100.55200.02600.46300.004
rs1556358chr6:4815825876.7732   00.47400.0100.5500.02200.46400.008
rs2032553chr6:4924075276.9489   00.48800.0100.54900.02100.46400.009
rs1471539chr6:4956811177.003CENPQ
00.49100.0100.54800.0200.46300.01
rs1923523chr6:5078704077.3597   00.41-0.0070.00600.42200.01300.337-0.0040.006
rs283548chr6:5107443377.4533   00.388-0.0090.00500.38900.01100.304-0.0050.005
rs283545chr6:5107593177.454   00.388-0.0090.00500.38900.01100.303-0.0050.005
rs966707chr6:5173617877.8834PKHD1
00.29-0.0180.00100.23700.00200.151-0.0090.001
rs875142chr6:5233618478.535PAQR8
00.259-0.036-0.00500.164-0.01100.0010.062-0.015-0.005
rs1542896chr6:5526138682.2307   00.041-0.257-0.1800.001-0.082-0.0870.0650-0.027-0.086
rs1925165chr6:5609647882.9COL21A1
00.01-0.364-0.26700-0.089-0.1070.0380-0.047-0.133
rs2038149chr6:5615253782.9417COL21A1
00.009-0.371-0.27200-0.089-0.1080.0360-0.048-0.136
rs1925152chr6:5621066882.9849COL21A1
00.007-0.378-0.27800-0.09-0.110.0350-0.05-0.139
rs1925154chr6:5621248182.9862COL21A1
00.007-0.378-0.27800-0.09-0.110.0350-0.05-0.139
rs2599697chr6:5690722183.4476   00.003-0.416-0.31100-0.094-0.110.0360-0.046-0.136
rs3908886chr6:5813656683.9586   00-0.457-0.34700-0.1-0.110.0380-0.04-0.13
rs12197273chr6:6203046184.1741   00.002-0.462-0.35200-0.105-0.1150.0350-0.049-0.139
rs9378077chr6:6207835984.177   00.002-0.462-0.35200-0.105-0.1150.0350-0.049-0.139
rs977382chr6:6211832384.1795   00.002-0.462-0.35200-0.105-0.1150.0350-0.049-0.139
rs1040802chr6:6353040184.266   00.002-0.463-0.35300-0.108-0.1180.0340-0.053-0.143
rs1630182chr6:6426617184.4075   00.004-0.464-0.35400-0.112-0.1220.0320-0.06-0.15
rs1922964chr6:6502081484.6738EYS
00.006-0.467-0.35700-0.12-0.130.0280-0.074-0.164
rs1418903chr6:6832667786.6077   00.056-0.422-0.33400-0.078-0.0880.020-0.064-0.16
rs1016461chr6:6909297086.9887   00.065-0.41-0.3300-0.07-0.080.0220-0.06-0.16
rs2210867chr6:6980277587.3615BAI3
00.054-0.41-0.3300-0.063-0.0760.0260-0.06-0.16
rs1817255chr6:7036262087.7669   00.041-0.41-0.3300-0.055-0.0720.030-0.06-0.16
rs6910674chr6:7177954288.9981   00.017-0.3-0.2300.0020-0.010.0770-0.01-0.08
rs199630chr6:7230978189.4948   00.016-0.231-0.17100.0020-0.0050.0970-0.005-0.05
rs1321834chr6:7245451989.6317   00.016-0.212-0.15400.0020-0.0040.1020-0.004-0.042
rs1969530chr6:7291799790.0622RIMS1
00.015-0.156-0.10600.0020.0020.0010.11700.002-0.019
rs1416546chr6:7317862790.3133   00.017-0.138-0.09100.0010.0090.0060.11500.009-0.014
rs1935515chr6:7359248090.703KCNQ5
00.02-0.111-0.06800.0010.0210.0140.11300.021-0.006
rs2000203chr6:7375378790.843KCNQ5
00.021-0.101-0.059000.0250.0170.11300.025-0.003
rs2796051chr6:7390259690.972KCNQ5
KCNQ5-AS1
00.022-0.092-0.052000.0290.0190.11200.029-0.001
rs1370436chr6:7458113591.4505CD109
00.032-0.085-0.0500.0020.0350.0250.06500.0210
rs675497chr6:7511427091.7884   00.039-0.082-0.0500.0040.0380.0280.0300.0140
rs508557chr6:7537474191.9428   00.043-0.081-0.0500.0050.0390.0290.01400.0110
rs2998367chr6:7622823392.3261FILIP1
00.042-0.08-0.0500.0070.040.030.00500.0070
rs12606chr6:7668146192.4758MYO6
00.041-0.08-0.0500.0080.040.030.00400.0050
rs1486039chr6:7696525692.599   00.04-0.08-0.0500.0090.040.030.00300.0040
rs6907703chr6:7723506992.7145   00.04-0.08-0.0500.010.040.030.00200.0030
rs9352376chr6:7747187492.8345   00.039-0.08-0.0500.0110.040.030.00100.0020
rs1462476chr6:7757223592.8857   00.039-0.08-0.0500.0110.040.030.00100.0010
rs1398576chr6:7858157793.4881   00.067-0.041-0.02600.0320.0790.069000.0150.005
rs1567095chr6:7939070793.9832   00.096-0.001-0.00100.0520.1190.109000.0290.01
rs2063123chr6:7971525494.146PHIP
00.1080.0090.00900.0550.1330.12000.0370.016
rs1537740chr6:8003523394.2794   00.1170.0170.01700.0570.1450.13000.0440.021
rs932492chr6:8053129194.4914   00.1330.0290.02900.0590.1640.144000.0550.03
rs239558chr6:8077776494.5785TTK
00.1390.0350.03500.0610.1720.15000.0590.033
rs1040596chr6:8109702194.6576BCKDHB
00.1450.0390.03900.0620.1790.156000.0630.036
rs1436876chr6:8128524694.722   00.150.0430.04300.0620.1850.161000.0660.039
rs533393chr6:8170636394.8802   00.1610.0530.05300.0640.1990.172000.0740.045
rs310389chr6:8183463694.9357   00.1650.0560.05600.0650.2040.175000.0770.047
rs6454240chr6:8255547695.2552   00.1670.0680.0700.0640.1820.1600.0030.0650.04
rs885582chr6:8266891695.3334   00.1660.070.07300.0640.1730.15300.0030.060.037
rs770906chr6:8314006095.6718   00.1620.080.08700.0610.1360.12600.0070.040.023
rs4111785chr6:8353718595.9595   00.1580.0890.09800.0590.1040.10300.010.0220.012
rs983087chr6:8401098396.2899ME1
00.2010.1020.11700.0820.1170.12300.0340.0230.013
rs2296412chr6:8462564396.597   00.2460.1140.13600.1060.1360.14800.060.0260.016
rs2025427chr6:8500985996.7207   00.2640.1190.14300.1150.1430.15800.070.0270.017
rs1887504chr6:8547392696.8364   00.2810.1230.1500.1240.150.16700.0790.0280.018
rs946296chr6:8736442897.006   00.3050.130.1600.1370.160.1800.0930.030.02
rs513640chr6:8753268197.0731   00.3010.1330.16200.1320.1610.1800.0890.030.019
rs910563chr6:8811560497.3961C6orf163
0.0010.2840.1460.17200.1080.1680.1800.070.030.016
rs6940716chr6:8819969897.4378C6orf165
0.0010.2810.1480.17300.1050.1690.1800.0680.030.016
rs1051131chr6:8827826597.4903SLC35A1
0.0010.2790.150.17500.1010.170.1800.0650.030.015
rs632385chr6:8872866097.861   0.0030.2590.1640.18600.0730.1770.1800.0440.030.011
rs1884831chr6:8895185398.0945   0.0040.2470.1740.19400.0620.180.17800.0350.030.01
rs2246529chr6:8934145898.5757   0.0070.2240.1930.21300.0550.180.16800.0310.030.01
rs1040676chr6:8957786698.8855RNGTT
0.0090.2090.2050.22500.0510.180.16200.0290.030.01
rs205224chr6:8980011899.2257   0.010.1880.2050.23200.0430.1750.15800.0230.030.012
rs1980986chr6:8981872699.2548   0.010.1860.2050.23300.0430.1750.15700.0230.030.013
rs7773548chr6:8987719699.3528SRSF12
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rs675162chr6:160696315174.2387SLC22A3
00.0010.0080.00800.0150.0250.05800.09400.045
rs783182chr6:161088538174.5597PLG
00.0020.0040.00400.0110.0190.04200.09100.039
rs1247555chr6:161109008174.5798   00.0020.0040.00400.010.0180.04100.09100.038
rs1080085chr6:161632025175.3165   00.001-0.003-0.00300.0030.0070.01400.0700.027
rs1893098chr6:162196867176.3839PARK2
00-0.014-0.022000000.02200.016
rs1954948chr6:162521711177.0007PARK2
00-0.02-0.04000000.00100.01
rs1333962chr6:163188894178.2774PACRG
00.0010.0030000.0130.006000.0160.026
rs942731chr6:164585475180.3255   00.0980.0370.037000.050.0530.00600.070.06
rs1886672chr6:164641899180.3855   00.10.0380.038000.050.0540.00600.070.06
rs727811chr6:164965324180.8344   00.1120.0470.04700.0010.050.0580.01300.070.06
rs646444chr6:165642335182.0952C6orf118
00.090.0610.0600.0450.0590.060.0250.0130.0830.051
rs491253chr6:165685823182.1787PDE10A
00.0930.0620.0600.0540.0580.060.0240.0180.0850.052
rs875590chr6:165989348182.8575PDE10A
00.110.0690.0600.1280.0510.060.0160.0560.1060.059
rs3002430chr6:166210146183.4839   00.1350.080.0700.1840.0550.0650.0130.0870.1290.07
rs1445282chr6:166445194184.2702   00.1460.0820.07200.2160.0490.0590.0120.1170.1450.072
rs880900chr6:167059469186.3274RPS6KA2
00.0590.0170.01700.12000.0260.1310.0930.017
rs533810chr6:167109679186.52RPS6KA2
00.0480.0150.01500.109000.0270.1250.090.015
rs2981963chr6:167630537188.4403UNC93A
00.0030.010.0100.06000.0160.0410.0570.006
rs1532145chr6:168299050190.6142   000.0160.0100.0070-0.006000.004-0.006
rs1884477chr6:168694014191.6161SMOC2
000.0320.0100.0010-0.010.00400-0.01
rs9364286chr6:168898564192.0297   000.040.01000-0.010.00700.001-0.01
rs4708557chr6:169081526192.3618   000.0360.01000-0.0060.01900.007-0.006
rs727619chr6:170548119194.0313FAM120B
000.040.0100000.11400.080.03
rs909475chr6:170655714194.0639   000.040.0100000.11500.0810.031
rs909472chr6:170656108194.0641   000.040.0100000.11500.0810.031
rs1474555chr6:170674695194.0702   000.040.0100000.11500.0810.031
rs756519chr6:170692787194.0805PSMB1
000.040.0100000.11500.0810.031
rs2076318chr6:170720350194.1075TBP
000.040.0100000.11600.0810.031
rs8770chr6:170728456194.1154PDCD2
000.040.0100000.11600.0810.031

Table Legend: Tabular display of linkage analysis results for 12 different phenotype by genotype models across the chromosome. The yellow row marks the location of the selected gene, and the whitened rows correspond to 20 Mb
around the gene.

 

Phenotype Models
ASMI: Affecteds include bipolar I and schizoaffective manic sub-type disorders
ASMII: Affecteds include ASMI plus bipolar II disorders
ASMIII: Affecteds include ASMII plus recurrent major depression

 

Genetic Models
Dom_HLOD: Parametric heterogeneity dominant model (risk allele frequency 0.01, penetrances 0.01, 0.70, 0.70)
Rec_HLOD: Parametric heterogeneity recessive model (risk allele frequency 0.1, penetrances 0.01, 0.01, 0.70)
Exp_LOD: Non-parametric linkage (NPL) analysis with SAll under the exponential model
Pairs_LOD: Non-parametric linkage (NPL) analysis with SPairs under the linear model

 

 

References

 

Badner JA, Koller D, Foroud T, Edenberg H, Nurnberger JI Jr, Zandi PP, Willour VL, McMahon FJ, Potash JB, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu CY, Gershon ES, McMahon W, Lyon GJ, Robinson R, Ross J, Byerley W. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Mol Psychiatry. 2012 Jul;17(8):818-26. doi: 10.1038/mp.2011.89. Epub 2011 Jul 19. PubMed PMID: 21769101