Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: p13.3    Gene: ADCY9

 

MD - Genomewide Association Studies for ADCY9


 

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Description

 
Shown here are the results for gene ADCY9 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
16rs25319793974068TC0.92040.02660.8982.73802380860219(Index SNP)
16rs10349054068954TC0.9791.0950.0026322.579714115058080.00842
16rs80641514054277CG0.9711.0890.0048922.310513551635750.01015
16rs72049874050194TC0.9780.9410.0060792.216167856615560.01067
16rs110768064055494TC0.9721.0860.0061622.210278306019080.01189
16rs22384433975898AG0.9361.0690.0080872.092212556889380.75715
16rs26017883947087TC0.5531.0930.0081812.087193607338710.02113
16rs65005774062423AT0.9750.94360.0089872.046385258309360.01158
16rs25320194064301TG0.9690.94070.013721.862645888629270.01881
16rs124449204047143AG0.9271.0810.014041.852632892206210.01132
16rs10755814075899AG1.011.0820.020561.686976889676760.0061
16rs25319823973098AG0.670.93110.021521.667157733005650.28357
16rs71959134110412CG0.9720.92670.022911.63997491081060.01114
16rs80460073945522TC0.8951.0440.056831.245422343955270.10118
16rs129334234027513AG0.9551.0640.056861.245193144645580.02747
16rs19664193944794AG0.910.960.066371.178028182357960.10689
16rs26018314036512TC0.9481.0610.070071.154467882506420.02558
16rs107753504026862TG0.9250.95830.10210.990974257913090.02807
16rs22384253943055AC0.9710.96640.1120.9507819773298180.07148
16rs26017964027977AG0.9530.96040.11790.9284861949049110.02452
16rs24442173978388AG0.8781.0370.11950.9226320947158440.31436
16rs116492873979969AG0.9331.0380.1380.8601209135987640.15105
16rs22384554071884AG0.9810.96890.1580.8013429130455770.00386
16rs80611824010334TC0.8970.96820.15840.8002448227465250.00483
16rs22393053977919AG0.9540.9630.15880.7991495019089230.11279
16rs8796203955730TC0.951.0320.16150.7918274733328780.07159
16rs25319953953468TC0.9641.0280.22240.652865217089980.07159
16rs171991283986042CG0.5771.0790.24240.6154673845057510.0251
16rs26017773975069AG0.890.97320.250.6020599913279620.24882
16rs72061424111702AG0.9991.0320.27720.5572067740602310.00016
16rs4371154096424TC0.9820.97740.28520.5448504788201720.00182
16rs25320014109390AG10.97490.30430.5166980476418330.002
16rs116478283991514TC0.8381.0240.31090.5073792779568080.00672
16rs4099634072923TC0.9011.0280.32090.4936302829044960.00105
16rs22307393973437TC0.8040.97660.36990.4319156686846060.21303
16rs22393114006192TC0.8871.040.37570.4251588049366150.01342
16rs4076424092319CG0.9770.98330.46680.3308691526266670.00317
16rs21089874048908TC0.980.98160.47130.3267025602403640.00101
16rs22384313948231TC0.6511.0230.48140.3174939140609890.04285
16rs47864503976156TC11.0170.48590.3134531009369940.08732
16rs25319673992487AG0.8840.98110.48930.3104247842400620.00665
16rs26018284043872TC0.9451.0180.49480.3055703090429170.01861
16rs413366544084899AG0.4290.94260.49580.3046934775681970.00505
16rs22834923977526TC0.9960.98320.49650.30408074716860.08192
16rs3650104092191AC0.9761.0150.50840.2937944581180290.00317
16rs19673084005678TC0.8920.97950.51190.2908148704497550.00872
16rs121492743994691TC0.9410.97810.52870.2767906895948897e-05
16rs71935524073077AC0.9951.0130.55260.2575891194195070.00036
16rs22393073982450TC0.8691.0170.55730.25391095694380.09846
16rs71933694073014TC0.9941.0120.57440.2407855687657560.00036
16rs25320024109252AG0.990.98820.58250.2347040703019430
16rs47859534094852AG0.980.98290.590.2291479883578566e-05
16rs3884304075563TC0.9520.98820.60650.2171691947974080.00126
16rs116456554000336AG0.9560.98270.61480.2112661411722920.00039
16rs25320154068632TC0.9580.98930.62660.2030096094543140.00526
16rs22561564102761TC0.9620.98960.64490.1905076230626588e-05
16rs110768004014909TC0.821.0260.64670.1892971390528830.01647
16rs129358103989366AG0.7991.0110.64680.1892299887656360.00343
16rs37301193997604AG0.9010.9860.64930.1875545971272440.01219
16rs22384323954142AG0.6540.96340.6520.185752404268080.00022
16rs3992184091588TC0.9731.010.65560.1833610551015390.00427
16rs116435963997896TC0.9751.0150.66350.1781590727995467e-05
16rs20797313997134TG1.010.98630.67920.1680023227641040.00015
16rs19673094005584AG0.8350.99010.68010.167427225153820.00132
16rs22393104000662AG0.8511.0090.6970.1567672219019910.00559
16rs80454264093207TC0.9791.0120.71440.146058554119510.00046
16rs4371874092000TG0.8641.0130.74080.1302990263261220.01533
16rs25262974113629CG0.9740.99280.74220.1294790499872365e-05
16rs22384393971349AG0.9120.99140.74790.1261564667765640.05387
16rs4229554115360AG10.99340.76050.1189007816109837e-05
16rs20723423978907TC0.9210.98520.76860.114299619871670.01914
16rs3782004083182TC0.9341.010.7750.110698297493690.01003
16rs4457464089768AT0.9450.99020.78360.1059055726773010.00971
16rs25262964113728TC0.9030.98930.79630.09892328427374520.01544
16rs26017753968061AG0.9110.99370.81490.0888956821959640.05387
16rs65005674023106AG0.8761.0640.82360.08428366205400620.00862
16rs107753494019824CG0.8240.99180.82370.08423093401631590.00226
16rs121489743975500AC0.8391.0080.82830.08181233864107440.0486
16rs22384383970796AG0.681.0060.83560.0780015686917290.11179
16rs115433173956050AG0.9140.99080.84480.0732460948102630.01325
16rs47864544016137AG0.8030.99380.84630.07247565912497130.02801
16rs22307384104365TC0.7390.99460.84890.07114346641808930.00019
16rs22307423956677AG0.9651.0050.86580.06258241852286220.01499
16rs26017874003552AG0.8441.0080.86590.06253226035662250.00812
16rs172562603993514AT0.8761.0060.87330.05883653984152680.00882
16rs25319923961735AG0.9621.0050.87710.05695088899159320.01399
16rs4321664096858AC0.9661.0030.88790.05163594401163070.00471
16rs20723383996928AG0.8631.0070.8940.04866248120408230.0156
16rs9333923972717TG0.930.9960.89520.04807992647970640.03411
16rs25319994110524TG0.9641.0040.90740.04220122507000210.00237
16rs20723463967424TC0.9091.0030.91130.04033862972650460.04013
16rs99277674108171AT0.9850.99680.93490.02923484021923230.0028
16rs171366924008814AG0.9341.0030.95090.02186515260171050.00129
16rs129216973999747TC0.9581.0020.95870.01831727262871460.00726
16rs121033094040269TG0.1071.0680.96110.01723142274898819e-05
16rs20723413979142AG0.9310.9980.96920.01358659453453140.01914
16rs22407353967606TC0.891.0010.970.01322826573375510.06079
16rs37301383956944AG0.4870.99650.97030.01309396861927880.00022
16rs20581664040325TC0.8310.99930.97910.009172949432521150.00015
16rs71968324016753AG0.8460.99940.98090.008375265465994640.03053
16rs47864564023362TC0.9111.0010.98710.005638848091998980.00525
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.