Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q21.2    Gene: ANK3

 

MD - Genomewide Association Studies for ANK3


 

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Description

 
Shown here are the results for gene ANK3 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
10rs239357661471026TC1.0610.02180.9562.14886400498843(Index SNP)
10rs1099417161484058TC0.9630.93960.0075612.121420761937780.40855
10rs1082170561661975TG0.9880.95020.016311.787546038959720.00447
10rs413313061654103TC0.9980.95230.021111.675511766692340.00644
10rs435915561484423TC0.9380.94730.021761.662341108973860.14203
10rs1099425761652054TC0.9961.0530.022171.654234306885510.0098
10rs100244261473068TG0.9630.94230.028781.540909210399410.20819
10rs988803461472732AC0.9491.0450.045651.340559218129680.57757
10rs134065561651253AC0.991.0430.048631.313095730431820.00215
10rs647970661678714AG0.9921.0460.050931.293026323823820.00776
10rs1082169961627174AG0.9271.0440.051431.288783475678910.00194
10rs494839861636761TC0.9881.0420.053531.271402756616570.00354
10rs195413461639604AG0.9810.95950.054911.260348556290620.00419
10rs1099425961654610TC0.9860.96010.057731.238598442501370.00221
10rs239361061490607TG0.9680.93790.06561.183096160624340.1029
10rs1720857661504579AG0.9541.0620.085471.068186296040860.1029
10rs1099421461556616TG0.9471.0380.088991.05065879322950.05116
10rs790290561496417TC0.9420.96210.090841.04172287445230.15637
10rs1099416061468779TC0.9330.94670.090921.041340572947070.11644
10rs1099421061548220TC0.9581.0380.094171.02608742958030.08031
10rs1276150661556052TC0.9511.0370.096391.015968019728820.04734
10rs2893217161501296TC0.9670.94450.10160.99310629205210.10416
10rs1021887561545282AG0.9620.96480.10470.9800533183211580.08485
10rs456895661493115AG0.9291.0380.10870.9637704559137050.10185
10rs1159916461501990TG0.9731.0570.11020.9578184054842340.1029
10rs1073375861552886AG0.9210.96510.11280.9476909003526770.03849
10rs239361461585961TC0.9260.96430.11990.9211808169011510.00141
10rs790167761675207TC0.9930.96660.12460.9044819576768490.0163
10rs239357961471148TC0.960.9510.12670.8972233851165590.13009
10rs790292361553990AG0.8851.0760.13540.8683813356508740.05652
10rs239360961485341AC0.8460.94710.14520.8380333836359250.07369
10rs155168361820365TC0.9951.0460.14690.8329782042097440.02067
10rs1050912361563151TG0.9541.0330.14840.8285660990569926e-05
10rs1181330761463526AG0.891.0330.14950.8253588073395520.34767
10rs791780061510173TC0.9011.0520.15090.821310760224410.1029
10rs494838361483691TG0.9490.96180.15130.8201610719768130.27551
10rs155168461820209AG0.9961.0450.15250.8167301563171950.02067
10rs1691467161691599TC0.7250.88990.15580.8074325466634540.00454
10rs789628761813800TC0.9991.0440.1570.8041003475907660.02067
10rs707887361457593AT0.9261.0320.15840.8002448227465250.0229
10rs145972961792760AG0.9940.97050.15930.7977842241988690.01722
10rs436934661541604AG0.9231.0320.1650.7825160557860940.06346
10rs789331361490637TC0.921.0320.16850.7734000947926430.13363
10rs1277903561546726TC0.9271.0330.17960.7456936676687140.01881
10rs494825461569339AT0.940.97010.180.7447274948966940.00041
10rs1099421161552371AC0.9220.970.18050.7435227937583230.06027
10rs647970061633765TC0.9771.0320.18140.7413627172759240.00262
10rs239359561512504AG0.90.95330.18140.7413627172759240.09709
10rs1159944761539065TC0.9290.93840.18220.7394516273630210.06114
10rs1278137161755924CG0.9530.97240.19740.7046528516663820.01946
10rs708107361630711TC0.9461.0330.19870.7018021328901850.00971
10rs1099419961533039TC0.9631.0510.19910.700928739972590.01848
10rs1235720661460389AG0.860.97140.2020.6946486305533760.32059
10rs1074001461635015TC0.9711.0320.20350.6914355864387610.01415
10rs1050912461563739TC0.9521.0290.20360.6912222263352795e-05
10rs424558561596196AG0.9861.0290.20520.6878226435602210.00909
10rs1082174461797900TC0.9930.97340.20570.6867657083052760.02092
10rs1099421961572095TC0.730.88770.20970.6784015695346560.01852
10rs1073240861635194TC0.9710.96980.21210.6734593314834380.01415
10rs1780563661636374AG0.6571.0740.21370.6701954778359310.03977
10rs1181658661456971TC0.8961.0330.21590.6657473576657690.00939
10rs1082172361752743AG0.990.97380.21630.6649434805609090.00269
10rs138045561802826AC0.9941.0270.21870.6601512169623630.02092
10rs494825561608258TC0.9821.0280.22050.6565914061961430.02837
10rs1691461361628125TC0.1320.04460.22250.652669984683050.00455
10rs1074000861540516AC0.9590.97310.23030.6377060620357690.03215
10rs134065461668066AC0.9821.030.23170.6350739662100240.01292
10rs104986261459278AG0.840.97290.23220.6341377845974450.30729
10rs1691465161679524TC0.7290.96180.23380.6311554931741790
10rs375080061538722AC0.9561.0270.24020.6194269969331130.03521
10rs790690561463801TC0.9341.0270.24130.6174426780912140.18324
10rs1276718661680529AG0.8830.97060.24330.6138578910691820.00948
10rs227942161451727AG0.9890.96140.24540.6101254416090150.00597
10rs1076145061517445TC0.9450.97140.24730.6067758836387030.00394
10rs790801161673395AG0.9981.0280.2510.6003262785189620.00962
10rs1691459161616066TC0.9651.050.25210.5984271543235540.00708
10rs1181475261624256AG0.8710.95550.25350.5960220363306450.00076
10rs1235590861607010TC0.990.97310.26630.5746288335610590.0207
10rs1691458561614118TC0.971.0480.27110.5668704824195140.00708
10rs229797961635631AG0.9961.0310.27340.5632014897681970.00273
10rs1691458261611281TG0.9511.0470.2810.551293680094920.00087
10rs379385461523062AG0.941.0250.28270.548674191510480.06891
10rs494838561520327TC0.9130.96690.28530.5446982283429240.00132
10rs1082167361523492TG0.9411.0240.2970.5272435506827880.06891
10rs136148661781623TC0.9931.0220.29750.5265130299354320.02004
10rs1076145161517552CG0.9460.97430.29750.5265130299354320.00395
10rs706895161522112AG0.9260.97650.30190.5201368869769020.06227
10rs790831261667891AC0.9881.0290.30630.5138530031934270.00436
10rs1082170161631168TC0.9891.0290.30860.5106040782728710.00413
10rs1181411061594867AG0.9290.97730.30880.5103227083363011e-05
10rs99068661768173AC0.2091.8170.30940.5094796906366510.00455
10rs1082170761667962AG0.9921.0280.31350.5037624548332650.00436
10rs228835861610905AG0.990.9780.32220.4918744639168010.01692
10rs1082165961463430AG0.9411.0220.33050.4808285361783410.2084
10rs1691481261592979AG0.9290.97890.34490.4623068056326093e-05
10rs1082173161769560TC0.990.98020.34580.4611750110620960.02004
10rs1082172961769179TC0.9830.98070.35910.4447845948739270.02091
10rs1082174661810846TC0.9991.020.36070.4428538576816370.00365
10rs1226596261457557TG0.9661.0860.36310.4399737510871080.00915
10rs1099414361451084AG0.9941.0840.36430.4385408287580840.00915
10rs1276397461478886AG0.8530.96440.3690.432973633840940.11464
10rs1082169761609792AG0.941.0220.38910.4099387691962570.04675
10rs228835961572029TC0.9161.0390.40150.39631445038530.02572
10rs710134061712740AG0.9641.0180.4050.3925449767853310.01487
10rs708626061561024TC0.9621.0190.41410.3828947694976220.00822
10rs239359961526867AG1.010.9690.45220.3446694419906590.03646
10rs1082168761572206TC0.9561.0370.45250.3443814164587780.01853
10rs154246261728402AG0.9641.0160.46080.3364875295848440.00027
10rs1050912561596872AC0.9791.0160.46860.3291977157390560.00154
10rs1082170061629067AC0.9660.98030.47530.3230321857052420.00351
10rs1691475861527549TC10.97090.48130.3175841383226410.03646
10rs1074000661501750AG0.9240.98280.48130.3175841383226410.03241
10rs1082169561609525AG0.9320.98270.48420.3149752148942860.04423
10rs707036461561038TC0.9550.98440.49030.3095381067538220.01037
10rs379385761527422TC1.011.0290.49290.3072411818452760.03646
10rs1204975661540675AG0.9041.0230.49310.3070649974688620.00437
10rs1082166861501277TC0.9270.98320.49590.304605891708890.02861
10rs1076144661487628TC0.9190.98250.49780.3029451077274260.02364
10rs1082171661740759TC0.9840.98540.49910.3018124301338780.00043
10rs1076144561465914AG0.9581.0190.49980.3012037482095690.14921
10rs494838461485373TC0.8281.020.50260.2987775157434430.02498
10rs456276661490520AG0.7641.1160.50710.2949063894521270.01148
10rs980419061509837TC0.9591.0170.50990.2925149880325260.19434
10rs790344161825314TC0.9871.0180.51020.2922595457262290.00742
10rs1235797261577913TC0.9660.96880.51070.291834142144460.01853
10rs147124761744286TC0.9921.0140.51640.2870137664056170.00011
10rs99723861737454TC0.9831.0140.52110.2830789268332390.00037
10rs239359661513573AC0.9731.0170.53510.2715650490257450.002
10rs708235561537569TG0.9041.0210.53650.270430273698030.00938
10rs452826961460337AG0.8210.98110.53770.2694599635228810.10579
10rs224857061571799TC0.931.0310.5380.2692177243336110.01853
10rs965130161530027AC0.8540.96610.540.2676062401770310.0333
10rs1099418061507167TC0.9060.9850.54750.2616158764878440.03775
10rs929944061740701AG0.9920.98720.55030.2594004871888440.00011
10rs1076148161746842TG0.9880.98730.55540.2553941245857610
10rs224153861509977AG0.9760.98540.55690.2542227821102410.02086
10rs1076145961552490AG0.9261.0160.55870.2528213286398360.0037
10rs964549561740656TC0.9880.98750.56210.2501864147070620.00011
10rs494839361568186TC0.9831.0120.56290.2495687513397980.01443
10rs1082174561806212TG0.9930.97350.56430.2484899497299590.01151
10rs1076146161553370TC0.9190.98420.5670.2464169411070930.00164
10rs1723065061608543AG0.9391.0160.56760.2459576132145640.07286
10rs437239261486742TC0.9230.98510.56930.2446588161884520.02016
10rs1099425361634758TC0.9691.0210.57050.2437443512457676e-04
10rs789565361813354TC0.9911.0150.57920.237171446810910.00742
10rs321382961563904TG0.9521.0120.58050.2361977759254070.01433
10rs1691461961630141AG0.9381.0190.59080.2285595133600880.00011
10rs1099417261484503AG0.6360.9210.60520.2181010806488510.01142
10rs1099421261552420AG0.9320.98640.60880.2155253562374840.0037
10rs1277115861733479TC0.9840.9850.60990.2147413666422990.01079
10rs1691466061684635AG0.8541.0120.62090.2069783401540170.00018
10rs1074000461471620TC0.9571.0110.62960.2009352806489920.34331
10rs105074561457255TC0.9911.0120.62980.2007973436994750.04742
10rs1691479161565553TC0.8080.97450.63880.1946350925335550.01381
10rs1050911861482473TC0.9710.98210.64370.1913164908710310.09421
10rs1099429361715704TC0.9161.0260.64510.190372958105950.01853
10rs1691464361484114AG0.9321.0180.64530.1902383348928750.09421
10rs1082170861683430AT0.9440.98780.64720.1889614913957840.0092
10rs647969461570362AC0.7211.060.65440.1841567093367330.00684
10rs494841261816582TC0.990.97940.65660.1826991216066790.01151
10rs1241321261684321AG0.941.0140.65760.1820381954680060.01008
10rs1691496861819549TC0.9931.0130.66070.1799956931916820.02133
10rs138045961767337TC0.9861.0210.66280.1786175002527010.01151
10rs380894361821021TC0.991.020.67130.173083352815080.01151
10rs1691486761773833CG0.2380.70410.67480.1708249260829120.00455
10rs1691467761693040TC0.9751.0140.68240.1659609818405330.00215
10rs198125161797933AG0.9921.0090.68890.1618438152478520.00163
10rs1050912661608557AT0.9330.98150.69120.1603962705291630.01062
10rs707793761529815TC0.9340.99130.69780.1562690348879080.02911
10rs791195361461045TG0.9830.98460.70180.1537866361206130.04558
10rs3493935361798512TC0.990.98860.70640.1509493094304880.02133
10rs219920961764744AG0.9790.99090.71980.1427881576831080.00313
10rs1099430861768958AG0.9871.0170.72330.1406815349028840.01151
10rs1074002261732692TC0.9690.99110.72410.1402014525194340.00432
10rs379385961531878TC0.9751.0080.72490.1397219002477650.03853
10rs1099424661611256AG0.9281.0170.73820.1318259591403620.02091
10rs1099428561685013TC0.8211.0190.74110.1301231867332330.01019
10rs966365561483123TG0.1841.2110.74620.127144755295190.001
10rs1691457161463452TC0.9260.98750.75130.1241866111602420.08289
10rs1074001961719436AG0.1730.75260.75640.1212484798269980.00407
10rs239358261471408TG0.9631.0080.76010.1191292674675770.28827
10rs1099414161450388AC0.4261.0470.76590.1158279304760870.01226
10rs1723378161723375AG0.9560.99150.7720.1123826996642640.00696
10rs1082172761769119TC0.9751.0070.77320.1117081546434850.00452
10rs1691467461692304AG0.9140.990.77740.1093554637047520.00067
10rs99140561764208AG0.9780.99280.7790.1084625423274360.00214
10rs145973161698803TC0.9860.99280.78560.1047985252211070.00166
10rs1099416561477444TC0.6381.0280.78580.1046879755242130.02092
10rs1099431061776175AG0.9940.99310.78620.104466960515930.00264
10rs1076143861450215AC0.9490.9940.79070.1019882612024980.00521
10rs452054961774522AG0.9931.0070.79810.09794268919153340.00264
10rs709625061776325AC0.9941.0060.80130.09620485725896470.00264
10rs462067361774710AG0.9931.0060.80130.09620485725896470.00264
10rs709800861706606TC0.9761.0060.80630.0935033402006470.04724
10rs709642661776551AG0.9930.99390.80960.09172950050427610.00264
10rs239360361472348AC0.9420.99390.81610.08825662214406830.20221
10rs239360761472567TG0.9410.99410.82130.08549817717268590.20819
10rs707707961448724AG0.9870.99540.84520.07304051161972420.0961
10rs867761458249AT0.8841.0070.85270.06920373701669980.05193
10rs708449961776888TC0.9930.99530.85410.06849127813338250.00264
10rs239362561789212TC0.9941.0050.85650.06727263269847070.00264
10rs138045161709660CG0.9541.0040.85890.06605739725873890.03934
10rs1074001161560943TG0.981.0040.85940.06580465065211560.00064
10rs1050912161487871AG0.9011.0050.86360.06368736633780682e-04
10rs494841061786053AG0.9951.0040.86540.06278310913729450.00264
10rs380894261820854TC0.9891.0040.87030.06033101647767350.00143
10rs1050912061483195TC0.5480.98430.87370.05863766428823890.02675
10rs224154061510466AG0.9360.99660.87960.05571477931124720.06408
10rs709571761718225TC0.9780.99580.88150.05477768336465920.02101
10rs790195161705507TC0.8720.99610.88340.05384260507762770.00717
10rs1780545661629033TC0.9971.0040.88640.05237025261564550.0345
10rs1082166261471745TC0.9441.0030.89570.04783742578553740.17771
10rs1691466361687326AG0.9711.0040.89850.04648191855500740.01343
10rs1780624561683073TC0.9841.0040.91090.04052929792489290.01241
10rs239360861472998AG0.9281.0030.91120.04038628892895610.18668
10rs379386161615019TC0.990.99740.91280.03962436858984180.00247
10rs790012361710139TC0.9891.0030.91610.03805711685861270.0332
10rs1159626061517046TC0.9630.99770.91660.03782014709123220.06408
10rs227942061451953AG0.9981.0040.92050.03597620715996650.04177
10rs101055561803887TC0.8450.99650.92170.03541041251009670.00548
10rs138045361704361TC0.9631.0020.9260.03338901331806570.04364
10rs1082170961711597TC0.9911.0020.9330.03011835625350010.04937
10rs1241173361793052AG0.9610.9980.93410.02960662792039990.00896
10rs1099419861526041AC0.981.0020.93450.02942069428514910.01122
10rs1074001861705375AG0.9611.0020.93910.02728815945293350.03978
10rs134065261748209TC0.9781.0020.94120.02631808149601630.0045
10rs1278280661712717TC0.9891.0020.9420.02594909720712260.0332
10rs1076148261755343TC0.9850.99830.94440.02484402159331060.00593
10rs92211661711475TC0.991.0020.94650.02387938170018440.04937
10rs1691468761697612TC0.9891.0020.95590.01958753839310850.01241
10rs431056161624482AG0.9451.0010.98150.008109696063974990.00888
10rs708748961615937AG0.9930.99990.99560.001915112063444390.00139
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.