Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q23.2    Gene: C10orf116

 

MD - Genomewide Association Studies for C10orf116


 

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Description

 
Shown here are the results for gene C10orf116 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
10rs379390088708813AC1.0760.02280.9362.84224111395314(Index SNP)
10rs76011288709549AG0.9520.93360.0069732.156580334795080.54882
10rs942040788711015TC0.9540.94360.012231.912573542963710.35044
10rs124039088715964AG0.9660.94040.015061.822175028135320.56739
10rs180037388708416AC0.8910.9470.015321.814741234703410.62816
10rs124037588723172TC0.9131.0520.028041.552221990705380.35366
10rs124038888716719AG0.8671.0540.030561.514846650096350.27441
10rs124037988721491AG0.8771.0530.035271.452594540332510.28366
10rs124038488717439TC0.7250.84080.043351.363010898187770.01703
10rs124038588717310AG0.7270.84190.044681.349886835556430.01703
10rs486988720292TC0.9010.95580.045321.343710098808640.35716
10rs385828888722010TC0.9031.0450.052821.277201603129090.38121
10rs493428288722456AC0.9051.0440.054581.262966468666120.38121
10rs124038688717258TC0.7550.85530.072041.14242629585250.01703
10rs796088720354TC0.8961.0290.20630.6855007720268480.21371
10rs493342188722644TC0.9020.97350.23260.633390289607570.2363
10rs1120228288728844TC0.9510.97050.31840.4970269409343690.0046
10rs74802688714440AG0.211.1210.81830.08708744882390310.00543
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.