Metamoodics Gene Information

 

  Chromosome: chr22    Cytoband: q11.21    Gene: COMT

 

MD - Genomewide Association Studies for COMT


 

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Description

 
Shown here are the results for gene COMT from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
22rs574848918307146AC1.0570.02210.931.90763030037088(Index SNP)
22rs574848518303415AG0.931.0570.012521.902395671125591
22rs154432518311668AG0.9291.0570.013041.88472240860411
22rs574684718301003TC0.9311.0560.014031.852942328971641
22rs17467318313778CG0.9010.90190.04561.341035157335560.03536
22rs599388318317638TG0.9271.040.071821.143754599209950.70078
22rs17467518314051TC0.8960.96120.10960.960189445851650.24812
22rs1698284218325333TC0.2360.03040.11150.952725132615820.00524
22rs76922418331804AG0.8891.1470.12360.9079815292472030.01585
22rs960503118301378TC0.9740.96460.13290.8764750190572680.30556
22rs814026518301641AG0.9760.96530.13970.8548035938858180.30781
22rs73786518310121AG0.991.0350.14460.8398317070414880.29557
22rs73786618310109TC0.9921.0350.14730.8317972531573690.29744
22rs202091718308884TC0.9850.96620.14870.8276890314780460.30556
22rs16581518339473TC0.9471.0450.16030.7950664776458550.03291
22rs16572818337023TC0.9731.0710.16690.7775436633207530.01315
22rs17469918334458TC0.971.070.16780.7752080435073190.02198
22rs818500218313048TG0.9891.0330.16860.7731424297112760.29744
22rs463318330235TC0.9081.0310.170.7695510786217260.22942
22rs88719918341955AG0.950.9590.18530.7321245806811020.03291
22rs17469718333832AG0.9430.93650.19190.7169250252645290.01315
22rs93327118311407TC0.8981.0330.19240.7157949322982060.24102
22rs111047718342380TC0.9861.0610.22690.6441655041150640.02256
22rs111047818342769TC0.9771.0390.25220.5982549177629370.06968
22rs16582418339366AG0.8841.0460.25930.5861974832306480.00024
22rs960503018301137TC0.8670.9640.26840.5712174885030460.10516
22rs468018331271AG0.911.0240.27630.5586191150834890.2383
22rs88720018343666TC0.9931.0370.28030.5523769022397140.06776
22rs599388218317533TG0.8721.0220.41240.3846813433885210.15648
22rs223939518342203TG11.0420.41460.3823707022421580.03537
22rs224071318341101TC0.9950.95960.41670.3801764995427220.03537
22rs75837318340394AG0.9850.96120.42980.3667335888445750.04337
22rs88720418347068AG0.9841.0170.49190.3081231774406690.15567
22rs1698287118345563TC0.1861.7310.49290.3072411818452760.00074
22rs599389118339746TC0.9860.96720.50180.2994693430214080.04337
22rs651859118304021AG0.8720.98360.56560.2474905992111570.10704
22rs1170561918304579TC0.810.98340.58310.2342569585789560.10829
22rs223939318330428AG0.931.0120.5990.2225731776106890.106
22rs464631018308806AG0.8691.0150.60880.2155253562374840.10643
22rs464631618332132TC0.9051.0130.63080.2001083153431350.00789
22rs74060118330763TG0.9281.0110.63190.1993516446360120.106
22rs17469618333176TC0.571.0170.63240.1990081387398290.00164
22rs464631218328337TC0.9161.010.66980.1740548567961520.1086
22rs1215820118346749TC0.9850.98160.67430.171146840323360.03735
22rs933237718335692TC0.8931.0090.76950.1137913758325020.03277
22rs1698284418327942AC0.4770.98930.87350.05873709068105030.09965
22rs933231618310274TC0.291.0060.95930.01804555553002640.00189
22rs930623518335157AG0.7441.0010.98020.008685301823389180.0474
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.