Metamoodics Gene Information

 

  Chromosome: chr11    Cytoband: q23.1-q23.2    Gene: DRD2

 

MD - Genomewide Association Studies for DRD2


 

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Description

 
Shown here are the results for gene DRD2 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
11rs6278112785934AC1.060.02970.9741.3128278954052(Index SNP)
11rs11214606112815079TC0.6570.89250.049221.307858390633220.00039
11rs1076560112788898AC0.9631.0560.066031.180258702726990.97016
11rs1079727112794392TC0.9750.94790.072981.136796140971370.96839
11rs1079597112801496TC0.9691.0530.084371.073811950892790.93947
11rs1125393112802559TC0.9681.0530.084761.071809051961240.93947
11rs1554929112783974TC0.9820.96390.085591.067576973623260.14717
11rs2471857112803549TC0.9721.0530.085751.066765871285190.93947
11rs2471854112804849CG0.9691.0520.089351.048905443158340.93947
11rs10891549112783657TC0.9841.0370.092551.033623576911080.14898
11rs1799978112851561TC0.9860.92220.09381.027797161620940.00428
11rs4648319112819573AG0.9221.050.11480.9400581119380450.96926
11rs1800497112776038AG0.9211.040.15540.8085489855351050.59043
11rs2734831112798806TG0.9431.0320.15790.8016178699917060.18306
11rs12363125112791126TC0.9770.97050.17180.7649768405047770.20549
11rs1116313112801317AG0.981.030.17370.7602001815529010.20857
11rs1076563112801119AC0.9821.030.18260.738499226801720.20998
11rs2734838112791711AG0.9831.0290.18530.7321245806811020.20857
11rs12364051112810524AG0.9661.0290.18840.7249191015431410.20857
11rs7131440112805120TC0.9670.97260.20570.6867657083052760.20549
11rs6274112786138AC0.2280.21250.31890.4963454807570410.02375
11rs2234689112783693CG0.9830.97490.35010.4558078892349670.0352
11rs4581480112829684TC1.010.96820.36450.4383024673460070.01381
11rs2734848112775584TC0.9910.9770.38960.4093810517934220.03481
11rs4648317112836742AG0.9980.97470.40330.3943717779923810.01
11rs11214611112835429AG0.991.0250.42330.373351731525990.01055
11rs10891551112837505AG10.9760.42530.3713046172859770.01
11rs7122454112832678CG10.9770.44570.3509573659138240.01
11rs12364283112852165AG0.9720.97040.46120.3361107013773392e-05
11rs4936270112823618TC11.0250.48860.3110465373625820.0151
11rs1124492112787485AC0.9890.97770.50480.2968806537639220.01966
11rs2440390112792088TC0.9981.020.53860.2687336509245080.0157
11rs4938019112846601TC11.0190.54540.2632848663943890.01114
11rs7125415112815891TC0.9940.97890.56690.246493543009030.01287
11rs12805897112829503AG0.9721.0220.59220.227531596946720
11rs4274224112824662AG0.9920.99120.67790.1688343660905580.04426
11rs4436578112811975TC0.9721.0130.68820.1622853317150890.01966
11rs10891556112857971TG10.98940.70020.1547778935709860.01522
11rs4936271112823915TC0.9871.0080.70640.1509493094304880.04568
11rs6275112788687AG0.9661.0090.70680.1507034591652740.0659
11rs2242592112784640AG10.99170.71730.1442991691645630.06771
11rs17115583112814112AG0.9750.9880.71970.1428484973125070.01966
11rs1124493112787505TG0.9911.0080.72140.1418238620176560.06862
11rs4620755112814829AG0.9810.98830.72610.1390035632428040.01966
11rs17115461112775938AG0.2730.60650.73370.1344814809252260.02375
11rs10891552112838881AT0.8781.0240.74150.1298888446355990.00359
11rs2587550112778135AG0.9990.99250.74480.1279603320267140.06862
11rs4986918112800452AG0.2330.6350.74960.1251704221202780.02375
11rs1003641112778846AG0.9941.0070.75010.1248808345374320.06862
11rs17529477112822277AG0.941.0070.75390.1226862566877620.04111
11rs4245147112823217TC0.9780.99380.76980.1136220932414280.04568
11rs4245146112823183TC0.9631.0060.77890.108518296160480.04426
11rs4648318112818599TC0.9860.99410.81260.09012318200960720.04203
11rs7131056112834984AC0.9990.99540.82770.08212704480115210.08869
11rs12422191112779220AG0.9131.0080.83960.07592757008963720.01046
11rs2002453112794508TC0.9941.0030.9010.0452752090209370.04065
11rs11601054112841382AG0.9981.0030.90720.04229695845116860.02669
11rs2245805112795909TG0.9941.0030.91370.03919637508823030.04096
11rs1076562112801218AG0.9961.0020.92170.03541041251009670.04029
11rs6589377112860946AG10.99790.9250.03385826726096740.02425
11rs4630328112839419AG0.961.0020.94120.02631808149601630.02379
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.