Metamoodics Gene Information

 

  Chromosome: chr3    Cytoband: q27.1    Gene: DVL3

 

MD - Genomewide Association Studies for DVL3


 

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Description

 
Shown here are the results for gene DVL3 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
3rs1969253185359206AC1.1010.02240.94.73873713120751(Index SNP)
3rs863615185347557AG0.9670.91880.000086054.065249125336420.84455
3rs1709642185364469AG0.9481.0880.00011283.947690900352680.89196
3rs843370185358516TC0.9671.0860.00020993.67798756141760.52826
3rs843364185383530AG0.9350.92680.00053573.271078353627140.70373
3rs843365185383423TC0.9351.0780.00063793.195247397849540.707
3rs4912527185352567TC0.9860.92580.00065553.18342730397390.4802
3rs844540185346507AT11.080.00066513.177113052165850.49351
3rs4575925185349537TC0.9951.0790.00078113.107293362194330.4802
3rs843367185383032TC0.9351.0760.00084193.074739490480560.707
3rs4912474185349180AC0.9960.92760.00084313.07412091069850.4802
3rs843346185376213TC0.8910.94160.024391.612788199686270.23898
3rs843369185379862AG0.9470.95120.032241.491604966866950.35794
3rs8478185382526TC0.9250.95080.073131.135904426575750.13416
3rs11919795185373562AG0.8741.0450.08911.050122295963130.27969
3rs2231216185379335TC0.7991.0390.1070.970616222314790.27158
3rs2231224185383975AG0.9080.95980.17860.7481185454474720.12602
3rs16858473185350316TC0.9280.95440.44630.3503731131594710.02538
3rs10937163185373831TC0.8020.97030.52360.2810003621212820.06681
3rs2231223185383886AG0.7011.0440.61790.2090818047854220.01771
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.