Metamoodics Gene Information

 

  Chromosome: chr9    Cytoband: p21.3    Gene: ELAVL2

 

MD - Genomewide Association Studies for ELAVL2


 

View in Genome Browser

 

Description

 
Shown here are the results for gene ELAVL2 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
Download:
   
Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
9rs1096606123730210AC0.91480.02460.9723.52287874528034(Index SNP)
9rs786164623722000TC0.9961.0910.00034433.463062977295330.94806
9rs1081196523731278TC0.9840.9150.00036883.433209087618410.88131
9rs132904123710904TC0.9680.91680.0004643.333482019445120.8629
9rs1205707123749368AC0.9930.89260.0010222.990549104201310.16207
9rs702422423769696TC0.951.1220.0010522.977984260182280.14977
9rs289118823746299TC0.9870.89730.0019032.720561211712980.13911
9rs1096609323822717TC0.9010.91090.0024442.611898798429480.06995
9rs165308123780800TC0.9670.89050.0037172.429807438904270.10918
9rs1690778223792442TC0.9161.1240.0040012.3978314486210.07621
9rs379357823728335TC0.951.1430.0050312.298345682674250.13366
9rs1081197423822176TC0.9350.93530.0072682.1385850813640.23017
9rs95909123765449AG0.9781.1110.0088062.055221318876490.08716
9rs1179032823684329AC0.9421.0620.011721.931072388317930.02767
9rs785465423696338TG0.9680.93530.013811.859806321421370.10332
9rs1690761823688649TG0.9841.0590.013931.856048883576040.03088
9rs185444223689886AG0.9850.93730.01551.809668301829710.12216
9rs784798923708363TC0.9381.0670.017091.767257937279260.11379
9rs185444323689733AG0.9470.93880.01791.747146969020110.12703
9rs382909023728298AG0.9851.0610.027311.563678299860270.67685
9rs1075744723720654TC0.9781.0580.033261.47807775511650.65474
9rs787072823819728TG0.9571.0480.03621.441291429466830.11661
9rs1755117423807548AG11.0620.039061.408267761048160.25494
9rs497788423677696TC0.8931.0580.041111.386052523219650.02152
9rs379360323803100AG11.0580.042431.372326968233380.18138
9rs1096606423737517CG0.8911.0750.044291.353694319715240.07607
9rs238326823671361AC0.9571.0450.044481.3518352214260.00254
9rs1096609023819865TC0.9610.95610.045481.34217954398430.09625
9rs132902823677097CG0.920.94840.049631.304255724802680.02667
9rs414214923821141AC0.9241.0450.051051.292004253577070.12451
9rs1328745623748914CG0.9241.1370.052441.280337316981950.05512
9rs1690769523743106AC0.9481.0690.076191.118102026426990.07711
9rs1073867923675236AC0.9561.0450.084031.075565636456770.0227
9rs379357723727627AG0.9830.96360.084451.073400346092970.34169
9rs1011977323726400AG0.9780.96440.093011.031470355625160.34169
9rs1692365123739865CG0.9210.93870.10450.9808837095529270.05796
9rs379358323763013AG0.9340.89850.10510.9783972839717580.05528
9rs497789223806554TG10.95720.11780.9288547095489170.17465
9rs1234179323819824AG0.9650.95630.12310.9097419470686840.07089
9rs204315323679584AC0.5841.1650.13020.8853890157678270.00036
9rs289118923751274AG0.9720.9660.14710.832387327272470.04731
9rs379360523814841TG0.9391.0410.15440.8113527040002830.1646
9rs379359523801127AC1.010.96430.17280.7624562618571260.12569
9rs136022423703125CG0.9071.0350.18180.7404061211140510.03291
9rs1223619523741700TC0.9691.0350.19230.716020715761520.00117
9rs497788723708520TG0.9280.97330.21710.663340176545580.00306
9rs202603723752529TC0.9780.96680.24530.6103024517936140.00289
9rs1690776923789111AG0.380.62360.30010.5227340045751470.01051
9rs379360223803023TC0.9980.97290.30680.5131446447230570.00317
9rs1073339223684188TC10.97610.31460.5022412817127320.04543
9rs277104623800888AC0.9731.0260.33850.4704413269788370.00032
9rs93288323676123AC0.9051.0220.36890.4330913447731970.00016
9rs1235294723731248TC0.4640.56590.36980.4320330931768460.02109
9rs1096608723806941TC0.9740.97580.37670.4240043797967320.00335
9rs70222323803840AC0.9840.98120.39290.4057179711881940.09314
9rs132904423737791TC1.010.97680.40020.3977229156998070.00123
9rs1690772223766228TC0.3370.57560.42970.3668346463160970.01051
9rs379357623727408AC0.8860.96990.47820.3203904282202440.0247
9rs497788623679717AC0.9720.9840.49980.3012037482095690.02413
9rs1748434723779442TG0.9080.94050.51430.288783475678910.00176
9rs379359123773162TC0.9711.0190.52350.2810833139851390.00397
9rs703852523762277TC1.011.0180.53140.2745784499257410.00023
9rs1268555223782601TC0.9791.0160.55830.2531323721495710.00089
9rs1235338923717356AT0.5770.890.58410.2335127937603060.04245
9rs78356223813399AG0.9440.98790.59010.2290743853610010.08566
9rs132902523688373AG0.7650.95970.60910.2153114004985790.0081
9rs102370423694310TG0.8991.0110.66010.1803902672484150.00086
9rs1690781323817873TC0.8230.96330.67560.1703103591010291e-05
9rs132902923675661TC0.9650.99020.6820.1662156253435210.02218
9rs969713123685277TC1.010.98530.70060.1545298670183260.02785
9rs221750423672669AG0.9210.9910.70390.1524890347967520.00142
9rs132902423696348TC1.021.0140.7180.14387555575770.02809
9rs1096602123675144TC0.9420.99230.74130.1300059998782580.00444
9rs132904323714149TC0.1271.4120.76230.1178740802299689e-04
9rs786980623821031AG0.9741.0080.82230.08496970974083920.13736
9rs382908823703680TC0.9731.0060.84120.07510073598571650.03389
9rs1096603123693900AG0.9551.0060.84430.07350321072677960.03155
9rs99254823777897AG0.9871.0040.89340.04895405186418020.00505
9rs1081195523687417AG0.9360.99630.89660.04740126547022690.01056
9rs238329223783644CG0.1741.0330.89680.04730440041308330.01051
9rs141084023692349TG0.9310.99650.90080.0453716224927290.01365
9rs136022623703284AG0.9971.0030.90490.04339941178682330.00323
9rs1096603923705981TC0.9621.0030.91460.03876880295533690.00024
9rs1096603223695108TC0.960.9970.92160.03545753392086320.02201
9rs132903623819911AG0.241.0440.9350.02918838912748220.01051
9rs1690780623804283AG0.2650.90340.9410.02641037657274310.01051
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.