Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: p21.31    Gene: FKBP5

 

MD - Genomewide Association Studies for FKBP5


 

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Description

 
Shown here are the results for gene FKBP5 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
6rs776276035745319AG0.36760.34640.272.41262582792693(Index SNP)
6rs380037335650454AC0.980.94130.010891.962972120244220.00094
6rs938052635766305TC0.960.94410.012231.912573542963710.00763
6rs94329735775838TC0.9431.0590.015151.819587367161680.00849
6rs936888135742266AG0.9631.0570.016331.787013815263330.00763
6rs947008035754413TC0.9541.0560.016831.773915884024180.00752
6rs939431435791037AG0.9240.94720.023241.633763876281710.00849
6rs471390435733125TC0.9580.94860.023861.622329560665680.00823
6rs136078035715549TC0.9851.0490.03861.413412695328250.00869
6rs239563435675738AG0.9871.0480.044361.353008462522880.00904
6rs946210435782823TC0.9550.95390.044661.350081281264580.00862
6rs936887835693592TC0.9780.95550.050111.300075597257520.00876
6rs775159835713178AG0.9841.0460.051461.288530218125670.00876
6rs281704035813584AG0.9361.0470.05981.223298816011590.01109
6rs1049873435667751AC0.9980.93570.064491.190507623062660.00021
6rs75565835657648TC0.9991.0680.066631.176330186731860.00021
6rs229480735663088TC11.0680.067281.172114017210140.00021
6rs1252789335693077TC0.9730.9380.071851.143573227529760.04057
6rs276653335793468AG0.961.0320.14310.8443603662402240.00347
6rs99210535663161AC0.9870.95910.14780.8303255659411930.00057
6rs1080715135648846TC0.9740.95920.14940.825649402520620.00057
6rs938052935783674AG0.9671.030.16720.7767637268970020.00304
6rs775703735656214AG0.9560.97090.17510.7567138539165540.00293
6rs380037435645384TC0.9851.0370.18780.7263044120699080.00066
6rs276653535799760AG0.9730.97690.27610.5589335933607370.00327
6rs1220049835793933AG0.9680.97090.2890.5391021572434520.00086
6rs775374635673400AG0.9840.9720.31550.5010006364198470.00057
6rs377774735686980AG0.9641.0220.32290.4909319549828380.00266
6rs471389935677259AG0.9951.0260.36750.4347426565797860.00057
6rs471390235722004TC0.8591.0210.4230.3736596326249580.00101
6rs774826635700722TC0.9961.0230.42860.367947833294190.00057
6rs214340435718659TC0.9781.0230.44050.3560540872519330.00057
6rs1045643235779629TC0.9131.0210.44350.3531063758322550.00982
6rs938052435697048AC0.7270.96960.45720.3398937782767560.00038
6rs379834635670618AG0.9671.0160.54270.2654401784205240.00775
6rs775169335803252AG0.9190.96520.56980.2442775550965423e-05
6rs276653435793692TG0.8751.0150.58380.2337359093480040.00111
6rs471390835755288AG0.920.95970.5870.2313618987523865e-05
6rs147577435727532AG0.9381.0370.62690.2028017301610415e-05
6rs2867567035709507AG0.9461.0370.62910.2012803148149945e-05
6rs947007935751041AG0.7970.98480.63390.1979792482280240.00082
6rs1687880635677097TC0.960.97180.69890.1555849595261765e-05
6rs1319295435741434AG0.6790.97740.70570.1513798825658660.00013
6rs1687859135660605AG0.960.97540.73710.1324735888002575e-05
6rs1687937835705681AC0.8850.97690.75290.1232627028593355e-05
6rs1217510435641647TC0.2761.1460.90910.04138834223512061
6rs281704135813870TC0.7970.99780.94190.02599520310258540.00101
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.