Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: q21    Gene: FOXO3

 

MD - Genomewide Association Studies for FOXO3


 

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Description

 
Shown here are the results for gene FOXO3 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
6rs2802288109002908AG1.0320.0220.9850.812479279163537(Index SNP)
6rs2490272109002079TC0.9660.96920.1570.8041003475907661
6rs2253310108995286CG0.9561.0310.17280.7624562618571261
6rs9398172109101519AG10.97110.20730.6834006979061390.5473
6rs2764264109041154TC0.9750.97130.20860.6806856959094880.52305
6rs4946936109110014TC0.991.0270.25970.5855280503706970.5473
6rs2153960109094877AG0.9970.97420.26030.5845258318907640.5473
6rs4946935109107435AG0.991.0270.26360.5790545940780280.52863
6rs3800229109103656TG10.97550.28610.5434821421947370.5473
6rs1935949109105980AG11.0240.29670.5276824536831580.5473
6rs1268165109115071TC0.9850.97730.30040.5223000716678690.34634
6rs2022464109052063AC0.9681.0240.30480.5159850373324370.59436
6rs1268169109114670TG0.9950.97780.31180.5061238891471770.34634
6rs1268164109115109AG0.9940.97780.31270.5048721187570670.34634
6rs2207731109120357AG0.9920.97810.3190.4962093169428190.34634
6rs4946932109081439AC0.9871.0230.32350.4901257149952810.60941
6rs3800227109100854AG0.9731.0240.32860.4833324409009570.46981
6rs1268167109114876AG0.9941.0220.3350.4749551929631550.34634
6rs1536057108992316TC0.9671.0230.34650.4602967610521740.68275
6rs2883881109004079AG0.9930.9680.3740.427128397799520.15801
6rs10499051109008873AG0.9930.96830.37830.4221636587072560.15476
6rs9372187108982338TG0.9971.0320.38470.4148778136931840.16083
6rs761779109118020AG0.9951.0250.39870.3993537643376060.28709
6rs12206094109012893TC0.9871.020.40570.3917949922956740.67282
6rs3813498109050858TC0.9850.9790.43590.3606131309823160.35861
6rs13220810109019894TC0.8921.020.45020.3465945093354990.21155
6rs7341233109046973TC0.9770.97510.46030.3369590251060260.14614
6rs12202209109066718TG0.9960.9750.46890.3289197672611510.14274
6rs9372190108996515TG1.010.97440.47420.3240384503578310.15801
6rs12207868109071578AG0.9940.97540.47710.3213905834410740.15205
6rs9384681108996762AG0.9660.96210.4820.316952961761150.06726
6rs9486916109120623TC0.9841.0190.48950.3102473038608430.31783
6rs17310529109064223TC0.9740.97610.49060.3092724561296330.15205
6rs11153120109081146AC0.981.0240.49410.3061851461105830.1343
6rs17598747109048086AG0.9930.97770.51870.2850837520064150.15205
6rs7746906108985506AG0.9911.0210.52590.2790968291865430.17611
6rs9480865109023266TC0.9710.98310.55420.2563334785537870.39459
6rs12203834109082255TC0.9691.020.55570.2551596032146210.15205
6rs9486902108984745TC0.9811.0170.55840.2530545903848950.39854
6rs12196996109090760AG0.990.97930.5670.2464169411070930.14026
6rs768024108982801AG0.9921.0180.59740.2237347817318910.16678
6rs9285397109058348TC0.9840.98720.65310.1850203162392430.31075
6rs3800230109104821TG10.98590.66240.1788796762231760.18838
6rs9480866109069335TC0.9981.0120.67150.1729539829952660.31075
6rs9480867109082339AG0.9951.0110.69880.1556471036891070.30646
6rs4946933109087810AG0.9821.0190.77910.1084067956510350.04075
6rs34754045109091842TC0.1021.0060.97220.01224438326147669e-05
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.