Metamoodics Gene Information

 

  Chromosome: chr12    Cytoband: p13.31    Gene: GNB3

 

MD - Genomewide Association Studies for GNB3


 

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Description

 
Shown here are the results for gene GNB3 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
12rs54456826441TC0.5880.26330.3671.35931984672233(Index SNP)
12rs107447206834474TC0.6371.0480.1430.8446639625349380.00151
12rs107447166810111AG0.7541.0290.2470.6073030467403340.00706
12rs22381146836001AC10.97580.28870.539553216119280.0111
12rs10477766818953AG0.8821.0250.28930.5386515663520170.0114
12rs23013396824885AG0.9210.97470.29030.5371529641683260.0114
12rs123029046816765TC0.3940.80950.2920.5346171485515826e-05
12rs49635186816754TC0.8261.0250.29670.5276824536831580.00415
12rs22269556835455AG0.9991.0240.30690.5130031115681770.0111
12rs54466826723TC0.9920.98090.40890.3883828894456640.00285
12rs49635176818061TC0.9131.0180.4390.3575354797578790.00817
12rs49635166818289TG11.0230.46570.3318937620672690.00089
12rs49635116813631AG0.920.97910.5230.2814983111327260.00089
12rs11296496818729TC0.980.98660.56160.2505729008782510.00322
12rs37593476817941AG0.981.0140.57260.242148656314420.00014
12rs54396819143AC0.8061.0110.7930.1007268126823960.00079
12rs10477716811282AG0.9581.0060.82120.08555105930144570
12rs54426825125AG0.7660.99460.90850.04167506835594690.00054
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.