Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: p12.1    Gene: GPR158

 

MD - Genomewide Association Studies for GPR158


 

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Description

 
Shown here are the results for gene GPR158 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
10rs710094225863759AC1.0790.02150.9843.39297412156521(Index SNP)
10rs708624925851441TC0.990.92990.00063823.195043200142510.84818
10rs1050869925861167AG0.9650.92980.00073463.133949075990730.87282
10rs193215025854301AG0.9861.0710.0018022.744245213356960.58999
10rs1074109225854533TG0.9851.0710.0018262.738499226801720.58999
10rs474752325827898AG0.9981.0680.001962.707743928643520.70506
10rs707270025828641AG0.9981.0680.0020582.686554629573590.70506
10rs388635025826153AT0.8910.93320.0022112.655411257421290.39867
10rs188792525832715TC10.93710.0024392.612788199686270.58412
10rs706874325827539TC0.9961.0660.0026592.575281662668430.70506
10rs1004726625851841TG0.9870.93810.0027822.555642874343970.52541
10rs747828525858939TG0.9810.93840.0029882.524619406856640.52541
10rs1082881025828674TC0.9921.0660.0033532.474566446571180.50742
10rs132925225831849TG0.9940.9440.0069872.155709256745660.47642
10rs82458925793355TC0.9830.94590.0091372.039196375088230.34955
10rs192836525822770TC0.9341.0590.0093552.028956208163970.35293
10rs132925525821413AG0.9660.94630.010251.989276134608230.35602
10rs298783825818879TC0.9260.94720.013421.872247484167030.29843
10rs82461025809791AG0.9810.950.016221.789949150124860.35144
10rs82460725810764CG0.9660.94990.016781.775208043507320.34917
10rs70298025802774TC10.9510.017581.754981129262250.33011
10rs1692591725795269TC0.9861.1210.022551.646853453786020.11466
10rs474905025905783AC0.9991.0520.027211.565271458220240.20072
10rs392065625818328AG0.3651.5080.030691.513003111568180.00519
10rs300519125816182AG0.9881.0470.030871.51046337051790.34819
10rs423737425907516TC0.9950.95190.032211.492009275180310.18531
10rs54590525647293AC0.9820.93830.034551.461551948289780.04299
10rs1101463125914521AG0.9960.95380.036051.443094730944550.19959
10rs1101461125896418AG0.9970.95490.036211.441171475182990.34586
10rs1755647825885760TC0.9991.0470.036651.435926021022850.35094
10rs1101462525909549TG0.9880.95330.037921.421131671333970.18958
10rs414585825877245AG0.9980.9570.046361.333856572708440.35293
10rs792275225887533TC0.9980.95930.050351.298000525110360.42445
10rs648249325887155TC11.0420.051031.292174431667770.38092
10rs648248725825194TG0.3660.71420.064031.193616498175830.01043
10rs474753025876455TC0.9980.96230.070531.15162611615540.37897
10rs141404125893527TC11.0390.074361.128660618900140.32759
10rs141404325893675TC0.9970.96290.074651.126970187938960.37116
10rs1074109425893865TC0.9980.96340.078261.106460156435340.37361
10rs133519925875731AC0.9970.96350.07991.097453220686010.37897
10rs710062925874932AT0.9951.0380.081011.091461367828040.3762
10rs133520025875638AG0.9960.96380.082131.085498177172690.37374
10rs82460025736160AG0.9910.95830.082461.083756669534660.04967
10rs1692547025558082AC0.8591.0810.082971.081078909908660.00036
10rs141405225885335TC10.96440.087141.059782444400260.37116
10rs177364925674545TC0.9770.95760.091481.038673844065290.00617
10rs1692589525787375AG0.7510.74890.094441.024844021593310.00178
10rs133405725713388AG0.9990.94770.095111.021773818325470.04989
10rs4152754725820233CG0.4920.72610.096391.015968019728820.00352
10rs1076456725934783TC0.9691.0410.098621.006035001804880.02526
10rs791482125916412AG10.9650.10490.9792245118064420.15084
10rs474753225905769CG0.9921.0360.11010.9582126810282480.17132
10rs177361525715164AG0.9920.94980.11010.9582126810282480.04989
10rs1101463225917657AG0.9880.96730.11870.9255492810454090.41751
10rs791481325916394AG10.96670.1230.9100948885606020.15084
10rs1235717425908591AG0.9940.96660.12460.9044819576768490.16183
10rs474904925904488AG0.9931.0330.12520.9023956711255890.43069
10rs423737125905867AG0.9930.96810.12780.8934691461776190.42009
10rs97636125913391AG0.9961.0340.12910.889073757733580.11669
10rs1692547825563372TG0.9430.94010.12910.889073757733583e-04
10rs141699525573542TC0.9211.0640.12930.8884014751196060.00055
10rs82460625811257AG0.9881.0340.12950.8877302315827290.11428
10rs141339625681996TC0.981.050.13010.8857227034384140.04989
10rs1101459925873413TC0.9661.0770.13240.8781120148963190.0015
10rs86686925808831TC0.9970.96750.1340.8728952016351920.12101
10rs1101447425587955AT0.9580.94010.13560.8677403104689560.00108
10rs298783725815847TG0.9921.0330.1390.8569851997459050.11866
10rs1101445225565663AT0.9460.94140.14130.8498578381514411e-05
10rs1050868925562286AG0.9631.0620.14130.8498578381514410.00108
10rs248034625799073AG0.9981.0330.14390.8419392060633950.12101
10rs95608825746238TG0.9990.95410.14440.840432806766380.04742
10rs57738225659281AC0.9871.0430.14810.8294449414787920.03284
10rs300518825819141AC0.9890.96890.1520.8181564120552270.11866
10rs1235895925573016CG0.940.94270.15250.8167301563171950.00108
10rs192836425804147AG0.9850.96880.15260.8164454663811380.10891
10rs1050869625804577AT0.991.0440.15270.8161609629435790.11241
10rs177368125746982AG0.9930.95510.15350.8138916201867950.04742
10rs790486625782287AG0.9410.96910.15520.809108283077830.06437
10rs141812725787594TG0.4960.75670.15830.8005190851376440.00519
10rs82460225739199TC0.9971.0460.15990.7961515362537650.04742
10rs278125625656479TC0.9170.94930.16290.7880789156914910.0169
10rs176071625679369TC0.9860.96720.16840.7736579128363690.00036
10rs1050869525804419TC0.9911.0430.16930.7713430418910650.11241
10rs280725525677534AG0.9890.96630.17240.7634627385113060.00358
10rs248034525741347CG0.9970.9680.17390.7597004179972870.04173
10rs279504425678187TC0.9881.0350.17530.7562180839062050.00494
10rs100194825506699AC0.9460.97020.17710.7517814388099250.03
10rs176071825679032AT0.9881.0340.1830.737548910269570.00358
10rs49533825660493AC0.9880.9690.19230.716020715761520
10rs177369125742562AG0.9990.97150.19490.7101881608823790.02253
10rs54385025670930AG0.9880.96690.21060.6765416331505320.01219
10rs1241553225787517TC0.9810.96080.21260.6724367398127220.09629
10rs82459125725370AT0.9590.96420.22560.6466609046886950.02764
10rs95608525746014CG0.9971.0340.22730.6434005642750290.02512
10rs708274525546922AG0.860.97180.23110.6362000545208910.0013
10rs1082876225494756AG0.9520.97350.23350.6317131150978690.00628
10rs1050869325733432TG0.9960.96940.23480.6293019074244230.01201
10rs1692617225929986AG0.9721.0720.2350.6289321377282640.00893
10rs177365025675566AT0.9640.96830.23570.6276404174756760.01723
10rs248035025787115TC0.91.0280.24090.6181632000016570.08425
10rs159125025714087AG11.0280.25190.5987718325018870.00466
10rs1050869725829102TG0.3530.56830.26220.5813673126459350.00519
10rs1226303725611950AG0.8661.0540.26690.5736514262124920.00363
10rs708765525889059TC0.9730.9390.26790.5720272863917910.00027
10rs1101452825733683AG0.9721.0430.26940.5696024086130330.03701
10rs790213525616498AG0.8370.94730.27350.563042669330550.00116
10rs56437125631915AG0.9620.96930.27510.5605094096103160.02113
10rs215221425868846TC0.9770.97670.28060.5519123333076590.19953
10rs792163525782110AG0.8611.0250.28180.5500590112266620.05508
10rs177368225746847TC0.9980.97180.28230.5492891218530810.016
10rs474902225747023CG0.9961.0290.28320.5479067509822690.016
10rs95608625745893AG11.0290.28420.5463759264085490.016
10rs739268725752010AG11.0290.28590.5437858446420110.016
10rs1101452525729282TG0.5371.4630.28660.5427238139386740.01043
10rs1076454825754751TC11.0290.28750.5413621509743510.016
10rs177365825766944AG11.0290.28770.5410601381096740.016
10rs1082880025755874AG10.97220.28890.5392524581558030.016
10rs91502925605063TC0.9120.95120.29280.5334289276136461e-05
10rs1101450725671365TC0.9810.97260.30030.5224446678010190.00011
10rs175428125746342AG0.9991.0280.30050.5221555236612420.016
10rs141339425614386TC0.8661.050.30050.5221555236612420.00363
10rs394931125762450AT0.9810.9730.30480.5159850373324370.02044
10rs1235472425695821TG0.9680.95030.31890.4963454807570410.00223
10rs109483025690040AG0.9611.0210.33460.4754740633736240.01712
10rs176072725718334TC11.0220.35330.4518563625651540.008
10rs51607125661336TC0.9910.97780.36060.4429742776136170.00022
10rs1276343625797101TG0.9821.030.36190.4414114168918010.1053
10rs176072825719089AG0.9860.97840.36230.4409316659654630.0078
10rs454543925783358TC0.961.030.3630.4400933749638880.0831
10rs177361625715130AC0.9981.0220.36370.4392566989452880.0087
10rs50928525665327AG0.9871.0220.36710.4352156154960130.00092
10rs1082882225883039AG0.9451.0560.3840.4156687756324690.03709
10rs1277881725680943AG0.9110.93040.39610.4021951575957074e-05
10rs82459725729236AT0.9940.98020.40160.3962062958630370.00205
10rs300519625925252TC0.9691.0340.4030.3946949538588910.06537
10rs112277625722026TC10.98150.43240.3641143147187270.00374
10rs1277701325681107AG0.9561.070.43260.3639134848969270.01075
10rs162898625711031AG0.9980.98090.43370.3628105778512380.00406
10rs998878825587124AG0.1494.9660.43690.3596179552904320.0052
10rs1082877725693023AG0.9830.98220.44860.3481407307530510.00491
10rs176076725708638TG0.9980.98160.45010.3466909870615210.00379
10rs1082882825894062TC0.9850.96360.45210.3447654929657060.0702
10rs1225447925734877CG0.9970.97010.46130.3360165453917330.02814
10rs791507425890004AG0.9850.97430.4630.3344190089820470.01271
10rs1181826125726906TC0.9960.97040.46890.3289197672611510.02818
10rs1101456625775864AG0.9891.2530.47010.3278097488117470.00178
10rs114815425694753TC0.9911.0180.47060.3273480771599980.00224
10rs791829525513934TC0.4530.760.47070.3272558016934010.01043
10rs1225186825736718AG0.9981.030.47340.3247717464069360.02814
10rs1101460325879118AG0.9470.95830.49280.3073293008436310.03223
10rs136163625757917AG11.0150.49310.3070649974688620.01486
10rs792055825833424TC0.911.0610.49460.3057458879747220.03196
10rs388635125826183TG0.6240.96660.50020.3008563126055160.05105
10rs195426125776213AG0.7941.0160.50170.2995558989722480.06493
10rs1276246225708784AG0.9960.97360.51680.2866774950129720.02818
10rs276571025551605AG0.9360.97530.52590.2790968291865430.00048
10rs474902325748507AG0.981.0160.53150.2744967311406840.01748
10rs1753622125657963TC0.9551.0330.53430.2722148258170940.03311
10rs95975125696844TC0.9920.97950.55080.2590060684151140.03278
10rs1226925625835368TC0.9161.0510.56310.2494144726589910.03169
10rs380251225930347TC0.9750.98380.56510.2478746927021020.08952
10rs280723125555073AG0.9521.0230.5670.2464169411070930
10rs280723725548767TC0.9311.0230.56890.2449640662322280.00048
10rs1101443325505333AG0.7221.0170.56910.2448114143916750.01892
10rs1159180725852381AC0.9881.0180.56990.2442013430261690.0029
10rs1277643125937098TC0.9761.0190.57290.2419211777503870.0262
10rs133405925571977TC0.9351.0220.57430.2408611837188340.01649
10rs790317125514034AC0.4041.230.57460.2406343783440710.01043
10rs1225305425776943TC0.7910.97070.58190.2351516428065890.00043
10rs161272625767661TG0.9820.98610.5910.2284125191187450.00175
10rs791125625896682TC0.9851.0190.60160.2206921724164140.01098
10rs1082877025622246TC0.9581.0130.60330.2194666746835960.00023
10rs1082881925879438AG0.9770.98020.60710.2167397671270510.00143
10rs82414625634365AT0.9930.98750.60760.2163822348092510
10rs1045032525676855AG0.9820.98780.60870.2155966982469920.00497
10rs175424825767037TC0.9951.0130.61220.2131066747386840.00236
10rs1074107525622089AC0.9561.0120.62110.2068384707544490.00023
10rs132925325831576AC0.4650.76510.62770.2022478713492890.0052
10rs177363425704262TC0.9991.010.63950.1941594511853270.01247
10rs280723825548043CG0.9551.0190.64680.1892299887656360.00075
10rs1050869125596489TC0.4161.3060.66350.1781590727995460.01043
10rs1050869425742286AG0.9940.98390.66960.1741845550147960.02991
10rs134000225664296TC0.8710.98090.67150.1729539829952660.02544
10rs1241198025521454TG0.9690.98570.68120.1667253607094370.00083
10rs177365425769610AG0.9511.0130.68770.1626009756579770.01815
10rs276571125554744TC0.951.0160.69030.1609621266116940.00075
10rs710020925897552AG0.9780.98740.72270.1410419452819940.01098
10rs1692551825595398TC0.161.7240.7260.1390633792999060.0052
10rs280725625595320AG10.99290.7370.1325325121409495e-05
10rs1101455825768499TG0.9911.010.74390.1284854412916180.00387
10rs134000025500769AG0.3770.8450.74610.1272029600104020.0052
10rs1101443125499756AG0.9880.98750.75960.119415043935020.00202
10rs278125925582917AG0.7941.0190.76190.1181020264269890.00081
10rs280724125540538TC0.9371.0120.76370.1170772093974010
10rs708630425520528TG0.9890.98780.76870.1142431189307330.00029
10rs276569725527512TC0.920.99110.79790.0980515349269166e-04
10rs707633425497906AG0.9751.0090.80560.09388054245443840.0034
10rs96102725629716AG0.971.0070.81050.09124698081546630.01084
10rs1692618725936726TC0.9691.0160.82530.0833881548906540.00576
10rs1101454525756077TC0.9941.0050.82920.08134070657817680.0077
10rs789746025916213AG0.171.2240.85060.07027462162199550.00178
10rs249119825599945TC0.9181.0040.85440.06833876031551880.00917
10rs55894725634799AG0.9990.99610.85530.06788152797087760.00015
10rs1235631525775637TC0.9410.99390.85630.06737405597821780.00093
10rs82414725639881AC0.9961.0040.86410.0634359948647340.00068
10rs280725025641039AG0.9990.99640.86510.06293368798257180.00014
10rs791770425885962AT0.9820.99320.86970.06063052992534010.01126
10rs248370225683531AG0.9950.9950.8810.05502409158795210.03159
10rs1276441525774065TC0.9881.0050.88430.05340037498486730
10rs134196325744445TC11.0030.88930.05095170768433620.00047
10rs1101459225850710TC0.9931.0060.890.05060999335508720.093
10rs1101457925826914AG0.970.99370.89160.04982994019179990.09119
10rs1082876925586424AG0.8210.99660.89830.04657860031896480.0049
10rs1277099025774418TC0.9820.99670.91510.03853144464921370
10rs709092925828439AC0.9940.99560.92340.03461012978487770.093
10rs790278325513753AG0.3540.97240.93010.03147035562516040.01043
10rs1692612325905750AG0.9971.0030.95430.02031507617297420.07568
10rs474751625617692AT0.5550.99550.96490.01551769359773720.00356
10rs1101458125831516TG0.8240.99720.96970.01336260438984618e-05
10rs1101462725911823AG0.9721.0020.97190.01237841787451620.08105
10rs1226825725904687TC0.9890.99910.97630.01041671068899480.15753
10rs1181537925902218TC0.9830.99940.98920.004715892310740320.04459
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.