Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q25.3    Gene: HABP2

 

MD - Genomewide Association Studies for HABP2


 

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Description

 
Shown here are the results for gene HABP2 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
10rs7079148115320376TC1.060.02280.9551.99225222199926(Index SNP)
10rs2240880115302596AG0.9530.93160.014851.828273546346770.05861
10rs911707115321608AC0.9830.93510.019021.72078948739860.47743
10rs3862019115318940TC0.6790.94330.030211.519849274726720.12028
10rs11575663115316093AG0.8531.0950.056811.245575210722740.00337
10rs7080536115338036AG0.8731.1210.05981.223298816011590.01276
10rs2419840115322088AC0.9720.96040.060681.216954427885310.29979
10rs3740530115324114TC0.9971.0420.067841.168514160751340.63323
10rs4918852115317808AG0.7540.95560.07111.148130399270230.01017
10rs11575661115315778CG0.9350.9210.088291.054088483180730.00413
10rs10885478115338906AG0.9490.94530.091031.040815457268810.10401
10rs11575750115325690AG0.170.15340.093391.029699624597820.00592
10rs1535426115325413TG0.971.0370.095051.022047878798540.31446
10rs11575631115309651TC0.9841.0510.10690.9710222947912220.00722
10rs2419836115316403TC0.7670.96290.11810.9277501023864850.00896
10rs11575634115311814TC0.9831.0490.12370.9076303003708790.00722
10rs11196389115341995AG0.9511.0520.12430.9055288713583550.11
10rs2240877115333576TC0.9260.950.13240.8781120148963190.10401
10rs11575624115307252TC0.9621.0490.13390.8732194229879910.00422
10rs11575625115307701AG0.9811.0480.14250.8461851356554710.0047
10rs1535427115323741AT0.9871.0360.16420.7846268472165780.26368
10rs11575685115329964TC0.6851.0650.17220.7639668528823640.01614
10rs3850691115319336AG0.9631.0370.1780.7495799976911060.48216
10rs7923349115326357TG0.980.96720.18770.7265357273786540.28284
10rs4918859115343691AG0.9670.96660.19360.7130946470276250.17004
10rs2286744115328295TC0.9680.96790.20110.6965879294032580.28284
10rs3850690115316183AG0.8381.0690.23140.6356366453842690.00465
10rs1885434115340587AG0.9950.97480.25370.5956795327782690.06533
10rs2419837115317389AG0.6651.0370.26260.580705278246540.05453
10rs932650115337349TC0.9941.0240.28190.5499049241283980.04654
10rs17770901115292906AG0.9530.9580.29260.5337256782107080.00093
10rs11575670115318850TC0.6090.97260.30380.5174122304732320.07449
10rs7096084115321655AG0.9670.95810.33110.4800408192479320.0421
10rs11196383115324626TC0.9681.0440.33130.479778564118040.0421
10rs2286743115330263TC0.150.28750.35780.4463596637686460.00591
10rs11575725115320276AC0.8111.1130.35810.4459956789880970.01209
10rs2286742115330482AG0.9371.020.36350.4394955848049430.20291
10rs10509981115306715AC1.011.020.36450.4383024673460070.02713
10rs10885477115322403TC0.9631.0390.3790.4213607900319280.04393
10rs3850688115315857TC0.8451.0180.44060.3559555071852510.01158
10rs10885476115320711AG0.9350.97740.44520.3514448443373290.27614
10rs3781386115308011CG1.010.98490.4690.3288271572849170.03974
10rs10885479115341095TC0.9880.98230.47250.3255981871547180.0134
10rs7088038115314489AG1.010.98610.50780.2943073034622970.01699
10rs11575674115319876AG0.910.95260.51790.2857540889821060.10572
10rs12241995115347068AG0.9891.0160.5340.2724587429714440.0134
10rs2240878115303333AC0.9990.98630.54050.2672043017106710.03597
10rs885567115347169TC0.991.0150.54220.2658404867555330.0134
10rs7094824115311119TC1.011.0130.55940.2522775379644920.04956
10rs2000278115300088AC0.9970.98740.57480.2404832405378120.03597
10rs4918839115298740TC0.9281.0550.62070.2071182546146030.00592
10rs7093962115310488TC0.9191.0490.65820.1816421220416450.00592
10rs3781378115335840TC0.9411.0130.67670.1696038235165310.01607
10rs10787490115309978AG0.980.99240.74380.1285438259770460.00436
10rs911704115333690AG0.9610.99070.74620.127144755295190.02116
10rs3781375115337878AC0.7760.9640.74920.12540223129680.00591
10rs3758589115301037AC0.9591.0260.75030.1247650535498350.01763
10rs3758591115300542TC0.9741.0070.7520.1237821594083580.00019
10rs12252542115345185AG0.7041.0330.75910.1197010085742470.01187
10rs3781383115309479AT0.981.0070.77130.1127766686374770.00436
10rs3758590115300553AG0.9750.99340.77860.1086856006178570.00019
10rs2419842115336989CG0.9510.99430.7960.0990869322623310.00347
10rs11575668115317074AG0.8980.99050.80590.09371884422784690.00631
10rs1853204115298446AG0.9930.99520.84290.07422394616325370.00347
10rs11196379115314348AG0.9990.99510.84440.07345177536438120.01099
10rs2302373115333277TC0.9790.9960.85520.06793230779927840.00284
10rs1885437115327383AG0.9651.0040.85710.06696850489759460.00561
10rs2302374115326748AC0.9551.0050.85810.06646209802829530.10727
10rs4918851115315435AC0.9971.0040.86960.06068046892176190.01099
10rs10787493115340919AC0.9710.99630.88560.05276239212933360
10rs1157915115293502AG0.9921.0030.89870.04638525830935950.00347
10rs4387289115301876AG0.9480.98740.90470.04349540968330250.00592
10rs7071251115327331TC0.9531.0030.91360.03924390909822720.10727
10rs4918842115306802TC11.0030.93110.03100367335168771e-04
10rs11196391115345318AG0.9860.99690.9320.03058408764601860.05231
10rs932652115334779TG0.9711.0020.93470.02932775731028060.04258
10rs2245056115331743AG0.9521.0020.93930.02719567766342230.05049
10rs3862016115312912TC10.99850.94370.02516604495145990.01049
10rs10749134115316776AG0.8190.99820.9470.02365002099672660.02107
10rs10509980115304488AC11.0010.9580.01863449092145560.02827
10rs4545483115312143AC1.021.0010.97660.01028328005189530.04754
10rs3781387115307642AG0.9971.0010.98830.005111204635089372e-05
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.