Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q23.31    Gene: HTR7

 

MD - Genomewide Association Studies for HTR7


 

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Description

 
Shown here are the results for gene HTR7 from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
10rs658373592577480AC0.91530.021114.54852059487514(Index SNP)
10rs1088183292538743TC0.9930.91850.000061184.213390527351341
10rs493319492501347TC0.9881.0860.00010293.987584625237570.95167
10rs658373692583160AG0.9830.92140.00012323.909389292171590.96402
10rs791684892503857AT10.92330.00015433.811634073936850.98788
10rs790038692504010AC10.9240.00017863.748118545447470.98788
10rs1118630092504719AC1.011.0820.00020053.69788562304380.98788
10rs790357292508223TC11.0810.00020813.681727919788370.98788
10rs791640392549888TG0.9990.9240.00021613.665345233116760.63706
10rs708648492523709AG0.9890.93040.0029352.532391894416370.25116
10rs1118632092566428TC0.9981.0710.0034092.467372998771110.36071
10rs1078597392588151AC0.8931.0730.0036422.43866005854110.48752
10rs1088183892580213AG0.9991.0680.0048812.311491192343480.36071
10rs1159747192588747CG0.9981.0650.0071482.145815456166390.36071
10rs1159990292588803TC11.0640.0078792.103528899520720.36071
10rs1276685192552811TC0.9890.93350.0080552.093934455244760.19364
10rs1118630992551537TC0.9881.0710.0081142.090764996631690.19364
10rs193535192555705TC0.9890.93410.0085642.06732334137760.19364
10rs1278370392550393AG0.991.070.0087282.059085262419710.19364
10rs707252692519250TC0.9951.0670.01461.835647144215560.18976
10rs791216492509934TC0.9961.0670.015321.814741234703410.18591
10rs1181270892495245TC0.9961.0650.018141.741362717275920.18591
10rs1181736492488006AG0.9950.93930.019131.71828502997270.18591
10rs1226101192570787AG0.9821.0670.023131.635824367229380.19364
10rs1224937792582936AC0.9840.93970.030541.51513096727960.19364
10rs1226416092590065AG0.9830.94120.035531.449404792510670.19364
10rs1118633892604382AG0.990.9420.040331.394371777992380.18591
10rs110768892485316TC0.9880.93980.04441.352617029885380.14118
10rs222611692590219TG0.8941.0630.045791.33922935647230.18968
10rs141821392491630AG0.9740.94090.049891.301986496060820.14862
10rs792062792534625TC0.9861.10.054531.263364502313180.03783
10rs242020392497843TC0.9861.0610.057431.240861183718830.15973
10rs1050960892494034AG0.9871.0590.061971.207818503850320.15973
10rs1752669792490499AG0.8191.0690.08351.07831352451640.1218
10rs708412592614949TG0.9891.0580.083921.07613452481450.11113
10rs1088183092503229TG0.991.070.11240.9492336887669580.04066
10rs707471592599286AG0.9920.9520.13370.8738685927380160.10783
10rs708953392595344TC0.9960.95550.16560.7809396675511390.10783
10rs1159699192588438TC0.9870.95320.29120.5358086293590.04927
10rs1118629892501484CG0.9980.95730.29240.5340226317141770.10783
10rs1088182992501801AC0.9880.95710.29330.5326879370194480.1026
10rs374004692491448TC0.9880.97590.38350.4162346317150.21348
10rs1118633392595099AG10.96470.38690.4124012702787550.10783
10rs189131192608596AG0.9971.0340.43920.3573376685579650.10456
10rs290112792585046TC10.97020.46410.333388431580970.10783
10rs1159992192523921TC0.971.0180.50630.2955920726131590.20351
10rs1159651892544991AG0.9641.0140.60240.2201150368073560.20351
10rs1277518192554437CG0.9781.010.85260.06925467168888660.03213
10rs792382092517801TG0.1831.0890.87370.05863766428823890.00264
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.