Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT1H

 

MD - Genomewide Association Studies for MT1H


 

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Description

 
Shown here are the results for gene MT1H from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
16rs1270896355253165CG1.0960.03780.9141.80966830182971(Index SNP)
16rs719489555254592TG0.950.95730.053771.269459963522880.04861
16rs1270896255251876AG0.9760.95880.059691.224098421108330.04704
16rs1164779655254052AG0.9471.0430.062121.206768552943480.04704
16rs158747855255239TC0.8740.96410.10640.9730583720409710.06611
16rs201118655263370TC0.8580.97860.35090.4548166317845940.03381
16rs206254555261626AG0.7220.96170.49020.3096266930839411e-04
16rs453172955272021TC0.9250.98520.50230.2990368218404510.10123
16rs158747955255299TG0.8911.0140.55580.2550814575586470.06321
16rs1244865455259328TC0.80.98060.55850.2529768225483720.00067
16rs478470655255082AG0.841.0140.65410.1843558508680350.00458
16rs478470855261415CG0.7881.0240.65590.1831623690979650.00246
16rs187523055257002AC0.5850.98890.71870.1434523551432520.00981
16rs1107616255251731TC0.8230.97250.7420.1295960947209730.00259
16rs1164094955253316AG0.7631.0290.74310.1289527386945010.00258
16rs1244798655253047TC0.7650.98630.86930.06083032037482260.00258
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.