Metamoodics Gene Information

 

  Chromosome: chr16    Cytoband: q13    Gene: MT2A

 

MD - Genomewide Association Studies for MT2A


 

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Description

 
Shown here are the results for gene MT2A from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
16rs90477355209102AC1.0550.03050.751.09296504751658(Index SNP)
16rs216173755196735AG0.9680.96050.15520.809108283077830.72434
16rs181132255197206AT0.9630.96070.15840.8002448227465250.72489
16rs100876655197301CG0.8441.0290.21690.6637404479858070.30053
16rs992618455192479AG0.8771.0180.49470.3056580896358190.01952
16rs3539548955199450AG0.2981.1090.58320.2341824846900820.03287
16rs805210655192602AG0.9511.0110.6450.1904402853647320.0404
16rs1164205555201766AG0.6361.0150.67530.1705032502798180.04983
16rs478469555193253TG0.80.99440.88250.05428528594013980.06097
16rs805572455207138TC0.7570.99520.8880.0515870342213990.04356
16rs1293416655207975TG0.7890.99590.91220.03990993209508050.01335
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.