Metamoodics Gene Information

 

  Chromosome: chr7    Cytoband: p15.3    Gene: NPY

 

MD - Genomewide Association Studies for NPY


 

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Description

 
Shown here are the results for gene NPY from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
7rs1614824288863TC1.0360.02260.990.911509529817604(Index SNP)
7rs107331724287626AG0.981.0820.17960.7456936676687140.10144
7rs302511824294202TG0.990.92830.20390.690582774221860.10144
7rs695111024296716CG0.9851.0590.26390.578560609779950.01393
7rs390549724288093CG0.9810.97750.3460.4609239012072230.72755
7rs1614924288850AG0.9960.97880.37540.4255057317146720.72755
7rs1613824292020CG0.990.97890.37680.423889105879160.72755
7rs471976324305266TC0.9571.0210.3780.4225082001627750.81406
7rs1612324298660AG0.9851.0550.38760.4116162316212720.05361
7rs1647524298011AG0.9620.96580.40.3979400086720380.10182
7rs646178924299358CG0.9791.0170.47380.3244049436132540.68059
7rs1270052424287939AG0.9870.98040.50820.2939653392856490.09352
7rs1270052524304910AG0.960.98450.58930.2296635589048510.01663
7rs1610624306626TC0.9890.98530.60470.2184600313940580.04319
7rs1737404724302052AG0.9680.98640.63420.197773762308930.37062
7rs557424295658TC0.9871.0090.67240.1723722952325670.38512
7rs1613524294445AG0.9881.0150.71560.1453296681046650.00252
7rs218949524298339AG0.9810.99560.83820.07665234350217450.28206
7rs1612924297290AC0.9870.99590.84530.07298913102434890.28724
7rs1614724289935TC0.9860.99680.87940.05581353871631260.28683
7rs1612424298324TG0.9810.99710.89030.05046362662385740.28206
7rs1647224300594AG0.9871.0010.97470.01112903393535480.02348
7rs1610924305894TG0.9710.99920.97570.01068369501004860.49339
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.