Metamoodics Gene Information

 

  Chromosome: chr9    Cytoband: p13.2-p13.1    Gene: SHB

 

MD - Genomewide Association Studies for SHB


 

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Description

 
Shown here are the results for gene SHB from a mega-analysis of major depression carried out by the Psychiatric GWAS Consortium (PGC) of 9 GWAS studies. The total sample included 9,240 MDD cases and 9,519 controls all of European ancestry with data on ~1.2M genotyped and/or imputed SNPs.

 

Details of the methods for the mega-analysis are provided here.

 

 

Results Figure

 
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Figure Legend: A regional plot of association findings around the selected gene (+/-10Kb upstream and downstream of the union of the selected gene’s Refseq transcripts). The X-axis shows the position along the gene, the left Y-axis shows the -log10(p-value) and the right Y-axis shows the recombination rate estimated from HapMap data. Each point represents a SNP. The index SNP with the best p-value is depicted by a diamond, and the linkage disequilibrium of neighboring SNPs with the index SNP is color coded.

 

 

Results Table

 
CHR Marker pos_bp (hg18) A1 A2 INFO OR SE -LOG(10)P RSQUARE
9rs1097364338016801TC1.2220.0740.8482.17444406770964(Index SNP)
9rs224389337979893AG0.9560.94510.009262.033389013318070.04326
9rs487873438000085AT0.9971.0560.0097042.013049212141480.0465
9rs224376237981170TC0.9931.0560.0097342.011708658092510.0465
9rs702802037997747AG0.9971.0550.010841.964970717797630.0465
9rs224378237980693TC11.0550.010881.963371104637840.04484
9rs487873037988754AG0.9991.0550.011131.953504835665290.04484
9rs192823237979697AG11.0550.011221.950007143079860.04484
9rs487873338000025TC0.9950.94810.011991.921180816901150.04484
9rs1743950938006419AC0.970.91340.012681.896880746454291e-05
9rs374754737906408TC0.9740.91440.012951.887730231582730.00015
9rs218312838004322TC0.9941.0540.013281.8768019249680.04433
9rs704806337947229AG0.9970.94930.014281.845271792559840.04484
9rs1081463437954848AG10.95010.015351.813891620186790.0465
9rs702722737919809CG0.9731.0860.01611.793174123968150.00068
9rs1011434837950693AC11.0520.01621.790484985457370.04484
9rs113837437964743TC10.95090.017591.754734160542540.04433
9rs77602237924780TC0.9981.0560.017851.748361779551790.02155
9rs224473137972916TC11.0510.018251.738737131207510.04484
9rs380241437964481TG11.0510.01841.735182176990460.04484
9rs1073349137946724TC0.9981.0510.01911.718966632752270.04487
9rs786213037956970AG11.0510.019951.700057099977230.04484
9rs386100337942631AG10.95240.021011.677573947594050.04484
9rs73574137934489AG1.010.95250.021111.675511766692340.0417
9rs1178944137983303TG0.9781.0870.021811.66134433442131e-05
9rs1751677937945265TC0.9661.0850.024731.60677588363877e-05
9rs210324137940936TC0.9691.0840.024821.605198222837292e-05
9rs1329845137977297AG0.9541.0760.025861.587371479455620.28059
9rs382751837938432AG0.9891.0820.0261.585026652029180.00018
9rs702701437933571TC0.9750.92690.026851.571055709964430.00068
9rs786451237939638AG0.9711.0750.03461.460923901207220.00068
9rs209141537941176TC0.9770.93370.045821.338944915146627e-05
9rs1179010638037710AG0.9631.0710.053461.271971045579480.00046
9rs376167237898658AG0.9731.0370.087081.060081579630940.04272
9rs238177538014812AG0.9930.96150.089291.049197177035340.0201
9rs289078438014523AG0.9991.0390.095981.01781925440360.01982
9rs73574037934427AG0.9851.0560.098941.004628093971840.00158
9rs94393638017644TC0.9610.95760.12220.9129287940934650.00854
9rs1234588537993567TC0.9640.96090.12670.8972233851165590.00692
9rs1097363537986724TG11.0440.14180.8483237691529520.22644
9rs1081464538017524TG0.9741.0470.14970.8247781996569480.27353
9rs214954737980801AG11.0280.19950.7000570999772330.07294
9rs704705138010944AC10.96720.2070.6840296545430820.00163
9rs77601537932152AC0.9870.97350.21110.6755117666923440.06992
9rs192824438048665AG0.9961.0380.21130.6751005029476870.23155
9rs1200232337926503TC0.191.6260.21830.6609462642908610.06861
9rs192825138064715TC0.881.0920.2250.6478174818886380.00054
9rs238177437994509TC0.9141.0420.23360.6315271615596380.00442
9rs77601937929673TG10.97490.23520.6285626825958990.07266
9rs110577337969220AG11.0260.24110.6178027896225460.07294
9rs1097364638022374TC0.9921.0240.27670.5579908408590480.07517
9rs94393737973657TC11.0240.27720.5572067740602310.07266
9rs1075846938020982AC0.9850.97820.3110.5072396109731630.072
9rs787310238031142TG0.9861.0220.31370.5034854813022550.06992
9rs487817838027086TC0.9870.9790.32830.483729117270660.0736
9rs1046508537974109AG0.4790.84160.33820.4708263967382770.00068
9rs1235038838030114AC0.8270.92730.38680.4125135345890360.00013
9rs703056038038996CG0.9320.92320.41180.3853136577179870.00083
9rs785031138050968TC0.9761.0180.41340.3836295277087310.06903
9rs702530338030095TC0.9840.98360.44640.3502758140704780.07266
9rs1200117138067046TC0.8840.92920.53830.2689756201843120.00041
9rs1200022637910230AG0.9640.97370.78080.1074601953413650.00041
9rs1200026337917418AG0.9530.97740.8180.0872466963286770.00041
9rs146507137916448TG0.9511.0210.83530.07815751859414210.00041
9rs228178437909743TC0.9490.97980.83940.07603103512452870.00041
9rs77602137926464AC10.99560.85470.06818629604086070.01212
9rs77601837930439TC11.0040.85880.06610796423578890.01214
9rs1097360737901531TC1.010.99530.86680.06208109735221960.00735
9rs487874338048424TC0.9731.0040.87040.06028111764589530.01326
9rs1097360837902608CG1.010.99570.87920.05591232058456580.00752
9rs77602337924140TC0.9690.99730.89860.04643358574299340.04948
9rs487873738010544TG0.9861.0020.92720.03282657704446040.01214
9rs192824338025665AC0.9840.99860.95560.01972385892215970.01224
9rs289078338014458AG0.9870.99870.95670.01922422603737840.01214
9rs703175537913844TC0.9481.0030.97820.009572341514736470.00041
9rs108286537922314TC110.99450.002395212539545620.01224
Table Legend: Table of association results for SNPs across the selected gene (+10Kb upstream and downstream of the
union of the selected gene’s Refseq transcripts).

 

 

References

 

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3. PubMed PMID: 22472876.