Metamoodics Gene Information

 

  Chromosome: chr10    Cytoband: q21.2    Gene: ANK3

 

MD - Genomewide Linkage Studies for ANK3


 

View in Genome Browser

Description

 
Shown here are the results for gene ANK3 from a genomewide linkage analysis of major depression carried out with 656 families and including 1,494 informative all possible affected relative pairs genotyped at 418 microsatellite markers (Holmans et al. 2007; American Journal of Psychiatry)
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
Download:
Figure Legend: Graphical display of linkage analysis results for 2 different analytic models across the chromosome.
The yellow line marks the location of the selected gene on the chromosome, and the white window
shows 20 Mb around the gene.

Linear: Linear model with Spairs scoring function and equal weighting for all families
Exponential: Exponential model with Spairs scoring function and equal weighting for all families

 

 

 

 

Results Table

 

 


Marker chr:pos_bp (hg18) pos_cM Gene(s) dhat LOD (lin) NPL (lin) Zlr (lin) LOD (exp) NPL (exp) Zlr (exp)      
D10S1435Achr10:22332190   0.04960.18770.68080.92980.17110.68080.8876
D10S1435Bchr10:22332190.01   0.04960.18770.68080.92970.17110.68080.8875
D10S189Achr10:676187914.21   0.04590.19150.75070.93910.17310.75070.8929
D10S189Bchr10:676187914.22   0.04590.19150.75090.93920.17320.75090.893
D10S1412Achr10:930378719.99   0.04030.17150.76470.88870.16080.76470.8604
D10S1412Bchr10:930378720   0.04030.17150.76490.88870.16080.76490.8605
D10S2325Achr10:1283295125.5   0.04090.18370.80570.91970.17480.80570.8972
D10S2325Bchr10:1283295125.51   0.04090.18360.80540.91950.17470.80540.897
D10S1423Achr10:1947769938.69   0.01580.02440.27640.3350.02330.27640.3279
D10S1423Bchr10:1947769938.7   0.01580.02440.27630.33490.02330.27630.3278
D10S1426Achr10:3053565952.09   0.030.09160.54790.64940.08760.54790.6351
D10S1426Bchr10:3053565952.1   0.030.09170.54840.650.08780.54840.6357
D10S1208Achr10:3529763756.15   0.03880.15690.7270.850.15460.7270.8437
D10S1208Bchr10:3529763756.16   0.03880.1570.72730.85030.15470.72730.844
D10S1221Achr10:5719989169.36   -0.02470.0681-0.4917-0.56010.0689-0.4917-0.5633
D10S1221Bchr10:5719989169.37   -0.02470.0683-0.4924-0.56080.0691-0.4924-0.564
- chr10:61458164                
D10S1225Achr10:6442500475.04   -0.04890.2587-0.9406-1.09150.2484-0.9406-1.0696
D10S1225Bchr10:6442500475.05   -0.0490.2591-0.9413-1.09230.2488-0.9413-1.0704
C10S1218Achr10:6975176582.23   -0.07190.539-1.3283-1.57540.4945-1.3283-1.509
C10S1218Bchr10:6975918482.24   -0.07190.5389-1.3281-1.57540.4944-1.3281-1.5089
D10S1432Achr10:7432921888.4   -0.02990.0849-0.5071-0.62540.0762-0.5071-0.5925
D10S1432Bchr10:7432921888.41   -0.02980.0847-0.5064-0.62460.076-0.5064-0.5916
D10S2327Achr10:8038201493.29   -0.00910.0078-0.1542-0.19010.0073-0.1542-0.1833
D10S2327Bchr10:8038201493.3   -0.00910.0078-0.1535-0.18920.0072-0.1535-0.1824
D10S2470Achr10:92354575105.17   -0.00980.0098-0.1785-0.21250.0091-0.1785-0.2051
D10S2470Bchr10:92354575105.18   -0.00990.0099-0.1792-0.21340.0092-0.1792-0.2059
D10S677Achr10:95954299109.53   -0.00210.0004-0.0367-0.04420.0004-0.0367-0.0438
D10S1239Achr10:103186224116.24   0.02420.06230.46250.53580.06480.46250.5461
D10S1239Bchr10:103186224116.25   0.02420.06240.46270.5360.06480.46270.5463
D10S1237Achr10:116109968128.56   0.02190.05120.41940.48540.05280.41940.4932
D10S1237Bchr10:116109968128.57   0.02190.05120.41960.48560.05290.41960.4933
D10S1230Achr10:122732623139.04   0.02770.05640.36630.50950.05060.36630.4827
D10S1656Achr10:126091764145.8   0.02740.06520.42790.54810.05740.42790.5142
D10S1656Bchr10:126091764145.81   0.02730.06510.42760.54770.05730.42760.5138
D10S217Achr10:129430167154.28   0.05440.28530.9451.14620.26490.9451.1046
D10S217Bchr10:129430167154.29   0.05440.28550.94541.14660.26510.94541.105
D10S1248Bchr10:130982363163.62   0.07170.42051.06151.39160.40351.06151.3632
D10S212Achr10:134299489171.62   0.10110.75091.34241.85960.68261.34241.773
D10S212Bchr10:134299489171.63   0.10120.7511.34241.85970.68261.34241.773
Table Legend: Tabular display of linkage analysis results for linear and exponential models with the Spairs scoring
function across the chromosome. The yellow row marks the location of the selected gene, and the whitened
rows correspond to the region 20 Mb around the gene.

 

 

 

References