Shown here are the results for gene CACNA1C from a genomewide linkage analysis of major depression carried out with 656 families and including 1,494 informative all possible affected relative pairs genotyped at 418 microsatellite markers (Holmans et al. 2007; American Journal of Psychiatry)
Details of the methods for the linkage analysis are provided in methods section.
Figure Legend: Graphical display of linkage analysis results for 2 different analytic models across the chromosome.
The yellow line marks the location of the selected gene on the chromosome, and the white window shows 20 Mb around the gene.
Linear: Linear model with Spairs scoring function and equal weighting for all families Exponential: Exponential model with Spairs scoring function and equal weighting for all families
Table Legend: Tabular display of linkage analysis results for linear and exponential models with the Spairs scoring
function across the chromosome. The yellow row marks the location of the selected gene, and the whitened
rows correspond to the region 20 Mb around the gene.