Metamoodics Gene Information

 

  Chromosome: chr22    Cytoband: q11.21    Gene: COMT

 

MD - Genomewide Linkage Studies for COMT


 

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Description

 
Shown here are the results for gene COMT from a genomewide linkage analysis of major depression carried out with 656 families and including 1,494 informative all possible affected relative pairs genotyped at 418 microsatellite markers (Holmans et al. 2007; American Journal of Psychiatry)
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 2 different analytic models across the chromosome.
The yellow line marks the location of the selected gene on the chromosome, and the white window
shows 20 Mb around the gene.

Linear: Linear model with Spairs scoring function and equal weighting for all families
Exponential: Exponential model with Spairs scoring function and equal weighting for all families

 

 

 

 

Results Table

 

 


Marker chr:pos_bp (hg18) pos_cM Gene(s) dhat LOD (lin) NPL (lin) Zlr (lin) LOD (exp) NPL (exp) Zlr (exp)      
D22S420Achr22:162392800   0.04150.14040.60690.8040.13880.60690.7995
D22S420Bchr22:162396440.01   0.04150.14030.60670.80380.13870.60670.7993
- chr22:18309308                
D22S345Achr22:2281858615.84   0.03060.07860.4610.60150.07480.4610.5869
D22S345Bchr22:2281871815.85   0.03050.07840.46070.6010.07470.46070.5864
D22S689Achr22:2718633929.96   -0.01910.0418-0.3909-0.4390.0441-0.3909-0.4506
D22S689Bchr22:2718683329.97   -0.01910.0418-0.3907-0.43870.044-0.3907-0.4503
D22S685Achr22:3292547835.83   -0.01610.0312-0.3461-0.37890.0314-0.3461-0.3806
D22S685Bchr22:3292578735.84   -0.01610.0312-0.3462-0.3790.0315-0.3462-0.3807
D22S683Achr22:3484363637.67   -0.02210.0589-0.4753-0.52080.0603-0.4753-0.5271
D22S692Bchr22:3545549039.31   -0.02740.0881-0.574-0.6370.0899-0.574-0.6435
D22S445Achr22:3589584342.26   -0.02530.0699-0.4926-0.56750.0715-0.4926-0.5737
D22S445Bchr22:3589619042.27   -0.02530.0699-0.4922-0.56720.0714-0.4922-0.5733
D22S1169Bchr22:4778805965.86   0.01230.00880.12830.20160.00870.12830.1996
Table Legend: Tabular display of linkage analysis results for linear and exponential models with the Spairs scoring
function across the chromosome. The yellow row marks the location of the selected gene, and the whitened
rows correspond to the region 20 Mb around the gene.

 

 

 

References