Metamoodics Gene Information

 

  Chromosome: chr12    Cytoband: p13.31    Gene: GNB3

 

MD - Genomewide Linkage Studies for GNB3


 

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Description

 
Shown here are the results for gene GNB3 from a genomewide linkage analysis of major depression carried out with 656 families and including 1,494 informative all possible affected relative pairs genotyped at 418 microsatellite markers (Holmans et al. 2007; American Journal of Psychiatry)
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 2 different analytic models across the chromosome.
The yellow line marks the location of the selected gene on the chromosome, and the white window
shows 20 Mb around the gene.

Linear: Linear model with Spairs scoring function and equal weighting for all families
Exponential: Exponential model with Spairs scoring function and equal weighting for all families

 

 

 

 

Results Table

 

 


Marker chr:pos_bp (hg18) pos_cM Gene(s) dhat LOD (lin) NPL (lin) Zlr (lin) LOD (exp) NPL (exp) Zlr (exp)      
D12S372Achr12:34573930   -0.03770.1183-0.56-0.73810.1129-0.56-0.7209
D12S372Bchr12:34579810.01   -0.03770.1183-0.5601-0.73820.1129-0.5601-0.7209
- chr12:6819635                
C12S4912Achr12:878609912   0.00250.00070.04890.05660.00070.04890.0551
C12S4912Bchr12:879054312.01   0.00250.00070.04880.05650.00070.04880.055
D12S391Achr12:1234114020   -0.04010.1882-0.8308-0.93090.1822-0.8308-0.9161
D12S391Bchr12:1234149320.01   -0.04010.1882-0.8308-0.9310.1822-0.8308-0.9161
D12S373Achr12:1690619427.41   -0.04270.1767-0.7364-0.9020.1726-0.7364-0.8916
D12S373Bchr12:1690647827.42   -0.04270.1767-0.7366-0.90220.1727-0.7366-0.8918
D12S1042Achr12:2753859942.75   0.01190.0140.21150.25390.01360.21150.2499
D12S1042Bchr12:2753886242.76   0.01190.0140.21150.25390.01360.21150.2499
C12S916Achr12:3870338750.57   0.01550.02350.27260.32930.02170.27260.3163
C12S916Bchr12:3871768250.58   0.01550.02360.2730.32980.02180.2730.3167
D12S398Achr12:5148326559.51   0.03030.08610.51110.62970.08440.51110.6233
D12S398Bchr12:5148363559.52   0.03030.08610.51120.62990.08440.51120.6235
D12S1294Achr12:6622033274.14   0.02580.0780.54230.59950.0750.54230.5878
D12S1294Bchr12:6622065274.15   0.02580.07790.54190.59890.07490.54190.5872
D12S375Achr12:6723098576.46   0.04660.25941.00291.0930.26031.00291.0948
D12S375Bchr12:6723131876.47   0.04670.26051.0051.09520.26141.0051.0971
D12S1052Achr12:7389561079.83   0.05220.30741.06161.18980.30991.06161.1947
D12S1052Bchr12:7389590279.84   0.05220.30741.06161.18990.311.06161.1948
D12S1064Achr12:8934739892.45   0.06520.46131.27931.45760.47071.27931.4724
D12S1064Bchr12:8934768292.46   0.06520.46131.27941.45760.47071.27941.4723
D12S1300Achr12:97025041101.91   0.03330.10990.59320.71140.10540.59320.6969
D12S1300Bchr12:97025365101.92   0.03330.110.59350.71170.10550.59350.6972
PAHAchr12:101686386107.12   0.04010.16680.74730.87630.16560.74730.8734
PAHBchr12:101695350107.13   0.04010.16680.74740.87650.16570.74740.8735
D12S2070Achr12:114566940121.49   0.02620.07280.49930.57890.07840.49930.601
D12S2070Bchr12:114567214121.5   0.02620.07270.4990.57850.07830.4990.6005
D12S395Achr12:118672842132.26   -0.00930.0085-0.164-0.19810.0083-0.164-0.1959
D12S395Bchr12:118673186132.27   -0.00930.0086-0.1649-0.19920.0084-0.1649-0.1969
D12S2078Achr12:126527092144.7   -0.06230.4159-1.1792-1.3840.4293-1.1792-1.4061
D12S2078Bchr12:126527408144.71   -0.06230.4164-1.18-1.38480.4298-1.18-1.4069
D12S1045Achr12:128963423155.06   -0.07380.6373-1.5204-1.71320.6486-1.5204-1.7283
D12S1045Bchr12:128963784155.07   -0.07380.6379-1.5213-1.7140.6492-1.5213-1.7291
D12S392Achr12:129793217159.77   -0.07910.8056-1.7033-1.92610.838-1.7033-1.9645
D12S392Bchr12:129793557159.78   -0.07910.8049-1.7025-1.92520.8373-1.7025-1.9637
Table Legend: Tabular display of linkage analysis results for linear and exponential models with the Spairs scoring
function across the chromosome. The yellow row marks the location of the selected gene, and the whitened
rows correspond to the region 20 Mb around the gene.

 

 

 

References