Metamoodics Gene Information

 

  Chromosome: chr7    Cytoband: p15.3    Gene: NPY

 

MD - Genomewide Linkage Studies for NPY


 

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Description

 
Shown here are the results for gene NPY from a genomewide linkage analysis of major depression carried out with 656 families and including 1,494 informative all possible affected relative pairs genotyped at 418 microsatellite markers (Holmans et al. 2007; American Journal of Psychiatry)
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 2 different analytic models across the chromosome.
The yellow line marks the location of the selected gene on the chromosome, and the white window
shows 20 Mb around the gene.

Linear: Linear model with Spairs scoring function and equal weighting for all families
Exponential: Exponential model with Spairs scoring function and equal weighting for all families

 

 

 

 

Results Table

 

 


Marker chr:pos_bp (hg18) pos_cM Gene(s) dhat LOD (lin) NPL (lin) Zlr (lin) LOD (exp) NPL (exp) Zlr (exp)      
D7S2477Bchr7:2572550   0.10640.6551.11011.73680.59521.11011.6555
D7S3056Achr7:44595178.69   0.07110.36160.91451.29040.32770.91451.2284
D7S3056Bchr7:44598138.7   0.0710.36110.91411.28960.32730.91411.2278
D7S513Achr7:1161776122.62   -0.00790.0068-0.1534-0.17660.0069-0.1534-0.1781
D7S513Bchr7:1161813922.63   -0.00790.0068-0.154-0.17730.0069-0.154-0.1787
D7S3051Achr7:1849691832.34   -0.06190.4966-1.4076-1.51230.5502-1.4076-1.5918
D7S3051Bchr7:1850400232.35   -0.06190.497-1.4084-1.51290.5507-1.4084-1.5925
D7S1802Achr7:2067177435.41   -0.05740.4246-1.3018-1.39840.4699-1.3018-1.4711
D7S1802Bchr7:2067209435.42   -0.05730.4236-1.3002-1.39670.4688-1.3002-1.4693
- chr7:24290333                
D7S1808Achr7:2800402744.28   -0.0150.0262-0.3113-0.34730.0274-0.3113-0.355
D7S1808Bchr7:2800436044.29   -0.0150.0262-0.3114-0.34740.0274-0.3114-0.3551
D7S817Achr7:3210284452.16   -0.00640.0047-0.1321-0.14720.005-0.1321-0.1516
D7S817Bchr7:3210316852.17   -0.00640.0047-0.1322-0.14730.005-0.1322-0.1517
D7S2846Achr7:3810125959.12   -0.01610.0287-0.3174-0.36330.0302-0.3174-0.3732
D7S2846Bchr7:3810156959.13   -0.01610.0287-0.3177-0.36370.0303-0.3177-0.3735
D7S1818Achr7:4935935070.71   -0.03950.1689-0.7604-0.8820.1768-0.7604-0.9022
D7S1818Bchr7:4935963370.72   -0.03950.1689-0.7604-0.88180.1767-0.7604-0.902
D7S3046Achr7:6819009179.97   -0.02710.0856-0.5632-0.62780.0872-0.5632-0.6336
D7S3046Bchr7:6819066779.98   -0.02710.0855-0.5631-0.62760.0871-0.5631-0.6334
D7S2204Achr7:7796478092.32   0.000400.00770.008700.00770.0086
D7S2204Bchr7:7796508792.33   0.000400.00840.009500.00840.0094
D7S2212Achr7:8263470196.44   0.00740.00570.13870.1620.00560.13870.1599
D7S2212Bchr7:8263499296.45   0.00740.00570.13860.1620.00560.13860.1599
D7S821Achr7:95895436106.3   0.08370.69811.50861.7930.641.50861.7168
D7S821Bchr7:95895732106.31   0.08370.69921.51011.79450.64111.51011.7182
D7S1799Achr7:103982141113.12   0.0520.25580.88531.08540.23140.88531.0323
D7S1799Bchr7:103982655113.13   0.0520.25530.88451.08440.2310.88451.0314
D7S3061Achr7:123076428128.11   0.0370.13210.64280.78010.11960.64280.742
D7S3061Bchr7:123076823128.12   0.03690.13150.64130.77820.1190.64130.7403
D7S1804Achr7:131930138137.74   -0.00750.0059-0.1399-0.16490.0055-0.1399-0.1589
D7S1804Bchr7:131930474137.75   -0.00750.0059-0.14-0.1650.0055-0.14-0.159
D7S1824Achr7:139658940151.66   -0.04270.2155-0.8959-0.99620.2176-0.8959-1.001
D7S1824Bchr7:139659255151.67   -0.04270.2156-0.8962-0.99640.2177-0.8962-1.0013
D7S2195Achr7:143481169157.01   -0.06720.5152-1.3569-1.54040.51-1.3569-1.5325
D7S2195Bchr7:143481657157.02   -0.06730.5163-1.3583-1.5420.511-1.3583-1.5341
D7S3070Achr7:151197945165.57   -0.07910.9198-1.7601-2.05810.9083-1.7601-2.0452
D7S3070Bchr7:151198369165.58   -0.07910.9193-1.7596-2.05750.9076-1.7596-2.0444
D7S3058Achr7:154198762175.64   -0.05970.4219-1.2403-1.39390.431-1.2403-1.4088
D7S3058Bchr7:154199157175.65   -0.05960.4213-1.2396-1.39290.4304-1.2396-1.4078
D7S559Achr7:156165631182.96   -0.00760.0062-0.1452-0.16920.0065-0.1452-0.173
D7S559Bchr7:156166136182.97   -0.00760.0061-0.1444-0.16830.0064-0.1444-0.1721
Table Legend: Tabular display of linkage analysis results for linear and exponential models with the Spairs scoring
function across the chromosome. The yellow row marks the location of the selected gene, and the whitened
rows correspond to the region 20 Mb around the gene.

 

 

 

References