Metamoodics Gene Information

 

  Chromosome: chr17    Cytoband: q11.2    Gene: SLC6A4

 

MD - Genomewide Linkage Studies for SLC6A4


 

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Description

 
Shown here are the results for gene SLC6A4 from a genomewide linkage analysis of major depression carried out with 656 families and including 1,494 informative all possible affected relative pairs genotyped at 418 microsatellite markers (Holmans et al. 2007; American Journal of Psychiatry)
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 2 different analytic models across the chromosome.
The yellow line marks the location of the selected gene on the chromosome, and the white window
shows 20 Mb around the gene.

Linear: Linear model with Spairs scoring function and equal weighting for all families
Exponential: Exponential model with Spairs scoring function and equal weighting for all families

 

 

 

 

Results Table

 

 


Marker chr:pos_bp (hg18) pos_cM Gene(s) dhat LOD (lin) NPL (lin) Zlr (lin) LOD (exp) NPL (exp) Zlr (exp)      
D17S1308Achr17:5696990   0.02330.03870.29770.42210.03690.29770.4125
D17S1308Bchr17:5703130.01   0.02330.03870.29790.42230.0370.29790.4127
D17S1298Achr17:361327710   0.03370.07970.42590.60590.07580.42590.5909
D17S1298Bchr17:361358710.01   0.03370.07970.42590.60580.07580.42590.5908
D17S974Achr17:1045939027.73   0.07090.57171.48631.62250.65431.48631.7359
D17S974Bchr17:1045969727.74   0.07090.57151.48651.62230.65421.48651.7357
D17S1303Achr17:1080000930.95   0.06210.46291.36721.46010.52661.36721.5573
D17S1303Bchr17:1080036030.96   0.06210.46241.36631.45920.5261.36631.5564
D17S799Achr17:1311168036.7   0.04640.25911.01691.09240.29111.01691.1578
D17S799Bchr17:1311202936.71   0.04640.2591.01661.09210.29091.01661.1575
D17S2196Achr17:1720511747.02   0.03740.17460.84440.89660.19660.84440.9516
D17S2196Bchr17:1720539847.03   0.03740.17430.84370.89590.19630.84370.9508
D17S975Achr17:2512410152.48   0.03670.15940.78580.85670.17550.78580.8989
D17S975Bchr17:2512439452.49   0.03670.15960.78650.85740.17570.78650.8996
- chr17:25549031                
D17S1880Achr17:2803791855.3   0.05090.28881.0291.15330.3091.0291.1928
D17S1880Bchr17:2803829255.31   0.05090.28941.03011.15450.30961.03011.1941
D17S1299Achr17:3624783267.33   0.05630.31641.01461.2070.3251.01461.2234
D17S1299Bchr17:3624814767.34   0.05630.3161.0141.20630.32461.0141.2226
D17S2180Achr17:4402805374.02   0.05940.32220.97911.21810.30970.97911.1942
D17S2180Bchr17:4402834574.03   0.05940.32220.97911.2180.30970.97911.1942
D17S1290Achr17:5368639591.08   0.02450.05820.42550.51770.05280.42550.4929
D17S1290Bchr17:5368672991.09   0.02450.05810.4250.51720.05260.4250.4924
D17S2193Achr17:6405927999.04   -0.02260.0515-0.4052-0.48710.0508-0.4052-0.4838
D17S2193Bchr17:6405954199.05   -0.02260.0515-0.4052-0.48710.0508-0.4052-0.4839
D17S1301Achr17:70192380113.29   -0.00230.0005-0.0364-0.04640.0005-0.0364-0.0474
D17S1301Bchr17:70192704113.3   -0.00230.0005-0.036-0.04590.0005-0.036-0.0469
D17S784Achr17:75416715129.32   0.02130.04650.39170.46260.0460.39170.4602
D17S784Bchr17:75417019129.33   0.02120.04630.39110.46180.04580.39110.4594
D17S928Achr17:77846127135.37   -0.00340.0012-0.0633-0.07420.0012-0.0633-0.074
D17S928Bchr17:77846429135.38   -0.00340.0012-0.0634-0.07430.0012-0.0634-0.0741
Table Legend: Tabular display of linkage analysis results for linear and exponential models with the Spairs scoring
function across the chromosome. The yellow row marks the location of the selected gene, and the whitened
rows correspond to the region 20 Mb around the gene.

 

 

 

References