Metamoodics Gene Information

 

  Chromosome: chr6    Cytoband: q25.1-q25.2    Gene: SYNE1

 

MD - Genomewide Linkage Studies for SYNE1


 

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Description

 
Shown here are the results for gene SYNE1 from a genomewide linkage analysis of major depression carried out with 656 families and including 1,494 informative all possible affected relative pairs genotyped at 418 microsatellite markers (Holmans et al. 2007; American Journal of Psychiatry)
 
Details of the methods for the linkage analysis are provided in methods section.

 

 

Results Figure

 
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Figure Legend: Graphical display of linkage analysis results for 2 different analytic models across the chromosome.
The yellow line marks the location of the selected gene on the chromosome, and the white window
shows 20 Mb around the gene.

Linear: Linear model with Spairs scoring function and equal weighting for all families
Exponential: Exponential model with Spairs scoring function and equal weighting for all families

 

 

 

 

Results Table

 

 


Marker chr:pos_bp (hg18) pos_cM Gene(s) dhat LOD (lin) NPL (lin) Zlr (lin) LOD (exp) NPL (exp) Zlr (exp)      
D6S942Bchr6:7653040   0.0620.19970.57890.9590.19050.57890.9366
F13A1Achr6:523019511.22   0.03880.12130.55980.74730.11890.55980.74
F13A1Bchr6:611618811.23   0.03880.12130.55980.74730.11890.55980.7399
D6S2434Achr6:1405431331.18   0.01380.01630.21220.27430.01590.21220.2704
D6S2434Bchr6:1405462831.19   0.01380.01630.2120.2740.01580.2120.2701
D6S1660Achr6:2342175546.48   -0.04690.258-0.9748-1.09010.2603-0.9748-1.0949
D6S1660Bchr6:2342211846.49   -0.04690.2581-0.9753-1.09030.2604-0.9753-1.0951
D6S2439Achr6:2441467047.93   -0.04670.2642-1.0031-1.10310.2653-1.0031-1.1054
D6S2439Bchr6:2441496447.94   -0.04660.2639-1.0023-1.10230.2649-1.0023-1.1046
D6S2427Achr6:3958323458.62   0.02030.0480.42480.470.05050.42480.4822
D6S2427Bchr6:3958354358.63   0.02030.04810.42570.47090.05070.42570.4831
D6S1017Achr6:4178515163.49   0.0330.11890.64660.73980.12290.64660.7524
D6S1017Bchr6:4178548763.5   0.0330.11870.64630.73950.12280.64630.752
D6S2410Achr6:5075148673.36   0.03330.11020.59450.71240.10680.59450.7013
D6S2410Bchr6:5075178373.37   0.03330.11020.59440.71220.10670.59440.7011
D6S1053Achr6:6464811380.27   0.00690.00490.12770.14990.00460.12770.1456
D6S1053Bchr6:6464860180.28   0.00690.00490.12770.14990.00460.12770.1456
D6S1031Achr6:7751803289.15   0.01610.02560.28470.34310.0240.28470.3327
D6S1031Bchr6:7751834089.16   0.01610.02550.28450.34290.0240.28450.3324
D6S1056Achr6:94154218100.51   -0.030.1012-0.599-0.68280.0988-0.599-0.6747
D6S1056Bchr6:94154488100.52   -0.03010.1013-0.5993-0.68310.0989-0.5993-0.675
D6S1021Achr6:104780425107.16   -0.03210.1061-0.5852-0.69890.1041-0.5852-0.6924
D6S1021Bchr6:104780766107.17   -0.03210.1057-0.5842-0.69770.1038-0.5842-0.6912
D6S474Achr6:112985642115.67   0.00250.00060.0420.05170.00060.0420.0515
D6S474Bchr6:112985976115.68   0.00250.00060.04220.05190.00060.04220.0518
D6S1040Achr6:131027430127.83   -0.02080.045-0.3853-0.45520.0484-0.3853-0.4722
D6S1040Bchr6:131027712127.84   -0.02080.0451-0.3856-0.45560.0485-0.3856-0.4726
D6S1009Achr6:137343777138.77   -0.03680.1542-0.7414-0.84270.1637-0.7414-0.8683
D6S1009Bchr6:137344136138.78   -0.03680.1542-0.7414-0.84270.1637-0.7414-0.8683
C6S1848Achr6:144820420149.36   -0.0230.0562-0.4351-0.50870.0561-0.4351-0.5082
C6S1848Bchr6:145762512149.37   -0.0230.0563-0.4355-0.50920.0562-0.4355-0.5086
- chr6:152484514                
D6S2436Achr6:154177748161.28   -0.04930.2531-0.9123-1.07970.2562-0.9123-1.0861
D6S2436Bchr6:154178202161.29   -0.04930.2529-0.912-1.07920.256-0.912-1.0857
D6S1035Achr6:159946991169.77   -0.05710.3391-1.0539-1.24960.3497-1.0539-1.2689
D6S1035Bchr6:159947275169.78   -0.05710.3394-1.0545-1.25020.35-1.0545-1.2696
D6S1277Achr6:164217713176.13   -0.05840.3542-1.0773-1.27720.356-1.0773-1.2804
D6S1277Bchr6:164218094176.14   -0.05840.3541-1.0772-1.27710.3559-1.0772-1.2802
D6S1027Achr6:168951166190.13   -0.07380.5173-1.2432-1.54350.5339-1.2432-1.5681
D6S1027Bchr6:168951482190.14   -0.07380.518-1.244-1.54450.5346-1.244-1.5691
Table Legend: Tabular display of linkage analysis results for linear and exponential models with the Spairs scoring
function across the chromosome. The yellow row marks the location of the selected gene, and the whitened
rows correspond to the region 20 Mb around the gene.

 

 

 

References